Simulation-driven Wind Load Analysis and Prediction for Large Steerable Radio Telescopes

Large steerable radio telescopes can rotate in azimuth and elevation,with various upwind postures and complex wind load characteristics.In order to obtain the wind load distribution on the reflector and the wind force coefficients in different upwind postures,this work took the reflector of the Qi Tai Telescope in Xinjiang as the object.The wind pressure distribution,drag coefficient,side force coefficient,lift coefficient,and total force coefficient of 361 groups of reflectors with different upwind postures were calculated and analyzed by a numerical simulation method.The results show that the force on the reflector when the concave surface faces the wind is significantly greater than when the convex surface faces the wind.The surrogate models for calculating wind force coefficients were established based on the polynomial response surface model(PRSM) and regularized minimumenergy tensor-product spline(RMTS).The adjusted R-squared of RMTS is 0.98,and the root mean square error is below 0.1,which proves RMTS is significantly better than PRSM.Compared with the numerical simulation values,the absolute errors of the drag coefficient,side force coefficient,lift coefficient,and total force coefficient of the reflector with azimuth and elevation of 45° predicted by RMTS are 0.02,0.027,0.032,and 0.046,respectively.The relative errors are 2.42%,2.76%,2.23%,and 2.43%,respectively.It is proved that the RMTS surrogate model is reliable and that the predicted data can fast provide sufficient information for the wind-resistant design of the large steerable radio telescopes.

Multimodality-based Wind Speed Forecasting Method for the Wind Resistance Control of Large Radio Telescope

A large,fully steerable radio telescope is susceptible to the wind load,leading to structure deformation andpointing deviation of the telescope.To effectively suppress the influence of dynamic wind load,the wind resistancecontrol of the telescope is carried out based on wind speed forecasting.This study developed a wind speedforecasting model to efficiently forecast the wind speed at the telescope position.The proposed model successfullyeliminates the random noise of the original wind speed,effectively extracts the wind speed features and solves theautomatic optimization of the hyperparameters of the forecasting network.This model significantly improves theaccuracy and reliability of wind speed forecasting.To verify the forecasting performance of the proposed model,the wind data from the Qitai Radio Telescope site is examined as a case study.The wind speed forecasting model’sMAE,RMSE and MAPE are 0.0361,0.0703 and 3.87%,respectively.The performance of the proposed modelmeets the requirements of wind resistance control and can provide data support for the radio telescope.

肥胖儿童心率变异特征与血脂代谢、脂肪细胞因子含量的相关性分析

目的分析肥胖儿童心率变异特征与血脂代谢、脂肪细胞因子含量的相关性。方法选取2014年6月-2016年7月该院收治的肥胖儿童260例作为观察组,另取同期在该院接受疫苗接种的健康儿童200例作为对照组。采用24 h动态心电图获取两组研究对象的心率变异性指标,测定血液血脂代谢及脂肪细胞因子含量。进一步采用Pearson检验分析肥胖儿童心率变异特征与血脂代谢、脂肪细胞因子含量的相关性。结果观察组儿童的窦性心搏RR间期标准差(SDNN)、每5分钟RR间期平均值的标准差(SDANN)、全部相邻RR间期之差的均方根(RSMSSD)和每5分钟内RR间期标准差的平均值(SDNN Index)等心率变异性指标值均低于对照组儿童(P<0.05);观察组儿童的外周血脂质代谢指标中总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)含量均高于对照组儿童,高密度脂蛋白胆固醇(HDL-C)含量低于对照组儿童(P<0.05);观察组儿童的血清脂肪细胞因子瘦素(Leptin)、脂联素(APN)和视黄醇结合蛋白4(RBP-4)含量低于对照组儿童,白介素6(IL-6)含量高于对照组儿童(P<0.05);肥胖儿童的心率变异性指标SDNN、SDANN、RSMSSD及SDNN Index水平与脂质代谢指标及脂肪细胞因子含量均存在直接相关性(P<0.05)。结论肥胖儿童心率变异特征与机体脂质代谢及脂肪细胞因子含量间存在相关性,过度肥胖是导致儿童心功能异常的重要原因。

TE方案新辅助化疗前后60岁以上乳腺癌合并糖尿病患者肾功能指标的变化分析

目的探讨分析60岁以上乳腺癌合并糖尿病患者在TE方案新辅助化疗前后血肌酐(Scr)、尿素氮(BUN)、血清胱抑素C(Cys C)的变化规律及特征。方法选取哈励逊国际和平医院86例60岁以上乳腺癌合并糖尿病患者,分析TE方案新辅助化疗前后Scr、BUN、CysC检测结果情况。结果 60岁以上乳腺癌合并糖尿病患者新辅助化疗后Scr、BUN、Cys C检测结果均呈现增高趋势,Scr检测结果在新辅助化疗前后差异无统计学意义(P>0.05),BUN检测结果在新辅助化疗前后差异无统计学意义(P>0.05),Cys C检测结果在新辅助化疗前后差异有统计学意义(P<0.05)。结论 60岁以上乳腺癌合并糖尿病患者新辅助化疗后Cys C升高,表明TE方案新辅助化疗对有糖尿病既往病史的乳腺癌患者的肾功能造成一定损害,监测乳腺癌患者新辅助化疗过程中肾功能的变化有重要临床指导意义。

Prospective prediction and exploration situation of marine Mesozoic-Paleozoic oil and gas in the South Yellow Sea

The South Yellow Sea Basin is a large sedimentary basin superimposed by the Mesozoic-Paleozoic marine sedimentary basin and the Mesozoic-Cenozoic terrestrial sedimentary basin, where no oil and gas fields have been discovered after exploration for 58 years. After the failure of oil and gas exploration in terrestrial basins, the exploration target of the South Yellow Sea Basin turned to the marine Mesozoic- Paleozoic strata. After more than ten years' investigation and research, a lot of achievements have been obtained. The latest exploration obtained effective seismic reflection data of deep marine facies by the application of seismic exploration technology characterized by high coverage, abundant low-frequency components and strong energy source for the deep South Yellow Sea Basin. In addition, some wells drilled the Middle-Upper Paleozoic strata, with obvious oil and gas shows discovered in some horizons. The recent petroleum geological research on the South Yellow Sea Basin shows that the structure zoning of the marine residual basin has been redetermined, the basin structure has been defined, and 3 seismic reflection marker layers are traceable and correlatable in the residual thick Middle-Paleozoic strata below the continental Meso-Cenozoic strata in the South Yellow Sea Basin. Based on these, the seismic sequence of the marine sedimentary strata was established. According to the avaliable oil and gas exploration and research, the marine Mesozoic-Paleozoic oil and gas prospects of the South Yellow Sea were predicted as follows.(1) The South Yellow Sea Basin has the same sedimentary formation and evolution history during the sedimentary period of the Middle-Paleozoic marine basin with the Sichuan Basin.(2) There are 3 regional high-quality source rocks.(3) The carbonate and clastic reservoirs are developed in the Mesozoic- Paleozoic strata.(4) The three source-reservoir-cap assemblages are relatively intact.(5) The Laoshan Uplift is a prospect area for the Lower Paleozoic oil and gas, and the Wunansha Uplift is one for the marine Upper Paleozoic oil and gas.(6) The Gaoshi stable zone in the Laoshan Uplift is a favorable zone.(7) The marine Mesozoic-Paleozoic strata in the South Yellow Sea Basin has the geological conditions required to form large oil and gas fields, with remarkable oil and gas resources prospect. An urgent problem to be addressed now within the South Yellow Sea Basin is to drill parametric wells for the Lower Paleozoic strata as the target, to establish the complete stratigraphic sequence since the Paleozoic period, to obtain resource evaluation parameters, and to realize the strategic discovery and achieve breakthrough in oil and gas exploration understanding.

Preparation and Identification of Anti-rabies Virus Monoclonal Antibodies

To provide a foundation for the development of rapid and specific methods for the diagnosis of rabies virus infection, anti-rabies virus monoclonal antibodies were prepared and rabies virus nucleoprotein and human rabies virus vaccine strain (PV strain) were used as immunogens to immunize 6-8 week old female BALB/c mice. Spleen cells and SP2/0 myeloma cells were fused according to conventional methods: the monoclonal cell strains obtained were selected using the indirect immunofluorescence test; this was followed by preparation of monoclonal antibody ascitic fluid; and finally, systematic identification of subclass, specificity and sensitivity was carried out. Two high potency and specific monoclonal antibodies against rabies virus were obtained and named 3B12 and 4A12, with ascitic fluid titers of 1:8000 and 1:10000, respectively. Both belonged to the IgG2a subclass. These strains secrete potent, stable and specific anti-rabies virus monoclonal antibodies, which makes them well suited for the development of rabies diagnosis reagents.

Enhanced detection of freeze‒thaw induced landslides in Zhidoi county(Tibetan Plateau,China)with Google Earth Engine and image fusion

Freeze‒thaw induced landslides(FTILs)in grasslands on the Tibetan Plateau are a geological disaster leading to soil erosion.These landslides reduce biodiversity and intensify landscape fragmentation,which in turn are strengthen by the persistent climate change and increased anthropogenic activities.However,conventional techniques for mapping FTILs on a regional scale are impractical due to their labor-intensive,costly,and time-consuming nature.This study focuses on improving FTILs detection by implementing image fusion-based Google Earth Engine(GEE)and a random forest algorithm.Integration of multiple data sources,including texture features,index features,spectral features,slope,and vertical‒vertical polarization data,allow automatic detection of the spatial distribution characteristics of FTILs in Zhidoi county,which is located within the Qinghai‒Tibet Engineering Corridor(QTEC).We employed statistical techniques to elucidate the mechanisms influencing FTILs occurrence.The enhanced method identifies two schemes that achieve high accuracy using a smaller training sample(scheme A:94.1%;scheme D:94.5%)compared to other methods(scheme B:50.0%;scheme C:95.8%).This methodology is effective in generating accurate results using only~10%of the training sample size necessitated by other methods.The spatial distribution patterns of FTILs generated for 2021 are similar to those obtained using various other training sample sources,with a primary concentration observed along the central region traversed by the QTEC.The results highlight the slope as the most crucial feature in the fusion images,accounting for 93%of FTILs occurring on gentle slopes ranging from 0°to 14°.This study provides a theoretical framework and technological reference for the identification,monitoring,prevention and control of FTILs in grasslands.Such developments hold the potential to benefit the management of grassland ecosystem,reduce economic losses,and promote grassland sustainability.

Extraction and verification of miRNA from ginseng decoction

Objective: To verify the existence of microRNAs(miRNAs) extracted from fresh ginseng decoction.Methods: Fresh ginseng was prepared into decoction according to the conventional method. The miRNA were extracted from the condensed ginseng decoction by plant microRNA extraction kit. Then miRNA were treated by DNase I and subjected to agarose gel electrophoresis and Agilent 2100 bioanalysis. Mi R-159 and mi R-6135, which were highly expressed in ginseng, were selected and verified by real-time quantitative PCR to detect the expression in the decoction.Results: Ginseng miRNA were successfully extracted from fresh decoction. Mi R-159 and mi R-6135 were expressed in fresh decoction with lower levels than those of fresh ginseng.Conclusion: miRNAs stably existed after processing, and retained some stability after high-temperature treatment. The findings provide a valuables basis for the further studies on ginseng miRNAs.

A coumarin-based colorimetric and fluorescent probe for the highly selective detection of Au^(3+) ions

We develop a novel coumarin-all〈yne derivative （NC7-AL）, which can specifically react with Au^3＋ and give a colorimetric and fluorescent ＂turn-on＂ response toward Au3~, Notably, other alkynophilic metal species such as Au^＋, Ag^＋, Pd^2＋, Ni^2＋, Cu^2＋, and Hg^2＋ do not produce an interfering signal. A good linear relationship between emission intensity at 420 nm and Au^3＋ concentration from 0 to 2 equivalent is observed, and the detection limit （3σ/k） is estimated to be ca. 3.58 nmol/L. Harnessing the Au^3＋ .