Combined heat and electricity operation with variable mass flow rates promotes flexibility,economy,and sustainability through synergies between electric power systems(EPSs)and district heating systems(DHSs).Such combi...Combined heat and electricity operation with variable mass flow rates promotes flexibility,economy,and sustainability through synergies between electric power systems(EPSs)and district heating systems(DHSs).Such combined operation presents a highly nonlinear and nonconvex optimization problem,mainly due to the bilinear terms in the heat flow model—that is,the product of the mass flow rate and the nodal temperature.Existing methods,such as nonlinear optimization,generalized Benders decomposition,and convex relaxation,still present challenges in achieving a satisfactory performance in terms of solution quality and computational efficiency.To resolve this problem,we herein first reformulate the district heating network model through an equivalent transformation and variable substitution.The reformulated model has only one set of nonconvex constraints with reduced bilinear terms,and the remaining constraints are linear.Such a reformulation not only ensures optimality,but also accelerates the solving process.To relax the remaining bilinear constraints,we then apply McCormick envelopes and obtain an objective lower bound of the reformulated model.To improve the quality of the McCormick relaxation,we employ a piecewise McCormick technique that partitions the domain of one of the variables of the bilinear terms into several disjoint regions in order to derive strengthened lower and upper bounds of the partitioned variables.We propose a heuristic tightening method to further constrict the strengthened bounds derived from the piecewise McCormick technique and recover a nearby feasible solution.Case studies show that,compared with the interior point method and the method implemented in a global bilinear solver,the proposed tightening McCormick method quickly solves the heat–electricity operation problem with an acceptable feasibility check and optimality.展开更多
In this paper,we propose an analytical stochastic dynamic programming(SDP)algorithm to address the optimal management problem of price-maker community energy storage.As a price-maker,energy storage smooths price diffe...In this paper,we propose an analytical stochastic dynamic programming(SDP)algorithm to address the optimal management problem of price-maker community energy storage.As a price-maker,energy storage smooths price differences,thus decreasing energy arbitrage value.However,this price-smoothing effect can result in significant external welfare changes by reduc-ing consumer costs and producer revenues,which is not negligible for the community with energy storage systems.As such,we formulate community storage management as an SDP that aims to maximize both energy arbitrage and community welfare.To incorporate market interaction into the SDP format,we propose a framework that derives partial but sufficient market information to approximate impact of storage operations on market prices.Then we present an analytical SDP algorithm that does not require state discretization.Apart from computational efficiency,another advantage of the analytical algorithm is to guide energy storage to charge/discharge by directly comparing its current marginal value with expected future marginal value.Case studies indicate community-owned energy storage that maximizes both arbitrage and welfare value gains more benefits than storage that maximizes only arbitrage.The proposed algorithm ensures optimality and largely reduces the computational complexity of the standard SDP.Index Terms-Analytical stochastic dynamic programming,energy management,energy storage,price-maker,social welfare.展开更多
Gliding arc is a mostly used non-equilibrium plasma generation method whose characteristic is affected by the backbreakdown phenomenon.Mode transition induced by back-breakdown of the gliding arc is studied in this wo...Gliding arc is a mostly used non-equilibrium plasma generation method whose characteristic is affected by the backbreakdown phenomenon.Mode transition induced by back-breakdown of the gliding arc is studied in this work and effects of gas flow rate,applied voltage,electrode parameters on mode transition were studied.Experimental results show that there are two typical modes during the development of the gliding arc.Mode A comprises periodicitical development of the arc from the minimum gap breakdown to the longest extinguishment,while the arc in mode B continues to produce a back-breakdown at the ends of the electrodes.As the flow rate descends,the gliding arc gradually changes from mode A to B.It is the decrease of the arc velocity caused by lower flow rate leads to the occurrence of back-breakdown,which generates mode B.Smaller electrode opening angle,shorter length and wider minimum gap reduce the gliding speed,so that arc is more likely to enter mode B.As the applied voltage is increased,enhancing of the electric field strength on the breakdown path of the back-breakdown and thickening of the arc's diameter allow the gliding arc to enter mode B at a higher arc speed.展开更多
With the development of manufacturing technology,the propagation loss of the planar waveguide is getting lower and lower,and the shot-noise-limited sensitivity of an HOG will be greatly improved.When the propagation l...With the development of manufacturing technology,the propagation loss of the planar waveguide is getting lower and lower,and the shot-noise-limited sensitivity of an HOG will be greatly improved.When the propagation loss is getting lower,improper coupling-out waveguide in the waveguide coil may lead to non-ignorable bending loss and crosstalk because of the small radius of curvature and X-junction.In this paper,different couplingout waveguides have been designed.After calculation and optimization by the beam propagation method,we found the proper coupling-out waveguide having relatively low propagation loss,which can improve the sensitivity of the HOG.展开更多
Coactivator-associated arginine methyltransferase 1(CARM1)promotes the development and metastasis of estro-gen receptor alpha(ERa)-positive breast cancer.The function of CARM1 in triple-negative breast cancer(TNBC)is ...Coactivator-associated arginine methyltransferase 1(CARM1)promotes the development and metastasis of estro-gen receptor alpha(ERa)-positive breast cancer.The function of CARM1 in triple-negative breast cancer(TNBC)is still unclear and requires further exploration.Here,we report that CARM1 promotes proliferation,epithelial-mesen-chymal transition,and stemness in TNBC.CARM1 is upregulated in multiple cancers and its expression correlates with breast cancer progression.Genome-wide analysis of CARM1 showed that CARM1 is recruited by hypoxia-inducible factor-1 subunit alpha(HIF1A)and occupy the promoters of CDK4,Cyclin D1,β-Catenin,HIF1A,MALAT1,and SIX1 critically involved in cell cycle,HIF-1 signaling pathway,Wnt signaling pathway,VEGF signaling pathway,thereby modulating the proliferation and invasion of TNBC cells.We demonstrated that CARM1 is physically associated with and directly interacts with HIF1A.Moreover,we found that ellagic acid,an inhibitor of CARM1,can suppress the proliferation and invasion of TNBC by directly inhibiting CDK4 expression.Our research has determined the molecular basis of CARM1 carcinogenesis in TNBC and its effective natural inhibitor,which may provide new ideas and drugs for cancer therapy.展开更多
Prednisone is a synthetic glucocorticoid that is commonly used in both human and veterinary medication.Now,it is also recognized as an emerging environmental contaminant.Pregnantwomenmay be exposed to prednisone activ...Prednisone is a synthetic glucocorticoid that is commonly used in both human and veterinary medication.Now,it is also recognized as an emerging environmental contaminant.Pregnantwomenmay be exposed to prednisone actively or passively throughmultiple pathways and cause developmental toxicity to the fetus.However,the impact of prenatal prednisone exposure(PPE)on fetal kidney development remains unclear.In this study,pregnant mice were administered prednisone intragastrically during full-term pregnancy with different doses(0.25,0.5,or 1 mg/(kg·day)),or at the dose of 1 mg/(kg·day)in different gestational days(GD)(GD0-9,GD10-18,or GD0-18).The pregnant mice were euthanized on GD18.HE staining revealed fetal kidney dysplasia,with an enlarged glomerular Bowman’s capsule space and a reduced capillary network in the PPE groups.The expression of the podocyte and the mesangial cell marker genes was significantly reduced in the PPE groups.However,overall gene expression in renal tubules and collecting ducts were markedly increased.All of the above effects were more pronounced in high-dose,full-term pregnancy,and female fetuses.Studies on the mechanism of the female fetal kidney have revealed that PPE reduced the expression of Six2,increased the expression of Hnf1β,Hnf4α,and Wnt9b,and inhibited the expression of glial cell line-derived neurotrophic factor(GDNF)and Notch signaling pathways.In conclusion,this study demonstrated that there is a sex difference in the developmental toxicity of PPE to the fetal kidney,and the time effect is manifested as full-term pregnancy>early pregnancy>mid-late pregnancy.展开更多
基金This work was supported by the Science and Technology Program of State Grid Corporation of China(522300190008).
文摘Combined heat and electricity operation with variable mass flow rates promotes flexibility,economy,and sustainability through synergies between electric power systems(EPSs)and district heating systems(DHSs).Such combined operation presents a highly nonlinear and nonconvex optimization problem,mainly due to the bilinear terms in the heat flow model—that is,the product of the mass flow rate and the nodal temperature.Existing methods,such as nonlinear optimization,generalized Benders decomposition,and convex relaxation,still present challenges in achieving a satisfactory performance in terms of solution quality and computational efficiency.To resolve this problem,we herein first reformulate the district heating network model through an equivalent transformation and variable substitution.The reformulated model has only one set of nonconvex constraints with reduced bilinear terms,and the remaining constraints are linear.Such a reformulation not only ensures optimality,but also accelerates the solving process.To relax the remaining bilinear constraints,we then apply McCormick envelopes and obtain an objective lower bound of the reformulated model.To improve the quality of the McCormick relaxation,we employ a piecewise McCormick technique that partitions the domain of one of the variables of the bilinear terms into several disjoint regions in order to derive strengthened lower and upper bounds of the partitioned variables.We propose a heuristic tightening method to further constrict the strengthened bounds derived from the piecewise McCormick technique and recover a nearby feasible solution.Case studies show that,compared with the interior point method and the method implemented in a global bilinear solver,the proposed tightening McCormick method quickly solves the heat–electricity operation problem with an acceptable feasibility check and optimality.
基金supported in part by the Joint Funds of the National Natural Science Foundation of China(U2066214)in part by Shanghai Sailing Program(22YF1414500)in part by the Project(SKLD22KM19)funded by State Key Laboratory of Power System Operation and Control.
文摘In this paper,we propose an analytical stochastic dynamic programming(SDP)algorithm to address the optimal management problem of price-maker community energy storage.As a price-maker,energy storage smooths price differences,thus decreasing energy arbitrage value.However,this price-smoothing effect can result in significant external welfare changes by reduc-ing consumer costs and producer revenues,which is not negligible for the community with energy storage systems.As such,we formulate community storage management as an SDP that aims to maximize both energy arbitrage and community welfare.To incorporate market interaction into the SDP format,we propose a framework that derives partial but sufficient market information to approximate impact of storage operations on market prices.Then we present an analytical SDP algorithm that does not require state discretization.Apart from computational efficiency,another advantage of the analytical algorithm is to guide energy storage to charge/discharge by directly comparing its current marginal value with expected future marginal value.Case studies indicate community-owned energy storage that maximizes both arbitrage and welfare value gains more benefits than storage that maximizes only arbitrage.The proposed algorithm ensures optimality and largely reduces the computational complexity of the standard SDP.Index Terms-Analytical stochastic dynamic programming,energy management,energy storage,price-maker,social welfare.
基金the National Natural Science Foundation of China under grant no.51677105 and Shenzhen Science,Technology&Innovation Commission(SZSTI)Fund under grant no.JCYJ20180508152057527.
文摘Gliding arc is a mostly used non-equilibrium plasma generation method whose characteristic is affected by the backbreakdown phenomenon.Mode transition induced by back-breakdown of the gliding arc is studied in this work and effects of gas flow rate,applied voltage,electrode parameters on mode transition were studied.Experimental results show that there are two typical modes during the development of the gliding arc.Mode A comprises periodicitical development of the arc from the minimum gap breakdown to the longest extinguishment,while the arc in mode B continues to produce a back-breakdown at the ends of the electrodes.As the flow rate descends,the gliding arc gradually changes from mode A to B.It is the decrease of the arc velocity caused by lower flow rate leads to the occurrence of back-breakdown,which generates mode B.Smaller electrode opening angle,shorter length and wider minimum gap reduce the gliding speed,so that arc is more likely to enter mode B.As the applied voltage is increased,enhancing of the electric field strength on the breakdown path of the back-breakdown and thickening of the arc's diameter allow the gliding arc to enter mode B at a higher arc speed.
基金Project supported by the National Natural Science Foundation of China(Nos.61274066,61504138,61474115)the National Key Research and Development Program of China(No.2016YFA02005003)
文摘With the development of manufacturing technology,the propagation loss of the planar waveguide is getting lower and lower,and the shot-noise-limited sensitivity of an HOG will be greatly improved.When the propagation loss is getting lower,improper coupling-out waveguide in the waveguide coil may lead to non-ignorable bending loss and crosstalk because of the small radius of curvature and X-junction.In this paper,different couplingout waveguides have been designed.After calculation and optimization by the beam propagation method,we found the proper coupling-out waveguide having relatively low propagation loss,which can improve the sensitivity of the HOG.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.41931291,42125707,81802816,81902882,and 82273403)Major State Basic Research Development Program of China(2022YFA1103402)+1 种基金Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310027,2021-RC310-006)Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-018).
文摘Coactivator-associated arginine methyltransferase 1(CARM1)promotes the development and metastasis of estro-gen receptor alpha(ERa)-positive breast cancer.The function of CARM1 in triple-negative breast cancer(TNBC)is still unclear and requires further exploration.Here,we report that CARM1 promotes proliferation,epithelial-mesen-chymal transition,and stemness in TNBC.CARM1 is upregulated in multiple cancers and its expression correlates with breast cancer progression.Genome-wide analysis of CARM1 showed that CARM1 is recruited by hypoxia-inducible factor-1 subunit alpha(HIF1A)and occupy the promoters of CDK4,Cyclin D1,β-Catenin,HIF1A,MALAT1,and SIX1 critically involved in cell cycle,HIF-1 signaling pathway,Wnt signaling pathway,VEGF signaling pathway,thereby modulating the proliferation and invasion of TNBC cells.We demonstrated that CARM1 is physically associated with and directly interacts with HIF1A.Moreover,we found that ellagic acid,an inhibitor of CARM1,can suppress the proliferation and invasion of TNBC by directly inhibiting CDK4 expression.Our research has determined the molecular basis of CARM1 carcinogenesis in TNBC and its effective natural inhibitor,which may provide new ideas and drugs for cancer therapy.
基金supported by the National Key Research and Development Program of China(No.2020YFA0803900)the National Natural Science Foundation of China(No.81872943)。
文摘Prednisone is a synthetic glucocorticoid that is commonly used in both human and veterinary medication.Now,it is also recognized as an emerging environmental contaminant.Pregnantwomenmay be exposed to prednisone actively or passively throughmultiple pathways and cause developmental toxicity to the fetus.However,the impact of prenatal prednisone exposure(PPE)on fetal kidney development remains unclear.In this study,pregnant mice were administered prednisone intragastrically during full-term pregnancy with different doses(0.25,0.5,or 1 mg/(kg·day)),or at the dose of 1 mg/(kg·day)in different gestational days(GD)(GD0-9,GD10-18,or GD0-18).The pregnant mice were euthanized on GD18.HE staining revealed fetal kidney dysplasia,with an enlarged glomerular Bowman’s capsule space and a reduced capillary network in the PPE groups.The expression of the podocyte and the mesangial cell marker genes was significantly reduced in the PPE groups.However,overall gene expression in renal tubules and collecting ducts were markedly increased.All of the above effects were more pronounced in high-dose,full-term pregnancy,and female fetuses.Studies on the mechanism of the female fetal kidney have revealed that PPE reduced the expression of Six2,increased the expression of Hnf1β,Hnf4α,and Wnt9b,and inhibited the expression of glial cell line-derived neurotrophic factor(GDNF)and Notch signaling pathways.In conclusion,this study demonstrated that there is a sex difference in the developmental toxicity of PPE to the fetal kidney,and the time effect is manifested as full-term pregnancy>early pregnancy>mid-late pregnancy.