Antibiotic resistant bacteria(ARB)with antibiotic resistance genes(ARGs)can reduce or eliminate the effectiveness of antibiotics and thus threaten human health.The United Nations Environment Programme considers antibi...Antibiotic resistant bacteria(ARB)with antibiotic resistance genes(ARGs)can reduce or eliminate the effectiveness of antibiotics and thus threaten human health.The United Nations Environment Programme considers antibiotic resistance the first of six emerging issues of concern.Advanced oxidation processes(AOPs)that combine ultraviolet(UV)irradiation and chemical oxidation(primarily chlorine,hydrogen peroxide,and persulfate)have attracted increasing interest as advanced water and wastewater treatment technologies.These integrated technologies have been reported to significantly elevate the efficiencies of ARB inactivation and ARG degradation compared with direct UV irradiation or chemical oxidation alone due to the generation of multiple reactive species.In this study,the performance and underlying mechanisms of UV/chlorine,UV/hydrogen peroxide,and UV/persulfate processes for controlling ARB and ARGs were reviewed based on recent studies.Factors affecting the process-specific efficiency in controlling ARB and ARGs were discussed,including biotic factors,oxidant dose,UV fluence,pH,and water matrix properties.In addition,the cost-effectiveness of the UV-based AOPs was evaluated using the concept of electrical energy per order.The UV/chlorine process exhibited a higher efficiency with lower energy consumption than other UV-based AOPs in the wastewater matrix,indicating its potential for ARB inactivation and ARG degradation in wastewater treatment.Further studies are required to address the trade-off between toxic byproduct formation and the energy efficiency of the UV/chlorine process in real wastewater to facilitate its optimization and application in the control of ARB and ARGs.展开更多
In this research,two novel folded lattice-core sandwich cylinders were designed,manufactured,and tested.The lattice core has periodic zigzag corrugations,whose ridges and valleys are directed axially or circumferentia...In this research,two novel folded lattice-core sandwich cylinders were designed,manufactured,and tested.The lattice core has periodic zigzag corrugations,whose ridges and valleys are directed axially or circumferentially.Free vibration and axial compression experiments were performed to reveal the fundamental frequency,free vibration modes,bearing capacity,and failure mode of the cylinder.A folded lattice core effectively restricts local buckling by reducing the dimension of the local skin periodic cell,and improves the global buckling resistance by enhancing the shear stiffness of the sandwich core.The cylinders fail at the mode of material failure and possess excellent load-carrying capacity.An axially directed folded sandwich cylinder has greater load-carrying capacity,while a circumferentially directed folded sandwich cylinder has higher fundamental frequencies.These two types of folded lattices provide a selection for engineers when designing a sandwich cylinder requiring strength or vibration.This research also presents a feasible way to fabricate a large-dimensional folded structure and promote its engineering application.展开更多
The Chinese population is entering a new stage of development,marked by the fertility intentions of women of childbearing age continuing to decline and concerns over their consistently low fertility rates.The number o...The Chinese population is entering a new stage of development,marked by the fertility intentions of women of childbearing age continuing to decline and concerns over their consistently low fertility rates.The number of newborns has been decreasing annually,with 2022 figures falling below 10 million for the first time since the founding of the People’s Republic of China,resulting in negative population growth(1).Currently,China’s population over the age of 60 years is nearing 300 million and is projected to surpass 20%of the total population during the 14th Five-Year Plan period.展开更多
Evidence for the influence of chronic inflammation induced by microbial dysbiosis on aberrant DNA methylation supports a plausible connexion between disordered microbiota and precancerous lesions of gastric cancer(PLG...Evidence for the influence of chronic inflammation induced by microbial dysbiosis on aberrant DNA methylation supports a plausible connexion between disordered microbiota and precancerous lesions of gastric cancer(PLGC).Here,a comprehensive study including multi-omics data was performed to estimate the relationships amongst the gastric microbiome,inflammatory proteins and DNA methylation alterations and their roles in PLGC development.The results demonstrated that gastric dysbacteriosis increased the risk of PLGC and DNA methylation alterations in related tumour suppressor genes.Seven inflammatory biomarkers were identified for antrum and corpus tissues,respectively,amongst which the expression levels of several biomarkers were significantly correlated with the microbial dysbiosis index(MDI)and methylation status of specific tumour suppressor genes.Notably,mediation analysis revealed that microbial dysbiosis partially contributed to DNA methylation changes in the stomach via the inflammatory cytokines C-C motif chemokine 20(CCL20)and tumour necrosis factor receptor superfamily member 9(TNFRSF9).Overall,these results may provide new insights into the mechanisms that might link the gastric microbiome to PLGC.展开更多
Bragg filters are of essential importance for chip-scale photonic systems.However,the implementation of filters with sub-nanometer bandwidth and rejection beyond 70 dB is hindered by the high index contrast of the sil...Bragg filters are of essential importance for chip-scale photonic systems.However,the implementation of filters with sub-nanometer bandwidth and rejection beyond 70 dB is hindered by the high index contrast of the siliconon-insulator platform,which makes filters prone to fabrication imperfections.In this paper,we propose to combine coherency-broken cascading architecture and cladding modulation to circumvent the intrinsic limitation.The cascading architecture effectively prevents the accumulation of phase errors,while the cladding modulation offers additional design freedom to reduce the coupling coefficient.A bimodal Bragg filter with a testingequipment-limited rejection level of 74 dB and a 40 dB bandwidth of 0.44 nm is experimentally demonstrated.The minimum feature size is 90 nm,which significantly relieves the fabrication constraints.展开更多
Chlorine disinfection of saline wastewater effluents rich in bromide and iodide forms relatively toxic brominated and iodinated disinfection byproducts(DBPs). Ultrasonication is a relatively new water treatment techno...Chlorine disinfection of saline wastewater effluents rich in bromide and iodide forms relatively toxic brominated and iodinated disinfection byproducts(DBPs). Ultrasonication is a relatively new water treatment technology, and it is less sensitive to suspended solids in wastewaters. In this study, we examined the effects of ultrasonication(in terms of reactor type and combination mode with chlorination) on the DBP formation and toxicity in chlorinated primary and secondary saline wastewater effluents. Compared with the chlorinated wastewater effluent samples without ultrasonication, ultrasonic horn pretreatment of the wastewater effluent samples reduced the total organic halogen(TOX) levels in chlorination by ~30%, but ultrasonic bath pretreatment of the wastewater samples did not significantly change the TOX levels in chlorination, which might be attributed to the higher energy utilization and decomposition extent of organic DBP precursors in the ultrasonic horn reactor. Moreover, the TOX levels in the chlorinated samples with ultrasonic horn pretreatment(USH–chlorination), simultaneous treatment(chlorination + USH) and subsequent treatment(chlorination–USH) were also significantly reduced, with the maximum TOX reductions occurring in the samples with ultrasonic horn pretreatment. A toxicity index was calculated by weighting and summing the levels of total organic chlorine, total organic bromine and total organic iodine in each treated sample. The calculated toxicity index values of the chlorinated wastewater effluent samples followed a descending rank order of “chlorination” > “chlorination + USH” > “chlorination–USH” > “USH–chlorination”, with the lowest toxicity occurring in the samples with ultrasonic horn pretreatment. Then, a developmental toxicity bioassay was conducted for each treated sample. The measured toxicity index values of the chlorinated wastewater samples followed the same descending rank order.展开更多
This article analyzes the population dynamics in northwestern China from roughly 2010 to 2020.The area’s dynamics showed a slow,stable increase in population size,a stable increase in the population of non-Han ethnic...This article analyzes the population dynamics in northwestern China from roughly 2010 to 2020.The area’s dynamics showed a slow,stable increase in population size,a stable increase in the population of non-Han ethnic groups,which increased at a more rapidly than the Han population,and population rejuvenation coupled with a population structure that aged.The biological sex structure fluctuated within a balanced range in northwestern China.Urbanization advanced in northwestern China,throughout this period,but the area’s level of urbanization is still significantly lower than the average level of urbanization nationally.展开更多
基金supported by grants from the Research Grants Council of the Hong Kong SAR,China(T21-705/20-N and 16210221).
文摘Antibiotic resistant bacteria(ARB)with antibiotic resistance genes(ARGs)can reduce or eliminate the effectiveness of antibiotics and thus threaten human health.The United Nations Environment Programme considers antibiotic resistance the first of six emerging issues of concern.Advanced oxidation processes(AOPs)that combine ultraviolet(UV)irradiation and chemical oxidation(primarily chlorine,hydrogen peroxide,and persulfate)have attracted increasing interest as advanced water and wastewater treatment technologies.These integrated technologies have been reported to significantly elevate the efficiencies of ARB inactivation and ARG degradation compared with direct UV irradiation or chemical oxidation alone due to the generation of multiple reactive species.In this study,the performance and underlying mechanisms of UV/chlorine,UV/hydrogen peroxide,and UV/persulfate processes for controlling ARB and ARGs were reviewed based on recent studies.Factors affecting the process-specific efficiency in controlling ARB and ARGs were discussed,including biotic factors,oxidant dose,UV fluence,pH,and water matrix properties.In addition,the cost-effectiveness of the UV-based AOPs was evaluated using the concept of electrical energy per order.The UV/chlorine process exhibited a higher efficiency with lower energy consumption than other UV-based AOPs in the wastewater matrix,indicating its potential for ARB inactivation and ARG degradation in wastewater treatment.Further studies are required to address the trade-off between toxic byproduct formation and the energy efficiency of the UV/chlorine process in real wastewater to facilitate its optimization and application in the control of ARB and ARGs.
基金Support from the National Natural Science Foundation of China(11672130 and 11972184)the State Key Laboratory of Mechanics and Control of Mechanical Structures(MCMS-0217G03)Aerospace System Engineering Shanghai are gratefully acknowledged.
文摘In this research,two novel folded lattice-core sandwich cylinders were designed,manufactured,and tested.The lattice core has periodic zigzag corrugations,whose ridges and valleys are directed axially or circumferentially.Free vibration and axial compression experiments were performed to reveal the fundamental frequency,free vibration modes,bearing capacity,and failure mode of the cylinder.A folded lattice core effectively restricts local buckling by reducing the dimension of the local skin periodic cell,and improves the global buckling resistance by enhancing the shear stiffness of the sandwich core.The cylinders fail at the mode of material failure and possess excellent load-carrying capacity.An axially directed folded sandwich cylinder has greater load-carrying capacity,while a circumferentially directed folded sandwich cylinder has higher fundamental frequencies.These two types of folded lattices provide a selection for engineers when designing a sandwich cylinder requiring strength or vibration.This research also presents a feasible way to fabricate a large-dimensional folded structure and promote its engineering application.
文摘The Chinese population is entering a new stage of development,marked by the fertility intentions of women of childbearing age continuing to decline and concerns over their consistently low fertility rates.The number of newborns has been decreasing annually,with 2022 figures falling below 10 million for the first time since the founding of the People’s Republic of China,resulting in negative population growth(1).Currently,China’s population over the age of 60 years is nearing 300 million and is projected to surpass 20%of the total population during the 14th Five-Year Plan period.
基金funded by Grant of Science and Technology of Fujian,China(2019L3006)Special Funds of Fujian Finance Department(2020czbz01)High-level Talents Research Start-up Project of Fujian Medical University(XRCZX2017035 and XRCZX2020034).
文摘Evidence for the influence of chronic inflammation induced by microbial dysbiosis on aberrant DNA methylation supports a plausible connexion between disordered microbiota and precancerous lesions of gastric cancer(PLGC).Here,a comprehensive study including multi-omics data was performed to estimate the relationships amongst the gastric microbiome,inflammatory proteins and DNA methylation alterations and their roles in PLGC development.The results demonstrated that gastric dysbacteriosis increased the risk of PLGC and DNA methylation alterations in related tumour suppressor genes.Seven inflammatory biomarkers were identified for antrum and corpus tissues,respectively,amongst which the expression levels of several biomarkers were significantly correlated with the microbial dysbiosis index(MDI)and methylation status of specific tumour suppressor genes.Notably,mediation analysis revealed that microbial dysbiosis partially contributed to DNA methylation changes in the stomach via the inflammatory cytokines C-C motif chemokine 20(CCL20)and tumour necrosis factor receptor superfamily member 9(TNFRSF9).Overall,these results may provide new insights into the mechanisms that might link the gastric microbiome to PLGC.
基金Basic and Applied Basic Research Foundation of Guangdong Province(2020B1515130006,2021B515120056,2023A1515011944)Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20210324131614040,JCYJ20220531095604009)National Natural Science Foundation of China(U22A2093)。
文摘Bragg filters are of essential importance for chip-scale photonic systems.However,the implementation of filters with sub-nanometer bandwidth and rejection beyond 70 dB is hindered by the high index contrast of the siliconon-insulator platform,which makes filters prone to fabrication imperfections.In this paper,we propose to combine coherency-broken cascading architecture and cladding modulation to circumvent the intrinsic limitation.The cascading architecture effectively prevents the accumulation of phase errors,while the cladding modulation offers additional design freedom to reduce the coupling coefficient.A bimodal Bragg filter with a testingequipment-limited rejection level of 74 dB and a 40 dB bandwidth of 0.44 nm is experimentally demonstrated.The minimum feature size is 90 nm,which significantly relieves the fabrication constraints.
基金supported by the Research Grants Council of Hong Kong, China (Nos. 16212518 , 16210221 , T21-711/16R , and T21-705/20-N)the Guangdong Basic and Applied Basic Research of the Joint Regional Fund, Guangdong, China (No. 2019A1515110569)。
文摘Chlorine disinfection of saline wastewater effluents rich in bromide and iodide forms relatively toxic brominated and iodinated disinfection byproducts(DBPs). Ultrasonication is a relatively new water treatment technology, and it is less sensitive to suspended solids in wastewaters. In this study, we examined the effects of ultrasonication(in terms of reactor type and combination mode with chlorination) on the DBP formation and toxicity in chlorinated primary and secondary saline wastewater effluents. Compared with the chlorinated wastewater effluent samples without ultrasonication, ultrasonic horn pretreatment of the wastewater effluent samples reduced the total organic halogen(TOX) levels in chlorination by ~30%, but ultrasonic bath pretreatment of the wastewater samples did not significantly change the TOX levels in chlorination, which might be attributed to the higher energy utilization and decomposition extent of organic DBP precursors in the ultrasonic horn reactor. Moreover, the TOX levels in the chlorinated samples with ultrasonic horn pretreatment(USH–chlorination), simultaneous treatment(chlorination + USH) and subsequent treatment(chlorination–USH) were also significantly reduced, with the maximum TOX reductions occurring in the samples with ultrasonic horn pretreatment. A toxicity index was calculated by weighting and summing the levels of total organic chlorine, total organic bromine and total organic iodine in each treated sample. The calculated toxicity index values of the chlorinated wastewater effluent samples followed a descending rank order of “chlorination” > “chlorination + USH” > “chlorination–USH” > “USH–chlorination”, with the lowest toxicity occurring in the samples with ultrasonic horn pretreatment. Then, a developmental toxicity bioassay was conducted for each treated sample. The measured toxicity index values of the chlorinated wastewater samples followed the same descending rank order.
基金supported by China’s National Social Science Foundation(Grant No:20ARK007).
文摘This article analyzes the population dynamics in northwestern China from roughly 2010 to 2020.The area’s dynamics showed a slow,stable increase in population size,a stable increase in the population of non-Han ethnic groups,which increased at a more rapidly than the Han population,and population rejuvenation coupled with a population structure that aged.The biological sex structure fluctuated within a balanced range in northwestern China.Urbanization advanced in northwestern China,throughout this period,but the area’s level of urbanization is still significantly lower than the average level of urbanization nationally.
