The microhardness curve trend and its relationships with microstructure and misorientation were analyzed to enhance the comprehension of the microstructure and mechanical property of micro-areas in Ti6 Al4 V laser-wel...The microhardness curve trend and its relationships with microstructure and misorientation were analyzed to enhance the comprehension of the microstructure and mechanical property of micro-areas in Ti6 Al4 V laser-welded joints with different welding speeds. The microhardness measured on the fusion line(H_m) is the highest from the weld center to the base metal. H_m increases with increasing weld width in a welded joint and increasing degree of the non-uniformity in all studied welded joints. The microhardness decreases from the weld metal to the base metal with decreasing amount of martensite α’ and increasing amount of original α phase. When the microstructure is mainly composed of martensite α’, the microhardness changes with the cooling rate, grain size of the martensite, and peak values of the fraction of misorientation angle of the martensite in a wide weld metal zone or weld center at different welding speeds, whereas the difference is small in a narrow weld metal zone.展开更多
AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (T...AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher's exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and openended catheter use were signifi cant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically signifi cant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a signifi cant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P < 0.001). CONCLUSION: Increasing age, male gender, openended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.展开更多
This paper focuses on the heavy metal enrichment and heavy metal pollution degree associated with mining activities in some crops and the soils of different parent materials in the Xiaoqinling Gold Belt.According to t...This paper focuses on the heavy metal enrichment and heavy metal pollution degree associated with mining activities in some crops and the soils of different parent materials in the Xiaoqinling Gold Belt.According to the geochemical analysis results of the soils observed in the gold belt,the soils are most highly enriched in Pb,followed by Cr,Cu,and Zn.Furthermore,they are relatively poor in Hg,Cd,and As.It is also shown that the heavy metals in all kinds of soils have the same geochemical characteristics in the gold belt.As for the crops(such as corn and wheat)in the gold belt,Zn and Cu are the most abundant elements,followed by Pb and Cr.Meanwhile,Hg,Cd,and As were found to have relatively low concentrations in the crops.The heavy metals in wheat and corn have the same geochemical characteristics in the gold belt in general.Compared to the aeolian loess soils and the crops therein,heavy metals are more enriched in diluvial and alluvial soils and the crops therein.As shown by relevant studies,the Hg,Pb,Cd,Cu,and Zn pollution are mainly caused by mining activities.Corn and wheat in the gold belt have a high tendency of risk exposure to heavy metal pollution since they are mostly affected by mining activities and feature high background values of heavy metal concentrations.Furthermore,wheat is more liable to be enriched in heavy metals than corn is grown in all types of soils.The Hg pollution in soils leads to Hg accumulation,increasing the risk of Hg uptake in crops,and further affecting human health.This study will provide a scientific basis for the control and management of heavy metals in farmland soils of mining areas.展开更多
Asymmetric lowered-temperature rolling was applied to the fabrication of fine-grained ZK60 magnesium alloy sheet with weak basal texture along the rolling direction(RD).The results showed that multi-pass lowered-tempe...Asymmetric lowered-temperature rolling was applied to the fabrication of fine-grained ZK60 magnesium alloy sheet with weak basal texture along the rolling direction(RD).The results showed that multi-pass lowered-temperature rolling could significantly improve the microstructure homogeneity and refine the grain size.Meanwhile,a fiber texture along the transverse direction(TD)gradually developed during rolling process.Importantly,the shear deformation along the RD made the c-axis of basal plane rotate to the RD,weakening the basal texture along this direction.Influenced by such microstructure variation,the yield strength along the TD continuously increased due to the successive grain refinement and the increased activation of prismatic slips,whereas the uniform elongation decreased owing to the decline of strain hardening ability.In contrast,the continuous weakening of basal texture along the RD increased the activation of soft basal slips,greatly offsetting the strengthening effect contributed by grain refinement and thereby causing the slight decrease of yield strength.展开更多
High altitude,cold and dry climate,strong solar radiation,and high evapotranspiration intensity have created an extremely fragile ecological and geological environment on the Tibet Plateau.Since the heat in the vadose...High altitude,cold and dry climate,strong solar radiation,and high evapotranspiration intensity have created an extremely fragile ecological and geological environment on the Tibet Plateau.Since the heat in the vadose zone is primarily generated by the external solar radiation energy,and evapotranspiration is contingent on the consumption of vadose heat,the intensity of evapotranspiration is associated with the intensity of solar radiation and the heat budget in the vadose zone.However,the spatial and temporal variation of heat budget and thermodynamic transfer process of the vadose zone in the frigid region are not clear,which hinders the revelation of the dynamic mechanism of evapotranspiration in the vadose zone in the frigid region.With the moisture content of the vadose zone in the alpine regions being the research object,the paper conducts in-situ geothermal observation tests,takes meteorological characteristics into consideration,and adopts the method of geothermal gradient and numerical computation to analyse the temporal and spatial variation rule of heat budget and thermodynamic transmission process of the vadose zone in the high and cold regions.The results show there is a positive correlation between air temperature,ground temperature,and water content of the vadose zone in both thawing and freezing periods.According to the change law of geothermal gradient,the thermodynamic transfer process of the vadose zone has four stages:slow exothermic heating,fast endothermic melting,slow endothermic cooling,and fast exothermic freezing.From the surface down,the moisture freezing rate of the vadose zone is slightly higher than the melting rate.This is of great significance for understanding the evapotranspiration dynamic process of the vadose zone and protecting and rebuilding the ecological and geological environment in the high and cold regions.展开更多
In order to develop novel LpxC inhibitors with good activities and metabolic stability, two series of compounds with hydrophilic terminus have been synthesized and their in vitro antibacterial activities against Esche...In order to develop novel LpxC inhibitors with good activities and metabolic stability, two series of compounds with hydrophilic terminus have been synthesized and their in vitro antibacterial activities against Escherichial coil and Pseudomonas aemginosa were evaluated. Especially, compounds 22b and c exhibited comparable antibacterial activities to CHIR-090 and better metabolic stability than CHIR-090 and LPC-011 in liver microsomes (rat and mouse), which indicated the terminal methylsulfone may be a preferred structure in the design of LpxC inhibitors and worthy of further investigations.展开更多
基金supported by National Natural Science Foundation of China(Nos.51975146,52205344)the Natural Science Foundation of Shandong Province,China(No.ZR2020QE171)+1 种基金the Key Research and Development Plan in Shandong Province,China(No.2019JZZY010364)the National Defense Basic Scientific Research of China(No.JCK2018603C017)。
基金Project(51875442)supported by the National Natural Science Foundation of China。
文摘The microhardness curve trend and its relationships with microstructure and misorientation were analyzed to enhance the comprehension of the microstructure and mechanical property of micro-areas in Ti6 Al4 V laser-welded joints with different welding speeds. The microhardness measured on the fusion line(H_m) is the highest from the weld center to the base metal. H_m increases with increasing weld width in a welded joint and increasing degree of the non-uniformity in all studied welded joints. The microhardness decreases from the weld metal to the base metal with decreasing amount of martensite α’ and increasing amount of original α phase. When the microstructure is mainly composed of martensite α’, the microhardness changes with the cooling rate, grain size of the martensite, and peak values of the fraction of misorientation angle of the martensite in a wide weld metal zone or weld center at different welding speeds, whereas the difference is small in a narrow weld metal zone.
文摘AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher's exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and openended catheter use were signifi cant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically signifi cant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a signifi cant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P < 0.001). CONCLUSION: Increasing age, male gender, openended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.
基金funded by the survey projects initiated by the Ministry of Natural and Resources of the People’s Republic of China(DD20189220,1212010741003,1212011220224,and 121201011000150022)the Public Welfare Scientific Research Project launched by the Ministry of Natural and Resources of the People’s Republic of China(201111020)+1 种基金the project of 2015 Natural Science Basic Research Program of Shaanxi(2015JM4129)the project of 2016 Fundamental Research Funds for the Central Universities(open fund)(310829161128).
文摘This paper focuses on the heavy metal enrichment and heavy metal pollution degree associated with mining activities in some crops and the soils of different parent materials in the Xiaoqinling Gold Belt.According to the geochemical analysis results of the soils observed in the gold belt,the soils are most highly enriched in Pb,followed by Cr,Cu,and Zn.Furthermore,they are relatively poor in Hg,Cd,and As.It is also shown that the heavy metals in all kinds of soils have the same geochemical characteristics in the gold belt.As for the crops(such as corn and wheat)in the gold belt,Zn and Cu are the most abundant elements,followed by Pb and Cr.Meanwhile,Hg,Cd,and As were found to have relatively low concentrations in the crops.The heavy metals in wheat and corn have the same geochemical characteristics in the gold belt in general.Compared to the aeolian loess soils and the crops therein,heavy metals are more enriched in diluvial and alluvial soils and the crops therein.As shown by relevant studies,the Hg,Pb,Cd,Cu,and Zn pollution are mainly caused by mining activities.Corn and wheat in the gold belt have a high tendency of risk exposure to heavy metal pollution since they are mostly affected by mining activities and feature high background values of heavy metal concentrations.Furthermore,wheat is more liable to be enriched in heavy metals than corn is grown in all types of soils.The Hg pollution in soils leads to Hg accumulation,increasing the risk of Hg uptake in crops,and further affecting human health.This study will provide a scientific basis for the control and management of heavy metals in farmland soils of mining areas.
基金supported by the National Natural Science Foundation of China (Nos. 51975146, 51801192, 52205344)the Natural Science Foundation of Shandong Province, China (No. ZR2020QE171)+1 种基金Key Research and Development Plan in Shandong Province, China (No. 2019JZZY010364)the National Defense Basic Scientific Research of China (No. JCK2018603C017)
文摘Asymmetric lowered-temperature rolling was applied to the fabrication of fine-grained ZK60 magnesium alloy sheet with weak basal texture along the rolling direction(RD).The results showed that multi-pass lowered-temperature rolling could significantly improve the microstructure homogeneity and refine the grain size.Meanwhile,a fiber texture along the transverse direction(TD)gradually developed during rolling process.Importantly,the shear deformation along the RD made the c-axis of basal plane rotate to the RD,weakening the basal texture along this direction.Influenced by such microstructure variation,the yield strength along the TD continuously increased due to the successive grain refinement and the increased activation of prismatic slips,whereas the uniform elongation decreased owing to the decline of strain hardening ability.In contrast,the continuous weakening of basal texture along the RD increased the activation of soft basal slips,greatly offsetting the strengthening effect contributed by grain refinement and thereby causing the slight decrease of yield strength.
基金Science Foundation of China(41877199)the Key Research and Development Program of Shaanxi Province(2021ZDLSF05-01)+3 种基金the Key Scientific and Technological Innovation Team of Groundwater Hydrological Process and Supergene Ecology in Arid Regions of Shaanxi Province(2019TD-040)the Key Research and Development Program of Shaanxi(2022SF-327)the Science and Technology Program of Inner Mongolia Autonomous Region(2021GG0198)the Project of China Geological Survey(1212011220224,DD20221751,DD20211393,DD20190504).
文摘High altitude,cold and dry climate,strong solar radiation,and high evapotranspiration intensity have created an extremely fragile ecological and geological environment on the Tibet Plateau.Since the heat in the vadose zone is primarily generated by the external solar radiation energy,and evapotranspiration is contingent on the consumption of vadose heat,the intensity of evapotranspiration is associated with the intensity of solar radiation and the heat budget in the vadose zone.However,the spatial and temporal variation of heat budget and thermodynamic transfer process of the vadose zone in the frigid region are not clear,which hinders the revelation of the dynamic mechanism of evapotranspiration in the vadose zone in the frigid region.With the moisture content of the vadose zone in the alpine regions being the research object,the paper conducts in-situ geothermal observation tests,takes meteorological characteristics into consideration,and adopts the method of geothermal gradient and numerical computation to analyse the temporal and spatial variation rule of heat budget and thermodynamic transmission process of the vadose zone in the high and cold regions.The results show there is a positive correlation between air temperature,ground temperature,and water content of the vadose zone in both thawing and freezing periods.According to the change law of geothermal gradient,the thermodynamic transfer process of the vadose zone has four stages:slow exothermic heating,fast endothermic melting,slow endothermic cooling,and fast exothermic freezing.From the surface down,the moisture freezing rate of the vadose zone is slightly higher than the melting rate.This is of great significance for understanding the evapotranspiration dynamic process of the vadose zone and protecting and rebuilding the ecological and geological environment in the high and cold regions.
基金National Science and Technology Major Project for the support of this researchsupported by Key New Drug Creation and Manufacturing Program,China (No.2014ZX09507009-016)
文摘In order to develop novel LpxC inhibitors with good activities and metabolic stability, two series of compounds with hydrophilic terminus have been synthesized and their in vitro antibacterial activities against Escherichial coil and Pseudomonas aemginosa were evaluated. Especially, compounds 22b and c exhibited comparable antibacterial activities to CHIR-090 and better metabolic stability than CHIR-090 and LPC-011 in liver microsomes (rat and mouse), which indicated the terminal methylsulfone may be a preferred structure in the design of LpxC inhibitors and worthy of further investigations.