To screen effective active com pounds and targets of Fructus Tribuli(FT)for breast cancer,to further explore its molecular mechanism and compare the prognostic reliability of breast cancer patients.The potential activ...To screen effective active com pounds and targets of Fructus Tribuli(FT)for breast cancer,to further explore its molecular mechanism and compare the prognostic reliability of breast cancer patients.The potential active components of FT was screened using the TCMSP database.Relevant targets of breast cancer were collected on the GeneCards and OMIM databases.The biological processes,and pathways of FT anti-breast cancer were predicted by constructing the relationship network of herb-component-target using GO,KEGG,STRING.Survival of these the most significant differentially expressed genes were evaluated using KM database.7 main active components and 13 main targets for the treatment of breast cancer were identified.展开更多
On the hypothesis that telomerase reverse transcriptase (TERT) of cardiac myocytes (CMs) is consistent with cell cycle distribution as well as tumour cells, we plan to investigate the expression of TERT in CMs and how...On the hypothesis that telomerase reverse transcriptase (TERT) of cardiac myocytes (CMs) is consistent with cell cycle distribution as well as tumour cells, we plan to investigate the expression of TERT in CMs and how TERT is in keeping with CMs cycle distribution after birth and under hypoxia, and roughly understand how hypoxia affects activity of TERT promoter.展开更多
文摘To screen effective active com pounds and targets of Fructus Tribuli(FT)for breast cancer,to further explore its molecular mechanism and compare the prognostic reliability of breast cancer patients.The potential active components of FT was screened using the TCMSP database.Relevant targets of breast cancer were collected on the GeneCards and OMIM databases.The biological processes,and pathways of FT anti-breast cancer were predicted by constructing the relationship network of herb-component-target using GO,KEGG,STRING.Survival of these the most significant differentially expressed genes were evaluated using KM database.7 main active components and 13 main targets for the treatment of breast cancer were identified.
文摘On the hypothesis that telomerase reverse transcriptase (TERT) of cardiac myocytes (CMs) is consistent with cell cycle distribution as well as tumour cells, we plan to investigate the expression of TERT in CMs and how TERT is in keeping with CMs cycle distribution after birth and under hypoxia, and roughly understand how hypoxia affects activity of TERT promoter.
