掌握岩体的渗透性是精细化描述一个地区水文地质特征的重要工作。渗透系数是表征岩体渗透性的重要指标,研究渗透系数估算模型对于实际工程应用具有重要意义。在现有的渗透系数估算模型中,单因子模型忽略了其他因素对该地区渗透系数的综...掌握岩体的渗透性是精细化描述一个地区水文地质特征的重要工作。渗透系数是表征岩体渗透性的重要指标,研究渗透系数估算模型对于实际工程应用具有重要意义。在现有的渗透系数估算模型中,单因子模型忽略了其他因素对该地区渗透系数的综合影响,复合因子模型存在参数选取不够灵活、部分参数较难获取等问题。基于公开数据,分类整理和对比分析了影响裂隙岩体渗透性的正、负相关参数,提出一种拟合效果好、参数选取灵活的渗透系数估算模型PNC(Positive and Negative Correlation)模型。研究结果表明:在研究区一,PNC模型的拟合效果(可决系数R^(2)=0.964和R^(2)=0.801)优于HC模型的拟合效果(R^(2)=0.905和R^(2)=0.563);在研究区二,PNC模型的拟合效果(R^(2)=0.959)优于RMP模型的拟合效果(R^(2)=0.927);在研究区三,PNC模型的拟合效果(R^(2)=0.94~0.99)优于ZRF模型的拟合效果(R^(2)=0.92~0.99)。利用纳什效率系数(Nash-Sutcliffe Coefficient,NSE)进行模型误差分析,7组数据中有5组数据的误差系数在0.95以上。这说明PNC模型具有便利性和可靠性,可以为实际工程估算和验证渗透系数提供一定的参考。展开更多
In this study, biochars from rice straw （Oryza sativa L.） were prepared at 200-600 ℃ by oxygen-limited pyrolysis to investigate the changes in properties of rice straw biochars produced at different temperatures, a...In this study, biochars from rice straw （Oryza sativa L.） were prepared at 200-600 ℃ by oxygen-limited pyrolysis to investigate the changes in properties of rice straw biochars produced at different temperatures, and to examine the adsorption capacities of the biochars for a heavy metal, copper（II） （Cu（II））, and an organic insecticide of cyromazine, as well as to further reveal the adsorption mechanisms. The results obtained with batch experiments showed that the amount of Cu（II） adsorbed varied with the pyrolysis temperatures of rice straw biochar. The biochar produced at 400 ~C had the largest adsorption capacity for Cu（II） （0.37 mol kg-1） among the biochars, with the non-electrostatic adsorption as the main adsorption mechanism. The highest adsorption capacity for cyromazine （156.42 g kg-1） was found in the rice straw biochar produced at 600 ℃, and cyromazine adsorption was exclusively predominated by surface adsorption. An obvious competitive adsorption was found between 5 mmol L-1 Cu（II） and 2 g L-1 cyromazine when they were in the binary solute system. Biochar may be used to remediate heavy metal- and organic insecticide-contaminated water, while the pyrolysis temperature of feedstocks for producing biochar should be considered for the restoration of multi-contamination.展开更多
OBJECTIVE:To investigate the underlying mechanism of the effect of Fengreqing oral liquid(风热清口服液,FOL)on wind-heat pattern(WHP).METHODS:In this study,we predicted the potential targets of FOL via the approach of ...OBJECTIVE:To investigate the underlying mechanism of the effect of Fengreqing oral liquid(风热清口服液,FOL)on wind-heat pattern(WHP).METHODS:In this study,we predicted the potential targets of FOL via the approach of network pharmacology and verified it by in vitro inflammation model.In the network pharmacology part,two strategies,namely the direct target search and the indirect one,were used to collect the target sets of FOL in WHP treatment.The enrichment analysis was carried out by David database and Clue Go plug-in in Cytoscape.Furthermore,the potential targets were mapped in the candidate pathways.In the verification experiment section,in vitro model of lipopolysaccharide(LPS)induced RAW 264.7 was used to confirm the predictive results in the network pharmacology part.RESULTS:Through the two screening strategies,a total of 141 non-repetitive intervention targets of FOL on WHP were obtained.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis showed that the intervention effect was mainly focused on the anti-inflammatory effect,and the Toll-like receptor signaling pathway was one of the most critical regulatory pathways.Further mapping analysis showed that phosphatidylinositol 3-kinase(PI3 K)-protein kinase B(AKT)signaling transfer might be the key part of regulating the concentration of inflammation mediators of FOL in the Toll-like receptor signaling pathway.In vitro experiment showed that FOL significantly reduced the levels of NO,IL-1,IL-6,and TNF-αproduced by RAW264.7 induced by LPS.Further immunofluorescence found that this effect is related to the regulation of PI3 K-AKT pathway activity by FOL.CONCLUSION:FOL can intervene in WHP by regulating the content of inflammatory mediators via the PI3 K-AKT pathway.展开更多
文摘掌握岩体的渗透性是精细化描述一个地区水文地质特征的重要工作。渗透系数是表征岩体渗透性的重要指标,研究渗透系数估算模型对于实际工程应用具有重要意义。在现有的渗透系数估算模型中,单因子模型忽略了其他因素对该地区渗透系数的综合影响,复合因子模型存在参数选取不够灵活、部分参数较难获取等问题。基于公开数据,分类整理和对比分析了影响裂隙岩体渗透性的正、负相关参数,提出一种拟合效果好、参数选取灵活的渗透系数估算模型PNC(Positive and Negative Correlation)模型。研究结果表明:在研究区一,PNC模型的拟合效果(可决系数R^(2)=0.964和R^(2)=0.801)优于HC模型的拟合效果(R^(2)=0.905和R^(2)=0.563);在研究区二,PNC模型的拟合效果(R^(2)=0.959)优于RMP模型的拟合效果(R^(2)=0.927);在研究区三,PNC模型的拟合效果(R^(2)=0.94~0.99)优于ZRF模型的拟合效果(R^(2)=0.92~0.99)。利用纳什效率系数(Nash-Sutcliffe Coefficient,NSE)进行模型误差分析,7组数据中有5组数据的误差系数在0.95以上。这说明PNC模型具有便利性和可靠性,可以为实际工程估算和验证渗透系数提供一定的参考。
基金supported by the National Natural Science Foundation of China (Nos.41371245 and 41230855)the National Key Technology R&D Program of China (No.2012BAJ24B06)
文摘In this study, biochars from rice straw （Oryza sativa L.） were prepared at 200-600 ℃ by oxygen-limited pyrolysis to investigate the changes in properties of rice straw biochars produced at different temperatures, and to examine the adsorption capacities of the biochars for a heavy metal, copper（II） （Cu（II））, and an organic insecticide of cyromazine, as well as to further reveal the adsorption mechanisms. The results obtained with batch experiments showed that the amount of Cu（II） adsorbed varied with the pyrolysis temperatures of rice straw biochar. The biochar produced at 400 ~C had the largest adsorption capacity for Cu（II） （0.37 mol kg-1） among the biochars, with the non-electrostatic adsorption as the main adsorption mechanism. The highest adsorption capacity for cyromazine （156.42 g kg-1） was found in the rice straw biochar produced at 600 ℃, and cyromazine adsorption was exclusively predominated by surface adsorption. An obvious competitive adsorption was found between 5 mmol L-1 Cu（II） and 2 g L-1 cyromazine when they were in the binary solute system. Biochar may be used to remediate heavy metal- and organic insecticide-contaminated water, while the pyrolysis temperature of feedstocks for producing biochar should be considered for the restoration of multi-contamination.
基金Supported by the General Program of National Natural Science Foundation of China(No.81473399,82074094)Xinglin Scholar Project of Chengdu University of Traditional Chinese Medicine(No.BSH2020022)。
文摘OBJECTIVE:To investigate the underlying mechanism of the effect of Fengreqing oral liquid(风热清口服液,FOL)on wind-heat pattern(WHP).METHODS:In this study,we predicted the potential targets of FOL via the approach of network pharmacology and verified it by in vitro inflammation model.In the network pharmacology part,two strategies,namely the direct target search and the indirect one,were used to collect the target sets of FOL in WHP treatment.The enrichment analysis was carried out by David database and Clue Go plug-in in Cytoscape.Furthermore,the potential targets were mapped in the candidate pathways.In the verification experiment section,in vitro model of lipopolysaccharide(LPS)induced RAW 264.7 was used to confirm the predictive results in the network pharmacology part.RESULTS:Through the two screening strategies,a total of 141 non-repetitive intervention targets of FOL on WHP were obtained.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis showed that the intervention effect was mainly focused on the anti-inflammatory effect,and the Toll-like receptor signaling pathway was one of the most critical regulatory pathways.Further mapping analysis showed that phosphatidylinositol 3-kinase(PI3 K)-protein kinase B(AKT)signaling transfer might be the key part of regulating the concentration of inflammation mediators of FOL in the Toll-like receptor signaling pathway.In vitro experiment showed that FOL significantly reduced the levels of NO,IL-1,IL-6,and TNF-αproduced by RAW264.7 induced by LPS.Further immunofluorescence found that this effect is related to the regulation of PI3 K-AKT pathway activity by FOL.CONCLUSION:FOL can intervene in WHP by regulating the content of inflammatory mediators via the PI3 K-AKT pathway.
