Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome:A Systematic Review and Meta-Analysis

Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome(IBS)with a systematic review and meta-analysis.Methods We searched MEDLINE,Embase,the Cochrane Library,Web of Science,and IEEE Xplore databases until September 2023.Cross-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were identified.We estimated the pooled sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,and diagnostic odds ratio with a 95% confidence interval(CI),and plotted a summary receiver operat-ing characteristic curve and evaluated the area under the curve.Results Four studies were included.The pooled diagnostic sensitivity,specificity,positive likelihood ratio,nega-tive likelihood ratio,and diagnostic odds ratio were 0.94(95%CI,0.87‒0.97),0.89(95%CI,0.81‒0.94),8.43(95%CI,4.81‒14.78),0.07(95%CI,0.03‒0.15),and 118.86(95%CI,44.18‒319.75),respectively,with an area under the curve of 0.97(95%CI,0.95‒0.98).Conclusions Computerized bowel sound analysis is a promising tool for IBS.However,limited high-quality data make the results'validity and applicability questionable.There is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis of IBS.

Intestinal microecology-based treatment for inflammatory bowel disease:Progress and prospects

Inflammatory bowel disease(IBD)is a chronic,recurrent,and debilitating disorder,and includes Crohn’s disease and ulcerative colitis.The pathogenesis of IBD is closely associated with intestinal dysbiosis,but has not yet been fully clarified.Genetic and environmental factors can influence IBD patients’gut microbiota and metabolism,disrupt intestinal barriers,and trigger abnormal immune responses.Studies have reported the alteration of gut microbiota and metabolites in IBD,providing the basis for potential therapeutic options.Intestinal microbiota-based treatments such as pre/probiotics,metabolite supplementation,and fecal microbiota transplantation have been extensively studied,but their clinical efficacy remains controversial.Repairing the intestinal barrier and promoting mucosal healing have also been proposed.We here review the current clinical trials on intestinal microecology and discuss the prospect of research and practice in this field.