Objective: To evaluate the efficacy and safety of Buyanghuanwu (BYHW) decoction for the treatment of ischemic stroke convalescence. Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biom...Objective: To evaluate the efficacy and safety of Buyanghuanwu (BYHW) decoction for the treatment of ischemic stroke convalescence. Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), Pubmed, the Cochrane Library, Science Citation Index (SCI) and Elsevier SD databases were searched from the origin time to May 2018. Cochrane recommended bias risk assessment method was used to evaluate the bias risk. Review Manager 5.3 was used to perform meta-analysis. Results: A total of 12 studies with a 1246 cases were included in the study. The results of the analysis showed that the efficacy of BYHW decoction combined with western medicine treatment was better than that of control group (OR = 2.88, 95% CI (2.10,3.95), P < 0.001)]. The neurological deficit score in the treatment group was lower than that in the control group, and the difference was statistically significant [MD =-2.84, 95% CI (-3.22,-2.45), P < 0.001]. The scores of daily living ability in the treatment group were higher than those in the control group, and the difference was statistically significant [MD = 8.89, 95% CI (7.61, 10.16), P <0.00001]. In the safety aspect, the results of the study are different, and there was a lack of quantitative indicators to evaluate the objectivity of adverse reactions. Conclusion: BYHW decoction combined with the Western medicine is an effective treatment for the recovery period of cerebral infarction, which can significantly improve the clinical efficacy, improve patients' neurological symptoms and their quality of life.展开更多
收集1例血管内大B细胞淋巴瘤(intravascular large B-cell lymphoma,IVLBCL)的病例资料并复习相关参考文献。患者主要临床表现为多浆膜腔积液和发热,经骨髓病理活检确诊,经CHOP样方案化疗后好转。IVLBCL是一种少见的结外弥漫大B细胞淋巴...收集1例血管内大B细胞淋巴瘤(intravascular large B-cell lymphoma,IVLBCL)的病例资料并复习相关参考文献。患者主要临床表现为多浆膜腔积液和发热,经骨髓病理活检确诊,经CHOP样方案化疗后好转。IVLBCL是一种少见的结外弥漫大B细胞淋巴瘤,其确诊需要结合病理活检及免疫组织化学,需与原发渗出性淋巴瘤和原发性骨淋巴瘤进行鉴别。展开更多
Deuteron-driven spallation targets have garnered attention recently because they can provide high-energy neutrons to transmute long-lifetime fission products.In this study,the Geant4 toolkit was used to simulate the i...Deuteron-driven spallation targets have garnered attention recently because they can provide high-energy neutrons to transmute long-lifetime fission products.In this study,the Geant4 toolkit was used to simulate the inter-action between a deuteron beam at 500 MeV and a com-posite target composed of alternating lead-bismuth eutectic(LBE)and water.The water was used because it may be employed as a target coolant.The energy spectrum,neu-tron yield,average energy,and total energy of the emitted neutrons were calculated for different thicknesses and thickness ratios between the LBE and water.For a constant target thickness,the neutron yield increases with an increasing thickness ratio of LBE to H 2 O,while the aver-age energy of the emitted neutrons decreases with an increasing in the aforementioned thickness ratio.These two aspects support the use of a pure target,either LBE or water.However,with an increasing LBE-to-H 2 O thickness ratio,the total energy of the emitted neutrons increases and then decreases.This result supports the addition of water into the LBE target.The angular distributions of the emitted neutrons show that the rear of the target is suit-able for loading nuclear waste containing minor actinides and long-lifetime fission products.展开更多
Magnetic reconnection and tearing mode instability play a critical role in many physical processes.The application of Galerkin spectral method for tearing mode instability in two-dimensional geometry is investigated i...Magnetic reconnection and tearing mode instability play a critical role in many physical processes.The application of Galerkin spectral method for tearing mode instability in two-dimensional geometry is investigated in this paper.A resistive magnetohydrodynamic code is developed,by the Galerkin spectral method both in the periodic and aperiodic directions.Spectral schemes are provided for global modes and local modes.Mode structures,resistivity scaling,convergence and stability of tearing modes are discussed.The effectiveness of the code is demonstrated,and the computational results are compared with the results using Galerkin spectral method only in the periodic direction.The numerical results show that the code using Galerkin spectral method individually allows larger time step in global and local modes simulations,and has better convergence in global modes simulations.展开更多
Objective:To investigate the effect of Wei’s triple nine needling therapy on the N2-P2 wave of the flash visual evoked potential(FVEP)in rats of the of the transverse directional pulling model.Methods:Thirty-six Wist...Objective:To investigate the effect of Wei’s triple nine needling therapy on the N2-P2 wave of the flash visual evoked potential(FVEP)in rats of the of the transverse directional pulling model.Methods:Thirty-six Wistar rats were randomly grouped,nine were in normal control group without any treatment,and the remaining 27 were surgically modelled in the right eyes.Eighteen of these rats were randomly divided into a Wei’s triple nine needling therapy group and a model group of nine rats each after the TON model was made using the transverse quantitative retraction method.The other 9 rats were sham-operated,and only the optic nerve was exposed without retraction.On the next day of modelling,the Wei’s triple nine needling therapy group was treated with Wei’s triple nine needling therapy for 20 minutes/1 time/1 day for 14 days.The model group,sham-operated group and normal control group were not intervened.Wei's triple nine acupoints were represented as follows:1st link:"Jingming"(BL1)and"Chengqi"(ST1);2nd link:"Sizhukong"(SJ23)penetrating"Taiyang"(EX-HN5);and the third:"Fengchi"(GB 20)and"Taichong"(LV3).The FVEP of each group was observed on 1d,7d and 14d.The FVEP of each group was observed on 1d,7d and 14d.Results:Compared with the model group,the N2 wave latency and P2 wave latency were shortened in the Wei’s triple nine needling therapy on 1d(P<0.05,P<0.01);on 7d,their N2 wave latency was shortened(P<0.01)and the N2-P2 wave amplitude was increased compared with the model group(P<0.05);on 14d,their P2 wave latency was shortened(P<0.05)and the N2-P2 wave amplitude was increased.There was no statistical difference in N2 wave latency,P2 wave latency and N2-P2 wave amplitude in the sham-operated group on 1d,7d and 14d(P>0.05).The delayed N2 and P2 wave latencies in the model group did not improve from 1d to 14d(P>0.05)and the amplitude decreased throughout,showing a significant difference on 14d compared to 1d(P<0.05).In contrast,the N2 wave latency in Wei’s triple nine needling therapy group was not significantly different until 7d to 14d(P<0.05);its P2 wave latency,although significantly delayed from 1d to 7d(P<0.05),recovered on 14d and reached a level that was not statistically different from 1d and 7d(P>0.05).There was also no significant decrease in N2-P2 wave amplitude between 1d and 14d in Wei’s triple nine needling therapy group(P>0.05).Conclusion:In this experiment,the TON rat model was successfully established by the transverse quantitative retraction method,and the treatment of TON rats with Wei’s triple nine needling therapy reduced the P2 wave delay of the FVEP electrophysiological signal and increased the N2-P2 amplitude,which had a certain positive effect on the repair of optic nerve injury,probably related to its effect of improving the conduction function of the optic nerve and protecting the retinal ganglion cells that had not been degenerated and necrosed.展开更多
Objective:To observe the TCM(Traditonal Chinese Medcine)syndromes effect and safety of Shujinjianyao Pill in the treatment of LSS(Lumbar Spinal Stenosis)(Ganshenbuzu and Fengshiyuzu Syndrome).Methods:120 LSS patients ...Objective:To observe the TCM(Traditonal Chinese Medcine)syndromes effect and safety of Shujinjianyao Pill in the treatment of LSS(Lumbar Spinal Stenosis)(Ganshenbuzu and Fengshiyuzu Syndrome).Methods:120 LSS patients fit the inclusion criteria were separated into two groups,90 in the experimental group and 30 in the control group.No significant difference was existed in the basic data between the two groups.The experimental group was given Shujinjianyao Pill and Danlutongdu Tablet Simulator orally,while the control group was given Shujinjianyao Pill Simulator and Danlutongdu Tablet orally for 4 weeks.The VAS score,total TCM(Traditonal Chinese Medcine)syndrome score and single TCM symptom score on day 0,14 and 28 were observed,and adverse reactions were recorded.Result:There were significant differences in total TCM syndrome score between the two groups at baseline,14 day and 28 day(P<0.01).There was a significant difference in total TCM syndrome score between the two groups at 28 day(P<0.05).Significant differences were existed between this two groups in total effective rate of total TCM syndromes and waist-knee pain-weak in single TCM syndromes on the 28 day(P<0.05).There was no significant difference in the incidence of adverse events and serious adverse events between the two groups(P>0.05).Conclusion:Shujinjianyao Pill is effective on TCM syndromes in the treatment of Ganshenbuzu and fengshiyuzu syndrome LSS,especially in improving the score of total TCM syndromes and waist-knee pain-weak of single TCM syndrome,and has high safety.展开更多
In this work,monodisperseβ-NaLuF_(4):Yb,Er microcrystals with intense upconversion emission were synthesized via a modified hydrothermal method.With the increase of reactant concentration,their production yield is in...In this work,monodisperseβ-NaLuF_(4):Yb,Er microcrystals with intense upconversion emission were synthesized via a modified hydrothermal method.With the increase of reactant concentration,their production yield is increased obviously,and the upconversion emission intensity inβ-NaLuF_(4):Yb,Er microcrystals is also enhanced significantly.The luminescence enhancement should be attributed to minimal internal OH defects,validated by a combination of analytical X-ray diffraction(XRD),energy dispersive spectrum(EDS),and Eu^(3+)structural probe measurements.We also reveal that high Na^(+):RE~(3+)ratio in theβ-NaLuF_(4):Yb,Er microcrystals prepared under Na^(~)+-rich reaction will arouse the increased repulsive energy ofβ-NaLuF_(4)microcrystals between F^(~)-and OH^(~)-anions and then facilitate the substitution of large OH^(-)ions by small F^(~)-ions under F^(~)--rich reaction conditions.Minimal OH^(-)concentrations can limit nonradiative relaxation and promote excitation energy harvesting for high upconversion efficiency.The presented results not only offer a facile method for the simultaneous production yield and luminescence intensity increase ofβ-NaREF_(4)microcrystals,but also uncover a better insight into the upconversion emission alterations,which is favorable to broaden their practical applications.展开更多
文摘Objective: To evaluate the efficacy and safety of Buyanghuanwu (BYHW) decoction for the treatment of ischemic stroke convalescence. Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), Pubmed, the Cochrane Library, Science Citation Index (SCI) and Elsevier SD databases were searched from the origin time to May 2018. Cochrane recommended bias risk assessment method was used to evaluate the bias risk. Review Manager 5.3 was used to perform meta-analysis. Results: A total of 12 studies with a 1246 cases were included in the study. The results of the analysis showed that the efficacy of BYHW decoction combined with western medicine treatment was better than that of control group (OR = 2.88, 95% CI (2.10,3.95), P < 0.001)]. The neurological deficit score in the treatment group was lower than that in the control group, and the difference was statistically significant [MD =-2.84, 95% CI (-3.22,-2.45), P < 0.001]. The scores of daily living ability in the treatment group were higher than those in the control group, and the difference was statistically significant [MD = 8.89, 95% CI (7.61, 10.16), P <0.00001]. In the safety aspect, the results of the study are different, and there was a lack of quantitative indicators to evaluate the objectivity of adverse reactions. Conclusion: BYHW decoction combined with the Western medicine is an effective treatment for the recovery period of cerebral infarction, which can significantly improve the clinical efficacy, improve patients' neurological symptoms and their quality of life.
文摘收集1例血管内大B细胞淋巴瘤(intravascular large B-cell lymphoma,IVLBCL)的病例资料并复习相关参考文献。患者主要临床表现为多浆膜腔积液和发热,经骨髓病理活检确诊,经CHOP样方案化疗后好转。IVLBCL是一种少见的结外弥漫大B细胞淋巴瘤,其确诊需要结合病理活检及免疫组织化学,需与原发渗出性淋巴瘤和原发性骨淋巴瘤进行鉴别。
基金supported by the National Natural Science Foundation of China(No.11875328).
文摘Deuteron-driven spallation targets have garnered attention recently because they can provide high-energy neutrons to transmute long-lifetime fission products.In this study,the Geant4 toolkit was used to simulate the inter-action between a deuteron beam at 500 MeV and a com-posite target composed of alternating lead-bismuth eutectic(LBE)and water.The water was used because it may be employed as a target coolant.The energy spectrum,neu-tron yield,average energy,and total energy of the emitted neutrons were calculated for different thicknesses and thickness ratios between the LBE and water.For a constant target thickness,the neutron yield increases with an increasing thickness ratio of LBE to H 2 O,while the aver-age energy of the emitted neutrons decreases with an increasing in the aforementioned thickness ratio.These two aspects support the use of a pure target,either LBE or water.However,with an increasing LBE-to-H 2 O thickness ratio,the total energy of the emitted neutrons increases and then decreases.This result supports the addition of water into the LBE target.The angular distributions of the emitted neutrons show that the rear of the target is suit-able for loading nuclear waste containing minor actinides and long-lifetime fission products.
基金Project supported by the Sichuan Science and Technology Program(Grant No.22YYJC1286)the China National Magnetic Confinement Fusion Science Program(Grant No.2013GB112005)the National Natural Science Foundation of China(Grant Nos.12075048 and 11925501)。
文摘Magnetic reconnection and tearing mode instability play a critical role in many physical processes.The application of Galerkin spectral method for tearing mode instability in two-dimensional geometry is investigated in this paper.A resistive magnetohydrodynamic code is developed,by the Galerkin spectral method both in the periodic and aperiodic directions.Spectral schemes are provided for global modes and local modes.Mode structures,resistivity scaling,convergence and stability of tearing modes are discussed.The effectiveness of the code is demonstrated,and the computational results are compared with the results using Galerkin spectral method only in the periodic direction.The numerical results show that the code using Galerkin spectral method individually allows larger time step in global and local modes simulations,and has better convergence in global modes simulations.
基金National Natural Science Foundation of China(No.81904258)。
文摘Objective:To investigate the effect of Wei’s triple nine needling therapy on the N2-P2 wave of the flash visual evoked potential(FVEP)in rats of the of the transverse directional pulling model.Methods:Thirty-six Wistar rats were randomly grouped,nine were in normal control group without any treatment,and the remaining 27 were surgically modelled in the right eyes.Eighteen of these rats were randomly divided into a Wei’s triple nine needling therapy group and a model group of nine rats each after the TON model was made using the transverse quantitative retraction method.The other 9 rats were sham-operated,and only the optic nerve was exposed without retraction.On the next day of modelling,the Wei’s triple nine needling therapy group was treated with Wei’s triple nine needling therapy for 20 minutes/1 time/1 day for 14 days.The model group,sham-operated group and normal control group were not intervened.Wei's triple nine acupoints were represented as follows:1st link:"Jingming"(BL1)and"Chengqi"(ST1);2nd link:"Sizhukong"(SJ23)penetrating"Taiyang"(EX-HN5);and the third:"Fengchi"(GB 20)and"Taichong"(LV3).The FVEP of each group was observed on 1d,7d and 14d.The FVEP of each group was observed on 1d,7d and 14d.Results:Compared with the model group,the N2 wave latency and P2 wave latency were shortened in the Wei’s triple nine needling therapy on 1d(P<0.05,P<0.01);on 7d,their N2 wave latency was shortened(P<0.01)and the N2-P2 wave amplitude was increased compared with the model group(P<0.05);on 14d,their P2 wave latency was shortened(P<0.05)and the N2-P2 wave amplitude was increased.There was no statistical difference in N2 wave latency,P2 wave latency and N2-P2 wave amplitude in the sham-operated group on 1d,7d and 14d(P>0.05).The delayed N2 and P2 wave latencies in the model group did not improve from 1d to 14d(P>0.05)and the amplitude decreased throughout,showing a significant difference on 14d compared to 1d(P<0.05).In contrast,the N2 wave latency in Wei’s triple nine needling therapy group was not significantly different until 7d to 14d(P<0.05);its P2 wave latency,although significantly delayed from 1d to 7d(P<0.05),recovered on 14d and reached a level that was not statistically different from 1d and 7d(P>0.05).There was also no significant decrease in N2-P2 wave amplitude between 1d and 14d in Wei’s triple nine needling therapy group(P>0.05).Conclusion:In this experiment,the TON rat model was successfully established by the transverse quantitative retraction method,and the treatment of TON rats with Wei’s triple nine needling therapy reduced the P2 wave delay of the FVEP electrophysiological signal and increased the N2-P2 amplitude,which had a certain positive effect on the repair of optic nerve injury,probably related to its effect of improving the conduction function of the optic nerve and protecting the retinal ganglion cells that had not been degenerated and necrosed.
基金Guangdong science and technology plan project(No.2013A032500020)
文摘Objective:To observe the TCM(Traditonal Chinese Medcine)syndromes effect and safety of Shujinjianyao Pill in the treatment of LSS(Lumbar Spinal Stenosis)(Ganshenbuzu and Fengshiyuzu Syndrome).Methods:120 LSS patients fit the inclusion criteria were separated into two groups,90 in the experimental group and 30 in the control group.No significant difference was existed in the basic data between the two groups.The experimental group was given Shujinjianyao Pill and Danlutongdu Tablet Simulator orally,while the control group was given Shujinjianyao Pill Simulator and Danlutongdu Tablet orally for 4 weeks.The VAS score,total TCM(Traditonal Chinese Medcine)syndrome score and single TCM symptom score on day 0,14 and 28 were observed,and adverse reactions were recorded.Result:There were significant differences in total TCM syndrome score between the two groups at baseline,14 day and 28 day(P<0.01).There was a significant difference in total TCM syndrome score between the two groups at 28 day(P<0.05).Significant differences were existed between this two groups in total effective rate of total TCM syndromes and waist-knee pain-weak in single TCM syndromes on the 28 day(P<0.05).There was no significant difference in the incidence of adverse events and serious adverse events between the two groups(P>0.05).Conclusion:Shujinjianyao Pill is effective on TCM syndromes in the treatment of Ganshenbuzu and fengshiyuzu syndrome LSS,especially in improving the score of total TCM syndromes and waist-knee pain-weak of single TCM syndrome,and has high safety.
基金Project supported by the National Natural Science Foundation of China(11504317,51503177)the International Partnership Program of Chinese Academy of Sciences(121522KYSB20190022)。
文摘In this work,monodisperseβ-NaLuF_(4):Yb,Er microcrystals with intense upconversion emission were synthesized via a modified hydrothermal method.With the increase of reactant concentration,their production yield is increased obviously,and the upconversion emission intensity inβ-NaLuF_(4):Yb,Er microcrystals is also enhanced significantly.The luminescence enhancement should be attributed to minimal internal OH defects,validated by a combination of analytical X-ray diffraction(XRD),energy dispersive spectrum(EDS),and Eu^(3+)structural probe measurements.We also reveal that high Na^(+):RE~(3+)ratio in theβ-NaLuF_(4):Yb,Er microcrystals prepared under Na^(~)+-rich reaction will arouse the increased repulsive energy ofβ-NaLuF_(4)microcrystals between F^(~)-and OH^(~)-anions and then facilitate the substitution of large OH^(-)ions by small F^(~)-ions under F^(~)--rich reaction conditions.Minimal OH^(-)concentrations can limit nonradiative relaxation and promote excitation energy harvesting for high upconversion efficiency.The presented results not only offer a facile method for the simultaneous production yield and luminescence intensity increase ofβ-NaREF_(4)microcrystals,but also uncover a better insight into the upconversion emission alterations,which is favorable to broaden their practical applications.
