Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography

Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography（OCTA） based on optical microangiography（OMAG） measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA（Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.） scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network： vessel area density（VAD）, vessel skeleton density（VSD）, vessel diameter index（VDI）, vessel perimeter index（VPI）, vessel complexity index（VCI）, flux, and foveal avascular zone（FAZ）. Coefficient of variation（CV） and intraclass correlation coefficient（ICC） were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%（intravisit） and ≤ 4.6%（intervisit）] and interobserver reproducibility（ICCs ≥ 0.923） for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes.

Optical Coherence Tomography Features of Tuberculous Serpiginous-like Choroiditis and Serpiginous Choroiditis

Objective To investigate optical coherence tomography（OCT） characteristics of tuberculous serpiginous-like choroiditis（Tb-SLC） and serpiginous choroiditis（SC） and to perform OCT to differentiate between these conditions.Methods This retrospective,case-control study examined consecutively enrolled patients with active Tb-SLC or SC.Patients underwent comprehensive ocular examinations and imaging（OCT,color fundus photography,autofluorescence imaging,fluorescein angiography,and indocyanine green angiography）.Findings were examined and compared between eyes with SC and Tb-SLC.Results Nine patients with active Tb-SLC（14 eyes） and 8 with active SC（12 eyes） were included.The following OCT findings were observed significantly more often in the Tb-SLC group than in the SC group： vitreal hyper-reflective spots [5 Tb-SLC eyes（36%）,no SC eyes：P = 0.02],intraretinal edema [11 Tb-SLC eyes（79%）,3 SC eyes（25%）：P = 0.01],sub-retinal pigment epithelium（RPE） drusenoid deposits [11 Tb-SLC eyes（79%）,2 SC eyes（17%）：P 〈 0.01],and choroidal granulomas [8 Tb-SLC eyes（57%）,2 SC eyes（17%）：P = 0.03].A hyporeflective,wedge-shaped band was observed more often in the SC group [5 Tb-SLC eyes（36%）,9 SC eyes（75%）：P = 0.045] than in the Tb-SLC group.The incidence of other OCT signs did not differ between the groups and included outer nuclear layer hyper-reflection,outer retinal tabulation,and choriocapillaris point-like hyper-reflection.Conclusion Vitreal hyper-reflective spots,intraretinal fluid,sub-RPE drusenoid deposits,and choroidal granulomas on OCT images may indicate Tb-SLC.Additionally,a hyporeflective,wedge-shaped band may indicate SC.Therefore,OCT is likely helpful in differentiating between Tb-SLC and SC.

河北6市孕妇孕前风险暴露及妊娠结局分析

目的通过回顾性分析河北省6个项目点孕前健康检查中风险因素与妊娠结局的关系,为育龄夫妇在怀孕前对存在的危险因素进行早期干预提供科学依据。方法选取2014年1月1日-2016年12月31日,河北省六县市接受孕前优生检查的夫妇为研究对象,结合孕前健康检查家庭档案进行现场调查的记录,包括人口学特征、生活习惯、疾病史、用药情况、生育史、职业、环境暴露史、遗传危险因素及体格检查与实验室检查等,应用队列研究方法,电话随访妊娠结局,对相关因素进行卡方检验和Logistic回归分析。结果怀孕夫妇共8821例,其中正常生产7720例、早产231例、低体重儿229例、巨大儿289例、死胎94例、胎儿畸形引产17例、自然流产241例,总不良妊娠率为12.5%,其中死胎、自然流产、胎儿畸形引产等严重不良妊娠结局发生率为4.0%。吸烟、饮酒、理化有害物质、超重及肥胖等风险因素接触史的比例在不良妊娠结局组明显高于正常生育组(P<0.05),不良妊娠结局与男女双方多种风险因素暴露有关。结论通过孕前检查及时发现并指导计划怀孕的夫妇避免各种风险暴露,可减少不良妊娠的发生,也是有效降低出生缺陷的一道重要防线,效果显著。