THE BOUNDEDNESS OF OPERATORS ON WEIGHTED MULTI-PARAMETER LOCAL HARDY SPACES

Though atomic decomposition is a very useful tool for studying the boundedness on Hardy spaces for some sublinear operators,untill now,the boundedness of operators on weighted Hardy spaces in a multi-parameter setting has been established only by almost orthogonality estimates.In this paper,we mainly establish the boundedness on weighted multi-parameter local Hardy spaces via atomic decomposition.

Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells

BACKGROUND Gastric cancer(GC)is a prevalent malignant tumor of the gastrointestinal system.ZNF710 is a transcription factor(TF),and zinc finger protein 710(ZNF710)-AS1-201 is an immune-related long noncoding RNA(lncRNA)that is upregulated in GC cells.AIM To assess the correlation between ZNF710-AS1-201 and immune microenvir-onment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC cells.METHODS We obtained data from The Cancer Genome Atlas and Wujin Hospital.We assessed cell growth,migration,invasion,and programmed cell death using cell counting kit-8,EdU,scratch,Transwell,and flow cytometry assays.Quantitative real-time polymerase chain reaction(qRT-PCR)was used to identify the potential downstream targets of ZNF710-AS1-201.RESULTS In GC tissues with low ZNF710-AS1-201 expression,immunoassays detected significant infiltration of various antitumor immune cells,such as memory CD8 T cells and activated CD4 T cells.In the low-expression group,the half-maximal inhibitory concentrations(IC_(50)s)of 5-fluorouracil,cisplatin,gemcitabine,and trametinib were lower,whereas the IC_(50)s of dasatinib and vorinostat were higher.The malignant degree of GC was higher and the stage was later in the high-expression group.Additionally,patients with high expression of ZNF710-AS1-201 had lower overall survival and disease-free survival rates.In vitro,the overexpression of ZNF710-AS1-201 greatly enhanced growth,metastasis,and infiltration while suppressing cell death in HGC-27 cells.In contrast,the reduced expression of ZNF710-AS1-201 greatly hindered cell growth,enhanced apoptosis,and suppressed the metastasis and invasion of MKN-45 cells.The expression changes in ZNF710 were significant,but the corresponding changes in isocitrate dehydrogenase-2,Semaphorin 4B,ARHGAP10,RGMB,hsa-miR-93-5p,and ZNF710-AS1-202 were not consistent or statistically significant after overexpression or knockdown of ZNF710-AS1-201,as determined by qRT-PCR.CONCLUSION Immune-related lncRNA ZNF710-AS1-201 facilitates the metastasis and invasion of GC cells.It appears that ZNF710-AS1-201 and ZNF710 have potential as effective targets for therapeutic intervention in GC.Nevertheless,it is still necessary to determine the specific targets of the ZNF710 TF.

Series Reports from Professor Wei's Group of Chongqing University:Advancements in Electrochemical Energy Conversions(1/4):Report 1:High-performance Oxygen Reduction Catalysts for Fuel Cells

Two major challenges,high cost and short lifespan,have been hindering the commercialization process of lowtemperature fuel cells.Professor Wei's group has been focusing on decreasing cathode Pt loadings without losses of activity and durability,and their research advances in this area over the past three decades are briefly reviewed herein.Regarding the Pt-based catalysts and the low Pt usage,they have firstly tried to clarify the degradation mechanism of Pt/C catalysts,and then demonstrated that the activity and stability could be improved by three strategies:regulating the nanostructures of the active sites,enhancing the effects of support materials,and optimizing structures of the three-phase boundary.For Pt-free catalysts,especialiy carbon-based ones,several strategies that they proposed to enhance the activity of nitrogen-/heteroatom-doped carbon catalysts are firstly presented.Then,an indepth understanding of the degradation mechanism for carbon-based catalysts is discussed,and followed by the corresponding stability enhancement strategies.Also,the carbon-based electrode at the micrometer-scale,faces the challenges such as low active-site density,thick catalytic layer,and the effect of hydrogen peroxide,which require rational structure design for the integral cathodic electrode.This review finally gives a brief conclusion and outlook about the low cost and long lifespan of cathodic oxygen reduction catalysts.

Temperature field calculation of rail flash welding

The forging stage of rail flash welding has a decisive influence on joint strength,and the study of the temperature distribution in the process has an important role in further improving joint strength.In this paper,three calculation methods for the temperature field are given.First,the finite element model of the temperature field before forging rail flash welding is established by using the transient heat module of Ansys software and verified by infrared temperature measurement.Second,the temperature distribution of different parts of the rail before flash welding is obtained by using infrared thermal imaging equipment.Third,Matlab software is used to calculate the temperature of the non-measured part.Finally,the temperature distribution function along the rail axis is fitted through the temperature measurement data.The temperature distribution before the top forging of the rail flash welding can be used to analyze the joint and heat-affected zone organization and properties effectively and to guide the parameter setting and industrial production.

Is X-linked methyl-CpG binding protein 2 a new target for the treatment of Parkinson's disease?

X-linked methyl-CpG binding protein 2 mutations can induce symptoms similar to those of Parkinson’s disease and dopamine metabolism disorders, but the specific role of X-linked methyl-CpG binding protein 2 in the pathogenesis of Parkinson’s disease remains unknown. In the present study, we used 6-hydroxydopamine-induced human neuroblastoma cell （SH-SY5Y cells） injury as a cell model of Parkinson’s disease. The 6-hydroxydopamine （50 μmol/L） treatment decreased protein levels for both X-linked methyl-CpG binding protein 2 and tyrosine hydroxylase in these cells, and led to cell death. However, overexpression of X-linked methyl-CpG binding protein 2 was able to ameliorate the effects of 6-hydroxydopamine, it reduced 6-hydroxydopamine-induced apoptosis, and increased the levels of tyrosine hydroxylase in SH-SY5Y cells. These findings suggesting that X-linked methyl-CpG binding protein 2 may be a potential therapeutic target for the treatment of Parkinson’s disease.

Strengthening capacity-building in malaria and schistosomiasis control under China-Africa cooperation:Assessing a case study of Burkina Faso

Malaria and schistosomiasis are highly prevalent in Burkina Faso,whereas China has successfully eliminated malaria as well as schistosomiasis as a public health problem.To implement the China-Africa health cooperation initiative,a series of activities were launched since 2019 to enhance understanding and cooperation among malaria and schistosomiasis professionals in China and Burkina Faso.This study described the achievements of the First Virtual Symposium of China-Burkina Faso Cooperation on Schistosomiasis and Malaria Control.Pre-and post-test questionnaires were employed to study the knowledge changes of participants regarding malaria and schistosomiasis control and elimination,explore capacity-building priorities,and identify potential challenges.Chi-squared statistics were used to compare the differences between sub-groups,and p value<0.05 was considered statistically significant.Participants ranked their preferences for challenges and capacity-building priorities in future cooperation.The responses of participants from both China and Burkina Faso indicated effective improvement in their general knowledge about the diseases whereas the improvement in professional knowledge on malaria and schistosomiasis was limited.The total correct response rate increased from 54.08%to 66.78%.Chinese participants had better schistosomiasis knowledge than Burkina Faso participants did,but the same result was not found for malaria.Diseases control strategies,surveillance and response system,and diagnostics techniques were identified as the top three priorities for future capacity building.Participants from China and Burkina Faso shared almost the same views about challenges except with respect to pathogens,which the former saw as a major challenge and the latter did not.The study findings will help policymakers,health managers,and researchers to understand the future cooperation between Burkina Faso and China on malaria and schistosomiasis.

Standing-wave spectrometry in silicon nano-waveguides using reflection-based near-field scanning optical microscopy

Utilizing reflection-based near-field scanning optical microscopy(NSOM) to image and analyze standing-wave patterns, we present a characterization technique potentially suitable for complex photonic integrated circuits. By raster scanning along the axis of a straight nano-waveguide in tapping mode and sweeping wavelength, detailed information of propagating waves in that waveguide has been extracted from analyses in both space and wavelength domains. Our technique needs no special steps for phase stabilization, thus allowing long-duration and environment-insensitive measurements. As a proof-of-concept test, in a silicon single-mode waveguide with a few of etched holes, the locations and reflection strengths of the inner defects have been quantified. The measurement uncertainty of the reflection amplitude is less than 25% at current stage. Our technique paves the way for non-destructively diagnosing photonic circuits on a chip with sub-wavelength spatial resolution and detailed information extraction.

Recovery of Li, Ni, Co and Mn from spent lithium-ion batteries assisted by organic acids: Process optimization and leaching mechanism

The proper recycling of spent lithium-ion batteries(LIBs)can promote the recovery and utilization of valuable resources,while also negative environmental effects resulting from the presence of toxic and hazardous substances.In this study,a new environmentally friendly hydro-metallurgical process was proposed for leaching lithium(Li),nickel(Ni),cobalt(Co),and manganese(Mn)from spent LIBs using sulfuric acid with citric acid as a reductant.The effects of the concentration of sulfuric acid,the leaching temperature,the leaching time,the solid-liquid ratio,and the reducing agent dosage on the leaching behavior of the above elements were investigated.Key parameters were optimized using response surface methodology(RSM)to maximize the recovery of metals from spent LIBs.The maxim-um recovery efficiencies of Li,Ni,Co,and Mn can reach 99.08%,98.76%,98.33%,and 97.63%.under the optimized conditions(the sulfuric acid concentration was 1.16 mol/L,the citric acid dosage was 15wt%,the solid-liquid ratio was 40 g/L,and the temperature was 83℃ for 120 min),respectively.It was found that in the collaborative leaching process of sulfuric acid and citric acid,the citric acid initially provided strong reducing CO_(2)^(-),and the transition metal ions in the high state underwent a reduction reaction to produce transition metal ions in the low state.Additionally,citric acid can also act as a proton donor and chelate with lower-priced transition metal ions,thus speeding up the dissolution process.

Highly Porous Yet Transparent Mechanically Flexible Aerogels Realizing Solar-Thermal Regulatory Cooling

The demand for highly porous yet transparent aerogels with mechanical flexibility and solar-thermal dual-regulation for energy-saving windows is significant but challenging.Herein,a delaminated aerogel film(DAF)is fabricated through filtration-induced delaminated gelation and ambient drying.The delaminated gelation process involves the assembly of fluorinated cellulose nanofiber(FCNF)at the solid-liquid interface between the filter and the filtrate during filtration,resulting in the formation of lamellar FCNF hydrogels with strong intra-plane and weak interlayer hydrogen bonding.By exchanging the solvents from water to hexane,the hydrogen bonding in the FCNF hydrogel is further enhanced,enabling the formation of the DAF with intra-layer mesopores upon ambient drying.The resulting aerogel film is lightweight and ultra-flexible,which pos-sesses desirable properties of high visible-light transmittance(91.0%),low thermal conductivity(33 mW m^(-1) K^(-1)),and high atmospheric-window emissivity(90.1%).Furthermore,the DAF exhibits reduced surface energy and exceptional hydrophobicity due to the presence of fluorine-containing groups,enhancing its durability and UV resistance.Consequently,the DAF has demonstrated its potential as solar-thermal regulatory cooling window materials capable of simultaneously providing indoor lighting,thermal insulation,and daytime radiative cooling under direct sunlight.Significantly,the enclosed space protected by the DAF exhibits a temperature reduction of 2.6℃ compared to that shielded by conventional architectural glass.

rAAV在遗传性耳聋治疗中的研究进展

据世界卫生组织2021年报道,50%以上先天性听力损失是由遗传性因素变异引起的。临床上用于提高耳聋患者听力的几种主要方式(如佩戴助听器、植入人工耳蜗)都有一定局限性。近年来,重组腺相关病毒(recombination adeno-associated virus,r AAV)作为相对安全的基因治疗载体在遗传性疾病的临床及基础研究中被广泛应用。单r AAV由于包装载体大小受限,在大基因片段缺陷造成的疾病研究与治疗中的应用受限。目前已有团队开发了双重r AAV用于治疗大基因片段缺陷造成的疾病。文章着重介绍了双重r AAV在大基因片段缺陷造成的耳聋中的研究进展,为将来开发更多耳聋基因治疗r AAV提供帮助。

Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic:A multicenter cross-sectional study

BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2019(COVID-19)as well as worsening mental health problems and insomnia.These problems can persist for a long period,even after the pandemic.However,less is known about this topic.AIM To analyze mental health,insomnia problems,and their influencing factors in HCWs after the COVID-19 pandemic.METHODS This multicenter cross-sectional,hospital-based study was conducted from June 1,2023 to June 30,2023,which was a half-year after the end of the COVID-19 emergency.Region-stratified population-based cluster sampling was applied at the provincial level for Chinese HCWs.Symptoms such as anxiety,depression,and insomnia were evaluated by the Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Insomnia Severity Index.Factors influencing the symptoms were identified by multivariable logistic regression.RESULTS A total of 2000 participants were invited,for a response rate of 70.6%.A total of 1412 HCWs[618(43.8%)doctors,583(41.3%)nurses and 211(14.9%)nonfrontline],254(18.0%),231(16.4%),and 289(20.5%)had symptoms of anxiety,depression,and insomnia,respectively;severe symptoms were found in 58(4.1%),49(3.5%),and 111(7.9%)of the participants.Nurses,female sex,and hospitalization for COVID-19 were risk factors for anxiety,depression,and insomnia symptoms;moreover,death from family or friends was a risk factor for insomnia symptoms.During the COVID-19 outbreak,most[1086(76.9%)]of the participating HCWs received psychological interventions,while nearly all[994(70.4%)]of them had received public psychological education.Only 102(7.2%)of the HCWs received individual counseling from COVID-19.CONCLUSION Although the mental health and sleep problems of HCWs were relieved after the COVID-19 pandemic,they still faced challenges and greater risks than did the general population.Identifying risk factors would help in providing targeted interventions.In addition,although a major proportion of HCWs have received public psychological education,individual interventions are still insufficient.

凝灰质砂岩崩岗土体的渗透性研究

选取赣南凝灰质砂岩崩岗土体为研究对象,采用环刀法研究凝灰质砂岩崩岗土体入渗特性,并分析土体主要理化性质对其入渗特征的影响。结果表明:①凝灰质砂岩风化壳土体重度表现为上层小于下层;受土体相对密度的影响,不同土层土体总孔隙度大小并未呈现出与土壤容重相反的规律,同样表现为上层小于下层;不同土层之间的土壤重度与总孔隙度无显著相关性。②凝灰质砂岩下层土体初始渗透速率、稳定渗透速率、平均渗透速率、入渗量等渗透参数均显著高于上层土体(P<0.05),而稳定入渗时间低于上层土体。③凝灰质砂岩初始渗透速率与所选的指标均无显著的相关性,稳定渗透速率与土壤重度呈极显著负相关,平均渗透速率与总孔隙度、毛管孔隙度呈极显著正相关。

面向自动化拆蛋的卵细胞定位方法研究

卵细胞拆蛋是人工辅助生殖技术中至关重要的操作之一,但现有手动操作成功率低、丢卵现象时有发生。在自动化操作中,借助显微操作平台和智能运动平台对培养皿中的卵细胞进行反复吹打、清洗是常用的操作方法。设计了面向自动化拆蛋的卵细胞定位方法,利用培养皿内微滴的矩阵布置,通过三点定圆建立实物坐标系,并按回转路径扫描微滴,划分区域检测线,利用计算机视觉对比图像灰度值的方法检测定位卵细胞。结果表明,矩阵微滴内拆蛋和计算机视觉识别缩小了定位范围,提高了卵细胞的定位效率,成功率达到96%。

石洋湖水生态环境的现状问题及防治分析

通过对石洋湖现状进行调查分析,以“保证湖泊面积不萎缩、改善周边环境、提升景观效果、打造特色生态廊道”为原则,按照“一湖一策”的方案要求,提出了对石洋湖实施水系连通、水污染防治、水生态修复、湖泊缓冲带修复等多种水生态环境提升措施,实现湖泊生态良性持续循环,为湖泊治理提供参考。

Correction to:Highly Porous Yet Transparent Mechanically Flexible Aerogels Realizing Solar-Thermal Regulatory Cooling

Tianxi Liu was missed to be denoted as a corresponding author in the article.Both Chao Zhang and Tianxi Liu are the corresponding authors of this article.The original article has been corrected.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution,and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The images or other third-party material in this article are included in the article’s Creative Commons licence,unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.

媒介可供性视角下有声读物的实践逻辑与创新路向

媒介技术的进步促使有声读物需要在新的媒介技术框架下进行理念创新与实践创新。文章以媒介可供性为理论路径,从生产可供性、价值可供性、移动可供性、社交可供性、感知可供性、情感可供性六方面剖析了有声读物生产传播的实践逻辑。此分析过程是对西方引进理论媒介可供性在中国互联网情境下的实践探索和本土适应。为全面增强有声读物的可供性与服务力,文章进一步从内容生态范式革新、情感性移动阅读场景构建、社群成员身份认同强化、身体全感官要素激活等维度勾勒出有声读物出版创新的新图景。

乙型肝炎病毒大表面蛋白诱导内质网应激调控p27 IRES翻译活性的机制研究

目的探讨在乙型肝炎病毒大表面蛋白(LHB)诱导的内质网应激条件下,抑癌基因p275′UTR内部核糖体进入位点(IRES)的活性变化及其调控机制。方法构建双荧光素酶报告质粒,用双荧光素酶报告基因实验检测p275′UTR中IRES的活性;利用qRT-PCR和Western blotting检测LHB诱导的未折叠蛋白反应相关分子水平;RNA下拉、质谱技术和RNA免疫沉淀筛选并确认潜在的与p275′UTR结合的相关蛋白;siRNA转染建立PCBP2和ANXA2敲低细胞模型,用双荧光素酶报告基因检测在敲低PCBP2和ANXA2后p27 IRES翻译活性的变化。结果成功构建了检测p27 IRES活性的双荧光素酶报告质粒。LHB可以诱导内质网应激,同时显著提高p27的IRES翻译活性(P<0.01)。LHB过表达激活了PERK通路并提高了eIF2α的磷酸化水平,特异性PERK通路抑制剂GSK2606414使RERK和eIF2α的磷酸化水平降低,从而引起p275′UTR的IRES翻译活性显著降低(P<0.01,P<0.05)。同时,磷酸酶抑制剂Sal003能显著增加eIF2α磷酸化水平,使p27 IRES活性进一步增强(P<0.01,P<0.05)。最后,我们发现PCBP2和ANXA2作为潜在的反式作用因子可增强p27 IRES活性。结论LHB诱导的内质网应激通过eIF2α磷酸化增强p27 IRES翻译活性。反式作用因子PCBP2和ANXA2正向调控其IRES翻译活性。

区域性洪水影响评价方法研究

以城市开发区作为整体进行的区域性洪水影响评价与独立建设项目洪水影响评价在评价对象、评价内容和评价方法方面均有明显区别。以湖北省浠水经济开发区为例,对区域性洪水影响评价的技术路线和评价重点进行探索,根据地形特点将临近小支流因暴雨产生的洪水和内涝作为主要洪水来源,根据开发区规划和未来发展提出了更高的防洪标准,通过水动力学模型计算周边流域可能发生的洪水给开发区带来的风险。结果表明,防洪标准内的洪水导致浠水经济开发区受淹的可能性较大,推荐采用填高沿河场地的措施降低洪水对浠水经济开发区的威胁。区域性洪水影响评价可通过整体风险评价为开发区规划和建设过程中防范洪水风险提供技术支撑,也通过开发区整体提前审批代替了建设项目逐个单独审批,提高了行政审批效率。

管道流动体系中水合物颗粒粒径分布特性数值模拟

研究管道内水合物颗粒的粒径分布特性对深水流动安全保障具有十分重要的意义。为模拟管道流动体系中水合物颗粒的粒径分布特性,本文首先建立了基于水合物颗粒聚集动力学的群体平衡模型。该模型重点考虑水合物颗粒在流动过程中的碰撞频率、聚并效率、破碎频率及破碎后子颗粒的粒径分布函数,可较好地刻画管内水合物颗粒的流动行为。随后,根据文献中的实验装置建立三维几何模型,利用FLUENT 14.5软件对上述群体平衡模型和相关固液两相流模型进行联合求解,借此模拟水合物颗粒初始粒径分布、水合物体积分数、管内流速和水合物颗粒初始粒径大小对管内水合物颗粒粒径分布类型及分布规律的影响。本文模拟结果与文献中相关实验数据吻合良好,可为水合物防治技术的发展提供技术支持。