Since the outbreak of COVID-19,countries and regions worldwide have implemented multifaceted prevention and control measures,including vaccinations,antiviral drugs,mask wearing,and social distancing.However,omicron va...Since the outbreak of COVID-19,countries and regions worldwide have implemented multifaceted prevention and control measures,including vaccinations,antiviral drugs,mask wearing,and social distancing.However,omicron variants,with significantly increased endogenous and occult transmission.展开更多
Hand,foot,and mouth disease (HFMD) is an acute infection caused by enteroviruses that is commonly seen in children^([1]).High infectivity,large number of asymptomatic infections,complex transmission routes,and rapid s...Hand,foot,and mouth disease (HFMD) is an acute infection caused by enteroviruses that is commonly seen in children^([1]).High infectivity,large number of asymptomatic infections,complex transmission routes,and rapid spread make it difficult to control HFMD.Since 2008,China has reported> 23 million HFMD cases,including>0.15million severe cases^([2]).HFMD tops the list of notifiable infectious diseases in terms of case number and incidence rate,leading to a huge disease burden^([3]).Timely and accurate assessment of HFMD epidemics is essential for a holistic understanding of the outbreaks and for effective prevention and control strategies.Currently,there are no quantitative indicators to determine the duration and intensity of HFMD epidemics in Beijing.展开更多
Objective To investigate neutralizing antibody levels in symptomatic and asymptomatic patients with coronavirus disease 2019(COVID-19)at 6 and 10 months after disease onset.Methods Blood samples were collected at thre...Objective To investigate neutralizing antibody levels in symptomatic and asymptomatic patients with coronavirus disease 2019(COVID-19)at 6 and 10 months after disease onset.Methods Blood samples were collected at three different time points from 27 asymptomatic individuals and 69 symptomatic patients infected with severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).Virus-neutralizing antibody titers against SARS-CoV-2 in both groups were measured and statistically analyzed.Results The symptomatic and asymptomatic groups had higher neutralizing antibodies at 3 months and 1–2 months post polymerase chain reaction confirmation,respectively.However,neutralizing antibodies in both groups dropped significantly to lower levels at 6 months post-PCR confirmation.Conclusion Continued monitoring of symptomatic and asymptomatic individuals with COVID-19 is key to controlling the infection.展开更多
A population-based case-control study was conducted to evaluate the relative fac^tors in the environments, agricultural works, outdoor activities, and the effectiveness of Lyme borreliosis （LB）- associated personal ...A population-based case-control study was conducted to evaluate the relative fac^tors in the environments, agricultural works, outdoor activities, and the effectiveness of Lyme borreliosis （LB）- associated personal protective measure.c; in Beijing. Thirty-four cases and 272 controls were personally interviewed by well-trained interviewers. Venous blood samples were taken from eac：h subject. Sowing or harvesting in summer （OR=2.571, 95% CI： 1.109-5.962）, living in house with weeding in the yard （OR=2.247, 95% CI： 1.062-4.755）.展开更多
基金supported by the Ministry of Science and Technology of the People’s Republic of China。
文摘Since the outbreak of COVID-19,countries and regions worldwide have implemented multifaceted prevention and control measures,including vaccinations,antiviral drugs,mask wearing,and social distancing.However,omicron variants,with significantly increased endogenous and occult transmission.
基金supported by National Key R&D Program of China [2021ZD0114103]Capital’s Funds for Health Improvement and Research [2022-1G-3014]+3 种基金High Level Public Health Technical Talent Training Plan [xuekegugan-01-019]High Level Public Health Technical Talent Training Plan [xuekedaitouren-01-03]Beijing Natural Science Foundation[7202073]Key research projects of Beijing Natural Science Foundation-Haidian District Joint Fund [L192012]。
文摘Hand,foot,and mouth disease (HFMD) is an acute infection caused by enteroviruses that is commonly seen in children^([1]).High infectivity,large number of asymptomatic infections,complex transmission routes,and rapid spread make it difficult to control HFMD.Since 2008,China has reported> 23 million HFMD cases,including>0.15million severe cases^([2]).HFMD tops the list of notifiable infectious diseases in terms of case number and incidence rate,leading to a huge disease burden^([3]).Timely and accurate assessment of HFMD epidemics is essential for a holistic understanding of the outbreaks and for effective prevention and control strategies.Currently,there are no quantitative indicators to determine the duration and intensity of HFMD epidemics in Beijing.
基金supported by the National Natural Science Foundation of China[82041027]National Key R&D Program of China[2021ZD0114100,2021ZD0114103]+2 种基金The Capital Health Development and Research of Special[2022-1G-3014]Beijing Science and Technology Planning Project of Beijing Science and Technology Commission[Z211100002521015,Z211100002521019]Cooperation project[2022-jk-cd-009]。
文摘Objective To investigate neutralizing antibody levels in symptomatic and asymptomatic patients with coronavirus disease 2019(COVID-19)at 6 and 10 months after disease onset.Methods Blood samples were collected at three different time points from 27 asymptomatic individuals and 69 symptomatic patients infected with severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).Virus-neutralizing antibody titers against SARS-CoV-2 in both groups were measured and statistically analyzed.Results The symptomatic and asymptomatic groups had higher neutralizing antibodies at 3 months and 1–2 months post polymerase chain reaction confirmation,respectively.However,neutralizing antibodies in both groups dropped significantly to lower levels at 6 months post-PCR confirmation.Conclusion Continued monitoring of symptomatic and asymptomatic individuals with COVID-19 is key to controlling the infection.
基金supported by National Key Program for Infectious Diseases of China(2012ZX10004215-003-001)Beijing Natural Science Foundation(Project No.7133234)
文摘A population-based case-control study was conducted to evaluate the relative fac^tors in the environments, agricultural works, outdoor activities, and the effectiveness of Lyme borreliosis （LB）- associated personal protective measure.c; in Beijing. Thirty-four cases and 272 controls were personally interviewed by well-trained interviewers. Venous blood samples were taken from eac：h subject. Sowing or harvesting in summer （OR=2.571, 95% CI： 1.109-5.962）, living in house with weeding in the yard （OR=2.247, 95% CI： 1.062-4.755）.
