Measurement of laser differential confocal geometrical parameters for ICF capsule

Amethod based on the laser differential confocal principle is proposed formeasurement of the uniformity of the inner and outer radius and shell thickness for an inertial confinement fusion(ICF)capsule.Firstly,thismethod uses the laser differential confocalmeasurement system(LDCS)driven by a precision air-bearing slide to scan andmeasure radially theouter radius,R,inner radius,r,andshell thickness,T,accurately.Secondly,a precision air-bearing rotation system is used to drive the capsule to rotate an angle,u,in sequence,and the LDCS is used tomeasure R,r and T at the corresponding angle.Finally,the uniformity of the ICF capsule’s R,r and T can be calculated by the values of R,r and Tmeasured at the position of each rotation angle.Thismethod provides an approach for achieving high-precision,non-destructive,comprehensive,and rapid measurement of the uniformity of the inner and outer radius and shell thickness of an ICF capsule.Preliminary experiments indicate that measurement precision,using the proposed method for the uniformity of the outer radius,shell thickness and inner radius of the capsule,can reach 7.02×10^(25),5.87×10^(24) and 6.52×10^(25),respectively.

A high-precision multi-dimensional microspectroscopic technique for morphological and properties analysis of cancer cell

Raman and Brillouin scattering are sensitive approaches to detect chemical composition and mechanical elasticity pathology of cells in cancer development and their medical treatment researches.The application is,however,suffering from the lack of ability to synchronously acquire the scattering signals following three-dimensional(3D)cell morphology with reasonable spatial resolution and signal-to-noise ratio.Herein,we propose a divided-aperture laser differential confocal 3D Geometry-Raman-Brillouin microscopic detection technology,by which reflection,Raman,and Brillouin scattering signals are simultaneously in situ collected in real time with an axial focusing accuracy up to 1 nm,in the height range of 200μm.The divided aperture improves the anti-noise capability of the system,and the noise influence depth of Raman detection reduces by 35.4%,and the Brillouin extinction ratio increases by 22 dB.A high-precision multichannel microspectroscopic system containing these functions is developed,which is utilized to study gastric cancer tissue.As a result,a 25%reduction of collagen concentration,42%increase of DNA substances,17%and 9%decrease in viscosity and elasticity are finely resolved from the 3D mappings.These findings indicate that our system can be a powerful tool to study cancer development new therapies at the sub-cell level.

A High-Resolution Measurement Method for Inner and Outer 3D Surface Profiles of Laser Fusion Targets Using a Laser Differential Confocal–Atomic Force Probe Technique

The high-resolution and nondestructive co-reference measurement of the inner and outer threedimensional(3D)surface profiles of laser fusion targets is difficult to achieve.In this study,we propose a laser differential confocal(LDC)–atomic force probe(AFP)method to measure the inner and outer 3D surface profiles of laser fusion targets at a high resolution.This method utilizes the LDC method to detect the deflection of the AFP and exploits the high spatial resolution of the AFP to enhance the spatial resolution of the outer profile measurement.Nondestructive and co-reference measurements of the inner profile of a target were achieved using the tomographic characteristics of the LDC method.Furthermore,by combining multiple repositionings of the target using a horizontal slewing shaft,the inner and outer 3D surface profiles of the target were obtained,along with a power spectrum assessment of the entire surface.The experimental results revealed that the respective axial and lateral resolutions of the outer profile measurement were 0.5 and 1.3 nm,while the respective axial and lateral resolutions of the inner profile measurement were 2.0 nm and approximately 400.0 nm.The repeatabilities of the rootmean-square deviation measurements for the outer and inner profiles of the target were 2.6 and 2.4 nm,respectively.We believe our study provides a promising method for the high-resolution and nondestructive co-reference measurement of the inner and outer 3D profiles of laser fusion targets.