Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with gastric cancer undergoing chemotherapy by increasing ben...Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with gastric cancer undergoing chemotherapy by increasing beneficial gut bacteria and decreasing harmful bacteria.The present study aims to investigate the effect of JYD on gut fungi in patients with gastric cancer undergoing chemotherapy.Methods:A total of 73 patients with gastric cancer undergoing chemotherapy were recruited.Twenty-nine patients in the chemotherapy group were given standard chemotherapy and 44 patients in the observation group were given JYD plus standard chemotherapy.A control group(55 cases)was recruited from the healthy medical examiners.After 3 months of treatment,life-quality score was evaluated and fecal microbiota was tested by high-throughput sequencing based on the 18S rRNA gene.Results:After treatment,life-quality score in the observation group was significantly lower than that in the chemotherapy group(P<0.05).There was no significant difference between the observation and control groups’diversity and richness indices of intestinal fungi.The Chao index for intestinal fungi in the chemotherapy group was significantly lower than that in the observation group(P<0.05).There was a significant difference between the control and chemotherapy groups in the intestinal fungi according to Shannon and Simpson indices(P<0.05).Linear discriminant analysis effect size analysis showed no significant differences among the three groups,but significant difference in intestinal fungi was observed between the observation group and the chemotherapy group.At the genus level,the relative abundance of the Aspergillus genus in the observation and control groups was significantly lower(P<0.05),the relative abundance of the Cutaneotrichosporon,Galactomyces,and Ganoderma genus taxa was significantly higher compared with those in the chemotherapy group(P<0.05),and there was no significant difference between the observation group and control group.Conclusion:JYD can ameliorate chemotherapy-induced fungal dysbacteriosis in patients with gastric cancer undergoing chemotherapy and improve the quality of life of patients.展开更多
为了提高多视图深度估计结果精度,提出一种基于自适应空间特征增强的多视图深度估计算法。设计了由改进后的特征金字塔网络(feature pyramid network,FPN)和自适应空间特征增强(adaptive space feature enhancement,ASFE)组成的多尺度...为了提高多视图深度估计结果精度,提出一种基于自适应空间特征增强的多视图深度估计算法。设计了由改进后的特征金字塔网络(feature pyramid network,FPN)和自适应空间特征增强(adaptive space feature enhancement,ASFE)组成的多尺度特征提取模块,获取到具有全局上下文信息和位置信息的多尺度特征图像。通过残差学习网络对深度图进行优化,防止多次卷积操作出现重建边缘模糊的问题。通过分类的思想构建focal loss函数增强网络模型的判断能力。由实验结果可知,该算法在DTU(technical university of denmark)数据集上和CasMVSNet(Cascade MVSNet)算法相比,在整体精度误差、运行时间、显存资源占用上分别降低了14.08%、72.15%、4.62%。在Tanks and Temples数据集整体评价指标Mean上该模型优于其他算法,证明提出的基于自适应空间特征增强的多视图深度估计算法的有效性。展开更多
基金The present work was funded by National Natural Science Foundation of China(No.81473458)Project of Clinical Scientific Research of Medicine State Administration of Traditional Chinese Medicine(No.JDZX2015091).
文摘Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with gastric cancer undergoing chemotherapy by increasing beneficial gut bacteria and decreasing harmful bacteria.The present study aims to investigate the effect of JYD on gut fungi in patients with gastric cancer undergoing chemotherapy.Methods:A total of 73 patients with gastric cancer undergoing chemotherapy were recruited.Twenty-nine patients in the chemotherapy group were given standard chemotherapy and 44 patients in the observation group were given JYD plus standard chemotherapy.A control group(55 cases)was recruited from the healthy medical examiners.After 3 months of treatment,life-quality score was evaluated and fecal microbiota was tested by high-throughput sequencing based on the 18S rRNA gene.Results:After treatment,life-quality score in the observation group was significantly lower than that in the chemotherapy group(P<0.05).There was no significant difference between the observation and control groups’diversity and richness indices of intestinal fungi.The Chao index for intestinal fungi in the chemotherapy group was significantly lower than that in the observation group(P<0.05).There was a significant difference between the control and chemotherapy groups in the intestinal fungi according to Shannon and Simpson indices(P<0.05).Linear discriminant analysis effect size analysis showed no significant differences among the three groups,but significant difference in intestinal fungi was observed between the observation group and the chemotherapy group.At the genus level,the relative abundance of the Aspergillus genus in the observation and control groups was significantly lower(P<0.05),the relative abundance of the Cutaneotrichosporon,Galactomyces,and Ganoderma genus taxa was significantly higher compared with those in the chemotherapy group(P<0.05),and there was no significant difference between the observation group and control group.Conclusion:JYD can ameliorate chemotherapy-induced fungal dysbacteriosis in patients with gastric cancer undergoing chemotherapy and improve the quality of life of patients.
文摘为了提高多视图深度估计结果精度,提出一种基于自适应空间特征增强的多视图深度估计算法。设计了由改进后的特征金字塔网络(feature pyramid network,FPN)和自适应空间特征增强(adaptive space feature enhancement,ASFE)组成的多尺度特征提取模块,获取到具有全局上下文信息和位置信息的多尺度特征图像。通过残差学习网络对深度图进行优化,防止多次卷积操作出现重建边缘模糊的问题。通过分类的思想构建focal loss函数增强网络模型的判断能力。由实验结果可知,该算法在DTU(technical university of denmark)数据集上和CasMVSNet(Cascade MVSNet)算法相比,在整体精度误差、运行时间、显存资源占用上分别降低了14.08%、72.15%、4.62%。在Tanks and Temples数据集整体评价指标Mean上该模型优于其他算法,证明提出的基于自适应空间特征增强的多视图深度估计算法的有效性。
