目的提出一种纯粹从知识层面量化证素辨证的算法,用以得出各种症状体征与证素之间的具体数量关系,并应用于高血压人群的证素分析。方法使用正则表达式方法析出《中医临床诊疗术语》中症状体征与证素的语义关系用以构建知识图谱,并用语...目的提出一种纯粹从知识层面量化证素辨证的算法,用以得出各种症状体征与证素之间的具体数量关系,并应用于高血压人群的证素分析。方法使用正则表达式方法析出《中医临床诊疗术语》中症状体征与证素的语义关系用以构建知识图谱,并用语义距离算法构建证素辨证算法,基于所设计的算法,使用卡方检验、系统聚类、共现网络等方法分析高血压人群的证素分布情况。结果通过知识图谱语义距离可以形成证素积分算法。高血压证素分析可得不同体质量指数(body mass index,BMI)的高血压人群组间证素脾、胆、气滞、血热、血虚、阴虚、动风差异有统计学意义(P<0.05),不同腰臀比的高血压人群组间证素肺、肾、湿、燥、痰、血热、气虚、血虚、精亏差异有统计学意义(P<0.05)。病位证素心、肝、脾、肾在证素分析中聚为一类,病性证素阴虚、血虚、津液亏、精髓亏聚为一类,痰湿因素与各病位、病性证素有较强关联。结论证素积分算法能够从一定程度上量化症状体征与中医证素的映射关系,为高血压不同体质量、腰臀比的辨证提供参考,揭示不同证素之间的关联,为高血压的准确全面辨证提供临床价值。展开更多
Objective To analyze the differences in the correlation of tongue image indicators among patients with benign lung nodules and lung cancer.Methods From July 1;2020 to March 31;2022;clinical information of lung cancer ...Objective To analyze the differences in the correlation of tongue image indicators among patients with benign lung nodules and lung cancer.Methods From July 1;2020 to March 31;2022;clinical information of lung cancer patients and benign lung nodules patients was collected at the Oncology Department of Longhua Hos-pital Affiliated to Shanghai University of Traditional Chinese Medicine and the Physical Ex-amination Center of Shuguang Hospital Affiliated to Shanghai University of Traditional Chi-nese Medicine;respectively.We obtained tongue images from patients with benign lung nod-ules and lung cancer using the TFDA-1 digital tongue diagnosis instrument;and analyzed these images with the TDAS V2.0 software.The extracted indicators included color space pa-rameters in the Lab system for both the tongue body(TB)and tongue coating(TC)(TB/TC-L;TB/TC-a;and TB/TC-b);textural parameters[TB/TC-contrast(CON);TB/TC-angular second moment(ASM);TB/TC-entropy(ENT);and TB/TC-MEAN];as well as TC parameters(perAll and perPart).The bivariate correlation of TB and TC features was analyzed using Pearson’s or Spearman’s correlation analysis;and the overall correlation was analyzed using canonical correlation analysis(CCA).Results Samples from 307 patients with benign lung nodules and 276 lung cancer patients were included after excluding outliers and extreme values.Simple correlation analysis indi-cated that the correlation of TB-L with TC-L;TB-b with TC-b;and TB-b with perAll in lung cancer group was higher than that in benign nodules group.Moreover;the correlation of TB-a with TC-a;TB-a with perAll;and the texture parameters of the TB(TB-CON;TB-ASM;TB-ENT;and TB-MEAN)with the texture parameters of the TC(TC-CON;TC-ASM;TC-ENT;and TC-MEAN)in benign nodules group was higher than lung cancer group.CCA further demon-strated a strong correlation between the TB and TC parameters in lung cancer group;with the first and second pairs of typical variables in benign nodules and lung cancer groups indicat-ing correlation coefficients of 0.918 and 0.817(P<0.05);and 0.940 and 0.822(P<0.05);re-spectively.Conclusion Benign lung nodules and lung cancer patients exhibited differences in correla-tion in the L;a;and b values of the TB and TC;as well as the perAll value of the TC;and the texture parameters(TB/TC-CON;TB/TC-ASM;TB/TC-ENT;and TB/TC-MEAN)between the TB and TC.Additionally;there were differences in the overall correlation of the TB and TC be-tween the two groups.Objective tongue diagnosis indicators can effectively assist in the diag-nosis of benign lung nodules and lung cancer;thereby providing a scientific basis for the ear-ly detection;diagnosis;and treatment of lung cancer.展开更多
目的观察不同糖代谢状态老年人群的舌象客观化特征。方法选取2013年3月-2015年3月入住上海中医药大学附属曙光医院内分泌科病房的2型糖尿患者145例(DM组),糖尿病前期人群201例(IGR组),糖代谢正常人群206例(NOR组),采集糖脂代谢指标,通过...目的观察不同糖代谢状态老年人群的舌象客观化特征。方法选取2013年3月-2015年3月入住上海中医药大学附属曙光医院内分泌科病房的2型糖尿患者145例(DM组),糖尿病前期人群201例(IGR组),糖代谢正常人群206例(NOR组),采集糖脂代谢指标,通过TDA-1型小型舌诊仪采集患者的舌象指标,包括舌质及舌苔颜色参数(R、G、B、H、I、S、L、a、b)。结果与NOR组相比,DM组与IGR组Homa-IR升高(P<0.05,P<0.01);DM组TG、LDL、FFA、2 h FFA升高,HDL降低(P<0.05,P<0.01),IGR组FFA升高(P<0.05)。舌质方面,与NOR组、IGR组相比,DM组zhiR、zhiG、zhiB、zhiH、zhiI、zhiL降低(P<0.05,P<0.01),zhib升高(P<0.01)。舌苔方面,与NOR组、IGR组相比,DM组tai B、taiR、tahiG、taiH、taiI、tai L降低(P<0.01),taiS、taia、taib升高(P<0.01)。结论不同糖代谢状态老年人群具有不同的舌象客观化特征。舌象客观化指标可能与糖代谢水平相关。展开更多
基金National Natural Science Foundation of China(82104738)Capacity Building of Local Colleges and Universities under the Shanghai Municipal Science and Technology Commission (21010504400)Space Station Engineering Aerospace Medical Experiment Project(HYZHXM05001)。
文摘目的提出一种纯粹从知识层面量化证素辨证的算法,用以得出各种症状体征与证素之间的具体数量关系,并应用于高血压人群的证素分析。方法使用正则表达式方法析出《中医临床诊疗术语》中症状体征与证素的语义关系用以构建知识图谱,并用语义距离算法构建证素辨证算法,基于所设计的算法,使用卡方检验、系统聚类、共现网络等方法分析高血压人群的证素分布情况。结果通过知识图谱语义距离可以形成证素积分算法。高血压证素分析可得不同体质量指数(body mass index,BMI)的高血压人群组间证素脾、胆、气滞、血热、血虚、阴虚、动风差异有统计学意义(P<0.05),不同腰臀比的高血压人群组间证素肺、肾、湿、燥、痰、血热、气虚、血虚、精亏差异有统计学意义(P<0.05)。病位证素心、肝、脾、肾在证素分析中聚为一类,病性证素阴虚、血虚、津液亏、精髓亏聚为一类,痰湿因素与各病位、病性证素有较强关联。结论证素积分算法能够从一定程度上量化症状体征与中医证素的映射关系,为高血压不同体质量、腰臀比的辨证提供参考,揭示不同证素之间的关联,为高血压的准确全面辨证提供临床价值。
基金National Natural Science Foundation of China(82305090)Science and Technology Commission of Shanghai Municipality(22YF1448900)Shanghai Municipal Health Commission(20234Y0168).
文摘Objective To analyze the differences in the correlation of tongue image indicators among patients with benign lung nodules and lung cancer.Methods From July 1;2020 to March 31;2022;clinical information of lung cancer patients and benign lung nodules patients was collected at the Oncology Department of Longhua Hos-pital Affiliated to Shanghai University of Traditional Chinese Medicine and the Physical Ex-amination Center of Shuguang Hospital Affiliated to Shanghai University of Traditional Chi-nese Medicine;respectively.We obtained tongue images from patients with benign lung nod-ules and lung cancer using the TFDA-1 digital tongue diagnosis instrument;and analyzed these images with the TDAS V2.0 software.The extracted indicators included color space pa-rameters in the Lab system for both the tongue body(TB)and tongue coating(TC)(TB/TC-L;TB/TC-a;and TB/TC-b);textural parameters[TB/TC-contrast(CON);TB/TC-angular second moment(ASM);TB/TC-entropy(ENT);and TB/TC-MEAN];as well as TC parameters(perAll and perPart).The bivariate correlation of TB and TC features was analyzed using Pearson’s or Spearman’s correlation analysis;and the overall correlation was analyzed using canonical correlation analysis(CCA).Results Samples from 307 patients with benign lung nodules and 276 lung cancer patients were included after excluding outliers and extreme values.Simple correlation analysis indi-cated that the correlation of TB-L with TC-L;TB-b with TC-b;and TB-b with perAll in lung cancer group was higher than that in benign nodules group.Moreover;the correlation of TB-a with TC-a;TB-a with perAll;and the texture parameters of the TB(TB-CON;TB-ASM;TB-ENT;and TB-MEAN)with the texture parameters of the TC(TC-CON;TC-ASM;TC-ENT;and TC-MEAN)in benign nodules group was higher than lung cancer group.CCA further demon-strated a strong correlation between the TB and TC parameters in lung cancer group;with the first and second pairs of typical variables in benign nodules and lung cancer groups indicat-ing correlation coefficients of 0.918 and 0.817(P<0.05);and 0.940 and 0.822(P<0.05);re-spectively.Conclusion Benign lung nodules and lung cancer patients exhibited differences in correla-tion in the L;a;and b values of the TB and TC;as well as the perAll value of the TC;and the texture parameters(TB/TC-CON;TB/TC-ASM;TB/TC-ENT;and TB/TC-MEAN)between the TB and TC.Additionally;there were differences in the overall correlation of the TB and TC be-tween the two groups.Objective tongue diagnosis indicators can effectively assist in the diag-nosis of benign lung nodules and lung cancer;thereby providing a scientific basis for the ear-ly detection;diagnosis;and treatment of lung cancer.
文摘目的观察不同糖代谢状态老年人群的舌象客观化特征。方法选取2013年3月-2015年3月入住上海中医药大学附属曙光医院内分泌科病房的2型糖尿患者145例(DM组),糖尿病前期人群201例(IGR组),糖代谢正常人群206例(NOR组),采集糖脂代谢指标,通过TDA-1型小型舌诊仪采集患者的舌象指标,包括舌质及舌苔颜色参数(R、G、B、H、I、S、L、a、b)。结果与NOR组相比,DM组与IGR组Homa-IR升高(P<0.05,P<0.01);DM组TG、LDL、FFA、2 h FFA升高,HDL降低(P<0.05,P<0.01),IGR组FFA升高(P<0.05)。舌质方面,与NOR组、IGR组相比,DM组zhiR、zhiG、zhiB、zhiH、zhiI、zhiL降低(P<0.05,P<0.01),zhib升高(P<0.01)。舌苔方面,与NOR组、IGR组相比,DM组tai B、taiR、tahiG、taiH、taiI、tai L降低(P<0.01),taiS、taia、taib升高(P<0.01)。结论不同糖代谢状态老年人群具有不同的舌象客观化特征。舌象客观化指标可能与糖代谢水平相关。