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一体化建造在海洋平台中的应用与良好实践
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作者 王举田 吴克建 +2 位作者 王晓华 张浩然 刘延亭 《山东化工》 CAS 2024年第15期220-222,234,共4页
工艺管线、管线支架、电缆托架支架等的一体化建造从工期、成本等多方面极大促进了海洋石油平台建造效率与质量。一体化建造的实施受方案设计、图纸材料匹配下发、散件预制与安装进度多重因素影响。本文简述一体化建造流程与各关键控制... 工艺管线、管线支架、电缆托架支架等的一体化建造从工期、成本等多方面极大促进了海洋石油平台建造效率与质量。一体化建造的实施受方案设计、图纸材料匹配下发、散件预制与安装进度多重因素影响。本文简述一体化建造流程与各关键控制因素,结合具体工程项目做好一体化实施过程中各专业、各工序的有效衔接,并针对性总结出良好施工实践。 展开更多
关键词 一体化建造 预安装 预舾装 标准化
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缓冲材料对多层印制电路板压合的影响研究 被引量:1
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作者 吴科建 韩雪川 +2 位作者 陈文卓 曹宏伟 吴杰 《印制电路信息》 2024年第3期16-20,共5页
压合是印制电路板(PCB)生产过程中的重要制程之一。测试了不同缓冲材料的缓冲性能,并对比研究了不同缓冲材料的叠板结构对板厚均匀性、涨缩比例、可靠性、填胶的影响。研究结果表明,PacoPads缓冲材料压合叠板,在板厚均匀性、涨缩比例方... 压合是印制电路板(PCB)生产过程中的重要制程之一。测试了不同缓冲材料的缓冲性能,并对比研究了不同缓冲材料的叠板结构对板厚均匀性、涨缩比例、可靠性、填胶的影响。研究结果表明,PacoPads缓冲材料压合叠板,在板厚均匀性、涨缩比例方面表现最好,3 mm高多层PCB的板厚极差在0.2 mm以内,涨缩变化在0.04 mm内;铝片+三合一缓冲材料压合叠板,在填胶方面表现最好,可实现0.8mm节距的球栅阵列(BGA)和50mm×50mm无铜区的有效填胶。研究结果可为解决高多层PCB的板厚均匀性、缺胶等问题提供参考和借鉴。 展开更多
关键词 印制电路板 压合缓冲 叠板结构 板厚均匀性 缺胶
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医学高等数学与药物动力学交叉融合的案例探索与实践
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作者 吴克坚 成颖 徐清华 《高等数学研究》 2024年第2期34-38,共5页
本文将“药物动力学”的内容融入到“医学高等数学”各个章节的教学内容中,形成一条相互贯通、前后呼应的教学主线,加深了对现学数学知识的理解和应用,为医学院校数学与医学交叉融合的教学案例积累了素材,进行了新的探索和实践.
关键词 医学高等数学 药物动力学 房室模型
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生物类似药分析相似性评价的相关统计学方法考量 被引量:1
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作者 吴克坚 赵清波 +4 位作者 李婵娟 王陵 李晨 潘海涛 夏结来 《中国卫生统计》 CSCD 北大核心 2018年第3期343-348,共6页
目的在生物类似药的质量比对研究中,为评价候选药与参照药的分析相似性,FDA建议对3个不同层级的关键质量属性采用不同的评价方法。本文建立第1层级的关键质量属性分析相似性评价的步骤及方法,重点讨论如何确定候选药与参照药的样本量n_T... 目的在生物类似药的质量比对研究中,为评价候选药与参照药的分析相似性,FDA建议对3个不同层级的关键质量属性采用不同的评价方法。本文建立第1层级的关键质量属性分析相似性评价的步骤及方法,重点讨论如何确定候选药与参照药的样本量n_T,n_R。方法利用判断方差齐性的F检验介绍方差相似性检验假设及统计量的建立;利用高个体差异药物的生物等效性评价方法及双单侧检验的性质等建立分析相似性检验假设及统计量,并由推导得到的检验效能的精确公式确定样本量。结果在分析相似性评价过程中将n_R控制在[n_T,1.5n_T]内,根据数值模拟得到不同参数组合的样本量,提出了确定n_T,n_R的策略,在此基础上给出了评价生物类似药分析相似性的具体步骤和方法。结论本文提出的样本量确定策略及评价分析相似性的步骤与方法可应用到实际的分析相似性研究中;同时由推导得到的检验效能精确公式还可获得其他参数组合的样本量。 展开更多
关键词 生物类似药 分析相似性 关键质量属性 样本量
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股骨和胫骨畸形的矫正
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作者 吴克俭 《国际骨科学杂志》 2019年第1期5-10,共6页
第二届京沪骨科峰会于2018年7月21日在上海举行。美国梅奥医学中心Stephen Andrew Sems教授应邀作了“股骨和胫骨畸形的矫正”专题报告,深入浅出、言简意赅地将股骨和胫骨畸形的诊断与治疗要点阐述得淋漓尽致,与会者反响很好。现征得Sem... 第二届京沪骨科峰会于2018年7月21日在上海举行。美国梅奥医学中心Stephen Andrew Sems教授应邀作了“股骨和胫骨畸形的矫正”专题报告,深入浅出、言简意赅地将股骨和胫骨畸形的诊断与治疗要点阐述得淋漓尽致,与会者反响很好。现征得Sems教授同意,笔者将其演讲内容整理成文,与同道分享。 展开更多
关键词 胫骨畸形 股骨 矫正 梅奥医学中心 SEMS 专题报告
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池火灾环境中石化管廊管道失效的规律 被引量:2
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作者 周宁 吴露露 +6 位作者 李雪 李徐伟 吴克建 霍靖 曹林林 袁雄军 刘俊 《南京工业大学学报(自然科学版)》 CAS 北大核心 2021年第2期150-158,196,共10页
石化管廊池火灾事故对化工园区的安全生产构成严重威胁,有必要对在池火灾作用下的石化管廊管道失效规律进行深入研究。依据流体力学相似理论搭建缩比模型管廊,通过对各管道壁面温度及内部压力的测试和分析,开展石化管廊管道在池火灾作... 石化管廊池火灾事故对化工园区的安全生产构成严重威胁,有必要对在池火灾作用下的石化管廊管道失效规律进行深入研究。依据流体力学相似理论搭建缩比模型管廊,通过对各管道壁面温度及内部压力的测试和分析,开展石化管廊管道在池火灾作用下的热响应和压力响应的实验研究,并结合强度理论建立管道失效时间定量计算模型。结果表明:管廊管道温升受火源热释放速率的影响较大,管道与火源距离的不同,管道的升温速率明显不同;随着油池尺寸的增大,各层管架上管道之间的最高温差逐渐缩小;输送液相介质时管道内介质吸收传输热量,管道的升温幅度较输送气相介质管道的低;管道压力变化主要受温度、初始压力、介质相态共同影响,在相同受火条件下,液相介质的压力增幅比气相介质高10倍以上,而其管道失效温度比输气管道低200℃,其失效时间早于输气管道。 展开更多
关键词 石化管廊 池火灾 管道温升 管道失效
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Evaluation of the simulation capability of the Wavewatch Ⅲ model for Pacific Ocean wave 被引量:12
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作者 BI Fan SONG Jinbao +1 位作者 wu kejian XU Yao 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2015年第9期43-57,共15页
Wave climate analysis and other applications for the Pacific Ocean require a reliable wave hindcast. Five source and sink term packages in the Wavewatch III model (v3.14 and v4.18) are compared and assessed in this ... Wave climate analysis and other applications for the Pacific Ocean require a reliable wave hindcast. Five source and sink term packages in the Wavewatch III model (v3.14 and v4.18) are compared and assessed in this study through comprehensive observations, including altimeter significant wave height, advanced synthetic aperture radar swell, and buoy wave parameters and spectrum. In addition to the evaluation of typically used integral parameters, the spectra partitioning method contributes to the detailed wave system and wave maturity validation. The modified performance evaluation method (PS) effectively reduces attribute numbers and facilitates the overall assessment. To avoid possible misleading results in the root mean square error-based validations, another indicator called HH (indicating the two authors) is also calculated to guarantee the consistency of the results. The widely used Tolman and Chalikov (TC) package is still generally efficient in determining the integral properties of wave spectra but is physically deficient in explaining the dissipation processes. The ST4 package performs well in overall wave parameters and significantly improves the accuracy of wave systems in the open ocean. Meanwhile, the newly published ST6 package is slightly better in determining swell energy variations. The two packages (ACC350 and BIA) obtained from Wavewatch III v3.14 exhibit large scatters at different sea states. The three most ideal packages are further examined in terms of reproducing wave- induced momentum flux from the perspective of transport. Stokes transport analysis indicates that ST4 is the closest to the NDBC-buoy-spectrum-based transport values, and TC and ST6 tend to overestimate and underestimate the transport magnitude, respectively, in swell mixed areas. This difference must be considered, particularly in air-wave-current coupling research and upper ocean analysis. The assessment results provide guidance for the selection of ST4 for use in a background Pacific Ocean hindcast for high wave climate research and China Sea swell type analysis. 展开更多
关键词 Wavewatch III EVALUATION Pacific Ocean source and sink term packages wave-induced flux Stokes transport
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基于DPSIR模型的长岛地区可持续发展水平评价研究 被引量:1
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作者 田士政 马爱东 +3 位作者 张坤珵 吴克俭 武文 何广顺 《海洋开发与管理》 2022年第7期69-76,共8页
在“坚持陆海统筹,加快建设海洋强国”的背景下,我国海岛开发利用方式向绿色、生态、可持续发展转变,长岛海洋生态文明综合试验区成为我国海洋生态文明建设和海岛高质量发展的前沿阵地。基于上述考虑,文章运用DPSIR模型,从驱动力、压力... 在“坚持陆海统筹,加快建设海洋强国”的背景下,我国海岛开发利用方式向绿色、生态、可持续发展转变,长岛海洋生态文明综合试验区成为我国海洋生态文明建设和海岛高质量发展的前沿阵地。基于上述考虑,文章运用DPSIR模型,从驱动力、压力、状态、影响和响应5个方面构建长岛地区可持续发展水平评价指标体系,采用熵权法与层次分析法相结合的方法确定指标权重,搜集2011—2020年长岛地区的相关数据,并对其可持续发展水平进行评价。分析评价结果可知,长岛地区可持续发展水平在10年间呈缓慢波动上升趋势。研究结论可为长岛海洋生态文明综合试验区制定相关政策提供参考依据。 展开更多
关键词 可持续发展水平评价 DPSIR模型 层次分析法 熵权法 长岛地区
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The effect of Stokes drift on Ekman transport in the open sea 被引量:9
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作者 BI Fan wu kejian ZHANG Yuming 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2012年第6期12-18,共7页
By introducing the wave-induced Coriolis-Stokes forcing into ageostrophic motion equation, th1 Eulerian transport is modified by the wave-induced Stokes drift. The long-term mean contributions of the Stokes transport ... By introducing the wave-induced Coriolis-Stokes forcing into ageostrophic motion equation, th1 Eulerian transport is modified by the wave-induced Stokes drift. The long-term mean contributions of the Stokes transport with remotely generated swells being included to the ageostrophic transport are analyzed using the ECMWF (European Centre for Medium-Range X,Veather Forecasts) reanalysis data. The ratio of Stokes transport to Ekman transport in north-south (N-S) direction can reach maximum of over 50% in the subtropical region. The preliminary influence of the Stokes transport on the North Pacific gyre is all year persistent, while the effect on the North Atlantic gyre is only obvious in boreal winter and early spring. 展开更多
关键词 Stokes transport Ekman transport ocean swell ocean gyres
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Effects of wind waves of the Pacific westerly on the eastern Pacific wave transport 被引量:7
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作者 DENG Zeng' an wu kejian +1 位作者 ZHAO Dongliang YU Ting 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2009年第1期83-88,共6页
There exists a tongue-shaped swell-dominance pool known as Swell Pool(SP) in the Eastern Pacific region.The monthly-mean wave transports(WT) for each month of 2000 is computed using the wave products of ECMWF rean... There exists a tongue-shaped swell-dominance pool known as Swell Pool(SP) in the Eastern Pacific region.The monthly-mean wave transports(WT) for each month of 2000 is computed using the wave products of ECMWF reanalysis data.By comparing the 2000 monthly-mean WT and monthly-mean wind field from QUICKSCAT,large differences are found between the wave transport direction and the wind direction over the Eastern Pacific.This may serve as an evidence for the existence of the SP in this region.The work done in this study indicates that the sources of swell in the Tropical Eastern Pacific(TEP) are in the westerly regions of the Southern and Northern Pacific. 展开更多
关键词 swell pool wave transport Eastern Pacific WESTERLY
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Estimation and Prediction of Typhoons and Wave Overtopping in Qingdao, China 被引量:4
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作者 WANG Zhifeng LI Songtao +2 位作者 HAO Yan MA Yan wu kejian 《Journal of Ocean University of China》 SCIE CAS CSCD 2020年第5期1017-1028,共12页
This study aims to estimate and predict the impact of climate change on typhoons and wave overtopping during typhoon progresses in Qingdao, China. The SWAN wave model is used to simulate wave elements. The scale coeff... This study aims to estimate and predict the impact of climate change on typhoons and wave overtopping during typhoon progresses in Qingdao, China. The SWAN wave model is used to simulate wave elements. The scale coefficients of wave overtopping are estimated using an empirical prediction formula. A total of 75 tropical cyclones affected Qingdao from 1949 to 2019. These tropical cyclones can be grouped into eight categories according to typhoon tracks. Typhoon wind speed during Track G is projected to decrease, and those of the other seven typhoon progresses will increase by 0.35% – 0.75% in 2025, 0.69% – 1.5% in 2035, and 1.38% – 3.0% in 2055. The significant wave height and wave overtopping outside the bay are greater than those inside the bay. Among the 506 typical points selected, the maximum values of the significant wave height and wave overtopping inside the bay are mainly distributed in the range of 0 – 2 m and 0 – 60 m^3 km^(-1) s^(-1), respectively. The increments of the significant wave height and wave overtopping of Track F are most obvious. The significant wave height of Track F will increase by 50.5% in 2025, 51.8% in 2035, and 53.4% in 2055. In the 2℃ scenario, the maximum value of wave overtopping of Track F will increase by 21.9% in 2025, 24.3% in 2035, and 29.5% in 2055. In the 4℃ scenario, the maximum value of wave overtopping of Track F will increase by 21.9% in 2025, 24.3% in 2035, and 29.5% in 2055. 展开更多
关键词 climate change typhoon wind typhoon wave wave overtopping Qingdao
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The low-frequency variance of the ocean surface wave field in the area of the Antarctic Circumpolar Current 被引量:4
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作者 ZHANG Xiaoshuang wu kejian +1 位作者 WANG Bin WANG Zhifeng 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2013年第5期15-21,共7页
The low-frequency variance of the surface wave in the area of the Antarctic Circumpolar Current (ACC) and its correlation with the antarctic circumpolar wave (ACW) are focused on. The analysis of the series of 44 ... The low-frequency variance of the surface wave in the area of the Antarctic Circumpolar Current (ACC) and its correlation with the antarctic circumpolar wave (ACW) are focused on. The analysis of the series of 44 a significant wave height (SWH) interannual anomalies reveals that the SWH anomalies have a strong periodicity of about 4-5 a and this signal propagates eastward obviously from 1985 to 1995, which needs about 8 a to complete a mimacircle around the earth. The method of empirical orthogonal function (EOF) is used to analyze the filtered monthly SWH anomalies to study the spatio-temporal distributions and the propagation characteristics of the low-frequency signals in the wave field. Both the dominant wavenumber- 2 pattern in space and the propagation feature in the south Pacific, the south Atlantic and the south Indian ocean show strong consistency with the ACW. So it is reasonable to conclude that the ACW signal also exists in the wave field. The ACW is important for the climate in the Southern Ocean, so it is worth to pay more attention to the large- scale effect of the surface wave, which may also be important for climate studies. 展开更多
关键词 significant wave height antarctic circumpolar wave empirical orthogonal function low-frequ-ency variance
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海洋本草软珊瑚共附生曲霉属真菌EGF7-0-1和EGF15-0-3共培养中甾体类成分研究Ⅱ
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作者 司徒美霞 雷祖发 +7 位作者 杨倩茹 邓胜毅 吴科键 陈鸿皓 韦霞 樊浩 张伟 张翠仙 《热带海洋学报》 CAS CSCD 北大核心 2023年第5期161-170,共10页
文章模拟微生物自然生长环境,对两株海洋本草软珊瑚曲霉属真菌Aspergillus sp.EGF7-0-1和Aspergillus sp.EGF15-0-3进行共培养,以期发现新颖骨架成分。采用硅胶、反相色谱、羟丙基葡聚糖凝胶和高效液相色谱等方法对其次生代谢产物进行... 文章模拟微生物自然生长环境,对两株海洋本草软珊瑚曲霉属真菌Aspergillus sp.EGF7-0-1和Aspergillus sp.EGF15-0-3进行共培养,以期发现新颖骨架成分。采用硅胶、反相色谱、羟丙基葡聚糖凝胶和高效液相色谱等方法对其次生代谢产物进行分离、纯化;采用高分辨质谱、核磁共振、旋光及物理常数对照等方法对所分离得到的化合物进行结构鉴定;采用全球天然产物分子网络(Global Natural Products Social Molecular Networking,GNPS)方法对次生代谢产物进行分析。从两株软珊瑚来源的曲霉属真菌大米共培养中分离得到10个甾体类化合物:Chaxine(1)、Herbarulide(2)、dankasterones A(3)、25-hydroxyergosta-4,6,8(14),22-tetraen3-one(4)、Ganodermasides D(5)、Ergosta-4,6,8(14),22-tetraen-3-one(6)、Ergosta-4,7,22-trien-3-one(7)、Isocyathisterol(8)、Stigmasta-4,22-dien-3-one(9)和β-sitostenone(10)。化合物1~3均为高度氧化重排的甾体类化合物。化合物4、5、7和9首次从曲霉属真菌中分离得到。GNPS分析表明与菌株EGF7-0-1和EGF15-0-3单培养相比,两株真菌共培养能诱导出更为丰富的甾体类化合物。 展开更多
关键词 海洋本草软珊瑚 共附生曲霉属真菌 共培养 甾体
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Wave Effect on the Ocean Circulations Through Mass Transport and Wave-Induced Pumping 被引量:3
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作者 BI Fan wu kejian 《Journal of Ocean University of China》 SCIE CAS 2014年第2期175-182,共8页
The wave Coriolis-Stokes-Force-modified ocean momentum equations are reviewed in this paper and the wave Stokes transport is pointed out to be part of the ocean circulations. Using the European Centre for Medium-Range... The wave Coriolis-Stokes-Force-modified ocean momentum equations are reviewed in this paper and the wave Stokes transport is pointed out to be part of the ocean circulations. Using the European Centre for Medium-Range Weather Forecasts 40-year reanalysis data(ERA-40 data) and the Simple Ocean Data Assimilation(SODA) version 2.2.4 data, the magnitude of this transport is compared with that of wind-driven Sverdrup transport and a 5-to-10-precent contribution by the wave Stokes transport is found. Both transports are stronger in boreal winter than in summers. The wave effect can be either contribution or cancellation in different seasons. Examination with Kuroshio transport verifies similar seasonal variations. The clarification of the efficient wave boundary condition helps to understand the role of waves in mass transport. It acts as surface wind stress and can be functional down to the bottom of the ageostrophic layer. The pumping velocities resulting from wave-induced stress are zonally distributed and are significant in relatively high latitudes. Further work will focus on the model performance of the wave-stress-changed-boundary and the role of swells in the eastern part of the oceans. 展开更多
关键词 Stokes transport Sverdrup transport wave pumping velocity western boundary currents
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Improving the estimate of wind energy input into the Ekman layer within the Antarctic Circumpolar Current 被引量:3
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作者 ZHANG Yuming wu kejian +3 位作者 ZHANG Xiaoshuang BI Fan SONG Zhaoyang LIU Shouhua 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2013年第3期19-27,共9页
Based on the data and method offered by Liu et al. (2009), the direct wind and Stokes drift-induced energy inputs into the Ekman layer within the Antarctic Circumpolar Current (ACC) area are reestimated since the ... Based on the data and method offered by Liu et al. (2009), the direct wind and Stokes drift-induced energy inputs into the Ekman layer within the Antarctic Circumpolar Current (ACC) area are reestimated since the results of the former have been proved to be underestimated. And the result shows that the total rate of energy input into the Ekman-Stokes layer within the ACC area is 852.41 GW, including 649.75 GW of direct wind energy input (76%) and 202.66 GW of Stoke drift-induced energy input (24%). Total increased energy input, due to wave-induced Coriolis-Stokes forcing added to the classical Ekman model, is 52.05 GW, accounting for 6.5% of the wind energy input into the classical Ekman layer. The long-term variability of direct wind and Stokes drift-induced energy inputs into the Ekman layer within the ACC is also investigated, and the result shows that the Stokes drift hinders the decadal increasing trend of direct wind energy input. Meanwhile, there is a period of 4-5 a in the energy spectrums, as same as the Antarctic circumpolar wave. 展开更多
关键词 energy input Ekman-Stokes layer Coriolis-Stokes forcing Antarctic Circumpolar Current
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补骨脂二氢黄酮甲醚调控Gamma delta T细胞消减胃癌SGC-7901研究 被引量:4
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作者 丁钦 吴克俭 +1 位作者 郑璐 岳苏阳 《世界中医药》 CAS 2020年第20期3040-3045,共6页
目的:探讨补骨脂二氢黄酮甲醚调控γδT细胞消减胃癌SGC-7901程度。方法:获取人外周血中单个核细胞,体外扩增γδT细胞,不同浓度BVC诱导γδT细胞、SGC-7901细胞24 h、48 h和72 h,CCK-8检测BVC对γδT细胞增殖率、SGC-7901抑制率影响;... 目的:探讨补骨脂二氢黄酮甲醚调控γδT细胞消减胃癌SGC-7901程度。方法:获取人外周血中单个核细胞,体外扩增γδT细胞,不同浓度BVC诱导γδT细胞、SGC-7901细胞24 h、48 h和72 h,CCK-8检测BVC对γδT细胞增殖率、SGC-7901抑制率影响;流式细胞术测γδT细胞GZMB、PF、CD107a产生量;LDH法测γδT细胞消减SGC-7901程度。结果:体外扩增8 d,γδT细胞比例由3.54%增至85.34%。与对照组比较,BVC诱导24 h,浓度10~80 nmol/L促进γδT细胞增殖(P<0.05)。BVC诱导48 h、72 h,浓度5~80 nmol/L促进γδT细胞增殖(P<0.05)。同样浓度,72 hγδT细胞增殖率最大。BVC作用肿瘤细胞24 h、48 h、72 h,浓度160~640 nmol/L SGC-7901生长抑制率高于对照组(P<0.05),浓度10~40 nmol/L,GZMB、PF、CD107a表达高于对照组(P<0.05)。BVC诱导γδT细胞72 h,一定浓度该T细胞消减SGC-7901程度随浓度增高而增高,浓度40 nmol/L消减程度最大,后呈下降趋势。结论:BVC适宜浓度促进γδT细胞增殖,抑制SGC-7901生长,加强γδT细胞消减SGC-7901程度,机制考虑:PF、GZMB、CD107a表达提高增强γδT细胞消减能力。 展开更多
关键词 补骨脂二氢黄酮甲醚 ΓΔT细胞 胃癌 SGC-7901 杀伤活性 颗粒酶B 穿孔素 CD107a
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A proposed directional function and wind-wave directional spectrum 被引量:4
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作者 Wen Shengchang wu kejian +1 位作者 Guan Changlong Sun Shicai and Zhang Dacuo (Institute of Physical Oceanography, Ocean University of Oingdao, Oingdao 266003, China) 《Acta Oceanologica Sinica》 SCIE CAS CSCD 1995年第2期155-166,共12页
A directional function for frequencies equal to and larger than the peak frequency of a wind-wave frequency spectrum is constructed by fitting the angular spreading based on the analytically derived directional spectr... A directional function for frequencies equal to and larger than the peak frequency of a wind-wave frequency spectrum is constructed by fitting the angular spreading based on the analytically derived directional spectrum of Wen et al. (1993, Journal of Oceanography, 49(2), 131~147, 149~172). For frequencies smaller than the peak frequency, the directional function is obtained by comparing and analyzing existing formulas. The nondimensional wind-wave frequency spectrum of Wen et al. (1994, Progress in Natural Seience, 4(4). 407~427;4 (5), 586~596) has been used together with the directional function just mentioned to obtain the directional spectrum for easier application. 展开更多
关键词 Wind-wave directional function directional spectrum
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非酒精性脂肪肝患者的ALT水平及其影响因素和应用价值分析 被引量:9
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作者 桑梦珠 吴克俭 +1 位作者 李平静 王慧颖 《医学研究杂志》 2021年第4期99-105,共7页
目的探讨体检人群中非酒精性脂肪肝(non-alcoholic fatty liverdisease,NAFLD)患者丙氨酸氨基转移酶(alanine transaminase,ALT)水平的特点及其影响因素,评估ALT水平对NAFLD诊断和病情评估的价值。方法选取2020年5~7月在徐州医科大学附... 目的探讨体检人群中非酒精性脂肪肝(non-alcoholic fatty liverdisease,NAFLD)患者丙氨酸氨基转移酶(alanine transaminase,ALT)水平的特点及其影响因素,评估ALT水平对NAFLD诊断和病情评估的价值。方法选取2020年5~7月在徐州医科大学附属医院健康管理中心体检的4293例体检者,收集一般情况及体格检查、实验室指标检测、腹部超声检查的资料并进行统计分析。NAFLD的诊断及轻中重度分级采用彩超诊断标准,非酒精性脂肪肝纤维化评分(non-alcoholic fatty liver disease fibrosis score,NFS)以0.676和-1.455为界值,NFS>0.676为进展期肝纤维化可能,NFS<-1.455为无进展期肝纤维化。结果体检人群中NAFLD发生率为36.7%,NAFLD患者中ALT水平正常者占85.1%,Logistic回归分析显示高BMI、高TG、高LDL为男性NAFLD患者ALT升高的独立危险因素,高TG为女性患者ALT升高的独立危险因素,高ALT、高BMI、高SBP为重度NAFLD的独立预测因子。NAFLD患者中ALT升高组与ALT正常组NFS>0.676、NFS<-1.455、-1.455<NFS<0.676者比较差异均无统计学意义(P>0.05)。现有ALT标准诊断NAFLD的敏感度较差,ROC曲线计算出的ALT最佳截断值为女性13U/L,男性22U/L,敏感度为71.26%,特异性为59.88%,AUROC为0.656。结论ALT水平可用于评估NAFLD患者的等级,但利用ALT诊断NAFLD的准确性较差,且无法判断进展期纤维化情况。 展开更多
关键词 非酒精性脂肪肝 丙氨酸氨基转移酶 甘油三酯 进展期肝纤维化
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The Influence of Typhoon'Hongxia'on the Intrusion of the Kuroshio Current into the South China Sea 被引量:2
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作者 GAO Shumin HAN Shuzong +4 位作者 WANG Shicheng wu Dexing WANG Mingjie wu kejian LIU Lili 《Journal of Ocean University of China》 SCIE CAS CSCD 2023年第2期297-312,共16页
This paper uses the Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST)model to analyze the impact of typhoon‘Hongxia’on the velocity and position movement of the Kuroshio axis,the impact of typhoons on the Kur... This paper uses the Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST)model to analyze the impact of typhoon‘Hongxia’on the velocity and position movement of the Kuroshio axis,the impact of typhoons on the Kuroshio intrusion into South China Sea(SCS),the corresponding water,heat,and salt fluxes,and the impact of Kuroshio water in the northeastern SCS.When typhoon‘Hongxia’passed,the Kuroshio intrusion into the SCS was the most significant at 21?N latitude.In the vertical direction,the Kuroshio intrusion was strongest in the subsurface layer,leading to the most significant changes in temperature and salinity in the northeastern part of the SCS in the subsurface layer.Under the influence of the southeastern monsoon in summer,a large amount of low-salinity water accumulates at the surface of the northeastern part of the SCS,and Kuroshio intrusive water remains in the bottom and middle portions of the subsurface layer.The westward deviation of the Kuroshio axis caused by the typhoon displays a certain lag compared with the hot and salty water intrusion into the SCS approximately 7 d later.The impact of the typhoon on the Kuroshio intrusion into the SCS lasts for 20 d.The typhoon caused increases in the water,heat,and salt fluxes associated with the Kuroshio intrusion into the SCS,and the contribution of the typhoon to these fluxes was as high as 40%.Under typhoon conditions,the maximum Kuroshio intrusion flux reached more than twice that before the typhoon. 展开更多
关键词 TYPHOON Kuroshio intrusion South China Sea COAWST coupling model FLUX
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浅谈高等数学微课教学设计——以“函数最值的求法”为例 被引量:2
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作者 刘烁 马丽娜 +2 位作者 吴克坚 徐清华 赵清波 《高等数学研究》 2019年第5期55-57,共3页
本文以"函数最值的求法"教学为例,介绍了"提出问题-学习理论-解决问题"的微课教学设计思路.以实际问题引入新课,介绍解决问题所需要的理论知识,最后利用理论知识来解决实际问题.
关键词 高等数学 微课 教学设计
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