安罗替尼治疗难治型晚期结直肠癌Ⅲ期临床研究的单中心数据分析

目的:分析安罗替尼三线治疗难治型晚期结直肠癌的疗效及安全性。方法:收集并分析2014年9月至2016年8月中国医学科学院肿瘤医院收治的53例晚期结直肠癌患者临床信息,观察、评估安罗替尼的疗效及安全性。结果:患者随机分为安罗替尼组和安慰剂组。安罗替尼组与安慰剂组的中位总生存期(overall survival,OS)分别为9.37个月和8.23个月;中位无进展生存期(progression-free survival,PFS)分别为5.03个月和1.33个月(HR=0.27,95%CI:0.13~0.54)。两组患者客观缓解率(objective response rate,ORR)分别为2.94%和0;安罗替尼组的疾病控制率(disease control rate,DCR)显著高于安慰剂组(88.24%vs.36.84%,P<0.001)。26例RAS/BRAF野生型患者中,安罗替尼组中位PFS显著长于安慰剂组(5.37个月vs.1.33个月),DCR显著优于安慰剂组(93.33%vs.36.36%,P=0.003)。最常见的≥3级安罗替尼相关不良事件为高血压(17.65%)、腹泻(8.82%)和掌跖红肿综合征(8.82%)。结论:安罗替尼后线治疗晚期结直肠癌可改善患者无进展生存期(progression-free survival,PFS),提升DCR,且安全性良好,为晚期结直肠癌的治疗提供了新思路。然而对于RAS/BRAF野生型人群的临床获益趋势有待进一步验证。

Study on the Dynamic Characteristics of Light Steel Residential Structural System

The study on the dynamic characteristics of light steel residential structural system has both theoretical and practical significance for the application and promotion of light steel residential structural system. In this paper, we analyze several common types of light steel residential structural system, describe the dynamic characteristics of the light steel residential structural system for an overview on the basis of former related studies, and then summarize the advantages of light steel residential structure system.

Triaxial test on glass beads simulating coarse-grained soil

It is feasible to study the mechanical characteristics of coarse-grained soil by simulated granular materials such as glass beads.In this paper,3 mm diameter glass beads are used to conduct drained and undrained triaxial tests under different confining pressures to explore their strength,deformation and critical state characteristics.Specifically,the influence of drainage and confining pressure on the stick-slip phenomenon of glass beads is reported.The experimental findings from triaxial tests show that the stress-strain relationship of glass beads softens when the confining pressure is high.Under the undrained condition,the initial modulus increases with the increase in the confining pressure.In contrast,it is not significantly affected by the confining pressure in the drained condition.It is quite evident that the glass beads hardly contract during the shearing process,and their stress path is approximately a segmented straight line.The slope of the critical state line under the undrained condition is greater than that under the drained condition,and the friction angle of the glass beads under the undrained and drained conditions is calculated to be 28.1and 29.5,respectively.The phenomenon of stick-slip has been depicted for the different test conditions,and the stick-slip amplitude linearly increases with the confining pressure,especially in the undrained condition.It is also found that the maximum energy released from the phenomenon of stick-slip increases linearly with the confining pressure.

Responses of Patients with Disorders of Consciousness to Habit Stimulation:A Quantitative EEG Study

Whether habit stimulation is effective in DOC patient arousal has not been reported. In this paper, we analyzed the responses of DOC patients to habit stimulation. Nineteen DOC patients with alcohol consumption or smoking habits were recruited and 64-channel EEG signals were acquired both at the resting state and at three stimulation states. Wavelet transformation and nonlinear dynamics were used to extract the features of EEG signals and four brain lobes were selected to investigate the degree of EEG response to habit stimulation. Results showed that the highest degree of EEG response was from the callname stimulation, followed by habit and music stimulations. Significant differences in EEG wavelet energy and response coefficient were found both between habit and music stimulation, and between habit and call-name stimulation. These findings prove that habit stimulation induces relatively more intense EEG responses in DOC patients than music stimulation, suggesting that it may be a relevant additional method for eliciting patient arousal.

Response surface modeling-based source contribution analysis and VOC emission control policy assessment in a typical ozone-polluted urban Shunde,China

To develop a sound ozone（O_3） pollution control strategy,it is important to well understand and characterize the source contribution due to the complex chemical and physical formation processes of O_3.Using the ＂Shunde＂ city as a pilot summer case study,we apply an innovative response surface modeling（RSM） methodology based on the Community Multi-Scale Air Quality（CMAQ） modeling simulations to identify the O_3 regime and provide dynamic analysis of the precursor contributions to effectively assess the O_3 impacts of volatile organic compound（VOC） control strategy.Our results show that Shunde is a typical VOC-limited urban O_3 polluted city.The ＂Jiangmen＂ city,as the main upper wind area during July 2014,its VOCs and nitrogen oxides（NO_x） emissions make up the largest contribution（9.06%）.On the contrary,the contribution from local（Shunde） emission is lowest（6.35%） among the seven neighbor regions.The local VOCs industrial source emission has the largest contribution comparing to other precursor emission sectors in Shunde.The results of dynamic source contribution analysis further show that the local NO_x control could slightly increase the ground O_3 under low（10.00%） and medium（40.00%）reduction ratios,while it could start to turn positive to decrease ground O_3 under the high NO_x abatement ratio（75.00%）.The real-time assessment of O_3 impacts from VOCs control strategies in Pearl River Delta（PRD） shows that the joint regional VOCs emission control policy will effectively reduce the ground O_3 concentration in Shunde.

Development and case study of a new-generation model-VAT for analyzing the boundary conditions influence on atmospheric mercury simulation

Atmospheric models are essential tools to study the behavior of air pollutants. To interpret the complicated atmospheric model simulations, a new-generation Model Visualization and Analysis Tool （Model-VAT） has been developed for scientists to analyze the model data and visualize the simulation results. The Model-VAT incorporates analytic functions of conventional tools and enhanced capabilities in flexibly accessing, analyzing, and comparing simulated results from multi-scale models with diflbrent map projections and grid resolutions. The performance of the Model-VAT is demonstrated by a case study of investigating the influence of boundary conditions （BCs） on the ambient Hg formation and transport simulated by the CMAQ model over the Pearl River Delta （PRD） region. The alternative BC options are taken from （1） default time-independent profiles, （2） outputs from a CMAQ simulation of a larger nesting domain, and （3） concentration files from GEOS-Chem （re-gridded and re-projected using the Model-VAT）. The three BC inputs and simulated ambient concentrations and deposition were compared using the Model-VAT. The results show that the model simulations based on the static BCs （default profile） underestimates the Hg concentrations by --6.5%, dry depositions by -9.4%, and wet depositions by --43.2% compared to those of the model-derived （e. g. GEOS-Chem or nesting CMAQ） BCs. This study highlights the importance of model nesting approach and demonstrates that the innovative functions of Model-VAT enhances the efficiency of analyzing and comparing the model results from various atmospheric model simulations.