The utilization of processing capabilities within the detector holds significant promise in addressing energy consumption and latency challenges. Especially in the context of dynamic motion recognition tasks, where su...The utilization of processing capabilities within the detector holds significant promise in addressing energy consumption and latency challenges. Especially in the context of dynamic motion recognition tasks, where substantial data transfers are necessitated by the generation of extensive information and the need for frame-by-frame analysis. Herein, we present a novel approach for dynamic motion recognition, leveraging a spatial-temporal in-sensor computing system rooted in multiframe integration by employing photodetector. Our approach introduced a retinomorphic MoS_(2) photodetector device for motion detection and analysis. The device enables the generation of informative final states, nonlinearly embedding both past and present frames. Subsequent multiply-accumulate (MAC) calculations are efficiently performed as the classifier. When evaluating our devices for target detection and direction classification, we achieved an impressive recognition accuracy of 93.5%. By eliminating the need for frame-by-frame analysis, our system not only achieves high precision but also facilitates energy-efficient in-sensor computing.展开更多
Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation wa...Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were utilized.Microarray experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were performed.In MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity levels.HYSA reduced the Warburg effect and induced ferroptosis(FPT)in MG63 cells.Inhibiting ferroptosis diminished HYSA’s anti-cancer activities in MG63 cells.The stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 cells.HIF-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°C.HYSA significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand HYSA.Conclusively,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 pathway.HYSA is a possible therapeutic option for OC or other cancers.展开更多
动态链接库(dynamic link library,DLL)的出现给开发人员提供了极大的便利,也提高了操作系统与应用程序之间的交互性.然而,动态链接库本身存在的安全性隐患不容忽视,如何有效地挖掘Windows平台下安装程序执行过程中出现的DLL劫持漏洞是...动态链接库(dynamic link library,DLL)的出现给开发人员提供了极大的便利,也提高了操作系统与应用程序之间的交互性.然而,动态链接库本身存在的安全性隐患不容忽视,如何有效地挖掘Windows平台下安装程序执行过程中出现的DLL劫持漏洞是当下保障Windows操作系统安全的关键问题之一.搜集并提取大量安装程序的属性特征,从安装程序、安装程序调用DLL模式、DLL文件本身3个角度出发,使用双层BiLSTM(bi-directional long short-term memory)神经网络进行学习,抽取出漏洞数据集的多维特征,挖掘DLL劫持未知漏洞.实验可有效检测Windows平台下安装程序的DLL劫持漏洞,共挖掘10个未知漏洞并获得CNVD漏洞授权,此外通过和其他漏洞分析工具进行对比进一步验证该方法的有效性和完整性.展开更多
聚焦二十四式太极拳练习的动态过程,通过描述各指标变化特征与分析指标特征间的差异,揭示各指标的灵敏度与解释力,为太极拳的自主神经的指标解读与报告提供参考。文章共招募45名武术专业大学生为受试者,以5分34秒(一套二十四式太极拳练...聚焦二十四式太极拳练习的动态过程,通过描述各指标变化特征与分析指标特征间的差异,揭示各指标的灵敏度与解释力,为太极拳的自主神经的指标解读与报告提供参考。文章共招募45名武术专业大学生为受试者,以5分34秒(一套二十四式太极拳练习所需的时间)为数据截取基准,分别采集静息状态(T0)、运动中(T1、T2、T3,分别表示连续练习过程中第一遍、第二遍和第三遍,三个时间段)、恢复期(T4)的心率变异性数据。通过重复测量方差分析与事后成对比较分析得出,心率(Heart rate,HR)与相邻正常心跳间期差值平方和的均方根(The Square Root of The Mean Squared Differences of Successive NN Intervals,RMSSD)变化一致,在T0-T3时间段显著性增加、T3-T4显著性下降;低频(Low Frequency Power,LF)与高频(High Frequency Power,HF)变化一致,T0-T2显著性增加、T2-T3无显著性差异;低频比高频(LF/HF)运动期间无显著性变化,且数值均大于1。文章认为,二十四式太极拳练习的动态过程中,心率变异性频域指标相较于时域指标(RMSSD)更加灵敏和可靠,能更好地反映自主神经的变化,同时频域指标相较于HR指标可能更适合监测太极拳运动过程中的生理变化;但在LF的解释上仍需结合其它指标。建议今后的太极拳与自主神经相关研究以频域指标作为主要结局指标。展开更多
基金supported by the National Natural Science Foundation of China (52322210, 52172144, 22375069, 21825103, and U21A2069)National Key R&D Program of China (2021YFA1200501)+2 种基金Shenzhen Science and Technology Program (JCYJ20220818102215033, JCYJ20200109105422876)the Innovation Project of Optics Valley Laboratory (OVL2023PY007)Science and Technology Commission of Shanghai Municipality (21YF1454700)。
文摘The utilization of processing capabilities within the detector holds significant promise in addressing energy consumption and latency challenges. Especially in the context of dynamic motion recognition tasks, where substantial data transfers are necessitated by the generation of extensive information and the need for frame-by-frame analysis. Herein, we present a novel approach for dynamic motion recognition, leveraging a spatial-temporal in-sensor computing system rooted in multiframe integration by employing photodetector. Our approach introduced a retinomorphic MoS_(2) photodetector device for motion detection and analysis. The device enables the generation of informative final states, nonlinearly embedding both past and present frames. Subsequent multiply-accumulate (MAC) calculations are efficiently performed as the classifier. When evaluating our devices for target detection and direction classification, we achieved an impressive recognition accuracy of 93.5%. By eliminating the need for frame-by-frame analysis, our system not only achieves high precision but also facilitates energy-efficient in-sensor computing.
文摘Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were utilized.Microarray experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were performed.In MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity levels.HYSA reduced the Warburg effect and induced ferroptosis(FPT)in MG63 cells.Inhibiting ferroptosis diminished HYSA’s anti-cancer activities in MG63 cells.The stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 cells.HIF-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°C.HYSA significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand HYSA.Conclusively,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 pathway.HYSA is a possible therapeutic option for OC or other cancers.
文摘动态链接库(dynamic link library,DLL)的出现给开发人员提供了极大的便利,也提高了操作系统与应用程序之间的交互性.然而,动态链接库本身存在的安全性隐患不容忽视,如何有效地挖掘Windows平台下安装程序执行过程中出现的DLL劫持漏洞是当下保障Windows操作系统安全的关键问题之一.搜集并提取大量安装程序的属性特征,从安装程序、安装程序调用DLL模式、DLL文件本身3个角度出发,使用双层BiLSTM(bi-directional long short-term memory)神经网络进行学习,抽取出漏洞数据集的多维特征,挖掘DLL劫持未知漏洞.实验可有效检测Windows平台下安装程序的DLL劫持漏洞,共挖掘10个未知漏洞并获得CNVD漏洞授权,此外通过和其他漏洞分析工具进行对比进一步验证该方法的有效性和完整性.
文摘聚焦二十四式太极拳练习的动态过程,通过描述各指标变化特征与分析指标特征间的差异,揭示各指标的灵敏度与解释力,为太极拳的自主神经的指标解读与报告提供参考。文章共招募45名武术专业大学生为受试者,以5分34秒(一套二十四式太极拳练习所需的时间)为数据截取基准,分别采集静息状态(T0)、运动中(T1、T2、T3,分别表示连续练习过程中第一遍、第二遍和第三遍,三个时间段)、恢复期(T4)的心率变异性数据。通过重复测量方差分析与事后成对比较分析得出,心率(Heart rate,HR)与相邻正常心跳间期差值平方和的均方根(The Square Root of The Mean Squared Differences of Successive NN Intervals,RMSSD)变化一致,在T0-T3时间段显著性增加、T3-T4显著性下降;低频(Low Frequency Power,LF)与高频(High Frequency Power,HF)变化一致,T0-T2显著性增加、T2-T3无显著性差异;低频比高频(LF/HF)运动期间无显著性变化,且数值均大于1。文章认为,二十四式太极拳练习的动态过程中,心率变异性频域指标相较于时域指标(RMSSD)更加灵敏和可靠,能更好地反映自主神经的变化,同时频域指标相较于HR指标可能更适合监测太极拳运动过程中的生理变化;但在LF的解释上仍需结合其它指标。建议今后的太极拳与自主神经相关研究以频域指标作为主要结局指标。
