Based on new data from cores,drilling and logging,combined with extensive rock and mineral testing analysis,a systematic analysis is conducted on the characteristics,diagenesis types,genesis and controlling factors of...Based on new data from cores,drilling and logging,combined with extensive rock and mineral testing analysis,a systematic analysis is conducted on the characteristics,diagenesis types,genesis and controlling factors of deep to ultra-deep abnormally high porosity clastic rock reservoirs in the Oligocene Linhe Formation in the Hetao Basin.The reservoir space of the deep to ultra-deep clastic rock reservoirs in the Linhe Formation is mainly primary pores,and the coupling of three favorable diagenetic elements,namely the rock fabric with strong compaction resistance,weak thermal compaction diagenetic dynamic field,and diagenetic environment with weak fluid compaction-weak cementation,is conducive to the preservation of primary pores.The Linhe Formation clastic rocks have a superior preexisting material composition,with an average total content of 90%for quartz,feldspar,and rigid rock fragments,and strong resistance to compaction.The geothermal gradient in Linhe Depression in the range of(2.0–2.6)°C/100 m is low,and together with the burial history of long-term shallow burial and late rapid deep burial,it forms a weak thermal compaction diagenetic dynamic field environment.The diagenetic environment of the saline lake basin is characterized by weak fluid compaction.At the same time,the paleosalinity has zoning characteristics,and weak cementation in low salinity areas is conducive to the preservation of primary pores.The hydrodynamic conditions of sedimentation,salinity differentiation of ancient water in saline lake basins,and sand body thickness jointly control the distribution of high-quality reservoirs in the Linhe Formation.展开更多
目的应用实时剪切波弹性成像(SWE)技术测量睾丸硬度,探讨该项技术在男性少弱精症患者中的临床应用价值。方法选取我院诊断为少弱精症患者118例,其中轻度少弱精症组33例,中度少弱精症组35例,重度少弱精症组50例;另选睾丸正常且无泌尿系...目的应用实时剪切波弹性成像(SWE)技术测量睾丸硬度,探讨该项技术在男性少弱精症患者中的临床应用价值。方法选取我院诊断为少弱精症患者118例,其中轻度少弱精症组33例,中度少弱精症组35例,重度少弱精症组50例;另选睾丸正常且无泌尿系疾病的健康志愿者500例(对照组)。应用SWE技术测量各组睾丸弹性模量值,并对其进行比较;ROC曲线分析其诊断价值。结果轻、中度少弱精症组睾丸弹性模量最大值、平均值、最小值与对照组比较,差异均无统计学意义;重度少弱精症组弹性模量最大值和平均值与对照组比较,差异均有统计学意义(均P<0.05);且当睾丸弹性模量值最大值为4.25 k Pa时,受试者工作特征曲线下面积最大(0.88),其诊断重度少弱精症患者的敏感性和特异性分别为79.4%、76.0%。结论 SWE技术可以准确地评价睾丸组织的硬度及均匀程度,为临床诊断少弱精症患者提供依据。展开更多
基金Supported by the CNPC Science and Technology Project(2023ZZ022023ZZ14-01).
文摘Based on new data from cores,drilling and logging,combined with extensive rock and mineral testing analysis,a systematic analysis is conducted on the characteristics,diagenesis types,genesis and controlling factors of deep to ultra-deep abnormally high porosity clastic rock reservoirs in the Oligocene Linhe Formation in the Hetao Basin.The reservoir space of the deep to ultra-deep clastic rock reservoirs in the Linhe Formation is mainly primary pores,and the coupling of three favorable diagenetic elements,namely the rock fabric with strong compaction resistance,weak thermal compaction diagenetic dynamic field,and diagenetic environment with weak fluid compaction-weak cementation,is conducive to the preservation of primary pores.The Linhe Formation clastic rocks have a superior preexisting material composition,with an average total content of 90%for quartz,feldspar,and rigid rock fragments,and strong resistance to compaction.The geothermal gradient in Linhe Depression in the range of(2.0–2.6)°C/100 m is low,and together with the burial history of long-term shallow burial and late rapid deep burial,it forms a weak thermal compaction diagenetic dynamic field environment.The diagenetic environment of the saline lake basin is characterized by weak fluid compaction.At the same time,the paleosalinity has zoning characteristics,and weak cementation in low salinity areas is conducive to the preservation of primary pores.The hydrodynamic conditions of sedimentation,salinity differentiation of ancient water in saline lake basins,and sand body thickness jointly control the distribution of high-quality reservoirs in the Linhe Formation.
文摘目的应用实时剪切波弹性成像(SWE)技术测量睾丸硬度,探讨该项技术在男性少弱精症患者中的临床应用价值。方法选取我院诊断为少弱精症患者118例,其中轻度少弱精症组33例,中度少弱精症组35例,重度少弱精症组50例;另选睾丸正常且无泌尿系疾病的健康志愿者500例(对照组)。应用SWE技术测量各组睾丸弹性模量值,并对其进行比较;ROC曲线分析其诊断价值。结果轻、中度少弱精症组睾丸弹性模量最大值、平均值、最小值与对照组比较,差异均无统计学意义;重度少弱精症组弹性模量最大值和平均值与对照组比较,差异均有统计学意义(均P<0.05);且当睾丸弹性模量值最大值为4.25 k Pa时,受试者工作特征曲线下面积最大(0.88),其诊断重度少弱精症患者的敏感性和特异性分别为79.4%、76.0%。结论 SWE技术可以准确地评价睾丸组织的硬度及均匀程度,为临床诊断少弱精症患者提供依据。
文摘目的 探讨AMPK激动剂二甲双胍对脂多糖(LPS)诱导的小鼠急性肺损伤的保护作用及可能的机制。方法 6-8周雄性BALB/c小鼠15只随机分为3组:对照组(气管内滴注无菌PBS 60 μl),LPS模型组(LPS组,气管内滴注1 mg/ml LPS 60 μl,作用24 h),二甲双胍治疗组(Met+LPS组,于滴注LPS前30 min腹腔注射二甲双胍250 mg/kg,再气管内滴注LPS作用24 h)。观察小鼠肺组织病理学改变,肺泡灌洗液中细胞总数及中性粒性细胞数变化,测定肺组织内髓过氧化物酶(MPO)活性。Western blot法检测肺组织中AMPK、P-AMPK(Thr172)及PGC1α表达的变化。结果 与对照组比较,LPS模型组小鼠组织病理学显示,肺泡壁结构明显破坏,炎性细胞浸润及组织出血增加,肺泡灌洗液中细胞总数及中性粒细胞比例明显增高( P <0.01),肺组织内MPO活性显著升高( P <0.01),PGC1α表达减少( P <0.01),P-AMPK(Thr172)水平下降。与LPS模型组比较,二甲双胍治疗组小鼠肺泡壁破坏减轻,炎性细胞浸润及组织出血减轻,髓过氧化物酶活性下降( P <0.01),P-AMPK水平( P <0.01)及PGC1α( P <0.05)的表达明显增加。结论 本研究提示AMPK激动剂二甲双胍对LPS诱导急性肺损伤具有一定保护作用,这种保护作用可能与PGC1α上调有关。
