Four cruises were conducted during 2002--2003 in the Changjiang Estuary and adjacent coastal areas. The data presented show a clear coast to open sea gradient in nutrients related to the river inputs. Maximum values o...Four cruises were conducted during 2002--2003 in the Changjiang Estuary and adjacent coastal areas. The data presented show a clear coast to open sea gradient in nutrients related to the river inputs. Maximum values of chlorophyll a were typically observed at intermediate salinities at surface water and coincided with non-conservative decreases in nutrients along the salinity gradient, indicating that removal of nutrients was related to phytoplankton uptake. The seasonal variations of nutrient concentrations were just opposite to those of chlorophyll a, indicating that the seasonal variations of nutrients were mainly controlled by phytoplankton uptake, whereas riverine inputs merely weakened or balanced its extent. During the estuarine mixing, phosphate demonstrated some remobilization during all the four cruises; whereas both conservative and non-conservative behaviors for dissolved inorganic nitrogen and silicate were observed in the study area, indicating that both biotic and abiotic events may affect their behaviors during the estuarine mixing. Under the influence of freshwater inputs with high value of ratio of nitrogen to phosphorus, the estuarine and coastal waters impacted by the Changjiang plume were high （ 〉 30） in ratio of nitrogen to phosphorus, but rates of primary production were apparently not constrained by any kind of nutrient elements. However, the low （ 〈 1 ） ratio of silicate to nitrogen in most of the study area might be linked with the rapidly increasing frequency of harmful algal bloom （HAB） incidents in recent years in the coastal waters impacted by the Changjiang plume.展开更多
In this paper, a combination of field measurement, theoretical analysis and numerical simulation were used to study the main control factors of coal mine water inrush in a main aquifer coal seam and its control scheme...In this paper, a combination of field measurement, theoretical analysis and numerical simulation were used to study the main control factors of coal mine water inrush in a main aquifer coal seam and its control scheme. On the basis of revealing and analyzing the coal seam as the main aquifer in western coal mine of Xiao Jihan coal mine, the simulation software of PHASE-2D was applied to analyze the water inflow under different influencing factors. The results showed that water inflow increases logarithmically with the coal seam thickness, increases as a power function with the permeability coefficient of the coal seam, and increases linearly with the coal seam burial depth and the head pressure; The evaluation model for the factors of coal seam water inrush was gained by using nonlinear regression analysis with SPSS. The mine water inrush risk evaluation partition within the scope of the mining field was obtained,through the engineering application in Xiao Jihan coal mine. To ensure the safe and efficient production of the mine, we studied the coal mine water disaster prevention and control measures of a main aquifer coal seam in aspects of roadway driving and coal seam mining.展开更多
目的:基于网络药理学原理探讨消疕汤核心药对金银花-连翘干预银屑病的分子通路及作用机制。方法:应用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)检索...目的:基于网络药理学原理探讨消疕汤核心药对金银花-连翘干预银屑病的分子通路及作用机制。方法:应用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)检索金银花、连翘化学成分、作用靶点,并通过GeneCards数据库获取银屑病差异性靶点基因,预测中药与银屑病相关的作用靶点,通过STRING平台构建蛋白质-蛋白质相互作用信息网络(PPI),运用DAVID数据库对筛选出的靶点基因进行基因富集分析,获得基因本体论功能富集分析(gene ontology,GO)和KEGG富集分析(kyoto encyclopedia of genes and genomes,KEGG)信号通路注释结果,构建“中药成分-关键靶标-主要通路”的可视化网络图,探究金银花-连翘药对干预银屑病的分子作用机制。结果:金银花-连翘药对干预银屑病,共预测得到28个活性成分,涉及核心靶标基因127个,生物功能138个和信号通路155个。结论:金银花-连翘药对主要活性成分通过多靶点、多通路干预银屑病,主要涉及核受体的活性、转录因子活性、细胞因子受体结合、细胞因子生物功能等和白细胞介素17(interleukin-17,IL-17)信号通路、肿瘤坏死因子(tumor necrosis factor,TNF)信号通路、磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)-蛋白激酶B(protein kinase B,Akt)信号通路等。展开更多
基金The National Key Basic Research Program under contract Nos 2001CB409703 and2002CB714008the Natural Science Foundation of Chinaunder contract Nos NSFC-40136020 and NSFC-40376033+1 种基金the Doctoral Foundation under contract No. 20020423006the Key Project of the Ministry of Education of China under contract No.01110
文摘Four cruises were conducted during 2002--2003 in the Changjiang Estuary and adjacent coastal areas. The data presented show a clear coast to open sea gradient in nutrients related to the river inputs. Maximum values of chlorophyll a were typically observed at intermediate salinities at surface water and coincided with non-conservative decreases in nutrients along the salinity gradient, indicating that removal of nutrients was related to phytoplankton uptake. The seasonal variations of nutrient concentrations were just opposite to those of chlorophyll a, indicating that the seasonal variations of nutrients were mainly controlled by phytoplankton uptake, whereas riverine inputs merely weakened or balanced its extent. During the estuarine mixing, phosphate demonstrated some remobilization during all the four cruises; whereas both conservative and non-conservative behaviors for dissolved inorganic nitrogen and silicate were observed in the study area, indicating that both biotic and abiotic events may affect their behaviors during the estuarine mixing. Under the influence of freshwater inputs with high value of ratio of nitrogen to phosphorus, the estuarine and coastal waters impacted by the Changjiang plume were high （ 〉 30） in ratio of nitrogen to phosphorus, but rates of primary production were apparently not constrained by any kind of nutrient elements. However, the low （ 〈 1 ） ratio of silicate to nitrogen in most of the study area might be linked with the rapidly increasing frequency of harmful algal bloom （HAB） incidents in recent years in the coastal waters impacted by the Changjiang plume.
基金provided by the National Key Basic Research Program of China (No. 2013CB227905)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (No. 51421003)the Jiangsu Province Ordinary University Graduate Student Scientific Research Innovation Projects (No. KYLX16_0564)
文摘In this paper, a combination of field measurement, theoretical analysis and numerical simulation were used to study the main control factors of coal mine water inrush in a main aquifer coal seam and its control scheme. On the basis of revealing and analyzing the coal seam as the main aquifer in western coal mine of Xiao Jihan coal mine, the simulation software of PHASE-2D was applied to analyze the water inflow under different influencing factors. The results showed that water inflow increases logarithmically with the coal seam thickness, increases as a power function with the permeability coefficient of the coal seam, and increases linearly with the coal seam burial depth and the head pressure; The evaluation model for the factors of coal seam water inrush was gained by using nonlinear regression analysis with SPSS. The mine water inrush risk evaluation partition within the scope of the mining field was obtained,through the engineering application in Xiao Jihan coal mine. To ensure the safe and efficient production of the mine, we studied the coal mine water disaster prevention and control measures of a main aquifer coal seam in aspects of roadway driving and coal seam mining.
文摘目的:基于网络药理学原理探讨消疕汤核心药对金银花-连翘干预银屑病的分子通路及作用机制。方法:应用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)检索金银花、连翘化学成分、作用靶点,并通过GeneCards数据库获取银屑病差异性靶点基因,预测中药与银屑病相关的作用靶点,通过STRING平台构建蛋白质-蛋白质相互作用信息网络(PPI),运用DAVID数据库对筛选出的靶点基因进行基因富集分析,获得基因本体论功能富集分析(gene ontology,GO)和KEGG富集分析(kyoto encyclopedia of genes and genomes,KEGG)信号通路注释结果,构建“中药成分-关键靶标-主要通路”的可视化网络图,探究金银花-连翘药对干预银屑病的分子作用机制。结果:金银花-连翘药对干预银屑病,共预测得到28个活性成分,涉及核心靶标基因127个,生物功能138个和信号通路155个。结论:金银花-连翘药对主要活性成分通过多靶点、多通路干预银屑病,主要涉及核受体的活性、转录因子活性、细胞因子受体结合、细胞因子生物功能等和白细胞介素17(interleukin-17,IL-17)信号通路、肿瘤坏死因子(tumor necrosis factor,TNF)信号通路、磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)-蛋白激酶B(protein kinase B,Akt)信号通路等。
