21色流式检测人非小细胞肺癌组织中免疫细胞亚群方案的建立

背景与目的肺癌组织的免疫微环境已成为关注的重点,随着多色流式的兴起,流式检测肺癌免疫微环境成为重要的手段,但多为检测细胞亚群占比或主要细胞亚群功能,无法同时对两者进行检测。因此本研究建立了一种可靠的21色流式方案,以检测人非小细胞肺癌(non-small cell lung cancer,NSCLC)肿瘤组织中免疫细胞各亚群。方法选用细胞膜表面抗体细胞分化簇(cluster of differentiation,CD)45、CD3、CD19、CD4、CD8、程序性死亡受体1(programmed cell death 1,PD-1)、CD39、CD103、CD25、CD127、趋化因子受体8(chemokine receptor8,CCR8)、CD56、CD11c、人类白细胞抗原(human leukocyte antigen,HLA)-DR、CD38、CD27、CD69、CD62L、CD45RA、CCR7和核酸染料L/D制定方案。首先对各抗体进行抗体滴定实验、电压优化、减一色染色和单色染色实验,确定各实验条件及检测方案后,采用6例健康成年志愿者外周血单个核细胞(peripheral blood mononuclear cells,PBMCs)标本验证方案的可行性;检测分析6例NSCLC患者的肿瘤组织样本。结果采用建立的21色流式方案检测了6例NSCLC患者的肿瘤组织样本,可分析出肺癌组织中各细胞亚群的占比及主要细胞群的免疫表型和分化情况。结论成功建立的21色流式方案适用于PBMCs和NSCLC组织样本检测,为监测肺癌中免疫微环境状态提供了一种有效的新思路。

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy patients.These aggregates alter protein-protein interactions and compromise transcriptional activity.In this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic factor.Overexpressio n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor aggregation.Conversely.knocking down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor aggregation.Our findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

Microenvironment and electronic state modulation of Pd nanoparticles within MOFs for enhancing low-temperature activity towards DCPD hydrogenation

Precise control of the local environment and electronic state of the guest is an important method of controlling catalytic activity and reaction pathways.In this paper,guest Pd NPs were introduced into a series of host UiO-67 MOFs with different functional ligands and metal nodes,the microenvironment and local electronic structure of Pd is modulated by introducing bipyridine groups and changing metal nodes(Ce_(6)O_(6) or Zr_(6)O_(6)).The bipyridine groups not only promoted the dispersion Pd NPs,but also facilitated electron transfer between Pd and UiO-67 MOFs through the formation of Pd-N bridges.Compared with Zr6 clusters,the tunability and orbital hybridisation of the 4f electronic structure in the Ce_(6) clusters modulate the electronic structure of Pd through the construction of the Ce-O-Pd interfaces.The optimal catalyst Pd/UiO-67(Ce)-bpy presented excellent low-temperature activity towards dicyclopentadiene hydrogenation with a conversion of>99% and a selectivity of>99%(50℃,10 bar).The results show that the synergy of Ce-O-Pd and Pd-N promotes the formation of active Pd^(δ+),which not only enhances the adsorption of H_(2) and electron-rich C=C bonds,but also contributes to the reduction of proton migration distance and improves proton utilization efficiency.These results provide valuable insights for investigating the regulatory role of the host MOFs,the nature of host-guest interactions,and their correlation with catalytic performance.

Tunable superconducting resonators via on-chip control of local magnetic field

Superconducting microwave resonators play a pivotal role in superconducting quantum circuits.The ability to finetune their resonant frequencies provides enhanced control and flexibility.Here,we introduce a frequency-tunable superconducting coplanar waveguide resonator.By applying electrical currents through specifically designed ground wires,we achieve the generation and control of a localized magnetic field on the central line of the resonator,enabling continuous tuning of its resonant frequency.We demonstrate a frequency tuning range of 54.85 MHz in a 6.21-GHz resonator.This integrated and tunable resonator holds great potential as a dynamically tunable filter and as a key component of communication buses and memory elements in superconducting quantum computing.

Application of Immersive Media Technology in Ideological and Political Theory Courses Instruction at Shandong Vocational Colleges

This paper describes how virtual classrooms and out-of-classroom instruction can be used to help students in ideological and political theory courses strengthen their identities and improve the efficiency of their assignments.By using immersive media technology,the course is turned into a form of entertainment,enriched with content,and combined with methods such as digital video editing and manipulation to meet the needs of students in university ideological and political theory courses.Virtual reality technology can create realistic virtual environments created by computers,enabling students to perceive and manipulate a variety of virtual objects,interact with them,and create a sense of immersion in the virtual environment.Research has shown the potential benefits of using immersive media technologies and augmented reality in education.The potential of virtual reality in education has been increasingly emphasized and has been widely researched and applied.

Three-dimensional crystal plasticity and HR-EBSD analysis of the local stress-strain fields induced during twin propagation and thickening in magnesium alloys

Present work focuses on analysis of the stress and strain fields inside and around the individual {10–12} twin in magnesium alloy. The 3D crystal plasticity model represents twin as an ellipsoidal inclusion surrounded by the matrix. Five different twin thicknesses and three different lateral twin lengths are used for stress/strain analysis. The simulations are complemented with experimental observations using high-resolution electron backscattered diffraction. The simulations and experiments show a similar distribution of the shear stress and the spatial activity of individual slip systems(basal, prismatic, pyramidal). Plasticity induced inside the twin is dominantly caused by the prismatic dislocations slip and does not influence twin back stress which is identical to pure elastic twin. The twin with larger lateral dimension requires lower equilibrium stress which suggests anisotropic twin propagation and increased thickness of such twins. The lateral twin propagation is mostly influenced by prismatic and pyramidal slip in the twin vicinity. The twin thickness can reach a maximal level that is driven by the critical resolved shear stress values for dislocation slip with the significant influence of basal slip.

De Novo Transcriptome Analysis in Hevea brasiliensis to Unveil Genes Involved in Low Temperature Stress Response

Low temperature is one of the adversities threatening the growth and development and reduces the yield of rubber trees.However,molecular mechanisms toward rubber trees in response to low temperature are largely unclear.In this study,7,159 and 7,600 differentially expressed genes(DEGs)were identified in‘Reyan 73397’rubber trees.Through GO analysis,the catalytic activity was the representative of the GO term in the only DEGs at the two studied temperatures(room temperature and 4°C,respectively),while KEGG analysis showed that carbon metabolism was the most important grouping under the comparison of these two temperatures.In addition,expression of 9 members of transcription factor MYB family genes were further verified by qRT-PCR,and MYB family genes may play important roles in the regulation of rubber trees under low temperature stress.This study provided a theoretical foundation for(1)revealing the molecular mechanisms of rubber trees in response to low temperature and(2)breeding of tolerant varieties of rubber trees.

Extraction of Cinnamomum longepaniculatum deciduous leaves essential oil using solvent-free microwave extraction: Process optimization and quality evaluation

The optimal process conditions for solvent-free microwave extraction(SFME)of essential oils from Cinnamomum longepaniculatum deciduous leaves after moisture conditioning were established by response surface methodology(RSM).A Box-Behnken design(BBD)was applied to evaluate the effects of three independent variables:moisture content(A:54%–74%),microwave power(B:300–500 W)and microwave time(C:20–40 min),on the extraction yield of essential oil.The compounds of the essential oils obtained by SFME,hydro-distillation and microwaveassisted hydro-distillation(MADE)were identified by gas chromatography-mass spectrometry(GC-MS),and the total lipids of C.longepaniculatum fresh leaves and deciduous leaves were analyzed.The correlation analysis of the response regression model indicated that quadratic polynomial model could be employed to optimize the extraction of essential oil.The optimal extraction condition was A:58%,B:400 W and C:28 min.In the optimal condition,the maximum extraction yield was 4.475 mL/100 g dw and higher than that by MADE.The main compound of the essential oil was eucalyptol(63.54%),and total oxygenated compounds was 78.95%,mainly caused by SFME and the metabolism of endophytic bacteria with decreasing content of phospholipids and fatty acids.Analysis of variance under the extraction condition illustrated high fitness of the model and the success of RSM for optimizing and reflecting the expected process condition.SFME combined with moisture regulation was an effective method for extracting essential oil from C.longepaniculatum deciduous leaves.

Pretreatment of emulational manual acupuncture versus electroacupuncture against visceral traction pain in rats

BACKGROUND： Acupuncture and moxibustion against visceral noxious stimulation present different mechanisms in the peripheral and central nervous systems, involving release of neurotransmitter substance P, acetylcholine esterase, leucine-enkephalin, and c-Fos protein expression. However, there are few reports addressing changes in neurotransmitter expression following manual acupuncture and electroacupuncture against visceral traction pain.OBJECTIVE： To explore changes in neurotransmitter expression in the ileum and protein expression in the medullary visceral zone of visceral traction pain rats undergoing pretreatment of emulational manual acupuncture, and to investigate the differences between emulational manual acupuncture and electroacupuncture.DESIGN, TIME AND SETTING： The randomized, controlled study was performed at the Biomedical Engineering Laboratory, Shanghai University of Traditional Chinese Medicine, Shanghai, China from August 2008 to July 2009.MATERIALS： G6805 electroacupuncture apparatus （Shanghai Medical Electronic Machine Factory, China） and ZSF-I acupuncture manipulation simulation therapeutic system （Chinese Medical Engineering Room, Shanghai University of Traditional Chinese Medicine, Shanghai China） were used in the present study.METHODS： A total of 40 male Sprague Dawley rats were equally and randomly assigned to sham surgery, model, emulational manual acupuncture and electroacupuncture groups. In the emulational manual acupuncture and electroacupuncture groups, emulational manual acupuncture and electroacupuncture were applied at bilateral Zusanli （ST 36） acupoints for 30 minutes, and models of visceral traction pain were established immediately.MAIN OUTCOME MEASURES： Substance P expression, c-Fos and glial fibrillary acidic protein expression were measured using immunohistochemistry. Acetylcholine esterase activity was examined utilizing a colorimetric method. Leucine-enkephalin content was detected using a radioimmune assay. Degree of pain in rats was assessed by pain score.RESULTS： Pain score, substance P expression in the ileum, acetylcholine esterase activity, expression of c-Fos protein and glial fibrillary acidic protein in the medullary visceral zone were significantly decreased following pretreatment of emulational manual acupuncture and electroacupuncture in rats with visceral traction pain （P〈0.05）. Compared with the electroacupuncture group, the leucine-enkephalin content was significantly increased, and pain score was significantly diminished in the emulational manual acupuncture group （P〈0.05）.CONCLUSION： Emulational manual acupuncture pretreatment decreases acetylcholine esterase activity, increases leucine-enkephalin release, downregulates expression of c-Fos protein and glial fibrillary acidic protein and ultimately inhibits visceral traction pain by reducing substance P release. The effectiveness in inhibiting visceral traction pain is greater when using emulational manual acupuncture compared with electroacupuncture. This is because emulational manual acupuncture effectively increases leucine-enkephalin release.

Isolation and identification of novel casein-derived bioactive peptides and potential functions in fermented casein with Lactobacillus helveticus

The present study here establishes a complete and effective method for isolating,purifying and identifying extracellular and intracellular peptides,and also describes the characters and bioactivities of peptides from fermented casein with Lactobacillus helveticus.Intracellular peptides are much larger in quantity and more complex in composition than extracellular peptides,between which the correlation reveals proteolytic and metabolic mechanisms.In addition,totally 241 different peptide sequences were identified by Nano LC–MS/MS from casein(212)and Lactobacillus helveticus proteins(29).These casein-derived peptides mostly originated from-casein,followed byS1-casein,-casein,andS2-casein,and came from extracell(69)and intracell(143),in which common peptides have a total of 27.Forty-four of the identified peptides were previously described as bioactive,including angiotensinconverting enzyme(ACE)-inhibitory,antioxidant,immunomodulating,antimicrobial,DPP-IV inhibitory,antiamnesic and anticancer effects and so on.Thirteen peptides with the potential of some biological activities are obtained,which were described in previous studies.A total of 47 novel peptides of 5 to 26 amino acids that were not disclosed were obtained.The new sources of natural bioactive peptides may have the very high application value as potential new peptide drugs for treatment human diseases.The product peptide DELQDKIHPF found in both extracell and intracell was quantitatively analyzed using the MRM mode of UPLC-U3Q,23.1 and 9.76 ng/mL,respectively.The quantitative analysis of the potential bioactive peptide may also advance the production of peptide products in the future.

Identification and dipeptidyl peptidase Ⅳ(DPP-Ⅳ) inhibitory activity verification of peptides from mouse lymphocytes

The objective of this study was to isolate and identify the intracellular bioactive peptides from mouse lymphocytes before and after lipopolysaccharide(LPS)stimulation,to explore novel peptides and to research the bioactive function.Mouse spleen lymphocytes were isolated and cultured with LPS stimulation(experimental group)or not(control group)to collect intracellular peptides.Totally 385 peptides were analyzed by nanoliter liquid phase-Q Exactive quadrupole ultra-high resolution orbitrap mass spectrometer(Nano LC-Q Exactive Plus)and identifi ed by PEAKS X software.After compared with peptides reported,131 novel peptides were discovered,which then were predicted bioactivity by Peptide Ranker and 6 peptides with high bioactivity were predicted function by BIOPEP-UMW database.Prediction data showed that they may have dipeptidyl peptidase IV(DPP-IV)inhibitory activity.Finally,two peptides showed better potent inhibition were verifi ed with competitive and noncompetitive modes.

Shoot proliferation and callus regeneration from nodular buds of Drepanostachyum luodianense

This research reports on an efficient shoot proliferation and callus regeneration system for bamboo.Young, semi-lignified branches with one lateral bud from Drepanostachyum luodianense(Yi et R. S. Wang) Keng f.were used as explants. Disinfection with 0.1% HgCl2 for 8 min was the optimum treatment and the best medium for bud initiation was Murashige and Skoog(MS) medium containing 3.0 mg L-16-benzyladenine(BA). Multiple shoots were induced from nodal shoot segments on MS medium containing 5.0 mg L-1 BA, 0.5 mg L-1 kinetin(Kin), and 1.0 mg L-1 naphthaleneacetic acid(NAA). The highest frequency of callus formation(65.6%) was on MS medium containing 4.0 mg L-12,4-dichlorophenoxyacetic acid(2, 4-D), 0.5 mg L-1 NAA, and 0.1 mg L-1 thidiazuron(TDZ). The optimum medium for callus proliferation was MS medium with 4 mg L-12,4-D, 0.5 mg L-1 TDZ and 0.5 mg L-1 NAA, and the optimum hormone combination was 4 mg L-1 BA ? 0.5 mg L-1 NAA for callus redifferentiation(up to 85.6%). A 100% rooting was achieved on MS medium supplemented with 2.0 mg L-1 NAA and 0.5 mg L-13-indole butyric acid(IBA). Rooted plantlets were acclimatized in a greenhouse in humus soil ? perlite(1:1) substrate. These micropropagated callus induction and regeneration systems for bamboo will be useful for genetic engineering and multiplication.

Polymorphism Analysis of RXFP2 in Different Sheep Breeds from Qinghai-Tibet Plateau of China

Relaxin/insulin-like family peptide receptor 2 （RXFP2） is a robust candidate gene related to horn types in sheep. A series of independent genome-wide association studies have reported that RXFP2 underlies the existence and lack of horns. In this study, High-Resolution Melting （HRM） analysis and DNA sequencing were employed to detect the polymorphism of RXFP2 gene in three sheep breeds from Qinghai-Tibet Plateau of China （ Tibetan sheep, Qinghai fine wool sheep and Alpine Merino sheep） and to determine the impacts of genotypes of RXFP2 on expression of horn phenotypes. The results showed that one single nucleotide pol- ymorphism （SNP） was identified as RXFP 2SNP c. 29389966 A 〉 G. The frequency of genotype AA in Alpine Merino ram （polled） was significantly higher than that in Tibetan ram （horned） and Qinghai fine wool ram （horned） Ix2（1, N= 421） = 72.25, P〈 0.001; xZ（1, N= 402） = 4.28, P〈 0.005）]; the fre- quency of genotype AA in Qinghai fine wool ewe （polled） was also much higher than that in Qinghai fine wool ewe （horned） and Tibetan ewe （horned） [x2（1, N = 196） = 42.04, P 〈 0. 001 ; x2 （ 1, N = 192） = 24. 69, P 〈 0. 005 ） ]. This mutation could potentially be exploited in marker-assisted selection （MAS） pro- grams within sheep industry to breed horned or polled animals.

Preparation and bioactivity evaluation of low salt peptide from sunf lower seed meal

Sunflower seed meal peptide as one sort of bioactive peptide has intensively application prospects. However, preparation of low salt peptide from sunflower seed meal with high efficiency remains a challenge. In this study, single and compound proteases were optimized to hydrolyze protein. Results showed that hydrolysis at pH 7.0 by proteases resulted in ash content in the range of 5.66%-7.37% and small peptides. Among all hydrolysis processes, sequential hydrolysis of Alcalase with Flavourzyme and Alcalase with Protamex showed higher nitrogen recovery ratio (67.66% and 66.49%, respectively). Furthermore, biological activities of peptides were investigated by testing their ABTS (2,2-azinobis (3-ethylben-zothiazoline-6-sulfonic acid) diammonium salt) radical scavenging activity, DPPH (2,2-diphenyl-1-picrylhydrazil) radical scavenging activity and angiotensin converting enzyme (ACE) inhibitory activity. Peptide hydrolyzed by Alcalase with Papain presented the highest antioxidant activity, followed by Alcalase with Protamex, with ABTS scavenging rate as 63.01% and 31.75%, and DPPH scavenging rate as 56.04% and 28.06%, respectively. Synchronously, peptide hydrolyzed by Alcalase with Protamex and Alcalase with Alcalase had the highest ACE inhibitory activity (56.74%, 56.76%). In conclusion, hydrolysis by proteases Alcalase with Protamex at pH 7.0 was the most effective method for the preparation of low salt peptide from sunflower seed meal, which could be an alternative for anti-oxidants and anti-vasoconstrictor.

Influence of temperature on twinning dominated pop-ins during nanoindentation of a magnesium single crystal

The present paper examines the temperature sensitivity of tensile twinning in a magnesium single crystal during nanoindentation of the prismatic plane. High temperature indentations from 25 ℃ to 250 ℃ were employed on a well polished magnesium single crystal {10-10}plane. For a indentation curve displaying a pop-in, a single twin was seen on the sample surface using Atomic Force Microscopy(AFM)imaging. For indentations that produced no pop-in, no twinning was observed. We thus conclude the pop-in arises from a twinning event in the present case. With increasing temperature, the mean pop-in load(measured from 200 repeat indentations of each testing temperature)drops markedly. This is interpreted by the thermal activation of nucleation of lattice dislocations, which immediately trigger a twinning event.Thermal activation analysis yields activation energies that are consistent with this idea. With increasing temperature the pop-ins became deeper and the twins, after further indentation, showed more growth. It is likely that non-basal slip is activated in the stress concentrations that arise during twinning and the thermal activation of this slip accounts for the observed temperature effects. It is concluded that in interpreting the temperature sensitivity of twinning stresses, any associated lattice dislocation activity must be considered.

Functional Brain Network Learning Based on Spatial Similarity for Brain Disorders Identification

Functional brain network (FBN) measures based on functional magnetic resonance imaging (fMRI) data, has become important biomarkers for early diagnosis and prediction of clinical outcomes in neurological diseases, such as Alzheimer’s diseases (AD) and its prodromal state (i.e., Mild cognitive impairment, MCI). In the past decades, researchers have developed numbers of approaches for FBN estimation, including Pearson’s correction (PC), sparse representation (SR), and so on. Despite their popularity and wide applications in current studies, most of the approaches for FBN estimation only consider the dependency between the measured blood oxygen level dependent (BOLD) time series, but ignore the spatial relationships between pairs of brain regions. In practice, the strength of functional connection between brain regions will decrease as their distance increases. Inspired by this, we proposed a new approach for FBN estimation based on the assumption that the closer brain regions tend to share stronger relationships or similarities. To verify the effectiveness of the proposed method, we conduct experiments on a public dataset to identify the patients with MCIs from health controls (HCs) using the estimated FBNs. Experimental results demonstrate that the proposed approach yields statistically significant improvement in seven performance metrics over using the baseline methods.

Study on the mechanism of Wikstroemia indica in the treatment of inflammatory diseases based on network pharmacology

Wiksroemia indica belongs to the family of Thymelaeaceae.As a material of Traditional Chinese Medicine,it is mainly used to treat inflammation-related diseases.However,due to its complex composition,the scientific basis for its traditional application is still insufficient and the mechanism of action is still unclear.At present,most studies on its anti-inflammatory effect focus on a certain component and its different solvent fractions.There are few reports about the synergistic mechanism of the constituents from W.indica for the treatment of inflammatory diseases.Therefore,the present study aimed to uncover its potential mechanism from a holistic perspective using the network pharmacology approach.Firstly,compounds in W.indica and genes associated with inflammatory diseases were obtained.Then,the active compounds were screened out and their targets were predicted.After that,the key targets for W.indica to treat inflammatory diseases were screened out.Finally,the protein-protein interaction(PPI),Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of key targets were performed to further study the mechanism of W.indica in the treatment of inflammatory diseases.The results showed that the active constituents of W.indica might play an anti-inflammatory role through the key targets CYP19A1 and CYP1B1,which clarified the primary mechanism for the treatment of inflammatory diseases and provided a scientific basis for further study of this herb.

青藏高原东缘汶川地震断层陡坎类型与级联破裂模型(英文)

The post-earthquake field investigations reveal that the MW7.9 Wenchuan earthquake of 12th May 2008 ruptured three NE-striking imbricate reverse faults and another NW-trending reverse fault, along the middle Longmenshan fold-and-thrust belt at the eastern margin of the Tibetan plateau. The fault-scarp features can be categorized into eight groups: simple thrust scarp, hanging-wall collapse scarp, simple pressure ridge, dextral pressure ridge, fault-related fold scarp, back-thrust pressure ridge, local normal fault scarp and crocodile-mouth-like scarp. The local normal scarp is first discovered in the reverse-faulting earthquakes as ever reported in the world. Field observation indicates that the Wenchuan earthquake surface rupture is dominated by reverse faulting with a minus right-lateral component, but the relative ratio varies from site to site. Also, the surface ruptures can be divided, for the first order, into two segments, the Yingxiu and Beichuan segments, corresponding to MW7.8 and MW7.57 events, respectively. The two segments further can be divided, for the second order, into four sub-segments in total, which are equivalent to four sub-events of MW7.46, MW7.69, MW6.99 and MW7.52, respectively. The fault segmentation, for different orders, shows a cascade-rupturing pattern and can explain why the quake time of the Wenchuan earthquake was so long as up to 100 second. Aftershock focal mechanisms are also used to constrain the fault geometry for the sub-segments, indicating that the seismogenic faults are listric at depth and in general, the fault plane becomes steeper northward, which enables the fault to accommodate larger strike-slip motion. This earthquake also confirms that the crustal shortening across the Longmenshan fold-and-thrust belt should be responsible for the growth of high topographic relief along the eastern margin of the Tibetan Plateau.

一种实现任意窄带光谱检测的有机光电探测器通用策略

窄带光电探测器因其优异的综合性能,在光谱仪、激光雷达、光通信和监控等关键应用领域广受欢迎.尽管窄带硅基探测器在当前市场上占据主导地位,但其本征刚性、光学带隙固定和尺寸大的特性极大地限制了其在新兴领域的应用,尤其是在柔性和可穿戴光电子领域.在本工作中,我们报道了一种构筑窄带有机光电探测器(OPD)的简单通用策略.该策略通过溶液法将活性层中的给体和受体材料制备成光学调制层(OAL),并集成在OPD上,可实现对任意光谱的检测.利用该策略,我们成功地构筑了以750 nm为中心的窄带OPD,其半峰宽(FWHM)为40 nm,光谱响应率为3667,-3 dB截止频率为927 kHz,打破了自驱动窄带OPD的性能记录.值得注意的是,这种新颖的OAL策略在OPD中具有良好的通用性,可以实现对600至1000 nm范围内的任意窄光谱检测,具有FWHM可调(最小步长为2 nm)、响应度和探测率高、响应速度快的优势.受益于有机半导体固有的柔性特性,我们构筑了一种柔性且可弯曲的窄带近红外OPD线性阵列,并应用于全向激光雷达上,在无需机械旋转的情况下实现了360°水平扫描.

基于隧穿宽度调制的具有超高开态电流的二维Tl_(2)O隧穿场效应晶体管

隧穿场效应晶体管作为后CMOS时代的低功耗器件引起了人们的极大关注.基于带间隧穿机制,隧穿场效应晶体管具有抑制亚阈值摆幅低于60 mV dec^(-1)的潜力.然而,与金属氧化物半导体场效应晶体管相比,传统隧穿场效应晶体管的开态电流相对较低,阻碍了其实际应用.在此,我们提出二维Tl_(2)O材料具有直接且合适大小的带隙,小的电子和空穴有效质量,独特的三重简并和强各向异性电子结构,这适合作为口袋掺杂隧穿场效应晶体管的沟道材料.得益于口袋导致的降低的隧穿宽度,栅极长度为10 nm的二维Tl_(2)O隧穿场效应晶体管具有3449μAμm^(-1)的超高开态电流,具有亚热的亚阈值摆幅,其值为49 mV dec^(-1).值得注意的是,与未实施口袋掺杂的情况相比,开态电流的值提高到441%,并且成功满足了国际设备和系统路线图对于2028年高性能器件的要求.这项工作展示了二维Tl_(2)O口袋隧穿场效应晶体管在下一代低功耗高性能纳米电子学中的巨大潜力.