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Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine,Acetylenedicarboxylate, Aromatic Aldehyde and Ethyl Acetoacetate
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作者 WU Ping xia er-yan +1 位作者 SUN Jing YAN Chao-guo 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第4期652-655,共4页
An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction me... An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction mechanism involves the formation of β-enamino ester and its sequential Michael addition to arylidene acetoacetate. 展开更多
关键词 1 4-Dihydropyridine β-Enamino ester Domino reaction Four-component reaction
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