基于正交试验的再生透水混凝土路用性能研究

通过正交试验研究了粉煤灰、矿渣微粉、硅灰等矿物掺合料以及再生骨料替代率对再生透水混凝土抗压强度、有效孔隙率、透水系数、耐磨性的影响。结果表明:再生骨料替代率对再生透水混凝土28 d抗压强度和透水系数影响最显著,随再生骨料替代率的增加,28 d抗压强度逐渐降低,透水系数显著增大;粉煤灰掺量对磨坑长度的影响最显著,随粉煤灰掺量的增加,再生骨料透水混凝土的耐磨性显著提高。基于功效系数法,综合性能最优配比为:粉煤灰、矿渣微粉、硅灰掺量分别为15%、5%、8%,再生骨料替代率为30%,制得的再生透水混凝土28 d抗压强度为25.9 MPa,透水系数为2.04 mm/s,磨坑长度为31.7 mm。

Effective roles of exercise and diet adherence in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease(NAFLD)is characterized by symptoms of excessive fat accumulation and steatosis in the liver without alcohol intake in patients.The associated pathogenic mechanism is not completely understood and there are no specific drugs for patients with NAFLD.Exercise and diet adherence are the best options for the management of NAFLD patients.Questionnaire associated analysis models of adherence to these interventions are used to assess their effectiveness in the management of NAFLD patients using specificity,sensitivity,and so on.Studies have indicated that the relative ratio of NAFLD can be reduced by physical activity with diet control.In the future,the pathogenesis of NAFLD should be clarified with stratified efforts to develop appropriate drugs,and both exercise and diet adherence should be optimized using better questionnaire design and evaluation models for patients with NAFLD.

山东五莲七宝山铅锌多金属矿床硫化物微量元素分布特征及地质意义

为探讨五莲七宝山铅锌多金属矿中主要硫化物的微量元素分布特征,对矿床成因类型进行约束,在矿床地质研究的基础上,以不同成矿阶段形成的闪锌矿和方铅矿为研究对象,开展矿相学和矿物LA-ICPMS微量元素组成研究。结合野外地质调查和室内矿相学研究,将五莲七宝山铅锌多金属矿床的成矿过程划分为3个成矿阶段,分别是多金属硫化物+碎裂岩阶段(Ⅰ)、多金属硫化物+石英+白云石阶段(Ⅱ)和石英+白云石阶段(Ⅲ)。LA-ICP-MS分析结果表明,主要硫化物中闪锌矿富集Fe、Co、Mn和Cd元素,贫Ge、Se、Te、Re和Tl元素,方铅矿则主要富集Ag和Cd元素;闪锌矿中Cu、Cd、Fe、Mn、Co和In元素以类质同象的方式赋存在矿物中,偶见方铅矿显微包体,方铅矿中Ag元素以类质同象的形式赋存在矿物中,Cu、Zn和As元素则以显微包体的形式赋存在碳酸盐岩化矿石方铅矿中。闪锌矿微量元素成矿温度研究表明,Ⅰ阶段形成的碎裂—角砾岩化矿石以中温为主,Ⅱ阶段形成的碳酸盐岩化矿石则形成于低温环境。结合矿床地质和微量元素分布特征,认为七宝山铅锌多金属矿床属于与岩浆热液作用相关的中—低温热液脉型矿床。

A Second-Order Image Denoising Model for Contrast Preservation

In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in Zhu(J Sci Comput 88:46,2021)for the design of a regularization term.Due to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image contrast.The augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed algorithm.Numerical experiments are presented to demonstrate the features of the proposed model.

Urolithiasis: From pathogenesis to management (part two)

Embarking on a scholarly exploration of the intricate landscape of urolithiasis,the second part of the special section in the Asian Journal of Urology serves as a continuum to the scholarly discourse initiated in its predecessor.Urolithiasis is a common condition affecting 5%-10%of the global population[1].Despite significant progress in understanding the pathogenesis and management of urolithiasis,it remains a substantial public health concern.The objective of the special section in the Asian Journal of Urology is to provide an updated knowledge on the pathogenesis,diagnosis,and management of urolithiasis.In this part two of the special section,we stillfocus on the aspects of stone pathogenesis,treatment,complications prevention,and the application of new technologies.

Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 gene.Attentiondeficit/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in childhood.Genetic characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and ADHD.Magnetic resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and ADHD.The images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this editorial.In the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.

New regularization method and iteratively reweighted algorithm for sparse vector recovery

Motivated by the study of regularization for sparse problems,we propose a new regularization method for sparse vector recovery.We derive sufficient conditions on the well-posedness of the new regularization,and design an iterative algorithm,namely the iteratively reweighted algorithm(IR-algorithm),for efficiently computing the sparse solutions to the proposed regularization model.The convergence of the IR-algorithm and the setting of the regularization parameters are analyzed at length.Finally,we present numerical examples to illustrate the features of the new regularization and algorithm.

High expression of PD-L1 mainly occurs in non-small cell lung cancer patients with squamous cell carcinoma or poor differentiation

Background:Lung cancer is one of the most lethal cancers worldwide,but studies have shown that the higher the expression of programmed cell death protein 1 ligand 1(PD-L1)in non-small cell lung cancer(NSCLC),the more likely it will benefit from anti-PD-L1 immunotherapy.The purpose of our study was to collect and analyze abundant clinical samples in order to provide evidence for clinicians and patients who might consider anti-PD-L1 immunotherapy while jointly formulating treatment plans.Methods:On the one hand,we obtained cases from The Cancer Genome Atlas(TCGA)database,including 498 lung squamous cell cancer(LUSC)patients and 515 lung adenocarcinoma(LUAD)patients.We studied the lung caner driver gene in LUSC and LUAD.On the other hand,PD-L1 expression was detected in lung cancer tissues of 1,008 NSCLC patients with immunohistochemistry staining(IHC),and we studied the correlation between PD-L1 protein expression and clinicopathological characteristics.Results:PD-L1 expression was higher in LUSC than in LUAD at the mRNA level.In univariate analysis,PD-L1 expression at the protein level was higher in patients who were males,were LUSC,were smokers,had a tumor diameter>3 cm,had poor differentiation,or had stages Ⅲ-Ⅳ disease.In multivariate analysis,PD-L1 expression was higher in patients who were LUSC or in poor differentiation.Conclusion:In term of protein level,PD-L1 expression was higher in NSCLC patients who were LUSC or in poor differentiation.We recommend that PD-L1 IHC detection can be routinely performed in such populations that are likely to benefit most from PD-L1 immunotherapy.

Dynamic coupled thermo-hydro-mechanical problem for heterogeneous deep-sea sediments under vibration of mining vehicle

Due to the influence of deep-sea environment,deep-sea sediments are usually heterogeneous,and their moduli of elasticity and density change as depth changes.Combined with the characteristics of deep-sea sediments,the thermo-hydro-mechanical coupling dynamic response model of heterogeneous saturated porous sediments can be established to study the influence of elastic modulus,density,frequency,and load amplitude changes on the model.Based on the Green-Lindsay generalized thermoelasticity theory and Darcy’s law,the thermo-hydro-mechanical coupled dynamic response model and governing equations of heterogeneous deep-sea sediments with nonlinear elastic modulus and density are established.The analytical solutions of dimensionless vertical displacement,vertical stress,excess pore water pressure,and temperature are obtained by means of normal modal analysis,which are depicted graphically.The results show that the changes of elastic modulus and density have few effects on vertical displacement,vertical stress,and temperature,but have great effects on excess pore water pressure.When the mining machine vibrates,the heterogeneity of deep-sea sediments has great influence on vertical displacement,vertical stress,and excess pore water pressure,but has few effects on temperature.In addition,the vertical displacement,vertical stress,and excess pore water pressure of heterogeneous deep-sea sediments change more gently.The variation trends of physical quantities for heterogeneous and homogeneous deep-sea sediments with frequency and load amplitude are basically the same.The results can provide theoretical guidance for deep-sea mining engineering construction.

Fixed-time group consensus of second-order multi-agent systems based on event-triggered control

The problem of fixed-time group consensus for second-order multi-agent systems with disturbances is investigated.For cooperative-competitive network,two different control protocols,fixed-time group consensus and fixed-time eventtriggered group consensus,are designed.It is demonstrated that there is no Zeno behavior under the designed eventtriggered control.Meanwhile,it is proved that for an arbitrary initial state of the system,group consensus within the settling time could be obtained under the proposed control protocols by using matrix analysis and graph theory.Finally,a series of numerical examples are propounded to illustrate the performance of the proposed control protocol.

Miniaturization in percutaneous nephrolithotomy:What is new?

Objective:To summarize recent advancements in mini-percutaneous nephrolithotomy(mini-PCNL)in surgical technique,stone removal strategy,lithotripsy,and surgical model from the current literature.Methods:We conducted a narrative review of relevant English-language articles up to October 2022 using the PubMed and Web of Science databases.The following keywords were used in the search:“percutaneous nephrolithotomy”,“minimally invasive percutaneous nephrolithotomy”,“mini-PCNL”,“mini-perc”,“mPCNL”,and“miniaturization”.Results:A series of new progress has been made in many aspects of mini-PCNL,such as further reduction of tract sizedneedle perc and further improvement of robotic-assisted PCNLdartificial intelligence-powered robotic devices.Conclusion:Many studies and trials have been conducted to reduce morbidity and increase the safety and effectiveness of mini-PCNL.It is crucial to realize that miniaturization of PCNL requires not only a smaller percutaneous tract size,but also an adjustment strategically in renal access,stone removal,lithotripsy,and surgical model in general.More large-scale prospective research needs to be carried out to further validate and optimize the safety and effectiveness of mini-PCNL.

Urolithiasis:From pathogenesis to management(part one)

Urolithiasis is a common condition that affects 5%-10%of the population globally[1].Once afflicted,urolithiasis tends to be recurrent,with up to 50%in most cases in 5 years since the first stone event[2].Despite the significant progress in understanding the pathogenesis and management of urolithiasis,the condition remains a significant public health concern.The aim of this special issue of the Asian Journal of Urology was to provide an update on the current state of knowledge regarding the pathogenesis,diagnosis,and management of urolithiasis.

Baicalein Reduces Metastasis and Heightens Caspase-Induced Apoptosis in Human Colorectal Cancer Cells

Current colorectal cancer (CRC) treatments exhibit unwanted cytotoxicity against healthy proliferating cells. Hence, these therapeutics demand higher specificity upon drug delivery, a task that may be facilitated by the discovery of anticancer agents bearing critical mechanisms of action. Baicalein is a flavonoid with promising anticancer activity, among other pharmacological benefits, and has therefore been of high clinical interest. We tested baicalein in vitro for its effect on several CRC hallmarks, including the suppression of metastasis (the spread of cancer cells from their initial site), the ability to induce apoptosis (cell death), and the inhibition of proliferation (the growth of cells). The suppression of the metastasis of CRC cells was recorded via two studies: the cell migration assay and the in silico docking of baicalein with toll-like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9). Results from the cell migration assay showed that baicalein inhibited metastasis by up to 25.76% (p 0.01) in a concentration-dependent manner. We then reinforced these results by docking baicalein with TLR4 (binding affinity: -8.4 kcal/mol) and docking baicalein with MMP-9 (binding affinity: -7.9 kcal/mol), classifying strong binding affinities as those less than -6.0 kcal/mol. The induction of cell death was measured using a caspase activity assay. Again, a docking study was done to reinforce the findings from the primary in vitro experiment, though this time between baicalein and caspase-3 (binding affinity: -7.1 kcal/mol). Despite mixed observations in concentration dependence, caspase activity, relative to control, reached a maximal increase of 88.6% (p 0.01), and results from the MTT assay demonstrated a survival rate, relative to control, of as low as 59.64%. Considerations for future studies include the testing of baicalein in vivo and on more aberrative CRC cell lines.

Discovering the efficacy and mechanism of Chinese herbal medicine for distal symmetric polyneuropathy via integrating meta-analysis and network pharmacology analysis

Objective Chinese herbal medicine(CHM)has been commonly used in Distal Symmetric Polyneuropathy(DSPN)treatment with satisfactory clinical effects,but the underlying pharmacological mechanism of CHM on DSPN remains unclear.We aimed to identify frequently used clinically effective CHM and its potential pharmacological mechanisms for DSPN by conducting meta-analysis and network pharmacology analysis.Methods We searched both Chinese and English databases from March 1990 to October 2022.Studies that met the inclusion criteria were selected for meta-analysis.After extracting the relevant data,we performed meta-analysis and frequency analysis.The active compounds and predicted targets of high-frequency herbs and DSPN-related targets were extracted from public databases.Then we conducted network construction,Gene Ontology(GO)enrichment,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to discover the potential pharmacological mechanisms.Results Sixteen articles were selected for meta-analysis,and nine high-frequency CHMs were identified,including Radix Astragali seu Hedysari,Rhizoma Ligustici,Caulis Spatholobi,Radix Salviae Miltiorrhizae,Radix Paeoniae Alba,Flos Carthami,Radix Notoginseng,Radix Rehmanniae Recens,Rhizoma Corydalis.Fourteen hub targets including STAT3,CTNNB1,MAPK14,SRC,AKT1,TP53,EGFR,JUN,RELA,MAPK1,FOS,CCND1,HSP90AA1,MYC,and ten active compounds including Quercetin,Kaempferol,Luteolin,Apigenin,beta-sitosterol,Stigmasterol,Caffeic Acid,Aeginetic Acid,Vanillin,and Lauric Acid were identified by network analysis.Enrichment analysis showed that the biological process of hub targets included transcriptional regulation,cell proliferation,redox processes,apoptosis processes,ERK1 and ERK2 cascades,hypoxia reactions,MAPK cascades,and inflammatory responses.The main signalling pathways included HIF,TNF,and PI3K-AKT pathways.Conclusion Nine herbs were involved in the clinical therapeutic effect of CHM on DSPN treatment,and they may exert an anti-DSPN effect by regulating cell proliferation,apoptosis,and redox processes.

全身亚低温联合人脐带血间充质干细胞移植改善新生大鼠缺氧缺血性脑损伤后认知障碍和能量衰竭的机制研究

目的探究全身亚低温联合人脐带血间充质干细胞(hCMNCs)移植改善新生大鼠缺氧缺血性脑损伤(HIBD)后认知障碍和能量衰竭的机制。方法7日龄新生SD乳鼠330只。随机分为11组,每组30只。空白对照组(A组)、HIBD常温组(B组)、HIBD亚低温持续72 h组(C组)、HIBD亚低温24 h干细胞移植组(D组)、HIBD亚低温48 h干细胞移植组(E组)、HIBD亚低温72 h移植组(F组)、HIBD亚低温24 h后持续3 d移植干细胞(G组)、HIBD 24 h干细胞移植组(H组)、HIBD 48 h干细胞移植组(I组)、HIBD 72 h干细胞移植组(J组)、HIBD 24 h、48 h、72 h干细胞移植组(K组)。乳鼠生长的第10天、第21天和第35天对其进行称重;通过Morris水迷宫实验检测乳鼠学习和记忆能力,超微电镜观察分析乳鼠脑组织神经元细胞及突触超微结构的变化,苏木精-伊红(HE)染色观察脑组织病理学变化,酶联免疫吸附试验检测乳鼠脑组织炎症因子和干细胞分化标记蛋白含量,免疫荧光染色检测脐带CD24和CD29阳性表达率,荧光显微镜测量线粒体膜电位。结果A、B、C、D、E、F、G、H、I、J、K组乳鼠生长第10天、第21天和第35天体重比较,采用重复测量设计的方差分析,结果:①不同时间点乳鼠体重有差异(F=13.285,P=0.000),各组乳鼠第21天与第35天体重比较,差异有统计学意义(P<0.05);②各组乳鼠体重有差异(F=20.097,P=0.000),B组乳鼠体重较A组降低(P<0.05),C~K组乳鼠体重较B组升高(P<0.05),G、I组乳鼠体重较B、C、D、E、F、H、J、K组均升高(P<0.05),且G组与I组乳鼠体重比较,差异无统计学意义(P>0.05);③各组乳鼠体重变化趋势有差异(F=28.712,P=0.000)。C~F组3种反射(悬崖调转反射、阴性趋地性、步态反射)时间较A组延长(P<0.05),但较B组缩短(P<0.05);C组3种反射时间较A、D~J组延长(P<0.05);G~K组3种反射时间与A组比较,差异无统计学意义(P>0.05);C~F组3种反射时间较G~K组延长(P<0.05)。HE染色结果显示,与A组比较,B~K组乳鼠HIBD模型复制成功后第3天,脑间质水肿,小血管间隙增宽,左侧大脑出现大片坏死,细胞溶解、破坏、消失;皮质海马神经元排列紊乱,核固缩、崩解,细胞浓染,并见小胶质细胞。第21天,B~K组与A组有差异,B~K组脑组织见不同程度的损伤,其中B组可见大的梗塞灶及液化空洞形成。C~K组表现为部分炎症细胞;B组与C~K组比较,脑损伤程度较大。其中G、J、K组脑损伤及炎症程度较C~F、H、I组小。B~K组逃避潜伏期较A组延长(P<0.05),G、J、K组逃避潜伏期较B~F、H组缩短(P<0.05)。B~K组神经元致密区长度较A组变短(P<0.05),厚度较A组变薄(P<0.05),而突触间隙宽度较A组变厚(P<0.05)。C~K组乳鼠神经元致密区长度较B组变长(P<0.05),厚度较B组变厚(P<0.05),突触间隙宽度较B组变薄(P<0.05)。G~J组乳鼠神经元致密区长度较D~F、K组变长(P<0.05),厚度较D~F、K组变厚(P<0.05),突触间隙宽度较D~F、K组变薄(P<0.05)。A、B、C、D、E、F、G、H、I、J、K组乳鼠HIBD模型复制成功后第3天、第8天、第12天的TNF-α、IL-6、Nestin、TUBB、MBP比较,采用重复测量设计的方差分析,结果:①不同时间点TNF-α、IL-6、Nestin、TUBB、MBP有差异(F=39.451、19.754、36.957、16.794和16.958,均P=0.000);②各组乳鼠TNF-α、IL-6、Nestin、TUBB、MBP有差异(F=10.719、10.159、43.271、5.947和11.217,P=0.000、0.000、0.000、0.012和0.000);B~K组TNF-α、IL-6在HIBD模型复制成功第3天、第8天和第12天较A组升高(P<0.05),C~K组TNF-α、IL-6较B组降低(P<0.05)。C~K组Nestin、TUBB和MBP较B组升高(P<0.05)。③各组乳鼠TNF-α、IL-6、Nestin、TUBB、MBP变化趋势有差异(F=22.678、25.483、6.597、20.159和20.154,P=0.000、0.000、0.003、0.000和0.000)。A~C组CD24和CD29阳性表达率较E~K组降低(P<0.05),G、I组较H、J、K组CD24和CD29阳性表达率升高(P<0.05)。B~K组线粒体膜电位较A组降低(P<0.05),C~K组线粒体膜电位较B组升高(P<0.05),G~J组线粒体膜电位较C~F组升高(P<0.05)。结论亚低温联合UCMSCs能改善HIBD乳鼠认知障碍和能量衰竭,对脑神经有保护作用。

陶瓷电容分压器幅度线性度研究

高功率电脉冲装置常使用电容分压器监测其电压值。电容分压器的幅度线性度表征了分压器在大电压与小电压下分压比的一致程度。线性度的好坏直接关系到监测的电压值的准确程度。本文对陶瓷电容分压器进行原理分析,并通过仿真软件在脉宽为200 ns的矩形脉冲高压源(500 V^4 kV)与半高宽约为10μs的冲击高压源(10~100 kV)下分别对陶瓷电容分压器的性能进行仿真,并设计加工。之后分别采用两种高压源对分压器进行实验研究,研究显示,陶瓷电容分压器的幅度线性度在500 V^100 kV之内为1.5%,线性度较好,可以将小信号下校准的分压比用于大信号的测量中。

阿维A治疗儿童泛发性脓疱性银屑病疗效及安全性分析

目的探讨阿维A治疗儿童泛发性脓疱性银屑病的疗效及安全性。方法选择2011年1月至2015年1月湖南省儿童医院收治的泛发性脓疱性银屑病患儿12例为研究对象。所有患儿均给予阿维A口服,初始剂量为0.4～0.8mg/(kg·d),每日1次,维持该剂量并持续治疗2周后评价患儿治疗效果,若治疗无效,则可根据患儿实际状况增加用药剂量,继续用药;若患儿皮损消失90%以上时,逐渐减少用药剂量,直至停药。根据患儿治疗前后的皮损面积及严重程度指数(PASI)评分进行疗效判定,检测谷丙转氨酶、白蛋白、甘油三酯、Ca^(2+)、K^+,观察不良反应,分析患儿的复发状况。结果治愈11例,显效1例,治疗总有效率为100.0%。患儿治疗后PASI评分为(1.5±1.4)分,显著低于治疗前(7.8±2.1)分,差异有统计学意义(P<0.05)。患儿治疗后谷丙转氨酶、血清白蛋白水平显著高于治疗前,甘油三酯水平显著低于治疗前,差异有统计学意义(P<0.05)。患儿治疗前后血中Ca^(2+)、K^+水平比较差异无统计学意义(P>0.05)。12例患儿中出现瘙痒6例,黏膜干燥2例,血脂轻微异常1例,肝酶升高3例,甲脆性增加3例,所有患儿不良反应症状均较轻,未出现明显肝肾功能异常,且患儿不良反应症状均在实施对症处理(饮食调理、改变用药剂量等)后消失,未影响用药过程。患儿随访1～2年,共5例患儿复发,复发率为41.7%。结论儿童泛发性脓疱性银屑病实施阿维A治疗的疗效及安全性均较高。

口服西罗莫司治疗小儿脉管异常类疾病的效果观察

目的初步探讨口服西罗莫司治疗小儿脉管异常类疾病的临床疗效。方法收集2019年12月至2020年12月在湖南省儿童医院皮肤科住院治疗的14例脉管异常类疾病患者作为研究对象,其中男性11例,女性3例,年龄6个月至10岁。病种:卡波西血管内皮瘤4例,Sturge-Weber综合征2例,静脉畸形3例,混合型脉管畸形3例,CLOVES综合征1例,结节性硬化症1例。住院期间给予西罗莫司每日1~1.5 mg/m^(2),分早晚两次口服,间隔12 h。住院期间监控不良反应,出院后继续口服药物,定期门诊复查,检测患者血常规、尿常规、肝肾功能、血脂全套、凝血功能、血药浓度等。结果所有患者口服西罗莫司治疗3~7个月,疗程结束后随访1~3个月。治疗效果:4例卡波西血管内皮瘤患者有效;2例Sturge-Weber综合征患者1例部分有效,1例无效;3例静脉畸形患者1例部分有效,2例无效;3例混合型脉管畸形1例部分有效,2例无效;1例CLOVES综合征患者部分有效;1例结节性硬化症患者无效。14例均未出现明显不良反应。结论西罗莫司治疗卡波西血管内皮瘤可获得较理想的疗效,无明显不良反应;西罗莫司治疗脉管畸形疗效不确定,需要进一步的研究。

回阳固元方对人乳头瘤病毒感染细胞凋亡的影响研究

目的探讨回阳固元方对人乳头瘤病毒感染细胞凋亡的影响。方法用不同浓度回阳固元方,经Transwell(转换池)吸收后,与尖锐湿疣患者皮损中提取的角质形成细胞-单细胞悬液作用,通过流式细胞仪测定其细胞周期及细胞凋亡。结果固定中药浓度20μg/ml,随着时间的变化,G1期细胞数量减少,G2期细胞数量逐渐增多,S期细胞数量较正常组减少,角质形成细胞的凋亡率也逐渐增加;固定时间48 h,随着中药浓度的增加,G1期细胞数量降低,G2期细胞数量极少,S期细胞较正常组减少,角质形成细胞的凋亡率呈逐渐增加的趋势(P<0.05)。结论回阳固元方可诱导人乳头瘤病毒感染细胞的凋亡。

Hom-LPNG代数的相关性质

先给出Hom-LPNG代数的概念,再用新定义的运算方法,解决Hom-LPNG代数构造的一些问题,得到了用Hom-交换结合代数、Novikov-Poisson代数和LPNG代数等构造Hom-LPNG代数及由已知Hom-LPNG代数生成新的Hom-LPNG代数的结果.