目的基于网络药理学方法及分子对接技术探讨益气解毒通络方(YQJDTLF)治疗肝硬化的作用靶点及信号通路,预测其潜在作用机制。方法基于TCMSP数据库提取YQJDTLF的有效活性成分及作用靶点,通过Drugbank、OMIM、TTD、DisGeNET获取肝硬化治疗...目的基于网络药理学方法及分子对接技术探讨益气解毒通络方(YQJDTLF)治疗肝硬化的作用靶点及信号通路,预测其潜在作用机制。方法基于TCMSP数据库提取YQJDTLF的有效活性成分及作用靶点,通过Drugbank、OMIM、TTD、DisGeNET获取肝硬化治疗靶点,筛选共同靶点;使用Cytoscape软件构建“药物有效活性成分-疾病靶点”可视化调控网络图,利用STRING数据库构建蛋白互作网络图(PPI),然后运用Cytoscape对PPI进行核心蛋白的筛选;最后,通过Metascape对核心靶点进行基因本体(GO)功能富集分析和KEGG通路富集分析,最后完成分子对接。结果共获得93个有效活性成分,135个共同靶点;主要活性化合物包括槲皮素、黄芩素、豆甾醇等;KEGG通路富集分析得出135条通路,涉及癌症信号通路(pathways in cancer)等通路;通过分子对接发现关键中药成分与关键靶点之间的结合活性良好。结论YQJDTLF具有多成分、多靶点、多通路的作用特点,可通过调节相关通路与靶点起到治疗肝硬化的作用。展开更多
Delta carbonate （Delta C, AC） method is a commonly- used surface geochemical exploration method for petroleum surveys. Delta C holds that light hydrocarbon gases leak into near-surface soils or sediments from underl...Delta carbonate （Delta C, AC） method is a commonly- used surface geochemical exploration method for petroleum surveys. Delta C holds that light hydrocarbon gases leak into near-surface soils or sediments from underlying petroleum accumulations, then partly oxidized to CO2, resulting in a special carbonate precipitation, which is termed as Delta carbonate （△C）.展开更多
Based on results of microscopic observation and laser Raman analysis about fluid in-clusions,multiple special forms of immiscible inclusions that contain sulphur,liquid hydrocarbon,bi-tumen,etc.were discovered in samp...Based on results of microscopic observation and laser Raman analysis about fluid in-clusions,multiple special forms of immiscible inclusions that contain sulphur,liquid hydrocarbon,bi-tumen,etc.were discovered in samples collected from the H_(2)S gas reservoir-containing carbonates in the Lower Triassic Feixianguan Formation in the Jinzhu-Luojia area,Kai County,Sichuan Province.Based on the lithology and burial history of the strata involved as well as measurement results of homogenization temperature of fluid inclusions,bitumen reflectivity,etc.,it is concluded that the H_(2)S in the gas reservoir resulted from the thermal reaction between hydrocarbons in reservoir and CaSO_(4)in the gypsum-bearing dolostone section at the high temperature(140℃―170℃)oil-cracked gas for-mation stage in Late Cretaceous.Thereafter,research on a great number of immiscible inclusions in the reservoir reveals that elemental sulphur resulted from oxidation of part of the earlier-formed H_(2)S and further reaction between sulphates,hydrocarbons and H_(2)S in geological fluids in H_(2)S-bearing gas reservoir at a temperature of 86℃―89℃and a pressure of 340×10^(5)Pa and during the regional uplift stage as characterized by temperature decrease and pressure decrease in Tertiary.Meanwhile,gyp-sum,anhydrite and calcite formed at this stage would trap particles like elemental sulphur and result in a variety of special forms of immiscible inclusions,and these inclusions would contain information concerning the complexity of the fluids in the reservoir and the origin of H_(2)S and natural sulphur in the gas reservoir.展开更多
Oil cracking gas plays an important role in the resources of natural gas in the basins with high and over mature marine source rocks in China. The prediction of the oil cracking gas resources becomes nec-essary and ur...Oil cracking gas plays an important role in the resources of natural gas in the basins with high and over mature marine source rocks in China. The prediction of the oil cracking gas resources becomes nec-essary and urgent in the gas exploration in these basins. A marine crude oil sample was pyrolyzed using sealed gold tubes system. The pyrolysates including gas,liquid and solid were quantitatively analyzed. Based on the pyrolysis data and kinetic calculation,the yield correlativity among gas,liquid and solid products was regressed with high correlative coefficients to establish a prediction model suitable for the resource estimation of oil cracking gas. The verification formula for this model was also established on the principle of mass conservation. The affecting factors and the application precondi-tions of this prediction model were discussed. This model would enlighten and provide some new ideas for the resource assessment of natural gas in the high and over mature marine carbonate source rock areas in China. It is expected to be valuable in gas exploration.展开更多
Oxy-fuel combustion power systems can utilize the cold energy released during the liquefied natural gas(LNG)regasification to reduce the power consumption of CO_(2) capture,but the specific LNG cold energy consumption...Oxy-fuel combustion power systems can utilize the cold energy released during the liquefied natural gas(LNG)regasification to reduce the power consumption of CO_(2) capture,but the specific LNG cold energy consumption of CO_(2) capture is still too large.To recover more CO_(2) with the limited LNG cold energy at a low energy cost,a novel natural gas-fired oxy-fuel power system with the cascade utilization of LNG cold energy is proposed in this work,where the LNG cold energy could be sequentially utilized in the air separation unit and the CO_(2) recovery process.The new system is evaluated with the Aspen Plus software.The results show that the net electrical efficiency and the specific primary energy consumption for CO_(2) avoided(SPECCA)of the new system are comparable to those of the chemical looping combustion cycle,and superior to those of the conventional O_(2)/CO_(2) cycles.Moreover,the specific LNG needed for CO_(2) avoided(SLNCC)of the new system is more than 67.2%lower than the existing oxy-fuel power systems utilizing the LNG cold energy.Furthermore,it is found that the O_(2) purity of 97.0 mol.%and the CO_(2) capture ratio of 97.0%are optimal conditions,because the SPECCA,the specific exergy consumption for CO_(2) avoided(SECCA)and the SLNCC are at the minimum of 1.87 GJLHV⋅t_(CO_(2))^(−1),2.60GJ⋅t_(CO_(2))^(−1) and 1.88tLNG⋅t_(CO_(2))^(−1),respectively.Meanwhile,the net electrical efficiency and the exergy efficiency of the new system reach 51.51%and 49.23%,respectively.展开更多
The carbon isotopic composition of individual light hydrocarbons generated from source rocks that had been pyrolysed in vacuum glass tube were determined by using the GC-IRMS techniques. The results indicate that abun...The carbon isotopic composition of individual light hydrocarbons generated from source rocks that had been pyrolysed in vacuum glass tube were determined by using the GC-IRMS techniques. The results indicate that abundant CO2 in the pyrolysates has a remarkable effect on the determination of CH4δ13C. Running cryogenically with an initial temperature of -40℃ can effectively eliminate the effect. In addition, it conduces to measuring the δ13C of C2+ hydrocarbons by increasing the injection volume and/or absorbing CO2 with the solution of sodium hydroxide. The above measures will help to get the carbon isotopic composition of C1-C7 components, which is of great significance for gas/source rock correlation and for study on the genesis of natural gas.展开更多
文摘目的基于网络药理学方法及分子对接技术探讨益气解毒通络方(YQJDTLF)治疗肝硬化的作用靶点及信号通路,预测其潜在作用机制。方法基于TCMSP数据库提取YQJDTLF的有效活性成分及作用靶点,通过Drugbank、OMIM、TTD、DisGeNET获取肝硬化治疗靶点,筛选共同靶点;使用Cytoscape软件构建“药物有效活性成分-疾病靶点”可视化调控网络图,利用STRING数据库构建蛋白互作网络图(PPI),然后运用Cytoscape对PPI进行核心蛋白的筛选;最后,通过Metascape对核心靶点进行基因本体(GO)功能富集分析和KEGG通路富集分析,最后完成分子对接。结果共获得93个有效活性成分,135个共同靶点;主要活性化合物包括槲皮素、黄芩素、豆甾醇等;KEGG通路富集分析得出135条通路,涉及癌症信号通路(pathways in cancer)等通路;通过分子对接发现关键中药成分与关键靶点之间的结合活性良好。结论YQJDTLF具有多成分、多靶点、多通路的作用特点,可通过调节相关通路与靶点起到治疗肝硬化的作用。
基金supported by National Natural Science Foundation of China(grant No.41302099)Open Foundation of State Key Laboratory of Organic Geochemistry(grant No.OG2015-03)Open Foundation of Key Laboratory of Marine Mineral Resources,Ministry of Land and Resources(grant No.KLMMR-2013-A-25)
文摘Delta carbonate （Delta C, AC） method is a commonly- used surface geochemical exploration method for petroleum surveys. Delta C holds that light hydrocarbon gases leak into near-surface soils or sediments from underlying petroleum accumulations, then partly oxidized to CO2, resulting in a special carbonate precipitation, which is termed as Delta carbonate （△C）.
基金This research was supported by the State Brainstorm Science Program for the Tenth Five-Year Pkn Period(Grant No.2001BA605A-0404)the Frontier Research Program Sponsared by Guangzhou Institute of Geochemistry of Chinese Ac ademy of Sciences(Grant No.GiGCX-04-08).
文摘Based on results of microscopic observation and laser Raman analysis about fluid in-clusions,multiple special forms of immiscible inclusions that contain sulphur,liquid hydrocarbon,bi-tumen,etc.were discovered in samples collected from the H_(2)S gas reservoir-containing carbonates in the Lower Triassic Feixianguan Formation in the Jinzhu-Luojia area,Kai County,Sichuan Province.Based on the lithology and burial history of the strata involved as well as measurement results of homogenization temperature of fluid inclusions,bitumen reflectivity,etc.,it is concluded that the H_(2)S in the gas reservoir resulted from the thermal reaction between hydrocarbons in reservoir and CaSO_(4)in the gypsum-bearing dolostone section at the high temperature(140℃―170℃)oil-cracked gas for-mation stage in Late Cretaceous.Thereafter,research on a great number of immiscible inclusions in the reservoir reveals that elemental sulphur resulted from oxidation of part of the earlier-formed H_(2)S and further reaction between sulphates,hydrocarbons and H_(2)S in geological fluids in H_(2)S-bearing gas reservoir at a temperature of 86℃―89℃and a pressure of 340×10^(5)Pa and during the regional uplift stage as characterized by temperature decrease and pressure decrease in Tertiary.Meanwhile,gyp-sum,anhydrite and calcite formed at this stage would trap particles like elemental sulphur and result in a variety of special forms of immiscible inclusions,and these inclusions would contain information concerning the complexity of the fluids in the reservoir and the origin of H_(2)S and natural sulphur in the gas reservoir.
基金Supported by the National Natural Science Foundation of China (Grant No. 40372070)
文摘Oil cracking gas plays an important role in the resources of natural gas in the basins with high and over mature marine source rocks in China. The prediction of the oil cracking gas resources becomes nec-essary and urgent in the gas exploration in these basins. A marine crude oil sample was pyrolyzed using sealed gold tubes system. The pyrolysates including gas,liquid and solid were quantitatively analyzed. Based on the pyrolysis data and kinetic calculation,the yield correlativity among gas,liquid and solid products was regressed with high correlative coefficients to establish a prediction model suitable for the resource estimation of oil cracking gas. The verification formula for this model was also established on the principle of mass conservation. The affecting factors and the application precondi-tions of this prediction model were discussed. This model would enlighten and provide some new ideas for the resource assessment of natural gas in the high and over mature marine carbonate source rock areas in China. It is expected to be valuable in gas exploration.
基金the financial support from the National Natural Science Foundation of China(No.51106063)the Dean Project of Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology(No.2013K004)。
文摘Oxy-fuel combustion power systems can utilize the cold energy released during the liquefied natural gas(LNG)regasification to reduce the power consumption of CO_(2) capture,but the specific LNG cold energy consumption of CO_(2) capture is still too large.To recover more CO_(2) with the limited LNG cold energy at a low energy cost,a novel natural gas-fired oxy-fuel power system with the cascade utilization of LNG cold energy is proposed in this work,where the LNG cold energy could be sequentially utilized in the air separation unit and the CO_(2) recovery process.The new system is evaluated with the Aspen Plus software.The results show that the net electrical efficiency and the specific primary energy consumption for CO_(2) avoided(SPECCA)of the new system are comparable to those of the chemical looping combustion cycle,and superior to those of the conventional O_(2)/CO_(2) cycles.Moreover,the specific LNG needed for CO_(2) avoided(SLNCC)of the new system is more than 67.2%lower than the existing oxy-fuel power systems utilizing the LNG cold energy.Furthermore,it is found that the O_(2) purity of 97.0 mol.%and the CO_(2) capture ratio of 97.0%are optimal conditions,because the SPECCA,the specific exergy consumption for CO_(2) avoided(SECCA)and the SLNCC are at the minimum of 1.87 GJLHV⋅t_(CO_(2))^(−1),2.60GJ⋅t_(CO_(2))^(−1) and 1.88tLNG⋅t_(CO_(2))^(−1),respectively.Meanwhile,the net electrical efficiency and the exergy efficiency of the new system reach 51.51%and 49.23%,respectively.
文摘The carbon isotopic composition of individual light hydrocarbons generated from source rocks that had been pyrolysed in vacuum glass tube were determined by using the GC-IRMS techniques. The results indicate that abundant CO2 in the pyrolysates has a remarkable effect on the determination of CH4δ13C. Running cryogenically with an initial temperature of -40℃ can effectively eliminate the effect. In addition, it conduces to measuring the δ13C of C2+ hydrocarbons by increasing the injection volume and/or absorbing CO2 with the solution of sodium hydroxide. The above measures will help to get the carbon isotopic composition of C1-C7 components, which is of great significance for gas/source rock correlation and for study on the genesis of natural gas.
