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宫颈癌组织CTNNB1和TP53表达特点及其临床意义研究 被引量:6
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作者 李志强 王琳冬 闫学花 《临床和实验医学杂志》 2020年第10期1081-1085,共5页
目的研究宫颈癌组织钙黏蛋白相关蛋白(CTNNB1)、肿瘤抑制因子P53(TP53)表达特点及其临床意义。方法采用回顾性研究方法,选取2016年1月至2019年10月河北北方学院附属第二医院收治的124例宫颈癌患者(宫颈癌组)及124例宫颈良性疾病患者(良... 目的研究宫颈癌组织钙黏蛋白相关蛋白(CTNNB1)、肿瘤抑制因子P53(TP53)表达特点及其临床意义。方法采用回顾性研究方法,选取2016年1月至2019年10月河北北方学院附属第二医院收治的124例宫颈癌患者(宫颈癌组)及124例宫颈良性疾病患者(良性组),比较不同组织中CTNNB1 mRNA、TP53 mRNA的表达情况及CTNNB1 mRNA、TP53 mRNA不同表达者的临床病理特征,采用Spearman分析CTNNB1 mRNA、TP53 mRNA与临床病理特征的相关性,采用受试者操作特征曲线(ROC)及ROC下面积(AUC)分析CTNNB1 mRNA、TP53 mRNA预测复发的价值。结果宫颈良性病变组织、癌旁组织、宫颈癌组织CTNNB1 mRNA表达分别为0.18±0.05、0.56±0.14、3.89±1.23,依次升高,TP53 mRNA表达分别为0.67±0.22、0.15±0.04、0.09±0.02,依次降低,组间比较差异均具有统计学意义(P<0.05);CTNNB1 mRNA、TP53 mRNA高低表达者国际妇产科联盟(FIGO)分期、分化程度、淋巴结转移比较,差异均具有统计学意义(P<0.05);CTNNB1 mRNA与FIGO分期(r=0.596)、腹主动脉旁淋巴结转移(r=0.648)、盆腔淋巴结转移(r=0.727)呈正相关,与分化程度(r=-0.312)呈负相关(P<0.05);TP53 mRNA与FIGO分期(r=-0.732)、腹主动脉旁淋巴结转移(r=-0.841)、盆腔淋巴结转移(r=-0.675)呈负相关,与分化程度(r=0.516)呈正相关(P<0.05);复发患者CTNNB1 mRNA为5.93±1.81,高于未复发患者的3.12±1.01,TP53 mRNA为0.10±0.02,低于未复发患者的0.06±0.02,差异有统计学意义(P<0.05);CTNNB1 mRNA预测复发的AUC为0.715,TP53mRNA预测复发的AUC为0.773,CTNNB1 mRNA+TP53 mRNA预测复发的AUC为0.881,差异有统计学意义(P<0.05)。结论宫颈癌组织中CTNNB1呈高表达,TP53呈低表达,与组织分化程度、淋巴结转移、肿瘤分期显著相关,并能预测宫颈癌术后复发的风险。 展开更多
关键词 宫颈癌 CTNNB1 TP53 病理特征 术后复发
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Paleoclimatic record from Chumbur-Kosa section in Sea of Azov region since Marine Isotope Stage 11 被引量:1
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作者 LIANG Ye YANG Tai-bao +6 位作者 Andrey Aleksevitch VELICHKO ZENG Biao SHI Pei-hong wang lin-dong HE Yi CHEN Jie CHEN Yu 《Journal of Mountain Science》 SCIE CSCD 2016年第6期985-999,共15页
Abstract: Loess-paleosol sequences preserve records of climatic change during the Quaternary, which is important for paleoclimate study. In this study, a loess-palaeosol sequence from the Chumbur- Kosa (CK) site in... Abstract: Loess-paleosol sequences preserve records of climatic change during the Quaternary, which is important for paleoclimate study. In this study, a loess-palaeosol sequence from the Chumbur- Kosa (CK) site in the Sea of Azov region was investigated to reconstruct climatic variability during the Marine Isotope Stage (MIS)11- MIS 1, using proxies of grain size (GS), magnetic susceptibility (xlf and Xfd(%)), carbonate content (CaCO3%) and soil color The results enabled formulation of a detailed description of the climatic characteristics related to each individual layer. The sequence indicates that the paleoclimate shifted progressively towards increasingly cooler, somewhat drier conditions. The CK section may thus be ideal for reconstructing climatie eondifions during the Middle and Late Pleistocene in the Sea of Azov region. However, the )Of value of paleosol $2 in the CK profile indicates different characteristics from the other paleosol layers, dilution of carbonate resulting from carbonate leaching in L2 may be the main reason for the decrease in magnetic susceptibility. Furthermore, through simple analysis part of the environmental evolution process in the Sea of Azov region and Serbia during Middle and Late Pleistocene cycles. The climate cycle expressed by Xfd(%) and Xlf variations show similar patterns, with rapidly alternating cold and warm intervals. Nevertheless, although the two areas had different climatic regimes, geographical settings, and loess source areas, both exhibited similar climate change trends since the MIS 11. 展开更多
关键词 LOESS PALEOSOL Magnetic susceptibility PALEOCLIMATE Sea of Azov
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