In conventional isochronous mass spectrometry(IMS)performed on a storage ring,the precision of mass measurements for short-lived nuclei depends on the accurate determination of the revolution times(T)of stored ions.Ho...In conventional isochronous mass spectrometry(IMS)performed on a storage ring,the precision of mass measurements for short-lived nuclei depends on the accurate determination of the revolution times(T)of stored ions.However,the resolution of T inevitably deteriorates due to the magnetic rigidity spread of the ions,limiting the mass-resolving power.In this study,we used the betatron tunes Q(the number of betatron oscillations per revolution)of the ions and established a correlation between T and Q.From this correlation,T was transformed to correspond to a fixed Q with higher resolution.Using these transformed T values,the masses of ^(63)Ge,^(65)As,^(67)Se,and ^(71)Kr agreed well with the mass values measured using the newly developed IMS(Bρ-IMS).We also studied the systematics of Coulomb displacement energies(CDEs)and found that anomalous staggering in CDEs was eliminated using new mass values.This method of T transformation is highly effective for conventional IMS equipped with a single time-of-flight detector.展开更多
A novel technique of isochronous mass spectrometry(IMS),termed Bρ-defned IMS,was developed at the experimental cooler-storage ring CSRe in Lanzhou for the frst time.Two time-of-fight detectors were installed in a str...A novel technique of isochronous mass spectrometry(IMS),termed Bρ-defned IMS,was developed at the experimental cooler-storage ring CSRe in Lanzhou for the frst time.Two time-of-fight detectors were installed in a straight section of the CSRe,thereby enabling simultaneous measurements of the velocity and revolution time of each stored short-lived ion.This technique boosts the broadband precision,efciency,sensitivity,and accuracy of mass measurements of short-lived exotic nuclides.Using Bρ-defned IMS,the masses of^(22)Al,^(62)Ge,^(64)As,^(66)Se,and^(70)Kr were measured for the frst time,and the masses of^(65)As,^(67)Se,and other 21 nuclides were redetermined with improved accuracy.Mass data have been used in studies of relevant issues regarding nuclear structures and nuclear astrophysics.Herein,we review the development of experimental techniques and main physical results and outline plans for future experiments.展开更多
BACKGROUND An increasing number of studies have begun to discuss the relationship between gut microbiota and diseases,yet there is currently a lack of corresponding articles describing the association between gut micr...BACKGROUND An increasing number of studies have begun to discuss the relationship between gut microbiota and diseases,yet there is currently a lack of corresponding articles describing the association between gut microbiota and hepatocellular carcinoma(HCC)and biliary tract cancer(BTC).This study aims to explore the relationship between them using Mendelian randomization(MR)analysis method.AIM To assess the relationship between gut microbiota and HCC and BTC.METHODS We obtained Genome-wide association study(GWAS)data for the gut microbiome from the intestinal microbiota genomic library(MiBioGen,https://mibiogen.gcc.rug.nl/).Additionally,we accessed data pertaining to HCC and BTC from the IEU open GWAS platform(https://gwas.mrcieu.ac.uk/).Our analysis employed fundamental instrumental variable analysis methods,including inverse-variance weighted,MR and Egger.To ensure the dependability of the results,we subjected the results to tests for multiple biases and heterogeneity.RESULTS During our investigation,we discovered 11 gut microbiota linked to an increased risk to BTC and HCC.The former included the genus Eubacterium hallii group(P=0.017),Candidatus Soleaferrea(P=0.034),Flavonifractor(P=0.021),Lachnospiraceae FCS020(P=0.034),the order Victivallales(P=0.018),and the class Lentisphaeria(P=0.0.18).The latter included the genus Desulfovibrio(P=0.042),Oscillibacter(P=0.023),the family Coriobacteriaceae(P=0.048),the order Coriobacteriales(P=0.048),and the class Coriobacteriia(P=0.048).Furthermore,in BTC,we observed 2 protective gut microbiota namely the genus Dorea(P=0.041)and Lachnospiraceae ND3007 group(P=0.045).All results showed no evidence of multiplicity or heterogeneity.CONCLUSION This study explores a causal link between gut microbiota and HCC and BTC.These insights may enhance the mechanistic knowledge of microbiota-related HCC and BTC pathways,potentially informing therapeutic strategies.展开更多
过滤器内部的流场不均导致使用时容易产生局部堵塞,堵塞分布受入口流速、颗粒粒径、流线轨迹等因素的共同影响。该文以计算流体力学-离散元法(computational fluid dynamics-discrete element method,CFD-DEM)耦合模拟不同流量下Y型网...过滤器内部的流场不均导致使用时容易产生局部堵塞,堵塞分布受入口流速、颗粒粒径、流线轨迹等因素的共同影响。该文以计算流体力学-离散元法(computational fluid dynamics-discrete element method,CFD-DEM)耦合模拟不同流量下Y型网式过滤器内部不同粒径的沙粒运动及分布,分析过滤器内部流态对沙粒运动分布的影响并通过试验加以证明。结果表明,滤网两侧的压差占总压差的77%。网面流量呈阶梯分布,最大流量位于出口侧滤网上端,最低流量位于进口侧滤网中心,前者是后者的5.9倍;对于通过滤网的颗粒,入口流速越高,颗粒通过点越集中;对于拦截颗粒,当粒径接近孔径时,颗粒稳定附着在滤网,增加入口流速使颗粒向侧面滤网聚积并产生局部堵塞,粒径远大于孔径时,颗粒在内腔中不停运动,难以稳定附着在滤网;降低入口流速将提高颗粒分布的均匀程度,延长过滤器高效段时间,减少冲洗难度。展开更多
基金supported in part by the National Key R&D Program of China (No. 2023YFA1606401)CAS Project for Young Scientists in Basic Research (No. YSBR-002)+3 种基金Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB34000000)the NSFC (Nos. 12305126, 12135017, 12121005)the support from the Youth Innovation Promotion Association of the Chinese Academy of Sciences (No. 2021419)the support from the Yong Scholar of Regional Development,CAS (No.[2023]15)
文摘In conventional isochronous mass spectrometry(IMS)performed on a storage ring,the precision of mass measurements for short-lived nuclei depends on the accurate determination of the revolution times(T)of stored ions.However,the resolution of T inevitably deteriorates due to the magnetic rigidity spread of the ions,limiting the mass-resolving power.In this study,we used the betatron tunes Q(the number of betatron oscillations per revolution)of the ions and established a correlation between T and Q.From this correlation,T was transformed to correspond to a fixed Q with higher resolution.Using these transformed T values,the masses of ^(63)Ge,^(65)As,^(67)Se,and ^(71)Kr agreed well with the mass values measured using the newly developed IMS(Bρ-IMS).We also studied the systematics of Coulomb displacement energies(CDEs)and found that anomalous staggering in CDEs was eliminated using new mass values.This method of T transformation is highly effective for conventional IMS equipped with a single time-of-flight detector.
基金National Key R&D Program of China(Grant No.2023YFA1606401)CAS Project for Young Scientists in Basic Research(Grant No.YSBR-002)+1 种基金Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB34000000)NSFC(Grant No.12305126)。
文摘A novel technique of isochronous mass spectrometry(IMS),termed Bρ-defned IMS,was developed at the experimental cooler-storage ring CSRe in Lanzhou for the frst time.Two time-of-fight detectors were installed in a straight section of the CSRe,thereby enabling simultaneous measurements of the velocity and revolution time of each stored short-lived ion.This technique boosts the broadband precision,efciency,sensitivity,and accuracy of mass measurements of short-lived exotic nuclides.Using Bρ-defned IMS,the masses of^(22)Al,^(62)Ge,^(64)As,^(66)Se,and^(70)Kr were measured for the frst time,and the masses of^(65)As,^(67)Se,and other 21 nuclides were redetermined with improved accuracy.Mass data have been used in studies of relevant issues regarding nuclear structures and nuclear astrophysics.Herein,we review the development of experimental techniques and main physical results and outline plans for future experiments.
基金Supported by Natural Science Foundation of China,No.82200706。
文摘BACKGROUND An increasing number of studies have begun to discuss the relationship between gut microbiota and diseases,yet there is currently a lack of corresponding articles describing the association between gut microbiota and hepatocellular carcinoma(HCC)and biliary tract cancer(BTC).This study aims to explore the relationship between them using Mendelian randomization(MR)analysis method.AIM To assess the relationship between gut microbiota and HCC and BTC.METHODS We obtained Genome-wide association study(GWAS)data for the gut microbiome from the intestinal microbiota genomic library(MiBioGen,https://mibiogen.gcc.rug.nl/).Additionally,we accessed data pertaining to HCC and BTC from the IEU open GWAS platform(https://gwas.mrcieu.ac.uk/).Our analysis employed fundamental instrumental variable analysis methods,including inverse-variance weighted,MR and Egger.To ensure the dependability of the results,we subjected the results to tests for multiple biases and heterogeneity.RESULTS During our investigation,we discovered 11 gut microbiota linked to an increased risk to BTC and HCC.The former included the genus Eubacterium hallii group(P=0.017),Candidatus Soleaferrea(P=0.034),Flavonifractor(P=0.021),Lachnospiraceae FCS020(P=0.034),the order Victivallales(P=0.018),and the class Lentisphaeria(P=0.0.18).The latter included the genus Desulfovibrio(P=0.042),Oscillibacter(P=0.023),the family Coriobacteriaceae(P=0.048),the order Coriobacteriales(P=0.048),and the class Coriobacteriia(P=0.048).Furthermore,in BTC,we observed 2 protective gut microbiota namely the genus Dorea(P=0.041)and Lachnospiraceae ND3007 group(P=0.045).All results showed no evidence of multiplicity or heterogeneity.CONCLUSION This study explores a causal link between gut microbiota and HCC and BTC.These insights may enhance the mechanistic knowledge of microbiota-related HCC and BTC pathways,potentially informing therapeutic strategies.
文摘过滤器内部的流场不均导致使用时容易产生局部堵塞,堵塞分布受入口流速、颗粒粒径、流线轨迹等因素的共同影响。该文以计算流体力学-离散元法(computational fluid dynamics-discrete element method,CFD-DEM)耦合模拟不同流量下Y型网式过滤器内部不同粒径的沙粒运动及分布,分析过滤器内部流态对沙粒运动分布的影响并通过试验加以证明。结果表明,滤网两侧的压差占总压差的77%。网面流量呈阶梯分布,最大流量位于出口侧滤网上端,最低流量位于进口侧滤网中心,前者是后者的5.9倍;对于通过滤网的颗粒,入口流速越高,颗粒通过点越集中;对于拦截颗粒,当粒径接近孔径时,颗粒稳定附着在滤网,增加入口流速使颗粒向侧面滤网聚积并产生局部堵塞,粒径远大于孔径时,颗粒在内腔中不停运动,难以稳定附着在滤网;降低入口流速将提高颗粒分布的均匀程度,延长过滤器高效段时间,减少冲洗难度。
