This paper focuses on the performance analysis of flexible reactive systems. The performance analysis consists of two phases: first system modeling, second performance evalua-tion. The paper models the flexible react...This paper focuses on the performance analysis of flexible reactive systems. The performance analysis consists of two phases: first system modeling, second performance evalua-tion. The paper models the flexible reactive system by the stochas-tic statecharts method, and uses the simulation method to evalu-ate the performance. To make use of the feature of event-triggered state transitions in the statecharts, a new method of simulation is proposed based on the techniques of the discrete-event system simulation. The new method solves the problem of computer imple-mentation of stochastic events, probabilistic transition, concurrent states, paral el actions, and broadcast communication mechanism in the stochastic statecharts. An example of a flexible manufactur-ing system is presented. The simulation result of the example is consistent with the analytical result, which shows the feasibility of the proposed new simulation method.展开更多
This paper presents a new nine⁃degree⁃of⁃freedom parallel mechanism,which can be applied as a flight simulator.The mechanism is composed by Stewart turntable and another three⁃axis turntable.The Stewart platform can r...This paper presents a new nine⁃degree⁃of⁃freedom parallel mechanism,which can be applied as a flight simulator.The mechanism is composed by Stewart turntable and another three⁃axis turntable.The Stewart platform can realize six⁃degree⁃of⁃freedom movement in space,but the working space is limited.After the three⁃axis turntable is installed,the rotation space can be increased to simulate more realistic flight conditions.This paper analyzes the new flight simulator from kinematics and dynamics aspects.In addition,the flight simulator is simulated and analyzed based on the MATLAB/Simulink simulation system.The results obtained from the numerical simulations is planned to be used for the practical manufacturing and applications of the new platform.展开更多
Platinum(Pt)-based electrocatalysts remain the only practical cathode catalysts for proton exchange membrane water electrolysis(PEMWE),due to their excellent catalytic activity for acidic hydrogen evolution reaction(H...Platinum(Pt)-based electrocatalysts remain the only practical cathode catalysts for proton exchange membrane water electrolysis(PEMWE),due to their excellent catalytic activity for acidic hydrogen evolution reaction(HER),but are greatly limited by their low reserves and high cost.Here,we report an interfacial engineering strategy to obtain a promising low-Pt loading catalyst with atomically Pt-doped molybdenum carbide quantum dots decorated on conductive porous carbon(Pt-MoCx@C)for high-rate and stable HER in PEMWE.Benefiting from the strong interfacial interaction between Pt atoms and the ultra-small MoCx quantum dots substrate,the Pt-MoCx catalyst exhibits a high mass activity of 8.00 A·mgPt−1,5.6 times higher than that of commercial 20 wt.%Pt/C catalyst.Moreover,the strong interfacial coupling of Pt and MoCx substrate greatly improves the HER stability of the Pt-MoCx catalyst.Density functional theory studies further confirm the strong metal-support interaction on Pt-MoCx,the critical role of MoCx substrate in the stabilization of surface Pt atoms,as well as activation of MoCx substrate by Pt atoms for improving HER durability and activity.The optimized Pt-MoCx@C catalyst demonstrates>2000 h stability under a water-splitting current of 1000 mA·cm^(−2)when applied to the cathode of a PEM water electrolyzer,suggesting the potential for practical applications.展开更多
Dear Editor,As an emerging drug discovery paradigm,Proteolysis targeting chimeras(PROTACs)facilitate ubiquitination and degradation of the targets by cellular endogenous proteasome system.Compared with traditional sma...Dear Editor,As an emerging drug discovery paradigm,Proteolysis targeting chimeras(PROTACs)facilitate ubiquitination and degradation of the targets by cellular endogenous proteasome system.Compared with traditional small molecular inhibitors,PROTACs work like enzymes and can operate with or without functional inhibition of the targets,which endows this strategy to degrade drug targets,especially useful for“undruggable”ones.展开更多
基金supported by the National Natural Science Foundation of China(61171120)
文摘This paper focuses on the performance analysis of flexible reactive systems. The performance analysis consists of two phases: first system modeling, second performance evalua-tion. The paper models the flexible reactive system by the stochas-tic statecharts method, and uses the simulation method to evalu-ate the performance. To make use of the feature of event-triggered state transitions in the statecharts, a new method of simulation is proposed based on the techniques of the discrete-event system simulation. The new method solves the problem of computer imple-mentation of stochastic events, probabilistic transition, concurrent states, paral el actions, and broadcast communication mechanism in the stochastic statecharts. An example of a flexible manufactur-ing system is presented. The simulation result of the example is consistent with the analytical result, which shows the feasibility of the proposed new simulation method.
文摘This paper presents a new nine⁃degree⁃of⁃freedom parallel mechanism,which can be applied as a flight simulator.The mechanism is composed by Stewart turntable and another three⁃axis turntable.The Stewart platform can realize six⁃degree⁃of⁃freedom movement in space,but the working space is limited.After the three⁃axis turntable is installed,the rotation space can be increased to simulate more realistic flight conditions.This paper analyzes the new flight simulator from kinematics and dynamics aspects.In addition,the flight simulator is simulated and analyzed based on the MATLAB/Simulink simulation system.The results obtained from the numerical simulations is planned to be used for the practical manufacturing and applications of the new platform.
基金the National Natural Science Foundation of China(Nos.22171287,21901136,51972342,51972345,22105226,and 51872056)Taishan Scholar Project of Shandong Province(Nos.tsqn202103046 and ts20190922)+3 种基金Natural Science Foundation of Shandong Province(Nos.ZR2022QE175 and ZR2019ZD51)Fundamental Research Funds for the Central Universities(Nos.20CX06024A,22CX01002A-1,and 21CX06002A)China Postdoctoral Science Foundation(Nos.2019M650027 and 2019TQ0169)National Natural Science Foundation of Beijing(No.2204082),and Shandong Province Postdoctoral Innovative Talent Support Program(No.SDBX20200004).
文摘Platinum(Pt)-based electrocatalysts remain the only practical cathode catalysts for proton exchange membrane water electrolysis(PEMWE),due to their excellent catalytic activity for acidic hydrogen evolution reaction(HER),but are greatly limited by their low reserves and high cost.Here,we report an interfacial engineering strategy to obtain a promising low-Pt loading catalyst with atomically Pt-doped molybdenum carbide quantum dots decorated on conductive porous carbon(Pt-MoCx@C)for high-rate and stable HER in PEMWE.Benefiting from the strong interfacial interaction between Pt atoms and the ultra-small MoCx quantum dots substrate,the Pt-MoCx catalyst exhibits a high mass activity of 8.00 A·mgPt−1,5.6 times higher than that of commercial 20 wt.%Pt/C catalyst.Moreover,the strong interfacial coupling of Pt and MoCx substrate greatly improves the HER stability of the Pt-MoCx catalyst.Density functional theory studies further confirm the strong metal-support interaction on Pt-MoCx,the critical role of MoCx substrate in the stabilization of surface Pt atoms,as well as activation of MoCx substrate by Pt atoms for improving HER durability and activity.The optimized Pt-MoCx@C catalyst demonstrates>2000 h stability under a water-splitting current of 1000 mA·cm^(−2)when applied to the cathode of a PEM water electrolyzer,suggesting the potential for practical applications.
基金supported in part by National Natural Science Foundation of China(81673304,81973160,and 81830083)Innovation Program of Shanghai municipal education commission(2017-01-07-00-05-E00011)+2 种基金Shenzhen Municipal Government of China(KQTD201708101602260820)the Fundamental Research Funds for the Central Universities(44300-19311-542500/006)ECNU Public Platform for Innovation(011).
文摘Dear Editor,As an emerging drug discovery paradigm,Proteolysis targeting chimeras(PROTACs)facilitate ubiquitination and degradation of the targets by cellular endogenous proteasome system.Compared with traditional small molecular inhibitors,PROTACs work like enzymes and can operate with or without functional inhibition of the targets,which endows this strategy to degrade drug targets,especially useful for“undruggable”ones.