To the Editor:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases globally,and this systemic disease carries a substantial economic burden and will result in a greater disease burde...To the Editor:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases globally,and this systemic disease carries a substantial economic burden and will result in a greater disease burden in the future.[1]Mass screening of asymptomatic individuals using ultrasonography is not cost-effective.Therefore,simple,noninvasive tests are required to identify patients with NAFLD.The fatty liver index(FLI)and hepatic steatosis index(HSI)are accurate and easy to obtain.展开更多
What is already known about this topic?The proportion of elderly living alone in China is approximately 10%.Living away from family poses enormous challenges for older adults.What is added by this report?Compared to t...What is already known about this topic?The proportion of elderly living alone in China is approximately 10%.Living away from family poses enormous challenges for older adults.What is added by this report?Compared to those living with family,elderly individuals living alone exhibit a lower registration rate with general practitioners and have less social support.What are the implications for public health practice?While the current health service system for elderly people living alone is working relatively well,there is a need for additional programs to enhance social support and improve their social well-being.展开更多
Ambient ozone(O3)exposure may be associated with a reduction of semen quality,yet the potential biological mechanisms remain unclear.We investigated the effects of certain seminal plasma metabolites on mediating the l...Ambient ozone(O3)exposure may be associated with a reduction of semen quality,yet the potential biological mechanisms remain unclear.We investigated the effects of certain seminal plasma metabolites on mediating the links between O3 exposure and the deterioration of semen quality.The untargeted metabolomics analysis was performed on semen samples of 200 Chinese adult men to determine candidate metabolites associated with characteristics of semen quality.Mediation analysis was adopted to examine whether these metabolites modulated the links between O3 exposure and semen quality.We found a significant reduction in sperm concentration by−28.1%(95%CI:−41.7%,−11.3%),and sperm count by−29.2%(95%CI:−43.7%,−11.0%)associated with each 10μg/m3 increase in ambient O3 concentration during the period of sperm development.We delineated 7 metabolites in seminal fluid that substantially mediated the links between O3 exposure and declined semen quality,including myristoleic acid,aspartyl-isoleucine,phenylethyl primeveroside,ACar(18:2),ACar(18:1),FAHFA(22:6/22:3),and LPS(22:5).Among these,myristoleic acid exhibited the most pronounced mediation effects,with its indirect effect of which accounts for 46.4%of the overall association.Our findings suggested that exposure to ozone decreased sperm quality by disrupting fatty acid metabolism,particularly myristoleic acid.展开更多
文摘To the Editor:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases globally,and this systemic disease carries a substantial economic burden and will result in a greater disease burden in the future.[1]Mass screening of asymptomatic individuals using ultrasonography is not cost-effective.Therefore,simple,noninvasive tests are required to identify patients with NAFLD.The fatty liver index(FLI)and hepatic steatosis index(HSI)are accurate and easy to obtain.
基金support from community health service centers in Xicheng and Daxing Districts,Beijingsupport from Provincial Center for Disease Control and Prevention in Zhejiang+1 种基金Provincial Patriotic Health and Health Promotion Center in JiangxiProvincial Health Education Center in Chongqing,Liaoning and Gansu.
文摘What is already known about this topic?The proportion of elderly living alone in China is approximately 10%.Living away from family poses enormous challenges for older adults.What is added by this report?Compared to those living with family,elderly individuals living alone exhibit a lower registration rate with general practitioners and have less social support.What are the implications for public health practice?While the current health service system for elderly people living alone is working relatively well,there is a need for additional programs to enhance social support and improve their social well-being.
文摘Ambient ozone(O3)exposure may be associated with a reduction of semen quality,yet the potential biological mechanisms remain unclear.We investigated the effects of certain seminal plasma metabolites on mediating the links between O3 exposure and the deterioration of semen quality.The untargeted metabolomics analysis was performed on semen samples of 200 Chinese adult men to determine candidate metabolites associated with characteristics of semen quality.Mediation analysis was adopted to examine whether these metabolites modulated the links between O3 exposure and semen quality.We found a significant reduction in sperm concentration by−28.1%(95%CI:−41.7%,−11.3%),and sperm count by−29.2%(95%CI:−43.7%,−11.0%)associated with each 10μg/m3 increase in ambient O3 concentration during the period of sperm development.We delineated 7 metabolites in seminal fluid that substantially mediated the links between O3 exposure and declined semen quality,including myristoleic acid,aspartyl-isoleucine,phenylethyl primeveroside,ACar(18:2),ACar(18:1),FAHFA(22:6/22:3),and LPS(22:5).Among these,myristoleic acid exhibited the most pronounced mediation effects,with its indirect effect of which accounts for 46.4%of the overall association.Our findings suggested that exposure to ozone decreased sperm quality by disrupting fatty acid metabolism,particularly myristoleic acid.
