Considering the accidents of ships for dangerous chemicals transportation in inland rivers,a numerical method for the simulation of the leakage and diffusion processes of dangerous chemicals in inland rivers is propos...Considering the accidents of ships for dangerous chemicals transportation in inland rivers,a numerical method for the simulation of the leakage and diffusion processes of dangerous chemicals in inland rivers is proposed in this paper.Geographic information,such as rivers and buildings in the model,is obtained through Google Earth and structures of rivers and buildings are described by Auto CAD.In addition,the Fluent is adopted to simulate the leakage and diffusion processes of the dangerous chemicals where the standard k-εmodel is used to calculate the turbulent flow.Considering the interaction between chemicals and water,the VOF method is used to describe the leakage,drift and diffusion process of dangerous chemicals groups on the water surface.Taking a section of the Yangtze River as an example,the leakage and diffusion processes from a ship carrying 3,000 tons of low-solubility and low-volatile dangerous chemicals are studied,and the characteristics of leakage and diffusion are analyzed in detail.During the simulation,the area of the maximum group of leaked dangerous chemicals reaches up to about 1800 m2,and the number reaches up to 45.Furthermore,the influence of density,viscosity,water velocity and leakage velocity on the leakage and diffusion processes is investigated in this paper.展开更多
Stimuli-triggered drug delivery systems hold vast promise in local infection treatment for the site-specific targeting and shuttling of drugs.Herein,chitosan conjugates(SPCS)installed with sialic acid(SA)and phenylbor...Stimuli-triggered drug delivery systems hold vast promise in local infection treatment for the site-specific targeting and shuttling of drugs.Herein,chitosan conjugates(SPCS)installed with sialic acid(SA)and phenylboronic acid(PBA)were synthesized,of which SA served as targeting ligand for coccidium and reversible-binding bridge for PBA.The enhanced drug-loading capacity of SPCS micelles was attributed to a combination assembly from hydrophobicity-driving and reversible borate bridges.The drug-loaded SPCS micelles shared superior biostability in upper gastrointestinal tract.After reaching the lesions,the borate bridges were snipped by carbohydrates under a higher pH followed by accelerated drug release,while SA exposure on micellar surface facilitated drug cellular internalization to eliminate parasites inside.The drugmicelles revealed an enhanced anti-coccidial capacity with a higher index of 185.72 compared with commercial preparation.The dual-responsive combination of physicochemical assembly could provide an efficient strategy for the exploitation of stable,safe and flexible anti-infectious drug delivery systems.展开更多
Constructing two-dimensional(2D)layered materials with traditional three-dimensional(3D)semiconductors into complex heterostructures has opened a new platform for the development of optoelectronic devices.Herein,large...Constructing two-dimensional(2D)layered materials with traditional three-dimensional(3D)semiconductors into complex heterostructures has opened a new platform for the development of optoelectronic devices.Herein,large-area high performance self-driven photodetectors based on monolayer WS2∕GaAs heterostructures were successfully fabricated with a wide response spectrum band ranging from the ultraviolet to near-infrared region.The detector exhibits an overall high performance,including high photoresponsivity of 65.58 A/W at 365 nm and 28.50 A/W at 880 nm,low noise equivalent power of 1.97×10^−15 W∕Hz1∕2,high detectivity of 4.47×10^12 Jones,and fast response speed of 30/10 ms.This work suggests that the WS2∕GaAs heterostructure is promising in future novel optoelectronic device applications,and also provides a low-cost,easy-to-process method for the preparation of 2D/3D heterojunction-based devices.展开更多
基金supported by the special fund for the basic research business of the central public welfare research institutes(TKS160222,TKS160211)the key technology projects of the transportation industry(TKS180403)+1 种基金the Tianjin Science and Technology Project(the project)(17YFZCSF01250)supported by National Natural Science Foundation of China(No.U1930402).
文摘Considering the accidents of ships for dangerous chemicals transportation in inland rivers,a numerical method for the simulation of the leakage and diffusion processes of dangerous chemicals in inland rivers is proposed in this paper.Geographic information,such as rivers and buildings in the model,is obtained through Google Earth and structures of rivers and buildings are described by Auto CAD.In addition,the Fluent is adopted to simulate the leakage and diffusion processes of the dangerous chemicals where the standard k-εmodel is used to calculate the turbulent flow.Considering the interaction between chemicals and water,the VOF method is used to describe the leakage,drift and diffusion process of dangerous chemicals groups on the water surface.Taking a section of the Yangtze River as an example,the leakage and diffusion processes from a ship carrying 3,000 tons of low-solubility and low-volatile dangerous chemicals are studied,and the characteristics of leakage and diffusion are analyzed in detail.During the simulation,the area of the maximum group of leaked dangerous chemicals reaches up to about 1800 m2,and the number reaches up to 45.Furthermore,the influence of density,viscosity,water velocity and leakage velocity on the leakage and diffusion processes is investigated in this paper.
基金financial support from National Key Research and Development Program(2017YFD0501403)National Natural Science Foundation of China(Nos.81872819)+4 种基金Natural Science Foundation of Jiangsu Province(No.BK20171390)supported by Double First-Rate construction plan of China Pharmaceutical University(CPU2018GY26)the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZCX201816)the National Science and Technology Major Project(2017ZX09101001)the financial support from Development Funds for Priority Academic Programs in Jiangsu Higher Education Institutions-Young Talent Program。
文摘Stimuli-triggered drug delivery systems hold vast promise in local infection treatment for the site-specific targeting and shuttling of drugs.Herein,chitosan conjugates(SPCS)installed with sialic acid(SA)and phenylboronic acid(PBA)were synthesized,of which SA served as targeting ligand for coccidium and reversible-binding bridge for PBA.The enhanced drug-loading capacity of SPCS micelles was attributed to a combination assembly from hydrophobicity-driving and reversible borate bridges.The drug-loaded SPCS micelles shared superior biostability in upper gastrointestinal tract.After reaching the lesions,the borate bridges were snipped by carbohydrates under a higher pH followed by accelerated drug release,while SA exposure on micellar surface facilitated drug cellular internalization to eliminate parasites inside.The drugmicelles revealed an enhanced anti-coccidial capacity with a higher index of 185.72 compared with commercial preparation.The dual-responsive combination of physicochemical assembly could provide an efficient strategy for the exploitation of stable,safe and flexible anti-infectious drug delivery systems.
基金National Natural Science Foundation of China(61804086)Natural Science Foundation of Shandong Province(ZR2019PF002)+1 种基金Jiangsu Province Science Foundation for Youths(BK20170431)Changzhou Science and Technology Project(CJ20190010).
文摘Constructing two-dimensional(2D)layered materials with traditional three-dimensional(3D)semiconductors into complex heterostructures has opened a new platform for the development of optoelectronic devices.Herein,large-area high performance self-driven photodetectors based on monolayer WS2∕GaAs heterostructures were successfully fabricated with a wide response spectrum band ranging from the ultraviolet to near-infrared region.The detector exhibits an overall high performance,including high photoresponsivity of 65.58 A/W at 365 nm and 28.50 A/W at 880 nm,low noise equivalent power of 1.97×10^−15 W∕Hz1∕2,high detectivity of 4.47×10^12 Jones,and fast response speed of 30/10 ms.This work suggests that the WS2∕GaAs heterostructure is promising in future novel optoelectronic device applications,and also provides a low-cost,easy-to-process method for the preparation of 2D/3D heterojunction-based devices.
