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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells
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作者 Meng Cong Jing-Jing Hu +9 位作者 Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi 《Neural Regeneration Research》 SCIE CAS 2025年第1期277-290,共14页
Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve repair.Cell-based therapy can enhance peripheral nerve rep... Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve repair.Cell-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular communication.Nevertheless,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain unclear.To investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose deprivation.The mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest cells.We performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest cells.Subsequently,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded miR-21-5p.Finally,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously restored.These findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in miRNA-21-5p.miRNA-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell secretome.This helps to explain the mechanism of action of the secretome and extracellular vesicles of neural crest cells in repairing damaged peripheral nerves,and also promotes the application of miR-21-5p in tissue engineering regeneration medicine. 展开更多
关键词 AXOTOMY cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors
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Regeneration of copper catalysts mediated by molybdenum-based oxides
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作者 Changyu Ding xiaoli Pan +7 位作者 Isla E.Gow xia wu Hongchen Cao Zhounan Yu xiaoyan Liu xiaofeng Yang Qinggang Liu Yanqiang Huang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第8期618-625,I0013,共9页
Cu catalysts,known for their unparalleled catalytic capabilities due to their unique electronic structure,have faced inherent challenges in maintaining long-term effectiveness under harsh hydrogenation conditions.Here... Cu catalysts,known for their unparalleled catalytic capabilities due to their unique electronic structure,have faced inherent challenges in maintaining long-term effectiveness under harsh hydrogenation conditions.Here,we demonstrate a molybdenum-mediated redispersion behavior of Cu under hightemperature oxidation conditions.The oxidized Cu nanoparticles with rich metal-support interfaces tend to dissolve into the MoO_(3)support upon heating to 600℃,which facilitates the subsequent regeneration in a reducing atmosphere.A similar redispersion phenomenon is observed for Cu nanoparticles supported on Zn O-modified MoO_(3).The modification of ZnO significantly improves the performance of the Cu catalyst for CO_(2)hydrogenation to methanol,with the high activity being well maintained after four repeated oxidation-reduction cycles.In situ spectroscopic and theoretical analyses suggest that the interaction involved in the formation of the copper molybdate-like compound is the driving force for the redispersion of Cu.This method is applicable to various Mo-based oxide supports,offering a practical strategy for the regeneration of sintered Cu particles in hydrogenation applications. 展开更多
关键词 Cu-based catalysts AGGREGATION REGENERATION OXIDATION CO_(2)hydrogenation
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Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study
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作者 Shi-Ju Chen Da-Ya Zhang +6 位作者 xia wu Fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai 《World Journal of Gastroenterology》 SCIE CAS 2024年第11期1572-1587,共16页
BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transpl... BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical phenomena.However,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been reported.AIM To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to WMT.METHODS We conducted a prospective,open-label,single-center clinical study.Eleven CD patients underwent WMT.Their clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the procedure.RESULTS Seven of the 11 patients(63.6%)showed an optimal clinical response three months post-WMT.Gut microbiome diversity significantly increased after WMT,consistent with improved clinical symptoms.Comparison of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia coli.In addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the donors.However,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after WMT.CONCLUSION WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s microbiome.Multi-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD. 展开更多
关键词 Crohn’s disease Clinical trials Fecal microbiota transplant METAGENOME Metatranscriptome METABOLOME
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特发性中枢性性早熟女童心理社会适应与自我意识、性别角色的相关分析 被引量:6
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作者 杨芳 周静茹 +4 位作者 张艳 吴霞 刘明会 宋晓艳 朱玲 《数理医药学杂志》 CAS 2023年第2期110-117,共8页
目的 调查中枢性性早熟女童心理社会适应、自我意识和性别角色的现状,分析它们之间的相关性。方法 采取便利抽样法,选取2021年8月至2022年8月在四川省德阳市人民医院儿科门诊就诊的252例特发性中枢性性早熟(idiopathic central precocio... 目的 调查中枢性性早熟女童心理社会适应、自我意识和性别角色的现状,分析它们之间的相关性。方法 采取便利抽样法,选取2021年8月至2022年8月在四川省德阳市人民医院儿科门诊就诊的252例特发性中枢性性早熟(idiopathic central precocious puberty,ICPP)女童作为研究对象,运用一般资料问卷、儿童心理社会适应评定量表(Social ADQ)、性别角色量表和Piers-Harris儿童自我意识量表进行调查。结果 ICCP女童ADQ得分为(96.04±19.41)分,27%的ICCP女童位于“边界”水平;自我意识得分为(50.78±19.21)分;双性化、男性化、女性化和未分化分别为108例(42.9%)、24例(9.5%)、20例(7.9%)和100例(39.7%)。Pearson相关分析结果显示,ICCP女童ADQ评分与自我意识存在正相关(r=0.367,P <0.01);4种性别角色的ICPP女童ADQ评分差异有统计学意义(F=2.988,P <0.05),不同性别角色的ICPP女童ADQ得分中,双性化得分最高(103.41±19.33),未分化得分最低(88.70±16.72)。结论 ICPP女童心理社会适应行为现状并不乐观,与自我意识和性别角色均存在相关性,建议可以依据这一路径干预ICPP女童心理社会适应行为,从而提升其面对疾病时的能力。 展开更多
关键词 中枢性性早熟 女童 心理社会适应 自我意识 性别角色 相关分析
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计量自动化系统中的电能计量装置监测研究 被引量:3
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作者 夏武 黄聪 +1 位作者 梁诚宁 梁君华 《无线互联科技》 2023年第7期47-49,67,共4页
在电力系统管理中,电能计量系统是提供基础数据的重要环节,管理和运维电能表、采集器等电能计量装置是保证电量统计准确性的前提。在当前计量自动化系统中,受产品质量、环境等因素的影响,仍会出现一定的计量差错或计量故障,不利于电量... 在电力系统管理中,电能计量系统是提供基础数据的重要环节,管理和运维电能表、采集器等电能计量装置是保证电量统计准确性的前提。在当前计量自动化系统中,受产品质量、环境等因素的影响,仍会出现一定的计量差错或计量故障,不利于电量的准确统计。在电能计量装置的故障严重时,还可能导致人身伤害等不良后果,不利于电网的安全运营。文章重点分析了变电站计量自动化系统的监测,介绍了线损异常、电能表故障等的判断方法,有助于提高电能计量系统的准确性与稳定性。 展开更多
关键词 计量自动化系统 变电站 电能计量监测 计量故障
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Global significance of the carbon cycle in the karst dynamic system:evidence from geological and ecological processes 被引量:14
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作者 Jian-hua Cao xia wu +4 位作者 Fen Huang Bill Hu Chris Groves Hui Yang Chun-lai Zhang 《China Geology》 2018年第1期17-27,共11页
On the basis of proposing the existence of a karst carbon cycle and carbon sink at a watershed scale,this paper provides four pieces of evidence for;the integration of geology and ecology during the carbon cycle proce... On the basis of proposing the existence of a karst carbon cycle and carbon sink at a watershed scale,this paper provides four pieces of evidence for;the integration of geology and ecology during the carbon cycle processes m the karst dynamic system,and estxmated the karst carbon sink effect using the methods of comparative monitoring of paired watersheds and the carbon stable isotope tracer technique.The results of the soil carbon cycle in Maocun,Guilin,showed that the soil carbon cycle in the karst area,the weathering and dissolution of carbonate rocks under the soil,resulted in a lower soil respiration of 25% in the karstoarea than in a non-karst area (sandstone and shale),and the carbon isotope results indicated that 13.46% of the heavy carbon of the hmestone is involved in the soil carbon cycle.The comparative monitoring results m paxred watersheds,suggesting that the HCO3 concentration m a karst spring is 10 times that of a rivulet in a non-karst area,while the concentration of inorganic carbon flux is 23.8 times.With both chemical stoichiometry and carbon stable isotopes,the proportion of carbon in karst springs derived from carbonate rocks was found to be 58.52% and 37.65% respectively.The comparison on carbon exchange and isotopes at the water-gas interface between the granite and carbonate rock basins in the Li River showed that the CO2 emission of the karst water is 10.92 times that of the allogenic water from the non-karst area,while the carbon isotope of HCO3^- in karst water is lighter by 8.62%.However,this does not mean that the karst water body has a larger carbon source effect.On the contrary,it means the karst water body has a greater karst carbon sink effect.When the karst subterranean stream in Zhaidi,Guilin,is exposed at the surface,carbon-rich karst water stimulated the growth of aquatic plants.The values of carbon stable isotopes in the same species of submerged plants gradually becomes heavier and heavier,and the 512 m flow process has a maximum range of 15.46%.The calculation results showed that 12.52% of inorganic carbon is converted into organic carbon.According to the data that has been published,the global karst carbon sink flux was estimated to be 0.53-0.58 PgC/a,equivalent to 31.18%-34.41% of the global forest carbon sink flux.In the meanwhile,the karst carbon sink flux in China was calculated to be 0.051 PgC/a,accounting for 68% of its forest carbon sink flux. 展开更多
关键词 KARST CARBON cycle CARBON stable ISOTOPE CARBON SINK effect SUBMERGED plants GUILIN
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Myocarditis presenting as typical acute myocardial infarction: A case report and review of the literature 被引量:7
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作者 Ya-Min Hou Peng-Xi Han +4 位作者 xia wu Jing-Ru Lin Fei Zheng Lin Lin Rui Xu 《World Journal of Clinical Cases》 SCIE 2020年第2期415-424,共10页
BACKGROUND Myocarditis refers to a variety of myocardial inflammatory lesions. A variety of factors such as infection and physical and chemical factors can cause myocarditis.Depending on the severity of myocardial dam... BACKGROUND Myocarditis refers to a variety of myocardial inflammatory lesions. A variety of factors such as infection and physical and chemical factors can cause myocarditis.Depending on the severity of myocardial damage, myocarditis patients can manifest heart failure, cardiogenic shock, and even sudden death. Here we present a case of viral myocarditis that mimicked acute coronary syndrome.CASE SUMMARY A middle-aged male patient presented with chest pain and elevated troponin I after a flu-like infection. This patient had a history of hypertension and a habit of alcohol and tobacco use. Electrocardiography showed typical changes in acute myocardial infarction, with the T-wave increasing. Coronary angiogram revealed no stenosis. Cardiac magnetic resonance imaging revealed edema of the middle and apical septal and apical anterior walls on T2-weighted images and the T1 mapping. Late gadolinium enhancement of the middle and apical septal and apical anterior walls could be found. Rubella virus immunoglobulin G and immunoglobulin M antibodies were abnormally elevated. The patient was given antiviral and antibiotic treatments, and serum biomarkers and electrocardiograph returned to normal after 5 d of treatment. After one-year follow-up, the patient showed no symptoms, and cardiac magnetic resonance showed that myocardial thickness was significantly thinner than before, and fibrosis was less than before.CONCLUSIONThis case illustrates the utility of cardiac magnetic resonance for diagnosis of infarction-like myocarditis when the angiogram is normal. 展开更多
关键词 MYOCARDITIS Myocardial infraction Magnetic resonance imaging CARDIOMYOCYTES Follow-up study Case report
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Impact of cap-assisted colonoscopy during transendoscopic enteral tubing:A randomized controlled trial 被引量:2
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作者 Quan Wen Kang-Jian Liu +11 位作者 Bo-Ta Cui Pan Li xia wu Min Zhong Lu Wei Hua Tu Yu Yuan Da Lin Wen-Hung Hsu Deng-Chyang wu Hong Yin Fa-Ming Zhang 《World Journal of Gastroenterology》 SCIE CAS 2020年第39期6098-6110,共13页
BACKGROUND Colonic transendoscopic enteral tubing(TET)requires double cecal intubation,raising a common concern of how to save cecal intubation time and make the tube stable.We hypothesized that cap-assisted colonosco... BACKGROUND Colonic transendoscopic enteral tubing(TET)requires double cecal intubation,raising a common concern of how to save cecal intubation time and make the tube stable.We hypothesized that cap-assisted colonoscopy(CC)might reduce the second cecal intubation time and bring potential benefits during the TET procedure.AIM To investigate if CC can decrease the second cecal intubation time compared with regular colonoscopy(RC).METHODS This prospective multicenter,randomized controlled trial was performed at four centers.Subjects≥7 years needing colonic TET were recruited from August 2018 to January 2020.All subjects were randomly assigned to two groups.The primary outcome was the second cecal intubation time.Secondary outcomes included success rate,insertion pain score,single clip fixation time,purpose and retention time of TET tube,length of TET tube inserted into the colon,and all procedurerelated(serious)adverse events.RESULTS A total of 331 subjects were randomized to the RC(n=165)or CC(n=166)group.The median time of the second cecal intubation was significantly shorter for CC than RC(2.2 min vs 2.8 min,P<0.001).In patients with constipation,the median time of second cecal intubation in the CC group(n=50)was shorter than that in the RC group(n=43)(2.6 min vs 3.8 min,P=0.004).However,no difference was observed in the CC(n=42)and RC(n=46)groups of ulcerative colitis patients(2.0 min vs 2.5 min,P=0.152).The insertion pain score during the procedure in CC(n=14)was lower than that in RC(n=19)in unsedated colonoscopy(3.8±1.7 vs 5.4±1.9;P=0.015).Multivariate analysis revealed that only CC(odds ratio[OR]:2.250,95%confidence interval[CI]:1.161-4.360;P=0.016)was an independent factor affecting the second cecal intubation time in difficult colonoscopy.CC did not affect the colonic TET tube’s retention time and length of the tube inserted into the colon.Moreover,multivariate analysis found that only endoscopic clip number(OR:2.201,95%CI:1.541-3.143;P<0.001)was an independent factor affecting the retention time.Multiple regression analysis showed that height(OR:1.144,95%CI:1.027-1.275;P=0.014)was the only independent factor influencing the length of TET tube inserted into the colon in adults.CONCLUSION CC for colonic TET procedure is a safe and less painful technique,which can reduce cecal intubation time. 展开更多
关键词 Transendoscopic enteral tube ENDOSCOPY COLONOSCOPY Fecal microbiota transplant Washed microbiota transplant COLON
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Bioprinting and in vitro characterization of alginate dialdehyde-gelatin hydrogel bio‑ink 被引量:4
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作者 Fu You xia wu +1 位作者 Michael Kelly Xiongbiao Chen 《Bio-Design and Manufacturing》 CSCD 2020年第1期48-59,共12页
Cell-laden cardiac patches have recently been emerging to renew cellular sources for myocardial infarction(MI,commonly know as a heart attack)repair.However,the fabrication of cell-laden patches with porous structure ... Cell-laden cardiac patches have recently been emerging to renew cellular sources for myocardial infarction(MI,commonly know as a heart attack)repair.However,the fabrication of cell-laden patches with porous structure remains challenging due to the limitations of currently available hydrogels and existing processing techniques.The present study utilized a bioprinting technique to fabricate hydrogel patches and characterize them in terms of printability,mechanical and biological properties.Cell-laden hydrogel(or bio-ink)was formulated from alginate dialdehyde(ADA)and gelatin(GEL)to improve the printability,degradability as well as bioactivity.Five groups of hydrogel compositions were designed to investigate the influence of the oxidation degree of ADA and hydrogels concentration on the properties of printed scaffolds.ADA-GEL hydrogels have generally shown favorable for living cells(EA.hy926 cells and hybrid human umbilical vein endothelial cell line).The hydrogel with an oxidation degree of 10%and a concentration ratio of 70/30(or 10%ADA70-GEL30)demonstrated the best printability among the groups examined.Formulated hydrogels were also bioprinted with the living cells(EA.hy926),and the scaffolds printed were then subject to the cell culture for 7 days.Our results illustrate that the scaffolds bioprinted from 10%ADA70–GEL30 hydrogels had the best homogenous cell distribution and also the highest cell viability.Taken together,in the present study we synthesized a newly formulated bio-ink from ADA and GEL and for the fist time,used them to bioprint cardiac patches,which have the potential to be used in MI repair. 展开更多
关键词 BIOPRINTING Alginate dialdehyde GELATIN Bio-ink
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Investigation of system structure and information processing mechanism for cognitive skywave over-the-horizon radar 被引量:8
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作者 xia wu Jianwen Chen Kun Lu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第4期797-806,共10页
Based on the cognitive radar concept and the basic connotation of cognitive skywave over-the-horizon radar(SWOTHR), the system structure and information processingmechanism about cognitive SWOTHR are researched. Amo... Based on the cognitive radar concept and the basic connotation of cognitive skywave over-the-horizon radar(SWOTHR), the system structure and information processingmechanism about cognitive SWOTHR are researched. Amongthem, the hybrid network system architecture which is thedistributed configuration combining with the centralized cognition and its soft/hardware framework with the sense-detectionintegration are proposed, and the information processing framebased on the lens principle and its information processing flowwith receive-transmit joint adaption are designed, which buildand parse the work law for cognition and its self feedback adjustment with the lens focus model and five stages informationprocessing sequence. After that, the system simulation andthe performance analysis and comparison are provided, whichinitially proves the rationality and advantages of the proposedideas. Finally, four important development ideas of futureSWOTHR toward "high frequency intelligence information processing system" are discussed, which are scene information fusion, dynamic reconfigurable system, hierarchical and modulardesign, and sustainable development. Then the conclusion thatthe cognitive SWOTHR can cause the performance improvement is gotten. 展开更多
关键词 cognitive radar skywave over-the-horizon radar system structure intelligence information processing information fusion target detection
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Evaluations of physico-chemical properties of TiO_(2)/clinoptilolite synthesized via three methods on photocatalytic degradation of crystal violet 被引量:1
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作者 Raza Ullah Jihong Sun +2 位作者 Anadil Gul Tallat Munir xia wu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第5期181-189,共9页
Different preparation routes for TiO_(2)-supported natural and synthetic clinoptilolite(TiO_(2)/CP)composites were thoroughly investigated on the basis of sol-gel,hydrothermal,and in-situ hydrothermal methods.The micr... Different preparation routes for TiO_(2)-supported natural and synthetic clinoptilolite(TiO_(2)/CP)composites were thoroughly investigated on the basis of sol-gel,hydrothermal,and in-situ hydrothermal methods.The micro-structural features and physicochemical properties of resultant TiO_(2)/CPs were characterized via X-ray diffraction patterns,scanning(transmission)electron microscope images,Fourier transform infrared spectra,inductively coupled plasma-optical emission spectrometry methods,BET-isotherms,UV-visible spectra,and surface charge potential distributions.The results showed that in-situ hydrothermal method led to well dispersions of loaded-TiO_(2) particles on the surface of leaf-like CP,while obviously aggregated TiO_(2) on a relatively distorted structure of CP was obtained using sol-gel and hydrothermal methods.Their adsorptive and photocatalytic efficiencies for removal of crystal violet(CV)dye in aqueous solution were also explored under UV-irradiations.The results demonstrated that TiO_(2)/CPs synthesized via sol-gel and in-situ hydrothermal methods presented the excellent performances with 98% removal efficiencies as compare to the bare commercial TiO_(2) which achieved 53%removal of CV dye.While,the in-situ hydrothermally synthesized TiO_(2)/CPs were the best due to their moderate energy cost,highest adsorption capacities and removal efficiencies.Particularly,the synthetic CPs as supports exhibited synergetic photocatalytic activities for the degradation of CV dye,which is attributed to their high surface areas,better adsorption capability,and fine dispersion of TiO_(2) particles.Adsorption and degradation kinetics of CV dye were found to follow the pseudo-second and pseudo-first order models,respectively. 展开更多
关键词 Adsorption Synthesis ZEOLITE Degradation TiO_(2) Crystal VIOLET
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基于500 kV线路区外故障引发的串补旁路分析
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作者 夏武 黄聪 欧俊延 《黑龙江电力》 CAS 2022年第3期254-258,共5页
该文在介绍串补火花间隙(GAP)自触发原理的基础上,结合某线路串补在500 k V相邻线路区外故障期间的火花间隙自触发现象,对故障期间波形进行详细分析,判断间隙自触发原因,提出解决方案,避免对设备进行过度的检查而造成高压输电线路不能... 该文在介绍串补火花间隙(GAP)自触发原理的基础上,结合某线路串补在500 k V相邻线路区外故障期间的火花间隙自触发现象,对故障期间波形进行详细分析,判断间隙自触发原因,提出解决方案,避免对设备进行过度的检查而造成高压输电线路不能在其最优的运行方式下运行,影响电力系统的稳定性。 展开更多
关键词 串补 区外故障 间隙触发
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Effects of different statins application methods on plaques in patients with coronary atherosclerosis 被引量:1
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作者 xia wu xiao-Bo Liu +2 位作者 Ting Liu Wen Tian Yu-Jiao Sun 《World Journal of Clinical Cases》 SCIE 2021年第4期812-821,共10页
BACKGROUND Discontinued application of statins may be related to adverse cardiovascular events.However,it is unclear whether different statins administration methods have effects on coronary artery plaques.AIM To eval... BACKGROUND Discontinued application of statins may be related to adverse cardiovascular events.However,it is unclear whether different statins administration methods have effects on coronary artery plaques.AIM To evaluate the effects of different statins application methods on plaques in patients with coronary atherosclerosis.METHODS A total of 100 patients diagnosed with atherosclerotic plaque by coronary artery computed tomography were continuously selected and divided into three groups according to different statins administration methods(discontinued application group,n=32;intermittent application group,n=39;sustained application group,n=29).The effects of the different statins application methods on coronary atherosclerotic plaque were assessed.RESULTS The volume change and rate of change of the most severe plaques were significantly reduced in the sustained application group(P≤0.001).The volume change of the most severe plaques correlated positively with low-density lipoprotein(LDL-C)levels only in the sustained application group(R=0.362,P=0.013).There were no changes in plaques or LDL-C levels in the intermittent and discontinued application groups.CONCLUSION Continuous application of statins is effective for controlling plaque progression,whereas discontinued or intermittent administration of statins is not conducive to controlling plaques.Only with continuous statins administration can a reduction in LDL-C levels result in plaque volume shrinkage. 展开更多
关键词 Coronary atherosclerotic plaque STATIN Coronary artery computed tomography Low-density lipoprotein Plaque volume
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Postoperative multidrug-resistant Acinetobacter baumannii meningitis successfully treated with intravenous doxycycline and intraventricular gentamicin: A case report 被引量:1
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作者 xia wu Lu Wang +1 位作者 Ying-Zi Ye Hui Yu 《World Journal of Clinical Cases》 SCIE 2019年第24期4342-4348,共7页
BACKGROUND Multidrug-resistant Acinetobacter baumannii(MDRAB) has emerged as an increasingly important pathogen that causes nosocomial meningitis. However,MDRAB-associated nosocomial meningitis is rarely reported in c... BACKGROUND Multidrug-resistant Acinetobacter baumannii(MDRAB) has emerged as an increasingly important pathogen that causes nosocomial meningitis. However,MDRAB-associated nosocomial meningitis is rarely reported in children.CASE SUMMARY We report the case of a 1-year-old girl with a choroid plexus papilloma, who developed postoperative nosocomial meningitis due to MDRAB. The bacterial strain was sensitive only to tigecycline and colistin, and showed varying degrees of resistance to penicillin, amikacin, ceftriaxone, cefixime, cefotaxime,ciprofloxacin, levofloxacin, gentamicin, meropenem, imipenem, and tobramycin.She was cured with intravenous doxycycline and intraventricular gentamicin treatment.CONCLUSION Doxycycline and gentamicin were shown to be effective and safe in the treatment of a pediatric case of MDRAB meningitis. 展开更多
关键词 Acinetobacter baumannii Meningitis DOXYCYCLINE GENTAMICIN Multidrug resistance Case report
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低压电力电容器投入过程的暂态分析 被引量:6
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作者 夏武 夏文 《电器与能效管理技术》 2020年第4期93-98,共6页
以低压普通型和抑制谐波型的分相补偿电力电容器为研究对象,考虑系统阻抗和负载阻抗等因数构建分补型低压电力电容器等效单相数学模型,进而分析其投入时的暂态过程,得到分相补偿电力电容器投入的最佳理想条件,为电力电容器的智能控制提... 以低压普通型和抑制谐波型的分相补偿电力电容器为研究对象,考虑系统阻抗和负载阻抗等因数构建分补型低压电力电容器等效单相数学模型,进而分析其投入时的暂态过程,得到分相补偿电力电容器投入的最佳理想条件,为电力电容器的智能控制提供理论支撑。最后,通过算例、仿真以及试验验证了上述分析的正确性。 展开更多
关键词 低压电力电容器 暂态分析 非齐次微分方程 数学模型
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标准化:养老服务业健康发展的必然选择 被引量:1
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作者 夏武 夏仕骏 《中国标准化》 2021年第13期155-157,共3页
本文阐明了在养老服务行业实行标准化管理的可行性和必要性,强调了建立和实施养老标准服务体系的重要性,探讨了养老标准化管理的有效途径和方法。
关键词 标准化 养老服务业
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基于FPGA的APF温度检测与分级控制保护策略 被引量:2
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作者 夏武 夏文 王宗臣 《电器与能效管理技术》 2018年第14期51-55,共5页
IGBT模块温度是有源电力滤波器(APF)可靠运行的关键因素之一。首先在分析常见温度检测和保护方法缺点的基础上,提出一种采用内置NTC热敏电阻直接测量IGBT结温,利用压频转换、光纤隔离传送、FPGA硬件测频的检测方案,并提出分级温度控制... IGBT模块温度是有源电力滤波器(APF)可靠运行的关键因素之一。首先在分析常见温度检测和保护方法缺点的基础上,提出一种采用内置NTC热敏电阻直接测量IGBT结温,利用压频转换、光纤隔离传送、FPGA硬件测频的检测方案,并提出分级温度控制和极限硬件保护的温控策略。最后,通过FPGA硬件实现测频计算温度,使用ModelSim进行时序仿真及试验,验证了所提出方法的可行性。 展开更多
关键词 有源电力滤波器 温度分级控制 硬件保护 FPGA硬件测频
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500 kV并联电抗器保护原理及现场校验调试方法研究 被引量:1
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作者 夏武 黄聪 《电工技术》 2021年第15期73-75,共3页
从超高压输电线路并联电抗器保护装置的工作原理入手,在详细介绍差动保护、匝间保护原理和动作特性的基础上,提出了一种电抗器保护原理、保护定值的现场调试方法。该调试方法能及时发现并消除设备缺陷,满足实际工程需要,为今后超高压输... 从超高压输电线路并联电抗器保护装置的工作原理入手,在详细介绍差动保护、匝间保护原理和动作特性的基础上,提出了一种电抗器保护原理、保护定值的现场调试方法。该调试方法能及时发现并消除设备缺陷,满足实际工程需要,为今后超高压输电线路并联电抗器保护装置的设计、运行和维护积累了宝贵的经验。 展开更多
关键词 电抗器保护 匝间保护 差动保护 调试
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壳聚糖包裹CdSe量子点组装体的水相可见光催化CO_(2)还原
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作者 夏雾 任颖异 +1 位作者 刘京 王锋 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2022年第7期22-31,共10页
通过壳聚糖(chitosan)中的氨基与MPA-CdSe(MPA=3-巯基丙酸)量子点(QDs)表面Cd^(2+)的配位作用,构建了MPA-CdSe@chitosan组装体.壳聚糖中丰富的氨基和疏水结构为量子点提供了富CO_(2)及疏水的微环境,从而提升了水相光催化CO_(2)还原效率... 通过壳聚糖(chitosan)中的氨基与MPA-CdSe(MPA=3-巯基丙酸)量子点(QDs)表面Cd^(2+)的配位作用,构建了MPA-CdSe@chitosan组装体.壳聚糖中丰富的氨基和疏水结构为量子点提供了富CO_(2)及疏水的微环境,从而提升了水相光催化CO_(2)还原效率和选择性.光催化实验结果表明,在以抗坏血酸钠(NaHA)为电子牺牲体的条件下,MPA-CdSe@chitosan组装体在水中可将CO_(2)光催化还原为CO,CO的生成效率和选择性分别比不含壳聚糖的MPA-CdSe QDs体系提升169倍和8.6倍.用组装体系光催化60 h后,CO的生成效率为73.6 mmol/g(基于量子点质量),对应的选择性达到51.0%,具有良好的稳定性. 展开更多
关键词 光催化 CO_(2)还原 组装体 CDSE量子点 壳聚糖
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变电站内电缆识别方法的探讨 被引量:1
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作者 罗义晖 杨雪飞 +2 位作者 欧俊延 夏武 黄承喜 《电工技术》 2019年第4期62-63,共2页
本文提出了一种变电站内电缆(光缆)识别的方法,改变了以往只在电缆两侧有电缆标识的现状,使得在繁杂的电缆沟内能够方便、快速、准确地查找出所需要的电缆,极大地降低误剪、误伤运行电缆的风险。
关键词 电缆 分类 标识
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