Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits

AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver.

计算机辅助手术系统在小儿胰腺实性假乳头状瘤手术中的应用

目的研究海信计算机辅助手术系统(CAS)在小儿胰腺实性假乳头状瘤手术中的应用价值及临床意义。方法对青岛大学附属医院2015年6月至2018年9月收治的5例胰腺实性假乳头状瘤行上腹部64排螺旋CT增强扫描,应用CAS进行三维重建,基于数字化三维模型制定手术方案,术前模拟肿瘤切除,术中辅助指导;分析手术时间、术中出血量、输血率等。结果数字化三维重建结果可清晰显示胰腺肿瘤与周围血管、脏器的毗邻关系,基于个性化模型虚拟手术,实现精准切除。术后病理结果均为胰腺实性假乳头状瘤。5例肿瘤中2例位于胰头,1例位于胰颈,2例位于胰体尾。手术时间为150~360 min,平均279 min,术中出血量平均40 mL,最少出血量为5 mL,输血率40%(2/5例),5例患儿均成功切除肿瘤,康复出院;随访6个月~3年,均未见复发和转移。结论CAS三维重建能清晰显示肿瘤与周围血管、脏器的毗邻关系,术前制定最佳手术方案,提高手术的精准性与安全性。