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通过实验和理论验证Pt0/SrTiO_(3)-δ复合催化剂双反应路径促进CO_(2)还原
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作者 李卓根 Qadeer Ul Hassan +6 位作者 张伟斌 朱陆军 高健智 石先进 黄宇 刘鹏 朱刚强 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2023年第3期113-124,共12页
在以H_(2)O为质子源的光催化二氧化碳还原反应(CO_(2)RR)过程中,光解H_(2)O产氢气(H_(2))被认为是一个竞争反应.因此,光催化CO_(2)RR过程需要抑制H_(2)的产生,以提高碳氢产物的选择性和产率.以CO_(2)和H_(2)为反应物的逆水气变换反应(RW... 在以H_(2)O为质子源的光催化二氧化碳还原反应(CO_(2)RR)过程中,光解H_(2)O产氢气(H_(2))被认为是一个竞争反应.因此,光催化CO_(2)RR过程需要抑制H_(2)的产生,以提高碳氢产物的选择性和产率.以CO_(2)和H_(2)为反应物的逆水气变换反应(RWGS)是常见的CO_(2)加氢反应,在较高的温度和催化剂作用下生成CO和H_(2)O.目前,光催化CO_(2)RR研究主要聚焦于产物的选择性,而有关光解H_(2)O产生的还原性气体H_(2)在光热效应的促进下成为CO_(2)RR中新的质子源研究较少.光热催化是一种新的高效催化反应方式,在反应过程中需要光照和加热.光照能够促进半导体光生载流子的激发,热效应则能降低反应物分子的活化势垒,并能够促进中间产物的表面迁移以及生成物的脱附.利用光热催化热力学和动力学上的有利条件,为以H_(2)O为质子源的光热催化CO_(2)RR中RWGS反应提供了H_(2)源以及所需的能量.本文合成了具有强电子转移能力、高热稳定性和化学稳定性的Pt纳米颗粒(NPs)负载在具有丰富氧空位(OVs)的SrTiO_(3)-δ纳米片,形成金属-半导体相互作用的Pt-OVs-STO纳米复合催化剂,并利用该纳米复合催化剂系统地研究了以H_(2)O为质子源的光热催化CO_(2)RR的反应路径.结合X射线粉末衍射、X射线光电子能谱、高角度环形暗场和明场球差校正扫描电子显微镜、电子顺磁共振和紫外可见吸收光谱等表征手段,研究了表面负载的Pt^(0)NPs与SrTiO_(3)-δ之间的相互作用.这种金属-半导体之间的强相互作用和独特的电子结构促进了复合半导体结构的光吸收能力,提升了光生载流子的分离以及对反应物分子的吸附.由H_(2)O分解产生的H_(2)能够有效地促进在Pt-OVs-STO纳米复合结构的双路径CO_(2)还原反应:CO_(2)直接质子化和RWGS反应.DFT理论计算结果表明,该纳米复合结构能够有效地促进半导体表面电荷转移和H_(2)生成,并且降低RWGS反应和CO_(2)质子化的反应势垒.综上,本文阐明了在H_(2)O为质子源的光热催化CO_(2)RR中Pt^(0)/SrTiO_(3)-δ纳米复合结构上光解H_(2)O产生的H_(2)和RWGS反应之间的关系,并为后续的CO_(2)RR的研究提供了新视角. 展开更多
关键词 光热催化 析氢反应 逆水煤气反应 钙钛矿 金属-半导体相互作用
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Highly transparent and super-wettable nanocoatings hybridized with isocyanate-silane modified surfactant for multifunctional applications 被引量:2
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作者 Man Kwan Law Ying Zhao +5 位作者 weibin zhang Rui Wang Mingcheng Shi Yunxiao zhang Shusheng Chen Jinglei Yang 《Nano Materials Science》 EI CAS CSCD 2022年第2期151-168,共18页
Highly transparent and super-wettable nanocoatings for multifunctional applications with outstanding physical properties are in high demanded.However,such nanocoatings resistant to water invasion and Ultraviolet(UV)we... Highly transparent and super-wettable nanocoatings for multifunctional applications with outstanding physical properties are in high demanded.However,such nanocoatings resistant to water invasion and Ultraviolet(UV)weathering remain a significant challenge.In this work,physically durable coatings based on inorganic nanoparticles(NPs)and an organic segment(isocyanate-silane modified surfactant)have been synthesized via a sol-gel approach.It is noteworthy the isocyanate-silane with-NH-C=O-functional group creates a strong bonding between the highly hydrophilic surfactant and the inorganic NPs.This in-house synthesized organic segment can render the coating long-lasting wetting properties and resist to be washed away by water,while the inorganic NPs can form sturdy covalent bonds with the nano-scale hierarchical structure on the glazing substrate to improve the durability.This nanocoating demonstrates high transparency with superwetting property(water contact angle,WCA=4.4±0.3°),effective de-frosting performance.Water invasion or UV accelerated weathering tests do not significantly affect the self-cleaning performance of nanocoating.Physical properties,including coating adhesion,hardness,Young's modulus,and abrasion resistance are systematically investigated.Interestingly,this clear coating shows prominent infrared shielding property attributed to Antimony-doped tin oxide(Sb-doped SnO_(2))NPs.The developed nanocoating process is easy to scale up for larger areas that require multipurpose self-cleaning functions. 展开更多
关键词 NANOCOATING Sol-gel approach Multifunctionality High transparency Superwetting Durability
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The design and fabrication of Co3O4/Co3V2O8/Ni nanocomposites as high-performance anodes for Li-ion batteries 被引量:1
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作者 Yang Li Lingbin Kong +2 位作者 Maocheng Liu weibin zhang Long Kang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2017年第3期494-500,共7页
The CoO/CoVO/Ni nanocomposites were rationally designed and prepared by a two-step hydrothermal synthesis and subsequent annealing treatment. The one-dimensional(1D) CoOnanowire arrays directly grew on Ni foam, wher... The CoO/CoVO/Ni nanocomposites were rationally designed and prepared by a two-step hydrothermal synthesis and subsequent annealing treatment. The one-dimensional(1D) CoOnanowire arrays directly grew on Ni foam, whereas the 1D CoVOnanowires adhered to parts of CoOnanowires.Most of the hybrid nanowires were inlayed with each other, forming a 3D hybrid nanowires network.As a result, the discharge capacity of CoO/CoVO/Ni nanocomposites could reach 1201.8 mAh/g after100 cycles at 100 mA/g. After 600 cycles at 1 A/g, the discharge capacity was maintained at 828.1 mAh/g.Moreover, even though the charge/discharge rates were increased to 10 A/g, it rendered reversible capacity of 491.2 mAh/g. The superior electrochemical properties of nanocomposites were probably ascribed to their unique 3D architecture and the synergistic effects of two active materials. Therefore, such CoO/CoVO/Ni nanocomposites could potentially be used as anode materials for high-performance Li-ion batteries. 展开更多
关键词 CO3O4 Co3V2O8 Ni foam NANOCOMPOSITES Li-ion batteries
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Predicted High-Temperature Superconductivity in Rare Earth Hydride ErH2 at Moderate Pressure
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作者 Yiding Liu Qiang Fan +3 位作者 Jianhui Yang Lili Wang weibin zhang Gang Yao 《Chinese Physics Letters》 SCIE EI CAS CSCD 2022年第12期84-88,共5页
Hydrides offer an opportunity to study high critical temperature(high-Tc)superconductivity at experimentally achievable pressures.However,the pressure needed remains extremely high.Using density functional theory calc... Hydrides offer an opportunity to study high critical temperature(high-Tc)superconductivity at experimentally achievable pressures.However,the pressure needed remains extremely high.Using density functional theory calculations,herein we demonstrate that a new rare earth hydride ErH2could be superconducting with Tc~80 K at 14.5 GPa,the lowest reported value for compressed hydrides to date.Intriguingly,due to Kondo destruction,superconductivity was prone to exist at 15 GPa.We also reveal an energy gap at 20 GPa on the background of normal metallic states.At 20 GPa,this compressed system could act as a host of superconductor judged from a sharp jump of spontaneous magnetic susceptibility with an evanescent spin density of state at Fermi level.Finally,electron pairing glue for ErH2at these three typical pressures was attributed to the antiferromagnetic spin fluctuation. 展开更多
关键词 RARE KONDO SUPERCONDUCTOR
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Long term treatment of recurring pathological fractures due to Mccune Albright Syndrome: Case report and literature review
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作者 Yoshvin Sunnassee Yuhui Shen +2 位作者 Rong Wan Jianqiang Xu weibin zhang 《Case Reports in Clinical Medicine》 2013年第9期562-567,共6页
McCune Albright syndrome is a rare genetic disorder which is characterized by café au lait skin pigmentation, precocious puberty and polyostotic fibrous dysplasia. Treating recurring pathological fractures due to... McCune Albright syndrome is a rare genetic disorder which is characterized by café au lait skin pigmentation, precocious puberty and polyostotic fibrous dysplasia. Treating recurring pathological fractures due to Albright syndrome is a very challenging endeavor, and more so when it is accompanied by poor bone quality and deformity. We hereby present the case of a 23-year-old male patient who is treated several times for recurrent pathological fractures of the femur at our center. We analyze the difficulties associated with treating a patient with poor bone quality over several years, discuss our treatment options, review the literature for similar cases and look at what we could have done differently. We weigh in on the difficulties in treating a severely deformed shepherd’s crook, the ways of achieving proper internal fixation and the dangers of using plating instead of an IM nail as suggested in the literature. Our main goal in reporting this case is to bring forth the unusual challenges encountered when treating patients with Albright syndrome and discussing the options of the orthopedic surgeons when treating these types of patients. 展开更多
关键词 McCune ALBRIGHT SYNDROME Surgical TREATMENT Polyostotic FIBROUS DYSPLASIA
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High strength mullite-bond SiC porous ceramics fabricated by digital light processing 被引量:1
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作者 Jian Sun Jingde zhang +6 位作者 Xu zhang Zihe Li Jianzhang Li Sijie Wei weibin zhang Weili Wang Guifang Han 《Journal of Advanced Ceramics》 SCIE EI CAS CSCD 2024年第1期53-62,共10页
Fabricating SiC ceramics via the digital light processing(DLP)technology is of great challenge due to strong light absorption and high refractive index of deep-colored SiC powders,which highly differ from those of res... Fabricating SiC ceramics via the digital light processing(DLP)technology is of great challenge due to strong light absorption and high refractive index of deep-colored SiC powders,which highly differ from those of resin,and thus significantly affect the curing performance of the photosensitive SiC slurry.In this paper,a thin silicon oxide(SiO_(2))layer was in-situ formed on the surface of SiC powders by pre-oxidation treatment.This method was proven to effectively improve the curing ability of SiC slurry.The SiC photosensitive slurry was fabricated with solid content of 55 vol%and viscosity of 7.77 Pa·s(shear rate of 30 s^(−1)).The curing thickness was 50μm with exposure time of only 5 s.Then,a well-designed sintering additive was added to completely convert low-strength SiO_(2) into mullite reinforcement during sintering.Complexshaped mullite-bond SiC ceramics were successfully fabricated.The flexural strength of SiC ceramics sintered at 1550℃in air reached 97.6 MPa with porosity of 39.2 vol%,as high as those prepared by spark plasma sintering(SPS)techniques. 展开更多
关键词 digital light processing(DLP) SiC ceramics PRE-OXIDATION mullite-bond SiC mechanical properties
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肝神经内分泌肿瘤和肝细胞癌超声影像学特征对比
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作者 汪瀚韬 张炜彬 +4 位作者 范培丽 董怡 陆清 朱正 王文平 《中华医学超声杂志(电子版)》 CSCD 北大核心 2023年第1期70-77,共8页
目的对比肝神经内分泌肿瘤(HNEN)和肝细胞癌(HCC)的超声影像学特征,探讨超声在二者鉴别诊断中的临床应用价值。方法回顾性分析2009年9月至2020年12月于复旦大学附属中山医院病理诊断为HNEN的40例患者的常规超声及超声造影声像图特征,并... 目的对比肝神经内分泌肿瘤(HNEN)和肝细胞癌(HCC)的超声影像学特征,探讨超声在二者鉴别诊断中的临床应用价值。方法回顾性分析2009年9月至2020年12月于复旦大学附属中山医院病理诊断为HNEN的40例患者的常规超声及超声造影声像图特征,并随机选取同时期40例病理诊断为HCC患者的常规超声及超声造影声像图作为对照;常规超声的观察指标包括病灶的数目、边界、回声水平、动脉血流信号检出率等;超声造影的观察指标包括病灶的增强时间、增强方式、峰值表现、门脉期及延迟期表现等。分析比较2组病灶上述超声影像学特征:采用独立样本t检验或Mann-Whitney U检验比较2组间超声造影的增强开始时间、达峰时间及消退时间的差异;采用χ^(2)检验或精确概率检验比较2组间病灶数目、边界、回声水平、动脉血流信号检出率的差异。结果肿瘤数目、增强的消退时间、增强方式、峰值表现、门脉期及延迟期表现在HNEN和HCC之间差异具有统计学意义(P<0.05)。与HCC相比,HNEN更多表现为多发病灶(27/40 vs 5/40,P<0.001)。超声造影上,HNEN增强消退时间早于HCC[40.0(33.0,49.3)s vs 67.0(48.8,120.0)s],差异具有统计学意义(Z=4.592,P=0.001);HNEN以向心性增强方式增强、峰值时表现为环形强化、门脉期及延迟期表现为明显减退的比例高于HCC(8/40 vs 0/40,P=0.005;5/40 vs 0/40,P=0.048;29/40 vs 9/40,P<0.001;36/40 vs 22/40,P=0.002)。结论HNEN和HCC具有不同的超声影像学特征,超声对二者的鉴别诊断有一定帮助。 展开更多
关键词 超声检查 超声造影 肝细胞癌 神经内分泌肿瘤
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Metal support interaction of defective-rich CuO and Au with enhanced CO low-temperature catalytic oxidation and moisture resistance
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作者 Yahang Wang Lujun Zhu +5 位作者 Jingwei Li weibin zhang Xianjin Shi Yu Huang Mirabbos Hojamberdiev Gangqiang Zhu 《Advanced Powder Materials》 2023年第4期1-9,共9页
Water is considered to be an inhibitor of CO oxidation.The mechanism of retarding the reaction is thought to contribute to the practical application of CO oxidation,which is investigated by constructing the coupling o... Water is considered to be an inhibitor of CO oxidation.The mechanism of retarding the reaction is thought to contribute to the practical application of CO oxidation,which is investigated by constructing the coupling of Au nanoparticles and defective CuO to form metal-support interactions(MSI)and oxygen vacancies(OVs).The introduction of Au forms a new CO adsorption site,which successfully solves the competitive adsorption problem of CO with H2O and O_(2).Due to the coupling of MSI and OVs,the reduced ability of catalyst and the activation and migration ability of oxygen are enhanced simultaneously.Au-CuO has the ability to oxidize CO at room temperature with high stability under a humid environment.Theoretical calculation confirmed the competitive adsorption and the influence of MSI and OVs coupling on the catalyst performance.The mechanism of water resistance in CO catalytic oxidation was also explained. 展开更多
关键词 Au loading Metal-support interactions(MSI) Water resistance CO oxidation Competitive adsorption
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Alkali-metal(Li, Na, and K)-adsorbed MoSi_(2)N_(4) monolayer: an investigation of its outstanding electronic, optical, and photocatalytic properties 被引量:1
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作者 Zhiyuan Sun Jing Xu +5 位作者 Nsajigwa Mwankemwa Wenxing Yang Xianwen Wu Zao Yi Shanjun Chen weibin zhang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2022年第1期96-104,共9页
Single-layer MoSi_(2)N_(4),a high-quality two-dimensional material,has recently been fabricated by chemical vapor deposition.Motivated by this latest experimental work,herein,we apply first principles calculations to ... Single-layer MoSi_(2)N_(4),a high-quality two-dimensional material,has recently been fabricated by chemical vapor deposition.Motivated by this latest experimental work,herein,we apply first principles calculations to investigate the electronic,optical,and photocatalytic properties of alkali-metal(Li,Na,and K)-adsorbed MoSi_(2)N_(4) monolayer.The electronic structure analysis shows that pristine MoSi_(2)N_(4) monolayer exhibits an indirect bandgap(E_(g)=1.89 eV).By contrast,the bandgaps of one Li-,Na-,and K-adsorbed MoSi_(2)N_(4) monolayer are 1.73 eV,1.61 eV,and 1.75 eV,respectively.Moreover,the work function of MoSi_(2)N_(4) monolayer(4.80 eV)is significantly reduced after the adsorption of alkali metal atoms.The work functions of one Li-,Na-,and K-adsorbed MoSi_(2)N_(4) monolayer are 1.50 eV,1.43 eV,and 2.03 eV,respectively.Then,optical investigations indicate that alkali metal adsorption processes substantially increase the visible light absorption range and coefficient of MoSi_(2)N_(4) monolayer.Furthermore,based on redox potential variations after alkali metals are adsorbed,Li-and Na-adsorbed MoSi_(2)N_(4) monolayers are more suitable for the water splitting photocatalytic process,and the Li-adsorbed case shows the highest potential application for CO_(2) reduction.In conclusion,alkali-metal-adsorbed MoSi_(2)N_(4) monolayer exhibits promising applications as novel optoelectronic devices and photocatalytic materials due to its unique physical and chemical properties. 展开更多
关键词 MoSi_(2)N_(4) FIRST-PRINCIPLES alkali metal adsorbed electronic structure optical properties photocatalysis
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Flower-like Bi^0/CeO2-δ plasmonic photocatalysts with enhanced visible-light-induced photocatalytic activity for NO removal 被引量:1
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作者 Junli Nie Jianzhi Gao +4 位作者 Qian Shen weibin zhang Fei Rao Mirabbos Hojamberdiev Gangqiang Zhu 《Science China Materials》 SCIE EI CSCD 2020年第11期2272-2280,共9页
Plasmonic bismuth(Bi^0)nanoparticle-decorated flower-like CeO2-δ(Bi^0/CeO2-δ)photocatalysts with abundant oxygen vacancies(OVs)were synthesized via a solvothermal method.The OVs can not only improve the separation o... Plasmonic bismuth(Bi^0)nanoparticle-decorated flower-like CeO2-δ(Bi^0/CeO2-δ)photocatalysts with abundant oxygen vacancies(OVs)were synthesized via a solvothermal method.The OVs can not only improve the separation of electron-hole pairs,but also facilitate the adsorption and activation of gas molecules(NO/O2).In addition,the Bi^0 nanoparticles can enhance the visible light response and prevent the recombination of charge carriers by virtue of the surface plasmon resonance(SPR)effect,achieving an excellent ability for NO elimination and NO2 inhibition under visible light irradiation.Density functional theory(DFT)calculations confirm that the Schottky barrier between Bi^0 and CeO2-δaccompanied with the OVs are pivotal for the migration of photogenerated charge carriers to involve in the photocatalytic NO removal.Trapping experiments and in situ FTIR spectroscopy were conducted to explore the mechanism of the photocatalytic NO removal,suggesting that the photocatalytic NO removal can be significantly enhanced by introducing abundant OVs and the involvement of Bi^0 metal nanoparticles. 展开更多
关键词 cerium oxide bismuth nanoparticles oxygen vacancy surface plasmon resonance Schottky barrier NO removal
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肝细胞腺瘤与肝细胞癌超声造影特征对比 被引量:1
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作者 陈凯玲 张炜彬 +4 位作者 毛枫 韩红 李超伦 董怡 王文平 《中华医学超声杂志(电子版)》 CSCD 北大核心 2022年第11期1218-1224,共7页
目的对比分析肝细胞腺瘤(HCA)与肝细胞癌(HCC)的超声造影特征差异。方法回顾性分析2014年3月至2019年5月在复旦大学附属中山医院超声科行肝超声造影检查并经病理证实为HCA的30例(共30个病灶)及HCC的56例(共56个病灶)患者的超声造影资料... 目的对比分析肝细胞腺瘤(HCA)与肝细胞癌(HCC)的超声造影特征差异。方法回顾性分析2014年3月至2019年5月在复旦大学附属中山医院超声科行肝超声造影检查并经病理证实为HCA的30例(共30个病灶)及HCC的56例(共56个病灶)患者的超声造影资料,超声造影动脉期增强方式、包膜下增强血管影、门脉期及延迟期减退变化等方面的差异比较使用χ^(2)检验或Fisher确切概率法。采用诊断四格表评价超声造影征象诊断HCA和HCC的效能。结果HCA和HCC在动脉期均呈高增强,且主要表现为整体增强(86.7%vs94.6%),两者在动脉期增强方式和达峰时均匀性方面比较,差异均无统计学意义(P均>0.05)。动脉期分别有43.3%(13/30)的HCA和8.9%(5/56)的HCC病灶见包膜下增强血管影(χ^(2)=11.971,P=0.001)。在门脉期,HCA呈高增强或等增强的比例高于HCC(13.4%/0vs43.3%/17.9%),差异具有统计学意义(χ^(2)=15.605,P<0.001)。延迟期HCC呈低增强的比例高于HCA(92.9%vs56.7%),差异具有统计学意义(χ^(2)=16.184,P<0.001)。以超声造影“动脉期高增强、门脉期及延迟期低增强”为依据诊断HCC,其敏感度、特异度、准确性分别为92.9%、80.0%、88.4%;以“动脉期高增强、门脉期及延迟期高增强或等增强”或“包膜下增强血管影”任何一种征象为依据诊断HCA,其敏感度、特异度、准确性分别为77.4%、89.1%、84.9%。结论HCA与HCC在超声造影动脉期包膜下增强血管影、门脉期及延迟期增强表现方面有差异,有助于两者的鉴别。 展开更多
关键词 肝细胞腺瘤 肝细胞癌 超声造影 包膜下增强血管影
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Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination
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作者 Zhiwei Xiao Huiyi Wei +19 位作者 Yi Xu Ahmed Haider Junjie Wei Shiyu Yuan Jian Rong Chunyu Zhao Guocong Li weibin zhang Huangcan Chen Yuefeng Li Lingling zhang Jiyun Sun Shaojuan zhang Hai-Bin Luo Sen Yan Qijun Cai Lu Hou Chao Che Steven H.Liang Lu Wang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2022年第4期1963-1975,共13页
As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium... As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium spiny neurons of the striatum,it has been implicated in a variety of neurological disorders.Indeed,inhibition of PDE10A has proven to be of potential use for the treatment of central nervous system(CNS)pathologies caused by dysfunction of the basal ganglia–of which the striatum constitutes the largest component.A PDE10A-targeted positron emission tomography(PET)radioligand would enable a better assessment of the pathophysiologic role of PDE10A,as well as confirm the relationship between target occupancy and administrated dose of a given drug candidate,thus accelerating the development of effective PDE10A inhibitors.In this study,we designed and synthesized a novel ^(18)F-aryl PDE10A PET radioligand,codenamed[^(18)F]P10A-1910([^(18)F]9),in high radiochemical yield and molar activity via spirocyclic iodonium ylide-mediated radiofluorination.[^(18)F]9 possessed good in vitro binding affinity(IC_(50)=2.1 nmol/L)and selectivity towards PDE10A.Further,[^(18)F]9 exhibited reasonable lipophilicity(logD=3.50)and brain permeability(P_(app)>10×10^(−6) cm/s in MDCK-MDR1 cells).PET imaging studies of[^(18)F]9 revealed high striatal uptake and excellent in vivo specificity with reversible tracer kinetics.Preclinical studies in rodents revealed an improved plasma and brain stability of[^(18)F]9 when compared to the current reference standard for PDE10A-targeted PET,[^(18)F]MNI659.Further,dose–response experiments with a series of escalating doses of PDE10A inhibitor 1 in rhesus monkey brains confirmed the utility of[^(18)F]9 for evaluating target occupancy in vivo in higher species.In conclusion,our results indicated that[^(18)F]9 is a promising PDE10A PET radioligand for clinical translation. 展开更多
关键词 Phosphodiesterase 10A PET radioligand 18F Spirocyclic iodonium ylide Nonhuman primate Target occupancy
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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma
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作者 Hongyi Wang Zhuochao Liu +8 位作者 Jun Wang Fangqiong Hu Qi Zhou Li Wei Qiyuan Bao Jizhuang Wang Jing Liang Zhihong Liu weibin zhang 《Frontiers of Medicine》 SCIE CSCD 2022年第6期883-895,共13页
Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcoma.Identifying the relevant factors that drive metastasis and drug resistance is the key to improving the therapeutic ... Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcoma.Identifying the relevant factors that drive metastasis and drug resistance is the key to improving the therapeutic outcome of osteosarcoma.Here,we reported that autophagy was highly activated in metastatic osteosarcoma.We found increased autophagolysosomes in metastatic osteosarcoma cell lines by using electron microscopy,Western blot,and immunofluorescence experiments.We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients through immunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis of osteosarcoma.Knockdown of Beclin1 and LC3B reduced invasion,metastasis,and proliferation in metastatic osteosarcoma cells.In vitro and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growth and metastasis.Moreover,we demonstrated that autophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1 decreased the metastasis of osteosarcoma.Overall,our findings highlighted the association of autophagy with osteosarcoma progression and shed new light on autophagy-targeting therapy for osteosarcoma. 展开更多
关键词 OSTEOSARCOMA AUTOPHAGY METASTASIS drug resistance BECLIN1 LC3B
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Au nanoparticles loaded on hollow BiOCl microstructures boosting CO_(2)photoreduction
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作者 Siwen Gong Fei Rao +6 位作者 weibin zhang Qadeer-Ul Hassan Zhaoqing Liu Jianzhi Gao Jiangbo Lu Mirabbos Hojamberdiev Gangqiang Zhu 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第9期4385-4388,共4页
The BiOCl(BOC)synthesized by the water bath heating method was treated with sodium borohydride(NaBH_(4))to introduce oxygen vacancies(OVs).At the same time,Au nanoparticles were loaded to prepare a series of Au/BiOCl ... The BiOCl(BOC)synthesized by the water bath heating method was treated with sodium borohydride(NaBH_(4))to introduce oxygen vacancies(OVs).At the same time,Au nanoparticles were loaded to prepare a series of Au/BiOCl samples with different ratios.OVs and Au nanoparticles can promote the light absorption of host photocatalyst in the visible region.The calculated work function of BiOCl and Au can verify the existence of Ohmic contact between the interface of them,which is conducive to the separation of charge carriers.Through a series of photoelectric tests,it was verified experimentally that the separation of charge carriers is indeed enhanced.The high-energy hot electrons produced by Au under the surface plasmon resonance(SPR)effect can increase the counts of electrons to participate in the CO_(2)reduction reaction.Especially for 1.0%-Au/BOC,the yields of CO can reach 43.16μmol g^(−1)h^(−1),which is 6.6 times more than that of BOC.Therefore,loading precious metal on semiconductors is an effective strategy to promote the photocatalytic performance of CO_(2)reduction reactions. 展开更多
关键词 BiOCl Au nanoparticles Oxygen vacancy Ohmic contact CO_(2)photoreduction
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Computational exploration and screening of novel Janus MA2Z4 (M = Sc–Zn, Y–Ag, Hf–Au;A=Si, Ge;Z=N, P) monolayers and potential application as a photocatalyst
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作者 weibin zhang Woochul Yang +2 位作者 Yingkai Liu Zhiyong Liu Fuchun zhang 《Frontiers of physics》 SCIE CSCD 2022年第6期51-61,共11页
By high-throughput calculations,13 thermally and environmentally stable Janus MA_(2)Z_(4) monolayers were screened from 104 types of candidates.The 13 stable monolayers have very high charge carrier concentrations(... By high-throughput calculations,13 thermally and environmentally stable Janus MA_(2)Z_(4) monolayers were screened from 104 types of candidates.The 13 stable monolayers have very high charge carrier concentrations(×10^(15) cm^(–2)),which are better than those of the well-known graphene and TaS_(2).Because of their excellent conductivity,the 6 monolayers with band gaps less than 0.5 eV are identified as potential electrode materials for hydrogen evolution reaction applications.For potential applications as photoelectric or photocatalytic materials,bandgaps(Eg-HSE)higher than 0.5 eV remained,which resulted in 7 potential candidates.Based on optical absorption analysis in the visible-light range,H-HfSiGeP_(4) and HMoSiGeP_(4) have higher absorption ability and optical conductivity,which is quite impressive for optoelectronic,solar cell device,and photocatalysis applications.Additionally,the transmittance coefficient of Janus MA_(2)Z_(4) monolayers is approximately 70%–80%in the visible-light range,which implies that these monolayers show good light transmittance.For potential applications as photocatalysts,the redox potential and charge effective mass analysis indicate that H-HfSiGeP_(4),HMoSiGeP_(4),T-ScSiGeN_(4),and T-ZrSiGeN_(4) are suitable photocatalysts for CO_(2) reduction reactions.Using high-throughput identification,13 types of new and stable Janus MA2Z4 monolayers were explored,and the basic properties and potential applications were investigated,which can reduce the time for experiments and provide basic data for the material genome initiative. 展开更多
关键词 Janus MA2Z4 high-throughput identification charge carrier concentration electronic structure optical properties
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