抑郁情绪对阿尔茨海默病患者认知功能的影响

目的:探讨抑郁情绪对阿尔茨海默病(Alzheimer's disease, AD)患者各认知领域功能的影响。方法:对2021年6月至2023年6月就诊于日照市人民医院神经内科门诊及记忆门诊的62例AD轻、中度患者进行详细的神经心理量表评估,采用简易智能状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评价AD轻、中度患者的整体认知功能,并分别对记忆、语言、注意力、视空间、执行功能等5个不同维度的单认知领域功能进行评估,采用汉密尔顿抑郁量表(HAMD)评价患者抑郁状况,HAMD≤7分为AD不伴发抑郁组,HAMD> 7分为AD伴发抑郁组,比较两组总体认知功能及各认知领域功能的情况。结果:62例AD患者中,有28例合并抑郁状态,占比45.16%,AD患者HAMD评分与DST-顺背呈负相关,与TMT-B和Stroop色词测验-时间呈正相关(P <0.05)。合并抑郁的AD患者与不合并抑郁的AD患者DST-顺背、TMT-B和Stroop色词测验-时间得分差异有统计学意义(P <0.05)。结论:抑郁会影响AD患者的注意力、执行功能等认知功能。

Night warming increases wheat yield by improving pre-anthesis plant growth and post-anthesis grain starch biosynthesis

Global climate change is characterized by asymmetric warming,i.e.,greater temperature increases in winter,spring,and nighttime than in summer,autumn,and daytime.Field experiments were conducted using four wheat cultivars,namely‘Yangmai 18’(YM18),‘Sumai 188’(SM188),‘Yannong 19’(YN19),and‘Annong 0711’(AN0711),in the two growing seasons of 2019-2020 and 2020-2021,with passive night warming during different periods in the early growth stage.The treatments were night warming during the tillering-jointing(NW_(T-J)),jointing-booting(NWJ-B),and booting-anthesis(NWB-A)stages,with ambient temperature(NN)as the control.The effects of night warming during different stages on wheat yield formation were investigated by determining the characteristics of dry matter accumulation and translocation,as well as sucrose and starch accumulation in wheat grains.The wheat yields of all four cultivars were significantly higher in NW_(T-J)than in NN in the 2-year experiment.The yield increases of semi-winter cultivars YN19 and AN0711 were greater than those of spring cultivars YM18 and SM188.Treatment NW_(T-J)increased wheat yield mainly by increasing the 1,000-grain weight and the number of fertile spikelets,and it increased dry matter accumulation in various organs of wheat at the anthesis and maturity stages by increasing the growth rate at the vegetative growth stage.The flag leaf and spike showed the largest increases in dry matter accumulation.NW_(T-J)also increased the grain sucrose and starch contents in the early and middle grain-filling stages,promoting yield formation.Overall,night warming between the tillering and jointing stages increased the pre-anthesis growth rate,and thus,wheat dry matter production,which contributed to an increase in wheat yield.

Lightweight Multi-Resolution Network for Human Pose Estimation

Human pose estimation aims to localize the body joints from image or video data.With the development of deeplearning,pose estimation has become a hot research topic in the field of computer vision.In recent years,humanpose estimation has achieved great success in multiple fields such as animation and sports.However,to obtainaccurate positioning results,existing methods may suffer from large model sizes,a high number of parameters,and increased complexity,leading to high computing costs.In this paper,we propose a new lightweight featureencoder to construct a high-resolution network that reduces the number of parameters and lowers the computingcost.We also introduced a semantic enhancement module that improves global feature extraction and networkperformance by combining channel and spatial dimensions.Furthermore,we propose a dense connected spatialpyramid pooling module to compensate for the decrease in image resolution and information loss in the network.Finally,ourmethod effectively reduces the number of parameters and complexitywhile ensuring high performance.Extensive experiments show that our method achieves a competitive performance while dramatically reducing thenumber of parameters,and operational complexity.Specifically,our method can obtain 89.9%AP score on MPIIVAL,while the number of parameters and the complexity of operations were reduced by 41%and 36%,respectively.

Seasonal variation of melatonin secretion across various segments of the gastrointestinal tract in rats

Objective:To investigate whether melatonin(MT)secretion in different parts of the gastrointestinal tract(GIT)exhibits seasonal variations and its correlation with immune regulation.Methods: Sixty Sprague-Dawley rats were divided into control and model groups,and the pineal gland was removed in the model group.Stomach,jejunum,ileum,and colon tissues were obtained during the spring equinox,summer solstice,beginning of autumn,autumn equinox,and winter solstice.The levels of MT,MT receptors(MR),arylalkylamine N-acetyltransferase(AANAT),hydroxyindole-O-methyltransferase(HIOMT),interleukin-2(IL-2),and interleukin-10(IL-10)in the GIT were measured using enzyme-linked immunosorbent assay.Results: Except for the stomach,the jejunum,ileum,and the colon showed seasonal tendencies in MT secretion.In the control group,MT secretion in the jejunum and ileum was the highest in the long summer,and colonic MT secretion was the highest in winter.In the model group,MT levels in the colon were highest in the summer.The seasonal rhythms of the MR,AANAT,HIOMT,IL-2,and IL-10 in the colon were roughly similar to those of MT,and changed accordingly after pinealectomy.Conclusions: Gastrointestinal MT secretion is related to seasonal changes,and MT secretion in each intestinal segment is influenced by different seasons.The biological effects of MT in the gut are inextricably linked to the mediation of MR,and a hormone-receptor linkage exists between MT and MR.The effect of seasonal changes on the gastrointestinal immune system may be mediated through the regulation of seasonal secretion of MT.

Correlation between Neutrophil Percentage-to-albumin Ratio and Coronary Heart Disease Complicated with Diabetes Mellitus

[Objectives]This study was conducted to explore the relationship between neutrophil percentage-to-albumin ratio(NPAR)and coronary heart disease complicated with diabetes.[Methods]A total of 603 patients with coronary heart disease who underwent coronary angiography in Pingquan County Hospital from January,2023 to December,2023 and met the inclusion criteria were included as the research object.All the patients were divided into a coronary heart disease complicated with diabetes group(CAD+T2DM group)(n=298 cases)and a control group(CAD group)(n=305 cases),according to patients medical history,heart color ultrasound and biochemical test results.The clinical data,biochemical test results and coronary artery imaging data of patients were recorded,and the Gensini score was calculated.The neutrophil percentage(NEUT%)and albumin count were determined to calculate NPAR.[Results]The NPAR value of the coronary heart disease complicated with diabetes mellitus group was(1.6±0.42),which was significantly higher than that of the control group(1.47±0.49),and the difference was statistically significant(P<0.05).The area under the ROC curve was 0.619(95%CI:0.591-0.675,P<0.05),and the prediction of coronary heart disease complicated with diabetes using NPAR showed a Youden index of 0.31,a sensitivity of 60.4%,a specificity of 40.3%,and a best cut-off score of 1.4506.[Conclusions]The neutrophil percentage-to-albumin ratio(NPAR)is closely related to coronary heart disease complicated with diabetes mellitus,and NPAR has clinical application value in the diagnosis of coronary heart disease complicated with diabetes mellitus.

实施早期预防性侵犯教育的必要性及其实验效果

性侵犯严重威胁儿童身心健康,受害儿童中约有25%～35%是幼儿,因此在幼儿期开始预防教育非常重要。本研究在北京选取92名幼儿,以班为单位,随机分为教育组(N=44)和对照组(N=48),使用中国版《个人安全手册》,教授幼儿预防知识和技能,如认识隐私部位,辨别安全和不安全身体接触,面对不安全接触说"不"、快跑、向信任的人披露性侵犯事件。在连续教育5天后,教育组幼儿预防知识和技能水平显著提高,且保持了3～5个月。幼儿园应使用具体形象和游戏化教育材料,采用以行为规则为主的方法开展幼儿预防性侵犯教育,同时积极开展教师培训和家校合作,提高教师与家长的预防知识和能力。

碳基氧还原电催化剂:机理研究和多孔结构

由于快速增长的能源需求和日益紧迫的环境问题,清洁和可再生能源的开发受到全球范围的高度关注.质子交换膜燃料电池(PEMFC)可以直接把燃料所具有的化学能转换为电能,具有转化效率高、环境污染小和比能量高等优点,广泛应用于汽车、飞机等交通工具以及固定电站等领域.PEMFC中阴极侧的氧还原反应(ORR),由于多重质子-电子转移和固有的缓慢动力学,是影响燃料电池整体效率的重要因素.Pt基催化剂由于能够提供较好的催化性能而被认为是较好的阴极材料.然而,广泛使用的Pt基催化剂因成本较高和资源短缺等问题严重阻碍了PEMFC的大规模应用.因此,设计开发非贵金属阴极催化剂对于降低催化剂的成本十分必要.其中,碳基催化剂因具有较好的导电性和化学稳定性,已经成为ORR领域中贵金属催化剂强有力的替代品之一.本文从碳基催化剂的活性位点和孔道结构出发,系统总结和讨论了提高催化剂活性、稳定性和抗中毒性能等方面的研究进展.首先,简单介绍了ORR反应的机理以及碳基催化剂在反应过程中存在的主要问题,即本征活性低,活性位密度低,体积密度小以及稳定性差等.然后,针对以上问题,提出了构筑高活性和高稳定性碳基催化剂的策略.在碳载体中掺杂适量的杂原子和金属原子有助于构建具有高本征活性的催化位点,将金属纳米颗粒设计成原子级和超小纳米团簇有助于增加活性位点的数目.对于目前使用最广泛的Fe-N-C催化剂,从理论上解释了其在酸性介质中活性位点极易失活的主要原因,提出制备具有优异稳定性ORR催化剂的解决方案.孔道结构作为催化剂微观结构的重要组成部分,对活性位点的分布和传质具有十分重要的影响.从合成策略和不同孔径大小对ORR性能影响的两个角度出发,具体论述了现有文献中所报道的制备微孔、介孔和大孔三种孔道结构的方法,同时详细讨论了三种孔结构在ORR中的作用.最后,基于活性位点的设计和多孔结构的构建,对设计和制备高效碳基电催化剂进行了总结,展望了碳基催化剂未来的发展和研究思路.

腹腔灌注治疗在晚期胃癌腹膜转移患者中的应用效果

目的:探讨腹腔灌注治疗对胃癌腹膜转移患者生存的影响。方法:回顾性分析2014年1月至2020年12月哈尔滨医科大学附属肿瘤医院收治的353例晚期胃癌合并腹膜转移患者临床资料。根据是否腹腔灌注给药分为灌注治疗组和未灌注治疗组,并对患者进行生存随访。Kaplan-Meier法绘制生存曲线,Cox风险比例模型分析影响患者预后的因素,根据病灶部位、分化程度等进行亚组分析。结果:灌注治疗组和未灌注治疗组中位总生存(overall survival,OS)期为9.50个月(95%CI:7.39~11.61)和7.83个月(95%CI:5.74~9.92,P=0.022)。体质量指数(BMI)>25及伴有腹水的胃癌腹膜转移患者更易从腹腔灌注中获益。多因素分析显示:腹腔积液(HR=1.52,95%CI:1.18~1.94)、全身系统治疗(HR=0.43,95%CI:0.33~0.56)、手术(HR=0.52,95%CI:0.39~0.70)、腹腔灌注治疗(HR=0.65,95%CI:0.52~0.82)是影响患者生存的因素。结论:胃癌伴有腹膜转移患者可进行腹腔灌注治疗,与未灌注治疗患者相比,其生存期明显延长。Cox多因素分析显示无腹水、接受手术治疗、接受全身系统治疗和腹腔灌注治疗的患者预后更佳。分层分析显示BMI>25及伴有腹水的胃癌腹膜转移患者更易从腹腔灌注治疗中获益。

Mobile Jammer-Aided Secure UAV Communications via Trajectory Design and Power Control

To further promote the achievable average secrecy rate for UAV-ground communications, a UAV-aided mobile jamming strategy was proposed in this paper. Specifically, an additional cooperative UAV is employed as a mobile jammer to transmit the jamming signal to help keep the source UAV closer to the ground destination, thus establishing more favorable legitimate link and enhancing the secrecy performance. We aimed to maximize the achievable secrecy rate by jointly optimizing the trajectories and transmit power of both source UAV and jammer UAV. To solve the considered non-convex optimization problem, we presented a block coordinate descent based iterative algorithm to address a sequence of approximated convex problems for the optimized parameter block by block to find a local optimal solution. Numerical results verify that the proposed algorithm can achieve significant secrecy rate gain compared to all the benchmark schemes.

Host-induced gene silencing of multiple pathogenic factors of Sclerotinia sclerotiorum confers resistance to Sclerotinia rot in Brassica napus

Sclerotinia sclerotiorum is generally considered one of the most economically damaging pathogens in oilseed rape(Brassica napus).Breeding for Sclerotinia resistance is challenging,as no immune germplasm available in B.napus.It is desirable to develop new breeding strategies.In the present study,hostinduced gene silencing(HIGS),developed based on RNA interference(RNAi),was applied to protect B.napus from S.sclerotiorum infection.Three pathogenicity genes,the endo-polygalacturonase gene(Ss PG1),cellobiohydrolase gene(Ss CBH),and oxaloacetate acetylhydrolase gene(Ss OAH1),were chosen as HIGS targets.Co-incubation of synthesized double-stranded RNAs(ds RNAs)with S.sclerotiorum in liquid medium significantly reduced the transcript levels of the target genes.Application to plant surfaces of ds RNA targeting the three genes conferred effective protection against S.sclerotiorum.Stable transgenic B.napus plants expressing small interfering RNAs with sequence identity to Ss PG1,Ss CBH,and Ss OAH1 were generated.HIGS transgenic B.napus prevented the expression of S.sclerotiorum target genes,slowed pathogenicity-factor accumulation,impeded fungal growth,and suppressed appressorium formation,thereby conferring resistance to S.sclerotiorum.Simultaneous silencing of Ss PG1,Ss CBH,and Ss OAH1 by stable expression of a chimeric hairpin RNAi construct in B.napus led to enhanced protection phenotypes(with disease lesion size reduced by 36.8%–43.7%).We conclude that HIGS of pathogenic-factor genes of S.sclerotiorum is a promising strategy for controlling Sclerotinia rot in oilseed rape.

The model of tracing drift targets and its application in the South China Sea

A Leeway-Trace model was established for the traceability analysis of drifting objects at sea.The model was based on the Leeway model which is a Monte Carlo-based ensemble trajectory model,and a method of realistic traceability analysis was proposed in this study by using virtual spatiotemporal drift trajectory prediction.Here,measured data from a drifting buoy observation experiment in the northern South China Sea in April 2019,combined with surface current data obtained from the finite volume community ocean model(FVCOM),were used for the traceability analysis of humanoid buoys.The results were basically consistent with the observations,and the assimilation of measured current data can significantly improve the accuracy of the traceability analysis.Several sensitive experiments were designed to discuss the effects of wind and tide on the traceability analysis,and their results showed that the wind-driven current and the wind-induced leeway drift are both important to the traceability analysis.The effect of tidal currents on traceability could not be ignored even though they were much weaker than the residual currents in the experimental area of the northern South China Sea.

Physiological characteristics,geochemical properties and hydrological variables influencing pathogen migration in subsurface system:What we know or not?

The global outbreak of coronavirus infectious disease-2019(COVID-19)draws attentions in the transport and spread of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)in aerosols,wastewater,surface water and solid wastes.As pathogens eventually enter the subsurface system,e.g.,soils in the vadose zone and groundwater in the aquifers,they might survive for a prolonged period of time owing to the uniqueness of subsurface environment.In addition,pathogens can transport in groundwater and contaminate surrounding drinking water sources,possessing long-term and concealed risks to human society.This work critically reviews the influential factors of pathogen migration,unravelling the impacts of pathogenic characteristics,vadose zone physiochemical properties and hydrological variables on the migration of typical pathogens in subsurface system.An assessment algorithm and two rating/weighting schemes are proposed to evaluate the migration abilities and risks of pathogens in subsurface environment.As there is still no evidence about the presence and distribution of SARS-CoV-2 in the vadose zones and aquifers,this study also discusses the migration potential and behavior of SARS-CoV-2 viruses in subsurface environment,offering prospective clues and suggestions for its potential risks in drinking water and effective prevention and control from hydrogeological points of view.

外泌体传递miR-145调控上皮性卵巢癌细胞转移及癌干细胞样特征研究

目的:探讨外泌体(exosome,Exo)来源的miR-145传递对上皮性卵巢癌SKOV3细胞增殖、迁移、侵袭、血管形成及癌干细胞样特性的影响。方法:卵巢癌SKOV3细胞转染miR-145 mimic、miR-145 inhibitor或miR-145阴性对照(NC)。分离并鉴定SKOV3细胞分泌的Exo和miR-145过表达/低表达的SKOV3细胞分泌的外泌体。采用RT-qPCR法检测miR-145的表达。SKOV3细胞与不同来源的外泌体共培养。MTT法和Transwell法检测细胞增殖、迁移和侵袭。血管形成实验检测外泌体miR-145对人脐静脉内皮细胞血管生成能力的影响。采用肿瘤球形成实验评估SKOV3细胞系中CD133^(+)/CD44^(+)细胞亚群的干细胞特征。结果:miR-145 mimic-Exo处理后SKOV3细胞中miR-145表达显著上调,miR-145 inhibitor-Exo处理后SKOV3细胞中miR-145表达明显下调(P<0.05)。卵巢癌细胞来源的Exo可促进SKOV3细胞增殖、迁移和侵袭(P<0.05)。高水平的外泌体miR-145可降低SKOV3细胞增殖、迁移和增殖,抑制人脐静脉内皮细胞的血管生成,抑制SKVO3细胞形成肿瘤球的能力(P<0.05)。然而,miR-145表达下调的外泌体具有相反的作用(P<0.05)。结论:通过外泌体传递miR-145能够抑制上皮性卵巢癌细胞迁移、侵袭以及血管生成,并调控上皮性卵巢癌干细胞样特征。

High-loading Pt-alloy catalysts for boosted oxygen reduction reaction performance

To improve performance of membrane electrode assembly(MEA)at large current density region,efficient mass transfer at the cathode is desired,for which a feasible strategy is to lower catalyst layer thickness by constructing high loading Pt-alloy catalysts on carbon.But the high loading may induce unwanted par-ticle aggregation.In this work,H-PtNi/C with 33%(mass)Pt loading on carbon and monodisperse distri-bution of 3.55 nm PtNi nanoparticles,was prepared by a bimodal-pore route.In electrocatalytic oxygen reduction reaction(ORR),H-PtNi/C displays an activity inferior to the low Pt loading catalyst L-PtNi/C(13.3%(mass))in the half-cell.While in H_(2)-0_(2) MEA,H-PtNi/C delivers the peak power density of 1.51 W·cm^(-2) and the mass transfer limiting current density of 4.4 A·cm^(-2),being 21%and 16%higher than those of L-PtNi/C(1.25 W·cm^(-2),3.8 A·cm^(-2))respectively,which can be ascribed to enhanced mass trans-fer brought by the thinner catalyst layer in the former.In addition,the same method can be used to pre-pare PtFe alloy catalyst with a high-Pt loading of 36%(mass).This work may lead to a range of catalyst materials for the large current density applications,such as fuel cell vehicles.

Chinese herbal medicine for incomplete immune reconstruction in patients with AIDS undergoing antiretroviral treatment: A systematic review of randomized trials

Objective:To evaluate the effectiveness and safety of Chinese herbal medicines(CHMs)for incomplete immune reconstruction in patients with HIV/AIDS.Methods:Eight electronic databases were searched for randomized controlled trials(RCTs)on the use of CHM for patients with HIV/AIDS with incomplete immune reconstruction.Outcomes included CD4þcell count,quality of life,and adverse events/effects.The Cochrane Risk of Bias was employed to evaluate the methodological quality of the included RCTs.Results:We identified 13 eligible RCTs,with an overall high risk of bias,on 10 different CHMs.There was a significant increase in CD4þcell count after the use of Jianpi Yiqi medicinal paste for 3 months;tripterygium glycosides tablets(TGTs)for 3 months(mean difference[MD]52.63 cells/mL,95%confidence interval[CI,46.98,58.28]),6,9,and 12 months;Wenshen Jianpi granules for 6 months;Shenling Fuzheng capsules for 6 months(MD 49.53 cells/mL,95%CI[8.45,90.61])and 12 months;Aikeqing granules for 9 months(MD 61.51 cells/mL,95%CI[16.25,106.77])and 12 months;Guipi decoction for 12 months;Mianyi No.2 granules(JT)for 12 and 18 months;and Chinese medicine granules for 18 months.The increase in the mean difference of CD4þcell count from 6 to 18 months was larger in Chinese medicine granules and Mianyi No.2 granules(JT).Guipi decoction and Jianpi Qushi decoction improved the Karnofsky score.Four RCTs reported the outcome of adverse events/effects,while four cases of minor adverse effects were reported in the TGTs group.Conclusion:Jianpi Yiqi medicinal paste,Wenshen Jianpi granules,Shenling Fuzheng capsules,Aikeqing granules,Guipi decoction,and TGTs may be effective in increasing CD4þwithin 12 months,and Mianyi No.2 granules(JT)and Chinese medicine granules may show long-term effects.High-quality large RCTs on the effectiveness and safety of CHMs are still warranted.

Applicability evaluation of ERA5 wind and wave reanalysis data in the South China Sea

Wind and wave data are essential in climatological and engineering design applications.In this study,data from 15 buoys located throughout the South China Sea(SCS)were used to evaluate the ERA5 wind and wave data.Applicability assessment are beneficial for gaining insight into the reliability of the ERA5 data in the SCS.The bias range between the ERA5 and observed wind-speed data was-0.78-0.99 m/s.The result indicates that,while the ERA5 wind-speed data underestimation was dominate,the overestimation of such data existed as well.Additionally,the ERA5 data underestimated annual maximum wind-speed by up to 38%,with a correlation coefficient>0.87.The bias between the ERA5 and observed significant wave height(SWH)data varied from-0.24 to 0.28 m.And the ERA5 data showed positive SWH bias,which implied a general underestimation at all locations,except those in the Beibu Gulf and centralwestern SCS,where overestimation was observed.Under extreme conditions,annual maximum SWH in the ERA5 data was underestimated by up to 30%.The correlation coefficients between the ERA5 and observed SWH data at all locations were greater than 0.92,except in the central-western SCS(0.84).The bias between the ERA5 and observed mean wave period(MWP)data varied from-0.74 to 0.57 s.The ERA5 data showed negative MWP biases implying a general overestimation at all locations,except for B1(the Beibu Gulf)and B7(the northeastern SCS),where underestimation was observed.The correlation coefficient between the ERA5 and observed MWP data in the Beibu Gulf was the smallest(0.56),and those of other locations fluctuated within a narrow range from 0.82 to 0.90.The intercomparison indicates that during the analyzed time-span,the ERA5 data generally underestimated wind-speed and SWH,but overestimated MWP.Under non-extreme conditions,the ERA5 wind-speed and SWH data can be used with confidence in most regions of the SCS,except in the central-western SCS.

Organic-inorganic hybrid hole transport layers with SnS doping boost the performance of perovskite solar cells

Perovskite solar cells(PSCs) have demonstrated excellent photovoltaic performance which currently rival the long-standing silicon solar cells’ efficiency. However, the relatively poor device operational stability of PSCs still limits their future commercialization. Binary sulfide is a category of materials with promising optoelectrical properties, which shows the potential to improve both the efficiency and stability of PSCs.Here we demonstrate that the inorganic tin monosulfide(Sn S) can be an efficient dopant in 2,2’,7,7’-tet rakis(N,N-di-p-methoxy-phenylamine)-9,9’-spirobifluorene(spiro-OMe TAD) to form a composite hole transport layer(HTL) for PSCs. Sn S nanoparticles(NPs) synthesized through a simple chemical precipitation method exhibit good crystallization and suitable band matching with the perovskites. The introduction of Sn S NPs in Spiro-OMTAD HTLs enhanced charge extraction, reduced trap state density, and shallowed trap state energy level of the devices based on the composite HTLs. Therefore, the resulting solar cells employing Sn S-doped spiro-OMe TAD HTLs delivered an improved stabilized power output efficiency of 21.75% as well as enhanced long-term stability and operational stability. Our results provide a simple method to modify the conventional spiro-OMe TAD and obtain PSCs with both high efficiency and good stability.

The Design of Internet of Things Smart Home System based on S3C2440 and Zigbee

In order to achieve the smart home system for remote management and wireless transmission function in the smart home networking system design, the article will combined with ARM technology and ZigBee wireless network technology based on samsung＇s $3C2440 chip and some related peripheral devices to form into home gateway of the system control platform, and the home control network using the internal ZigBee wireless network technologies. Practice has proved that the system is stable, is worth promoting.

Diagnostic Value of NPAR,MHR,GLU and Coronary Heart Disease Complicated with Type 2 Diabetes Mellitus

[Objectives]To explore the relationship between neutrophil percentage to albumin ratio(NPAR),monocyte to high density lipoprotein ratio(MHR),fasting blood glucose(GLU)and CAD+T2DM and its diagnostic value.[Methods]A total of 3937 patients who underwent coronary angiography in the Affiliated Hospital of Chengde Medical University from January 2016 to December 2018 were collected.The patients with Gensini score>0 and diabetes were selected as the experimental group(CAD+T2DM,n=756),and the patients with Gensini score=0 and without diabetes were taken as the control group(n=388),with a total of 1144 cases.The patient's medical record number,sex,age,contact number,biochemical test results,cardiac color ultrasound,coronary artery imaging and other data were recorded.NPAR,MHR,and GLU were calculated.A binary Logistic regression model was established combined with the receiver operating characteristic(ROC)curve.The predictive value of single index and joint test for CAD+T2DM was analyzed.[Results]The serum levels of NPAR,MHR and GLU in CAD+T2DM were significantly higher than those in the control group.Binary Logistic regression analysis showed that serum NPAR,MHR and GLU were risk factors for CAD+T2DM(P<0.05).The final prediction model is P=1/[1+e-(-3.722+0.014×NPAR+0.51×MHR+0.461×GLU)].ROC curve showed that the area under the curve of serum NPAR,MHR and GLU was 0.739,0.628 and 0.852,respectively,and the prediction probability of combined detection was 0.882,which was significantly higher than that of single index.[Conclusions]There was a close correlation between serum NPAR,MHR,GLU and CAD+T2DM in patients with coronary heart disease.The combined application of these indexes can significantly improve the predictive value of CAD+T2DM.

A Hybrid Conjugate Gradient Algorithm for Solving Relative Orientation of Big Rotation Angle Stereo Pair

The fast convergence without initial value dependence is the key to solving large angle relative orientation.Therefore,a hybrid conjugate gradient algorithm is proposed in this paper.The concrete process is:①stochastic hill climbing(SHC)algorithm is used to make a random disturbance to the given initial value of the relative orientation element,and the new value to guarantee the optimization direction is generated.②In local optimization,a super-linear convergent conjugate gradient method is used to replace the steepest descent method in relative orientation to improve its convergence rate.③The global convergence condition is that the calculation error is less than the prescribed limit error.The comparison experiment shows that the method proposed in this paper is independent of the initial value,and has higher accuracy and fewer iterations.