Development and application prospect of stem cell combined with 3D printing technology for oral disease

With organ transplantation facing many dilemmas,tissue and organ regeneration as an alternative has bright prospects.In regenerative medicine,Three-dimensional(3D)printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry,respectively.However,there are very few studies on the combination of the two,and even fewer clinical studies have been reported in dentistry.In this review,the current oral tissue engineering in vivo and in vitro based on 3D printing and stem cell technology will be summarized,and the discussion on the development prospects of this research direction will be given.Besides,the working principles and advantages&disadvantages of several types of 3D printers,as well as the mechanism of stem cells in tissue engineering will be elucidated.This review provides clinicians and researchers with the current state of research and trends in the combination of stem cells and 3D printing technology to treat oral-related diseases.In the future,3D bioprinters are poised for ongoing innovation with the advancement of relevant technologies,catalyzing an increase in clinical studies focused on treating oral diseases using stem cells and 3D scaffolds.Consequently,these developments will further advance the field of oral tissue engineering.

Measurements of the ^(107)Ag neutron capture cross sections with pulse height weighting technique at the CSNS Back-n facility

Silver indium cadmium(Ag–In–Cd) control rod is widely used in pressurized water reactor nuclear power plants,and it is continuously consumed in a high neutron flux environment. The mass ratio of ^(107)Ag in the Ag–In–Cd control rod is 41.44%. To accurately calculate the consumption value of the control rod, a reliable neutron reaction cross section of the ^(107)Ag is required. Meanwhile,^(107)Ag is also an important weak r nucleus. Thus, the cross sections for neutron induced interactions with ^(107)Ag are very important both in nuclear energy and nuclear astrophysics. The(n, γ) cross section of ^(107)Ag has been measured in the energy range of 1–60 eV using a back streaming white neutron beam line at China spallation neutron source. The resonance parameters are extracted by an R-matrix code. All the cross section of ^(107)Ag and resonance parameters are given in this paper as datasets. The datasets are openly available at http://www.doi.org/10.11922/sciencedb.j00113.00010.

Predicting the number of visceral leishmaniasis cases in Kashgar, Xinjiang, China using the ARIMA-EGARCH model

Objective:To forecast the visceral leishmaniasis cases using autoregress integrated moving average(ARIMA)and hybrid ARIMAEGARCH model,which offers a scientific basis to control visceral leishmaniasis spread in Kashgar Prefecture of Xinjiang,China.Methods:The data used in this paper are monthly visceral leishmaniasis cases in the Kashgar Prefecture of Xinjiang from 2004 to 2016.The sample data between 2004 and 2015 were used for the estimation to choose the best model and the sample data in 2016 were used for the forecast.Time series of visceral leishmaniasis started on 1 January 2004 and ended on 31 December 2016,consisting of 1790 observations reported in Kashgar Prefecture.Results:For Xinjiang,the total number of reported cases were 2187,the male-to-female ratio of cases was 1:1.42.Patients aged between 0 and 10 years accounted for 82.72%of all reported cases and the largest percentage of visceral leishmaniasis cases was detected among scattered children who accounted for 68.82%.The monthly incidences fitted by ARIMA(2,1,2)(1,1,1)12 model were consistent with the real data collected from 2004 to 2015.However,the predicted cases failed to comply with the observed case number;we then attempted to establish a hybrid ARIMA-EGARCH model to fit visceral leishmaniasis.Finally,the ARIMA(2,1,2)(1,1,1)12-EGARCH(1,1)model showed a good estimation when dealing with volatility clustering in the data series.Conclusions:The combined model has been determined as the best prediction model with the root-mean-square error(RMSE)of 7.23%in the validation phase,which means that this model has high validity and rationality and can be used for short-term prediction of visceral leishmaniasis and could be applied to the prevention and control of the disease.

关于设立面向全球科学研究基金的思考与建议

气候变化、健康危机和粮食安全等问题通常会超越国家间的地理边界,是典型的全球性挑战。随着不同挑战的日益加剧,设立全球科学研究基金已成为推动科技进步、探索创新解决方案和加强伙伴关系的重要手段。在此背景下,“研究设立面向全球的科学研究基金”是我国“十四五”时期(2021—2025年)完善科技创新体制的重要举措。为推进这一举措落实,本文在分析主要发达国家(美国、加拿大、英国、德国、日本、澳大利亚)和欧盟针对全球挑战的科研基金资助经验和广泛调研研讨的基础上,从人才项目、研究项目和大科学装置项目三个方面提出了我国未来设立面向全球的科学研究基金的建议,并探讨了相应的遴选、评估和管理机制,以期促进我国科研资助体系的创新发展,逐步提升我国在全球挑战研究中的国际影响力。

再论构造叠加晕找盲矿三个核心理论的创新性及应用效果

“原生晕轴向分带理论”、“原生叠加晕理论”和“构造叠加晕理论”是构造叠加晕找盲矿法指导发现异常→评价异常→深部预测的三个核心理论,是提高预测准确性的关键。“构造叠加晕理论”是用少而精的样品发现异常→强化弱异常→加大预测深度的一种理论,“原生晕轴向分带理论”和“原生叠加晕理论”相结合是异常评价、预测盲矿和判别矿体剥蚀程度的重要理论。构造叠加晕团队先后在17个省105个矿山邀请138次立项研究-预测应用,其中已有20个矿山提供了预测靶位验证证明,累计找到金金属量突破320 t,见矿效果非常好。实践进一步证明了三个核心理论在找盲矿中的正确性和先进性,也表明构造叠加晕找盲矿法在矿区深部及外围找盲矿是一种直接、准确、有效的方法。

机场道面水平钻孔注浆材料的制备与性能研究

为满足机场不停航施工道面下基层水平注浆工程对材料的需求,开展了复合硅酸盐水泥和硫铝酸盐水泥复配试验。制备出符合施工要求的硅酸盐-硫铝酸盐复合水泥砂浆,并使用维卡仪、截锥圆模、压力试验机等设备研究了材料的凝结时间、流动性、1d抗压强度等。结果表明:硫铝酸盐水泥掺加比例越高,凝结时间越短;水灰比及减水剂掺量对流动性影响较大,同时对其他性能有一定影响。在确认最佳配合比时,经圆柱体强度试件模拟的钻孔注浆和现场试验段重锤式弯沉仪及探地雷达实测结果表明:复合水泥砂浆具有良好的工作性能,道面强度及结构恢复至钻孔前水平,能满足机场不停航施工要求。

Weighted Pseudo Almost Periodic Solutions for a Class of Hematopoiesis Model with Time-Varying Delay

In this paper, firstly, a notion of a class of generalized weighted pseudo al- most periodic function is introduced, then we investigate some basic and essential properties of the space that consists of these functions. Finally, we study the exis- tence of weighted pseudo almost periodic solutions to hematopoiesis model with time- varying delay.

“新能源汽车技术”课程思政的教学改革与实践

文章以高职院校汽车专业群共享课“新能源汽车技术”课程为例,全面贯彻党的教育方针、落实立德树人根本任务,在教学实施过程中,结合1+X职业技能及实际工作岗位深挖思政元素,将习近平新时代中国特色社会主义思想贯穿到专业教学全过程,推进“课程思政”教学改革,积极探索“新能源汽车技术”课程思政课教学改革与实践。

A new method of weighted superposition for seismogram synthesis in depth domain

The extensive use of depth-imaged seismic data produced by pre-stack depth migration(PSDM)leads to the necessity to synthesize seismogram directly in depth domain.However,since seismic wavelet in depth domain is dependent on media velocities.The time-domain convolution operation directly used in depth domain does not meet the linear time-invariant condition.In this paper,we present a new method for genuine depth-domain seismic synthesis.This method constructs the velocity-dependent seismic wavelets varying adaptively with the corresponding interval velocities in the depth direction and weights them by the reflectivities,then the synthetic seismic record is obtained by the superposition of these weighted depth-varying wavelets.We applied this method to synthesize the seismic record of both a multi-layered geological model and the field data.The results show that the method can accommodate the intrinsic velocity-dependent variation characteristics of seismic events in depth domain and avoid the redundant depth-to-time and time-to-depth transformations.

Cu_(2)O柱阵列的Cu还原制备与表征

Cu_(2)O是一类重要的p型半导体材料,在气敏、光伏等领域具有广阔的应用前景。通过热氧化法,在Cu片上先制备CuO纳米线阵列为前驱体,然后再在N_(2)氛围中加热,通过Cu还原制备Cu_(2)O柱阵列,利用XRD、SEM对Cu_(2)O柱阵列结构进行表征。分析发现,只需控制气氛、温度和时长等,就能控制好前驱体CuO纳米线的长度和粒径,进而调控Cu_(2)O柱阵列的长径比等,该方法简单,对环境无污染,为制备Cu_(2)O阵列结构提供了新方法。

沙库巴曲缬沙坦联合马来酸左旋氨氯地平治疗原发性高血压伴稳定型心绞痛的效果

目的探讨沙库巴曲缬沙坦联合马来酸左旋氨氯地平治疗原发性高血压伴稳定型心绞痛(EH+SAP)的效果。方法选取2021年5月~2023年4月新疆生产建设兵团第一师医院EH+SAP患者128例,采用随机数字表法分为两组,各64例。两组均给予常规治疗,对照组采用奥美沙坦联合马来酸左旋氨氯地平治疗,观察组采用沙库巴曲缬沙坦联合马来酸左旋氨氯地平治疗。两组均连续治疗8周后进行疗效评估。比较两组治疗前、治疗8周血压、心绞痛情况、硝酸甘油用量变化,并检测中性粒细胞/高密度脂蛋白胆固醇比值(NHR)、心血管调节肽(salusin-β)水平。分析治疗8周NHR、salusin-β与血压、心绞痛情况、硝酸甘油用量的关系。统计两组治疗期间不良反应发生率。结果观察组治疗总有效率高于对照组[92.19%(59/64)比78.13%(50/64),P<0.05];治疗8周后两组24 h平均收缩压(24 h SBP)[(124.26±8.58)mmHg比(129.15±9.04)mm Hg]、24 h平均舒张压(24 h DBP)[(84.46±6.21)mmHg比(88.12±6.77)mmHg]、收缩压变异性(SBPV)[(9.54±2.42)mmHg比(10.63±2.30)mmHg]、舒张压变异性(DBPV)[(7.59±1.54)mmHg比(8.32±1.43)mmHg]、心绞痛发作次数[(0.33±0.10)次/周比(0.44±0.13)次/周]、心绞痛持续时间[(2.73±0.61)min比(3.42±0.98)min]、硝酸甘油用量[(0.17±0.05)mg/周比(0.23±0.06)mg/周]、NHR[(4.32±0.89)比(4.79±0.93)]、salusin-β[(3.65±0.57)nmol/L比(3.96±0.55)nmol/L]降低,且观察组低于对照组(P均<0.05);两组治疗8周NHR、salusin-β与24 h SBP、24 h DBP、SBPV、DBPV、心绞痛发作次数、心绞痛持续时间、硝酸甘油使用量均呈正相关(P<0.05);治疗期间两组水肿、头晕、潮红、心悸、低血压发生率比较,差异无统计学意义(P>0.05)。结论沙库巴曲缬沙坦联合马来酸左旋氨氯地平对EH+SAP疗效显著,可有效控制患者血压,减轻心绞痛症状,可能与调节NHR、salusin-β水平变化有关,且安全性有保障。

混合高斯噪声条件下稀疏表示方法及其在冲击类故障特征提取中的应用

传统稀疏表示方法因其在冲击类信号特征提取中的独特优势而在故障诊断领域被广泛研究。然而,传统稀疏表示理论基于对干扰噪声的高斯分布假设,导致其难以适用于多种噪声分布混合的实际现场。针对上述问题,提出一种混合高斯噪声条件下的冲击类故障特征稀疏表示方法。基于传统稀疏表示理论的贝叶斯框架,借助混合高斯分布的万有逼近性质,建立了基于db4小波字典的混合高斯噪声稀疏分解模型,并推导了基于EM(Expectation-maximum,EM)和ADMM(Alternating direction method of multipliers,ADMM)的优化求解算法用于模型求解。仿真和实验结果表明,所提出的方法能够有效提取混合噪声干扰下的冲击类微弱故障特征信号。

Lipid metabolism analysis in esophageal cancer and associated drug discovery

Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis.It is still being explored in depth due to its complex molecular mechanisms of occurrence and development.Lipids play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction processes,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant tumors.More and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment resistance.The inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid metabolism.Therefore,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers.

Application value research of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after stroke

BACKGROUND Stroke is a common disabling disease,whether it is ischemic stroke or hemorrhagic stroke,both can result in neuronal damage,leading to various manifestations of neurological dysfunction.AIM To explore of the application value of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after stroke.METHODS This study selected 86 patients with swallowing disorders after stroke admitted to our rehabilitation department from February 2022 to December 2023 as research subjects.They were divided into a control group(n=43)and an observation group(n=43)according to the treatment.The control group received swallowing rehabilitation training,while the observation group received swallowing treatment device in addition to the training.Both groups underwent continuous intervention for two courses of treatment.RESULTS The total effective rate in the observation group(93.02%)was higher than that in the control group(76.74%)(P=0.035).After intervention,the oral transit time,swallowing response time,pharyngeal transit time,and laryngeal closure time decreased in both groups compared to before intervention.In the observation group,the oral transit time,swallowing response time,and pharyngeal transit time were shorter than those in the control group after intervention.However,the laryngeal closure time after intervention in the observation group was compared with that in the control group(P=0.142).After intervention,average amplitude value and duration of the genioglossus muscle group during empty swallowing and swallowing 5 mL of water are reduced compared to before intervention in both groups.After intervention,the scores of the chin-tuck swallowing exercise and the Standardized Swallowing Assessment are both reduced compared to pre-intervention levels in both groups.However,the observation group scores lower than the control group after intervention.Additionally,the Functional Oral Intake Scale scores of both groups are increased after intervention compared to pre-intervention levels,with the observation group scoring higher than the control group after intervention(P<0.001).The cumulative incidence of complications in the observation group is 9.30%,which is lower than the 27.91%in the control group(P=0.027).CONCLUSION The combination of swallowing therapy equipment with swallowing rehabilitation training can improve the muscle movement level of the genioglossus muscle group,enhance swallowing function,and prevent the occurrence of swallowing-related complications after stroke.

Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel oils.In this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall catalyst.Compared with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an initiator.The sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of reaction.Furthermore,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in polarity.This work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

Strong metal–support interaction boosts the electrocatalytic hydrogen evolution capability of Ru nanoparticles supported on titanium nitride

Ruthenium(Ru)has been regarded as one of the most promising alternatives to substitute Pt for catalyzing alkaline hydrogen evolution reaction(HER),owing to its inherent high activity and being the cheapest platinum-group metal.Herein,based on the idea of strong metal–support interaction(SMSI)regulation,Ru/TiN catalysts with different degrees of TiN overlayer over Ru nanoparticles were fabricated,which were applied to the alkaline electrolytic water.Characterizations reveal that the TiN overlayer would gradually encapsulate the Ru nanoparticles and induce more electron transfer from Ru nanoparticles to TiN support by the Ru–N–Ti bond as the SMSI degree increased.Further study shows that the exposed Ru–TiN interfaces greatly promote the H_(2) desorption capacity.Thus,the Ru/TiN-300 with a moderate SMSI degree exhibits excellent HER performance,with an overpotential of 38 mV at 10 mA cm^(−2).Also,due to the encapsulation role of TiN overlayer on Ru nanoparticles,it displays super long-term stability with a very slight potential change after 24 h.This study provides a deep insight into the influence of the SMSI effect between Ru and TiN on HER and offers a novel approach for preparing efficient and stable HER electrocatalysts through SMSI engineering.

Phosphotungstic acid ionic liquid for efficient photocatalytic desulfurization:Synthesis,application and mechanism

An efficient mass transfer process is a critical factor for regulating catalytic activity in a photocatalytic desulfurization system.Herein,a phosphotungstic acid(HPW)active center is successfully composited with a quaternary ammonium phosphotungstate-based hexadecyltrimethylammonium chloride ionic liquid(CTAC-HPW)by the ion exchange method for the photocatalytic oxidative desulfurization of dibenzothiophene sulfide.The keggin structure of HPW and highly mass transfer performance of organic cations synergistically enhanced the photocatalytic activity towards the effective convertion of dibenzothiophene(DBT)with the excitation of visible light.The deep desulfurization(<10 mg·kg^(-1))is attained within 30 min,and well stability is demonstrated within 25 cycles.Moreover,the CTAC-HPW photocatalyst projects well selectivity to interference from coexisting compounds such as olefins and aromatic hydrocarbons and universality of dibenzothiophenes,for example,4-methyldibenzothiophene(4-MDBT)and 4,6-dimethyldibenzothiophene(4,6-DMDBT).Ultimately,a possible photocatalytic desulfurization mechanism is proposed according to the Gaschromatography-mass spectrometry(GC-MS),proving that the final product is the corresponding sulfone.The trapping experiment and electron spin resonance(ESR)analysis confirmed that h^(+)and,COOH played critical roles in the oxidation process.The work offers a practicable strategy for efficiently converting DBT to DBTO_(2) with added value.

Coupling of BiOCl Ultrathin Nanosheets with Carbon Quantum Dots for Enhanced Photocatalytic Performance

Over the past few decades,photocatalysis technology has received extensive attention because of its potential to mitigate or solve energy and environmental pollution problems.Designing novel materials with outstanding photocatalytic activities has become a research hotspot in this field.In this study,we prepared a series of photocatalysts in which BiOCl nanosheets were modified with carbon quantum dots(CQDs)to form CQDs/BiOCl composites by using a simple solvothermal method.The photocatalytic performance of the resulting CQDs/BiOCl composite photocatalysts was assessed by rhodamine B and tetracycline degradation under visible-light irradiation.Compared with bare BiOCl,the photocatalytic activity of the CQDs/BiOCl composites was significantly enhanced,and the 5 wt%CQDs/BiOCl composite exhibited the highest photocatalytic activity with a degradation efficiency of 94.5%after 30 min of irradiation.Moreover,photocatalytic N_(2)reduction performance was significantly improved after introducing CQDs.The 5 wt%CQDs/BiOCl composite displayed the highest photocatalytic N_(2)reduction performance to yield NH_3(346.25μmol/(g h)),which is significantly higher than those of 3 wt%CQDs/BiOCl(256.04μmol/(g h)),7 wt%CQDs/BiOCl(254.07μmol/(g h)),and bare BiOCl(240.19μmol/(g h)).Our systematic characterizations revealed that the key role of CQDs in improving photocatalytic performance is due to their increased light harvesting capacity,remarkable electron transfer ability,and higher photocatalytic activity sites.

FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

A dual-RPA based lateral flow strip for sensitive,on-site detection of CP4-EPSPS and Cry1Ab/Ac genes in genetically modified crops

Traditional transgenic detection methods require high test conditions and struggle to be both sensitive and efficient.In this study,a one-tube dual recombinase polymerase amplification(RPA)reaction system for CP4-EPSPS and Cry1Ab/Ac was proposed and combined with a lateral flow immunochromatographic assay,named“Dual-RPA-LFD”,to visualize the dual detection of genetically modified(GM)crops.In which,the herbicide tolerance gene CP4-EPSPS and the insect resistance gene Cry1Ab/Ac were selected as targets taking into account the current status of the most widespread application of insect resistance and herbicide tolerance traits and their stacked traits.Gradient diluted plasmids,transgenic standards,and actual samples were used as templates to conduct sensitivity,specificity,and practicality assays,respectively.The constructed method achieved the visual detection of plasmid at levels as low as 100 copies,demonstrating its high sensitivity.In addition,good applicability to transgenic samples was observed,with no cross-interference between two test lines and no influence from other genes.In conclusion,this strategy achieved the expected purpose of simultaneous detection of the two popular targets in GM crops within 20 min at 37°C in a rapid,equipmentfree field manner,providing a new alternative for rapid screening for transgenic assays in the field.