Predicting the Degradability of Bioceramics through a DFT-based Descriptor

Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and degradability.However,challenges remain in matching the rate between bioceramic degradation and new bone formation,necessitating a deeper understanding of their degradation properties.In this study,density functional theory(DFT)calculations was employed to explore the structural and electronic characteristics of silicate bioceramics.These findings reveal a linear correlation between the maximum isosurface value of the valence band maximum(VBM_(Fmax))and the degradability of silicate bioceramics.This correlation was subsequently validated through degradation experiments.Furthermore,the investigation on phosphate bioceramics demonstrates the potential of this descriptor in predicting the degradability of a broader range of bioceramics.This discovery offers valuable insights into the degradation mechanism of bioceramics and holds promise for accelerating the design and development of bioceramics with controllable degradation.

骨类器官的构建、评价与应用专家共识(2024版)

骨类器官能模仿骨组织复杂结构和功能,是类器官研究前沿技术,在骨疾病建模、骨损伤修复和药物筛选领域展现出巨大应用潜力。尽管当前骨类器官构建在矿化、骨髓、骨小梁、骨痂及编织骨等骨组织功能结构的研究中取得一定进展,但目前骨类器官研究存在诸多问题,如构建策略缺乏规范、评价缺少统一标准等,限制了其进一步推广应用。为规范骨类器官研究,由中国老年学和老年医学学会老年病学分会骨科专家委员会、中华医学会骨科学分会青年骨质疏松学组、中国医师协会骨科医师分会骨质疏松学组和上海中西医结合学会骨质疏松专业委员会组织有关专家,基于循证证据,制订《骨类器官的构建、评价与应用专家共识(2024版)》,共提出17条推荐意见,旨在规范骨类器官研究和临床应用,提升其在科研和临床应用中的价值。