Achieving structurally stable O3-type layered oxide cathodes through site-specific cation-anion co-substitution for sodium-ion batteries

O3-type layered oxides have garnered great attention as cathode materials for sodium-ion batteries because of their abundant reserves and high theoretical capacity.However,challenges persist in the form of uncontrollable phase transitions and intricate Na^(+)diffusion pathways during cycling,resulting in compromised structural stability and reduced capacity over cycles.This study introduces a special approach employing site-specific Ca/F co-substitution within the layered structure of O_(3)-NaNi_(0.5)Mn_(0.5)O_(2) to effectively address these issues.Herein,the strategically site-specific doping of Ca into Na sites and F into O sites not only expands the Na^(+)diffusion pathways but also orchestrates a mild phase transition by suppressing the Na^(+)/vacancy ordering and providing strong metal-oxygen bonding strength,respectively.The as-synthesized Na_(0.95)Ca_(0.05)Ni_(0.5)Mn_(0.5)O_(1.95)F_(0.05)(NNMO-CaF)exhibits a mild O3→O3+O'3→P3 phase transition with minimized interlayer distance variation,leading to enhanced structural integrity and stability over extended cycles.As a result,NNMO-CaF delivers a high specific capacity of 119.5 mA h g^(-1)at a current density of 120 mA g^(-1)with a capacity retention of 87.1%after 100 cycles.This study presents a promising strategy to mitigate the challenges posed by multiple phase transitions and augment Na^(+)diffusion kinetics,thus paving the way for high-performance layered cathode materials in sodium-ion batteries.

ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair

Reactive oxygen species(ROS)plays important roles in living organisms.While ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound healing.The Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill bacteria.Meanwhile,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) nanoparticles.Subsequently,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au NPs.These two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound healing.Such innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

堤坝管涌水下测距定位系统

当前堤坝管涌定位系统在堤坝渗漏检测方面表现优异,但无法测量水位深度。在原有堤坝管涌设备的基础上,采用STM32F4为控制核心的水声换能器作为接收端,设计了一个堤坝管涌水下定向测距定位系统。以设计中配置了STM32F4的TIM2发出的方波作为激励信号源,然后经过调理电路进行电压放大和功率放大,驱动发射端水声换能器向水中发射信号。发射信号经过一定距离的传播后,接收端换能器接收信号并进行幅值比较,确定峰值时刻的采样地址,最后根据采样点个数与点数之间的间隔实现对堤坝管涌仪的水下定向测距定位。在测量不同距离方面,提出了一种自适应脉冲算法,解决了单个脉冲测量不同距离误差较大的问题。现场测试结果表明,本系统在水下的定位误差范围在4%以内,可用于小型水库大坝管涌定位探测,为大坝管涌定位提供了一种新方法。

Comprehensive understanding and rational regulation of microenvironment for gas-involving electrochemical reactions

Substantial progress has been made in the understanding of gas-involving electrochemical reactions recently for the sake of clean,renewable,and efficient energy technologies.However,the specific influence mechanism of the microenvironment at the reaction interface on the electrocatalytic performance(activity,selectivity,and durability)remains unclear.Here,we provide a comprehensive understanding of the interfacial microenvironment of gas-involving electrocatalysis,including carbon dioxide reduction reaction and nitrogen reduction reaction,and classify the factors affecting the reaction thermodynamics and kinetics into gas diffusion,proton supply,and electron transfer.This categorization allows a systematic survey of the literature focusing on electrolyzer-level(optimization of the device,control of the experimental condition,and design of the working electrode),electrolytelevel(increase of gas solubility,regulation of proton supply,and substitution of anodic reaction),and electrocatalyst-level strategies(promotion of gas affinity,adjustment of hydrophobicity,and enhancement of conductivity),aiming to retrieve the correlations between the microenvironment and electrochemical performance.Finally,priorities for future studies are suggested to support the comprehensive improvement of next-generation gas-involving electrochemical reactions.

Insight into the reaction mechanism of sulfur chains adjustable polymer cathode for high-loading lithium-organosulfur batteries

Small molecules with adjustable sulfur atoms in the confined structure were acted as precursor for the synthesis of polymer cathodes for lithium-organosulfur batteries.Among them,poly(diallyl tetrasulfide)(PDATtS)delivered a high capacity of 700 mAh g^(-1),stable capacity retention of 85%after 300 cycles,high areal capacity~4 m Ah cm^(-2) for electrode with up to 10.3 mg cm^(-2) loading.New insight into the reaction mechanism of PDATtS electrode that radicals arisen from the homolytic cleavage of S-S bond in PDATtS reacted with Li+to generate thiolates(RSLi)and insoluble lithium sulfides(Li_(2)S)or lithium disulfide(Li_(2)S_(2))was clearly verified by in-situ UV/Vis spectroscopy,nuclear magnetic resonance(NMR)studies and density-functional theory(DFT)calculations.Therefore,based on the unique reaction mechanism,problems of rapid capacity fading due to the formation of soluble polysulfide intermediates and their serious shuttle effect in conventional lithium-sulfur(Li-S)batteries was totally avoided,realizing the dendrite-free lithium sulfur batteries.This study sets new trends for avenues of further research to advance Li-S battery technologies.

Preparation of Fe_(3)O_(4)@SW-MIL-101-NH_(2) for selective preconcentration of chlorogenic acid metabolites in rat plasma,urine,and feces samples

An innovative sandwich-structural Fe-based metal-organic framework magnetic material(Fe_(3)O_(4)@SWMIL-101-NH_(2))was fabricated using a facile solvothermal method.The characteristic properties of the material were investigated by field emission scanning electron microscopy,transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy,Fourier transform infrared spectroscopy,X-ray powder diffraction,vibrating sample magnetometry,and Brunauer-Emmett-Teller measurements.Fe_(3)O_(4)@SW-MIL-101-NH_(2) is associated with advantages,such as robust magnetic properties,high specific surface area,and satisfactory storage stability,as well as good selective recognition ability for chlorogenic acid(CA)and its metabolites via chelation,hydrogen bonding,and p-interaction.The results of the static adsorption experiment indicated that Fe_(3)O_(4)@SW-MIL-101-NH_(2) possessed a high adsorption capacity toward CA and its isomers,cryptochlorogenic acid(CCA)and neochlorogenic acid(NCA),and the adsorption behaviors were fitted using the Langmuir adsorption isotherm model.Then,a strategy using magnetic solid-phase extraction(MSPE)and ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF MS/MS)was developed and successfully employed for the selective pre-concentration and rapid identification of CA metabolites in rat plasma,urine,and feces samples.This work presents a prospective strategy for the synthesis of magnetic adsorbents and the high-efficiency pretreatment of CA metabolites.

Association Between Constipation and a Reduction in Lower Limb Muscle Strength in Preoperative Patients with Thoracic Spinal Tumors

Objective To investigate the clinical symptoms experienced by patients with thoracic spinal tumors and verify the associated symptoms that are predictive of a decline in muscle strength in the lower limbs.Methods A single-center,retrospective cross-sectional study was conducted on in-patients diagnosed with epidural thoracic spinal tumors between January 2011 and May 2021.The study involved a review of electronic medical records and radiographs and the collection of clinical data.The differences in clinical manifestations between patients with constipation and those without constipation were analyzed.Binary logistic regression analyses were performed to identify risk factors associated with a decline in muscle strength in the lower limbs.Results A total of 227 patients were enrolled,including 131 patients with constipation and 96 without constipation.The constipation group had a significantly higher proportion of patients who experienced difficulty walking or paralysis compared to those without constipation prior to surgery(83.2%vs.17.7%,χ~2=99.035,P 0.001).Constipation(OR=9.522,95%CI:4.150±21.849,P 0.001)and urinary retention(OR=14.490,95%CI:4.543±46.213,P 0.001)were independent risk factors for muscle strength decline in the lower limbs.Conclusions The study observed that patients with thoracic spinal tumors who experienced constipation symptoms had a higher incidence of lower limb weakness.Moreover,the analysis revealed that constipation and urinary retention were independent risk factors associated with a preoperative decline in muscle strength of lower limbs.

The expression of P63 protein in some keratinocyte original tissues and cells

Objective： To examine the expression patterns of p63 in tissues of particular keratinocyte original hyperproliferate diseases and variety cell types for determining if P63 is the marker of proliferative potential keratinocytes. Methods： P63 protein was detected and analyzed by immunoreactivity method and Western blot in biopsy specimens of keratinocyte original disorders including squamous cell carcinomas SCC, basal cell carcinomas BCC, Bowen＇ s disease and other tissues or cells, such as psoriasis vulgaris, normal skin tissues, primary cultured keratinocytes, immortal HaCaT cells, and epidermoid carcinoma cells A431. Results： P63 protein was expressed in the nuclei of basal and suprabasal layer of the epidermis, germinative cells of sebaceous glands in normal epidermal. P63 was strongly and diffusely detected in the majority of tumor cells in BCC and poorly-differentiated SCC. In Bowen＇ s disease, p63 expresses are remarkable in all cell layers. In the psoriasis plaque epidermal, p63 expressed mainly in basal cells and part of spinous cells. P63 expressed more strongly in primary cultured keratinocytes than in A431 cells or HaCaT cells. Conclusion： P63 is a nuclei marker of undifferentiated keratinocytes with the proliferative potential and may disrupt the terminal differentiation. The overexpression of p63 reflects immaturity of the tumor cells. The immunohistochemical staining of p63 may be useful for investigating the origin and differentiation of tumor cells.

Pig Price Fluctuations and Forecasting Model Based on Information Platform

Pork is common in people's daily life consumption,and it accounts for more than half of all meats. By collecting data information published by Bureau of Statistics and Bureau of Agriculture,this paper makes a statistical analysis of the influence of price fluctuation in the pork market on China's pork production,and finds that China's pork production shows a general trend of fluctuations due to the impact of price factors.According to the predecessors' studies on the factors influencing pig market price,combined with the actual situation of pig breeding in China,this paper uses the latest website data released by the government's public information platform to establish a forecasting model.

第46届中国家博会(上海)圆满落幕

由中国对外贸易中心(集团)、红星美凯龙家居集团股份有限公司、中国轻工工艺品进出口商会、广东省家具协会、广州市家具行业协会联合主办,中国对外贸易广州展览总公司、上海中贸美凯龙经贸发展有限公司承办的第46届中国家博会(上海)于9月10日在上海虹桥·国家会展中心圆满落下帷幕。本届展会得到行业鼎力支持,参展企业近1,000家,展览面积近25万平方米,规模继续保持领先。专业观众入场总人数达118,409,受疫情影响较上届有小幅回落。展会呈现"定位准、平台佳、设计优、软体强、布局全、活动精、服务专、安全稳"共八大亮点,整体品质进一步提升,大家共同见证了大家居行业盛事,实践"家居虹桥,链接未来"的大家居梦。

全球家居生活典范——第44届中国家博会（上海）参展商预览

9月是相聚的好日子,1500+国内外家居品牌,150000+专业观众,齐聚虹桥;9月是收获的好季节,品牌展示、新品发布、渠道维护;9月是总结的好时机,搜罗资讯、把脉行业、谋划未来。家不应只是床和沙发!餐厅是家、客厅是家,饰品是家、家纺是家,户外有家、办公也是家!设计是家、国际也有家!机械设备也决定了家具的优劣和家的品质!哪里有舒适的家具,哪里就是家!9月8-11日,家在虹桥国家会展中心中国家博会(上海),欢迎回家!

引领品牌建设 激发行业创新——第44届中国家博会(上海)CIFF圆满闭幕

中国对外贸易中心(集团)、红星美凯龙家居集团股份有限公司和中国轻工工艺品进出口商会、广东省家具协会、广州市家具行业协会联合主办,中国对外贸易广州展览总公司、上海中贸美凯龙经贸发展有限公司承办的2019中国家博会(上海)于9月11日在上海虹桥.国家会展中心圆满落下帷幕。本届展会得到行业鼎力支持,参展企业1500余家,规模继续保持领先。专业观众入场总人数150766,再创新高,共同见证了大家居行业的“全球家居生活典范”。

家居虹桥 链接全球——第46届中国家博会(上海)整装待发

7月30日,作为疫后国内首个超大型全产业链家具博览会,第45届中国家博会(广州)以入场观众145363人的成绩顺利收官,为家居市场的重启开了个好头。特殊时期,行业更加需要信仰坚定的领路人,中国对外贸易中心(集团)旗下中国家博会积极发挥自身优势,坚持创新求变,助力家居企业寻找和把握新机遇。

全球家居生活典范——第44届中国家博会（上海）前瞻

第44届中国家博会(上海)媒体见面会于2019年6月5日在上海机遇中心顺利举行,特邀新浪家居、网易家居、腾讯家居、《家具与室内装饰》、搜狐焦点家居、设计时代、诠释、齐家网、家具主流、九正建材网、土巴兔、锋镝传媒、id+c等50多家行业媒体出席,现场人气火爆、气氛热烈。见面会由中国家博会(上海)相关活动负责人唐琳女士主持,上海中贸美凯龙经贸发展有限公司(中贸美凯龙)副总经理吴奕东先生致辞。

Feasibility Study of Mixing Throat Swab Samples for Severe Acute Respiratory Syndrome Coronavirus-2 Screening

Dear Editor,The outbreak of coronavirus disease 2019(COVID-19)has been declared a pandemic by the World Health Organization(WHO)and has resulted in the worst public health crisis since World War II(Wang et al.2020).

Soil microbial ecology through the lens of metatranscriptomics

Metatranscriptomics is a cutting-edge technology for exploring the gene expression by,and functional activities of,the microbial community across diverse ecosystems at a given time,thereby shedding light on their metabolic responses to the prevailing environmental conditions.The double-RNA approach involves the simultaneous analysis of rRNA and mRNA,also termed structural and functional metatranscriptomics.By contrast,mRNA-centered metatranscriptomics is fully focused on elucidating community-wide gene expression profiles,but requires either deep sequencing or effective rRNA depletion.In this review,we critically assess the challenges associated with various experimental and bioinformatic strategies that can be applied in soil microbial ecology through the lens of functional metatranscriptomics.In particular,we demonstrate how recent methodological advancements in soil metatranscriptomics catalyze the development and expansion of emerging research fields,such as rhizobiomes,antibiotic resistomes,methanomes,and viromes.Our review provides a framework that will help to design advanced metatranscriptomic research in elucidating the functional roles and activities of microbiomes in soil ecosystems.

Single-cell RNA-sequencing reveals a profound immune cell response in human cytomegalovirus-infected humanized mice

Human cytomegalovirus(HCMV)is a common herpesvirus that persistently infects a large portion of the world's population.Despite the robust host immune response,HCMV is able to replicate,evade host defenses,and establish latency throughout the lifespan by developing multiple immunomodulatory strategies,making the studies on the interaction between HCMV infection and host response particularly important.HCMV has a strict host specificity that specifically infects humans.Therefore,most of the in vivo researches of HCMV rely on clinical samples.Fortunately,the establishment of humanized mouse models allows for convenient in-lab animal experiments involving HCMV infection.Single-cell RNA sequencing enables the study of the relationship between viral and host gene expressions at the single-cell level within host cells.In this study,we assessed the gene expression alterations of PBMCs at the single-cell level within HCMV-infected humanized mice,which sheds light onto the virus-host interactions in the context of HCMV infection of humanized mice and provides a valuable dataset for the related researches.

Design of antiviral AGO2-dependent short hairpin RNAs

The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals.RNA interference(RNAi)is a sequence-specific gene silencing mechanism that is triggered by small interfering RNAs(siRNAs)or short hairpin RNAs(shRNAs),which exhibits significant promise for antiviral therapy.AGO2-dependent shRNA(agshRNA)generates a single-stranded guide RNA and presents significant advantages over traditional siRNA and shRNA.In this study,we applied a logistic regression algorithm to a previously published chemically siRNA efficacy dataset and built a machine learning-based model with high predictive power.Using this model,we designed siRNA sequences targeting diverse RNA viruses,including human enterovirus A71(EV71),Zika virus(ZIKV),dengue virus 2(DENV2),mouse hepatitis virus(MHV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and transformed them into agshRNAs.We validated the performance of our agshRNA design by evaluating antiviral efficacies of agshRNAs in cells infected with different viruses.Using the agshRNA targeting EV71 as an example,we showed that the anti-EV71 effect of agshRNA was more potent compared with the corresponding siRNA and shRNA.Moreover,the antiviral effect of agshRNA is dependent on AGO2-processed guide RNA,which can load into the RNA-induced silencing complex(RISC).We also confirmed the antiviral effect of agshRNA in vivo.Together,this work develops a novel antiviral strategy that combines machine learning-based algorithm with agshRNA design to custom design antiviral agshRNAs with high efficiency.

一种新型隐身无人艇气水混合层水动力作用研究

该文研究的隐身型无人艇艏部为双体内凹结构,靠近艉部逐渐转换为多体,中间附体厚度沿纵向逐渐变大。为了研究此无人艇在不同航速下的阻力性能,首先采用物理水池试验研究了初始倾角、有无艏部整流板和排水量对艇体阻力性能的影响规律,然后基于CFD技术探讨了无人艇内凹滑行腔内气水层对艇体阻力性能影响的内在机制。计算结果表明:低速排水阶段内凹滑行腔聚集的兴波会造成阻力的增加,出现低速阻力峰;随着速度的增加,无人艇进入滑行阶段,内凹滑行腔产生气水混合层,当体积弗劳德数为4.69时,出现高速阻力峰,在艏部整流板的引导下,更多气体的进入使腔体的气水混合层加厚,将艇体托起,跨过阻力峰。研究表明双体内凹型腔和艏部整流板有助于兴波的聚集和气水混合层的形成。随着气水混合层对艇体支撑作用的提升,多体滑行艇高速滑行时的阻力处于下降趋势。上述结论可为隐身多体无人艇的设计及优化提供技术支撑。

Therapeutic effect of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients:a clinical two-center randomized controlled trial

OBJECTIVE:To evaluate the therapeutic effects of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients.METHODS:One hundred and twenty hemiplegia patients with stage I shoulder-hand syndrome were randomly divided into a group treated with standardized electric acupuncture and massage,and a group treated with rehabilitation therapy for 6 weeks.The primary indices evaluated were pain on passive movement of the shoulder using the numeric pain rating scale(NPRS),and the number of patients with shoulder-hand syndrome at Steinbrocker stage II or III after treatment.The secondary indices were Fugl-Meyer evaluation of functional movement of the upper limb and hand using the modified rankin scale(MRS).RESULTS:At post-treatment evaluation and a 12-week follow-up visit,NPRS score,number of patients with stage II or III shoulder-hand syndrome,and MRS score were all improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).On Fugl-Meyer evaluation,functional movement of the upper limb was also improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).CONCLUSION:Standardized acupuncture-massage therapy may have curative effects on shoulder-hand syndrome in hemiplegia patients.