Non-Hodgkin's lymphoma involving chronic difficult-to-heal wounds:A case report

BACKGROUND Non-Hodgkin's lymphoma(NHL)is a malignant tumor that originates from the lymphoid tissues and can potentially affect numerous organs within the body.Among these,the skin stands out as one of the primary sites affected by NHL,often presenting with multiple extra-nodal manifestations.In this report,we present an unusual case of NHL involving chronic wounds in the lower extremities that were difficult to heal.The scars were successfully treated using radiotherapy in combination with extended excision debridement and peroneal artery perforator flap grafting,resulting in satisfactory outcomes.CASE SUMMARY A 19-year-old male patient presented with ulceration of the skin on the left calf near the ankle accompanied by purulent discharge.Subsequent pathologic biopsy confirmed a diagnosis of NHL(extranodal NK/T-cell lymphoma,nasal type).Initial treatment comprised local radiotherapy and wound care;however,the wound exhibited prolonged non-healing.Consequently,the patient underwent a series of interventions including radiotherapy,wound enlargement excision debridement,and peroneal artery perforator flap grafting.Ultimately,successful healing was achieved with favorable postoperative outcomes characterized by good texture of the flap without any signs of rupture or infection.CONCLUSION The combination of radiotherapy,wound enlargement excision debridement,and peroneal artery perforator flap grafting may present a favorable treatment modality for chronic non-healing lower leg wounds resulting from NHL.

BARN:Behavior-Aware Relation Network for multi-label behavior detection in socially housed macaques

Quantification of behaviors in macaques provides crucial support for various scientific disciplines,including pharmacology,neuroscience,and ethology.Despite recent advancements in the analysis of macaque behavior,research on multi-label behavior detection in socially housed macaques,including consideration of interactions among them,remains scarce.Given the lack of relevant approaches and datasets,we developed the Behavior-Aware Relation Network(BARN)for multi-label behavior detection of socially housed macaques.Our approach models the relationship of behavioral similarity between macaques,guided by a behavior-aware module and novel behavior classifier,which is suitable for multi-label classification.We also constructed a behavior dataset of rhesus macaques using ordinary RGB cameras mounted outside their cages.The dataset included 65?913 labels for19 behaviors and 60?367 proposals,including identities and locations of the macaques.Experimental results showed that BARN significantly improved the baseline SlowFast network and outperformed existing relation networks.In conclusion,we successfully achieved multilabel behavior detection of socially housed macaques with both economic efficiency and high accuracy.

Projected near-surface wind speed and wind energy over Central Asia using dynamical downscaling with bias-corrected global climate models

Wind energy development in Central Asia can help alleviate drought and fragile ecosystems.Nevertheless,current studies mainly used the global climate models(GCMs)to project wind speed and energy.The simulated biases in GCMs remain prominent,which induce a large uncertainty in the projected results.To reduce the uncertainties of projected near-surface wind speed(NSW)and better serve the wind energy development in Central Asia,the Weather Research and Forecasting(WRF)model with bias-corrected GCMs was employed.Compared with the outputs of GCMs,dynamical downscaling acquired using the WRF model can better capture the high-and low-value centres of NSWS,especially those of Central Asia's mountains.Meanwhile,the simulated NSWS bias was also reduced.For future changes in wind speed and wind energy,under the Representative Concentration Pathway 4.5(RCP4.5)scenario,NSWS during 2031-2050 is projected to decrease compared with that in 19862005.The magnitude of NSwS reduction during 2031-2050 willreach 0.1 m s^(-1).and the maximum reduction is projected to occur over the central and western regions(>0.2 m s^(-1)).Furthermore,future wind power density(WPD)can reveal nonstationarity and strong volatility,although a downward trend is expected during 2031-2050.In addition,the higher frequency of wind speeds at the turbine hub height exceeding 3.0 m s^(-1)can render the plain regions more suitable for wind energy development than the mountains from 2031 to 2050.This study can serve as a guide in gaining insights into future changes in wind energy across Central Asia and provide a scientific basis for decision makers in the formulation of policies for addressing climate change.

Effects of Northern Hemisphere Annular Mode on terrestrial near-surface wind speed over eastern China from 1979 to 2017

Large-scale ocean‒atmosphere circulations(LOACs)have a pronounced effect on the near-surface wind speed(NSWS).In this study,we discussed the contributions of zonal and meridional flows to NSWS changes and identify the possible association between the Northern Hemisphere Annular Mode(NAM)and the NSWS changes over eastern China from 1979 to 2017.Results show that the reduction in NSWS over eastern China was mainly dominated by the weakening of the zonal wind component.NAM has a considerable effect on the NSWS over eastern China.When the NAM exhibits positive phases,the zonal-mean westerly weakens at low-to-mid-latitudes(10°-40°N).Meanwhile,descending flows prevail near 40°N,and ascending flows persist near 65°N in the troposphere.In the lower troposphere,there are northerly anomalies at low-to-mid-latitudes and southerly anomalies at mid-to-high latitudes(40°-70°N).The anomalous meridional flows transport heat from low to high latitudes and weaken the north‒south air temperature gradient.The decreased air temperature gradient over East Asia reduces the pressure gradient near the surface,decreasing NSWS in eastern China.NAM variations could dominate(32.0±15.8)%of the changes in the annual mean NSWS.Nevertheless,the contribution of NAM to the interannual changes of the zonal component in NSWS could reach(45.0±12.9)%.