With the continuous development of the mining industry,the number of abandoned mines is increasing,which brings many impacts on the geology and ecological environment around the mines.It is urgent to attach great impo...With the continuous development of the mining industry,the number of abandoned mines is increasing,which brings many impacts on the geology and ecological environment around the mines.It is urgent to attach great importance to the ecological management and environmental restoration of abandoned mines.The long-term traditional development path of rural areas,following the model of“pollution first,treatment later,”fails to meet the needs of sustainable development.The contradiction between mine economic development and ecological environment degradation is becoming increasingly prominent,which urgently needs to be solved.Under the guidance of the Party and the state,in order to implement the relevant policies of“green mountains and clear waters are gold and silver mountains,”we emphasize rural green development,and the transformation of rural green development path is imperative.This paper takes Datu Mine in Xinhe Village,Dadukou District,Chongqing as the research object,combines rural ecological development as the research basis,and innovatively integrates the“educational research”model,aiming to provide practical strategies for the sustainable development of rural landscapes in abandoned mines.展开更多
Rapid response and short time latency are very important for Time Domain Astronomy, such as the observations of Gamma-ray Bursts（GRBs） and electromagnetic（EM） counterparts of gravitational waves（GWs）. Based on n...Rapid response and short time latency are very important for Time Domain Astronomy, such as the observations of Gamma-ray Bursts（GRBs） and electromagnetic（EM） counterparts of gravitational waves（GWs）. Based on near real-time Fermi/GBM data, we developed a low-latency pipeline to automatically calculate the temporal and spectral properties of GRBs. With this pipeline, some important parameters can be obtained, such as T_（90） and fluence, within ～ 20 min after the GRB trigger.For ～ 90% of GRBs, T90 and fluence are consistent with the GBM catalog results within 2σ errors.This pipeline has been used by the Gamma-ray Bursts Polarimeter（POLAR） and the Insight Hard Xray Modulation Telescope（Insight-HXMT） to follow up the bursts of interest. For GRB 170817 A, the first EM counterpart of GW events detected by Fermi/GBM and INTEGRAL/SPI-ACS, the pipeline gave T90 and spectral information 21 min after the GBM trigger, providing important information for POLAR and Insight-HXMT observations.展开更多
Premenstrual dysphoric disorder(PMDD) affects nearly 5% of women of reproductive age. Symptomatic heterogeneity, together with largely unknown genetics, has greatly hindered its effective treatment. In the present stu...Premenstrual dysphoric disorder(PMDD) affects nearly 5% of women of reproductive age. Symptomatic heterogeneity, together with largely unknown genetics, has greatly hindered its effective treatment. In the present study, analysis of genomic sequencing-based copy number variations(CNVs) called from 100 kb white blood cell DNA sequence windows by means of semisupervized clustering led to the segregation of patient genomes into the D and V groups, which correlated with the depression and invasion clinical types,respectively, with 89.0% consistency. Application of diagnostic CNV features selected using the correlation-based machine learning method enabled the classification of the CNVs obtained into the D group, V group, total patient group, and control group with an average accuracy of 83.0%. The power of the diagnostic CNV features was 0.98 on average, suggesting that these CNV features could be used for the molecular diagnosis of the major clinical types of PMDD. This demonstrated concordance between the CNV profiles and clinical types of PMDD supported the validity of symptom-based diagnosis of PMDD for differentiating between its two major clinical types, as well as the predominantly genetic nature of PMDD with a host of overlaps between multiple susceptibility genes/pathways and the diagnostic CNV features as indicators of involvement in PMDD etiology.展开更多
基金National Innovation Training Project“Landscape Design of Educational Research Base Based on Mine Ecological Restoration:Taking the Restoration of Datu Mine in Xinhe Village,Dadukou District as an Example”(202312608002X)Chongqing Institute of Engineering Innovation Training Project“Yitian Xuegu”Innovative Design Research on Rural Education Practice Base in Longhe Town,Fengdu CountyChongqing Institute of Engineering School-Level Topic“Research on Urban Waterfront Landscape Design Based on the Concept of River Ecological Restoration:Taking the Section of Huaxi River in Chongqing Institute of Engineering as an Example”(2022xskz02)。
文摘With the continuous development of the mining industry,the number of abandoned mines is increasing,which brings many impacts on the geology and ecological environment around the mines.It is urgent to attach great importance to the ecological management and environmental restoration of abandoned mines.The long-term traditional development path of rural areas,following the model of“pollution first,treatment later,”fails to meet the needs of sustainable development.The contradiction between mine economic development and ecological environment degradation is becoming increasingly prominent,which urgently needs to be solved.Under the guidance of the Party and the state,in order to implement the relevant policies of“green mountains and clear waters are gold and silver mountains,”we emphasize rural green development,and the transformation of rural green development path is imperative.This paper takes Datu Mine in Xinhe Village,Dadukou District,Chongqing as the research object,combines rural ecological development as the research basis,and innovatively integrates the“educational research”model,aiming to provide practical strategies for the sustainable development of rural landscapes in abandoned mines.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23040400)the National Natural Science Foundation of China(Grant Nos.11403026,11503028and 11673023)+4 种基金the National Basic Research Program of China(973 program,Grant No.2014CB845800)the National Thousand Young Talents program of Chinafunded by China National Space Administration(CNSA)the Chinese Academy of Sciences(CAS)the University of Geneva(UNIGE)
文摘Rapid response and short time latency are very important for Time Domain Astronomy, such as the observations of Gamma-ray Bursts（GRBs） and electromagnetic（EM） counterparts of gravitational waves（GWs）. Based on near real-time Fermi/GBM data, we developed a low-latency pipeline to automatically calculate the temporal and spectral properties of GRBs. With this pipeline, some important parameters can be obtained, such as T_（90） and fluence, within ～ 20 min after the GRB trigger.For ～ 90% of GRBs, T90 and fluence are consistent with the GBM catalog results within 2σ errors.This pipeline has been used by the Gamma-ray Bursts Polarimeter（POLAR） and the Insight Hard Xray Modulation Telescope（Insight-HXMT） to follow up the bursts of interest. For GRB 170817 A, the first EM counterpart of GW events detected by Fermi/GBM and INTEGRAL/SPI-ACS, the pipeline gave T90 and spectral information 21 min after the GBM trigger, providing important information for POLAR and Insight-HXMT observations.
基金supported by grants to HX from University Grants Council(SRF116SC01UROP18SC06+10 种基金UROP20SC07)Innovation and Technology Commission(ITS/085/10ITS113/15FPITCPD/17-9ITT/023/17GPITT/026/18GP)of Hong Kong SARShenzhen Municipal Council of Science and Technology,Guangdong(JCYJ20170818113656988)Guangdong Province Basic and Applied Basic Research Fund(2021A1515011169)Shandong Province First Class Disciple Development Grant and Tai-Shan Scholar Program,Shandongand Ministry of Science and Technology(National Science and Technology Major Project,No.2017ZX09301064,2017ZX09301064004)People’s Republic of China,as well as grants from National Natural Science Foundation of China to M.Q.(8157151623)and J.W.(81603510)。
文摘Premenstrual dysphoric disorder(PMDD) affects nearly 5% of women of reproductive age. Symptomatic heterogeneity, together with largely unknown genetics, has greatly hindered its effective treatment. In the present study, analysis of genomic sequencing-based copy number variations(CNVs) called from 100 kb white blood cell DNA sequence windows by means of semisupervized clustering led to the segregation of patient genomes into the D and V groups, which correlated with the depression and invasion clinical types,respectively, with 89.0% consistency. Application of diagnostic CNV features selected using the correlation-based machine learning method enabled the classification of the CNVs obtained into the D group, V group, total patient group, and control group with an average accuracy of 83.0%. The power of the diagnostic CNV features was 0.98 on average, suggesting that these CNV features could be used for the molecular diagnosis of the major clinical types of PMDD. This demonstrated concordance between the CNV profiles and clinical types of PMDD supported the validity of symptom-based diagnosis of PMDD for differentiating between its two major clinical types, as well as the predominantly genetic nature of PMDD with a host of overlaps between multiple susceptibility genes/pathways and the diagnostic CNV features as indicators of involvement in PMDD etiology.
