Clinical Study on the Therapeutic Effect of Combined Traditional Chinese Medicine with Acupoint Injection and Herbal Paste Application in Treating Ovulatory Dysfunction in Polycystic Ovary Syndrome (PCOS)

Objective: To observe the therapeutic effect of combined traditional Chinese medicine (TCM) therapy with acupoint injection and herbal patch application on patients with ovulatory dysfunction associated with polycystic ovary syndrome (PCOS). Methods: A total of 80 PCOS patients who received treatment at the First Affiliated Hospital of Guangxi University of Chinese Medicine between October 2022 and March 2024 were enrolled in this study. They were randomly divided into a control group (n = 40) and an observation group (n = 40). The control group received conventional Western medical treatments, while the observation group was administered TCM combined with acupoint injection and herbal patch application. Pre- and post-treatment conditions were compared between the two groups. Results: After treatment, the overall effective rate was significantly higher in the observation group compared to the control group (P 0.05). Following treatment, both ovulation and pregnancy rates increased in both groups, but the increase was more evident in the observation group, showing a statistically significant difference (P < 0.01). Conclusion: For patients with oligoovulation or anovulation due to PCOS, the combined use of TCM, acupoint injection, and herbal patch application appears to be effective in improving systemic symptoms and achieving notable clinical outcomes.

Comparison of enhancement techniques based on neural networks for attenuated voice signal captured by flexible vibration sensors on throats

Wearable flexible sensors attached on the neck have been developed to measure the vibration of vocal cords during speech.However,highfrequency attenuation caused by the frequency response of the flexible sensors and absorption of high-frequency sound by the skin are obstacles to the practical application of these sensors in speech capture based on bone conduction.In this paper,speech enhancement techniques for enhancing the intelligibility of sensor signals are developed and compared.Four kinds of speech enhancement algorithms based on a fully connected neural network(FCNN),a long short-term memory(LSTM),a bidirectional long short-term memory(BLSTM),and a convolutional-recurrent neural network(CRNN)are adopted to enhance the sensor signals,and their performance after deployment on four kinds of edge and cloud platforms is also investigated.Experimental results show that the BLSTM performs best in improving speech quality,but is poorest with regard to hardware deployment.It improves short-time objective intelligibility(STOI)by 0.18 to nearly 0.80,which corresponds to a good intelligibility level,but it introduces latency as well as being a large model.The CRNN,which improves STOI to about 0.75,ranks second among the four neural networks.It is also the only model that is able to achieves real-time processing with all four hardware platforms,demonstrating its great potential for deployment on mobile platforms.To the best of our knowledge,this is one of the first trials to systematically and specifically develop processing techniques for bone-conduction speed signals captured by flexible sensors.The results demonstrate the possibility of realizing a wearable lightweight speech collection system based on flexible vibration sensors and real-time speech enhancement to compensate for high-frequency attenuation.

Pd-catalyzed sequential reaction for the synthesis of fused tricyclic compounds containing a dihydrofuran or isobenzofuranone unit

A novel Pd-catalyzed sequential reaction for the synthesis of fused tricyclic compounds with a dihydrofuran or isobenzofuranone unit was developed.

A Convenient Synthesis of Diacyl Selenides by Selenium Transfer Reaction of Primary Selenoamides

As a selenium transfer reagent, arylselenoamides react with acyl chlorides in chloroform to give diacyl selenides conveniently in good yield.

Regio- and stereo-selective synthesis of multi-substituted 3-pyrrolines

A regio- and stereo-selective synthesis of multi-substituted 3-pyrrolines has been developed. The multi-substituted 3-pyrrolines were synthesized in good yields by 1,3-dipolar cycloaddition of methyl 2-（phenylselanyl）acrylate with azomethine ylides, followed by N-acylation and oxidation-elimination of phenylseleno group. 2009 Xian Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

A Facile One-pot Method for the Synthesis of Vinyl Ethers from 2-Hydroxyalkyl Phenyl Selenides

A mild, one-pot procedure for the synthesis of vinyl ethers in good yields from 2-hydroxyalkyl phenyl selenides with primary or secondary organic halides has been developed.

Solid Phase Synthesis of 1,4-Disubstituted 1,2,3-Triazole from Polystyrene-supported Selenium Resin

We report here a solid-phase synthesis of 1, 4-disubstituted 1, 2, 3-triazole using polystyrene-supported selenium resin. The resin used here not only works as a simple linker, but also assists the crucial α-alkylation reaction and selenoxide syn-elimimation, which ensures the purity of the products.

Polymer-support Selenium-induced Electrophilic Cyclization:Solid-phase Synthesis of Flavonoids

The Lewis acid mediated polystyrene supported selenium cyclization of chalcones and oxidative cleavage of selenium resins flavonoids in good yields and purities have been reported. induced intramolecular gave the corresponding

The facile insertion of β-keto sulfones to arynes:The direct preparation of polysubstituted ortho-keto benzyl sulfones

One novel carbon-carbon bond insertion reaction of arynes has been developed. By this reaction β-keto sulfones can insert the triple bond of arynes to prepare polysubstituted ortho-keto benzyl sulfones.

Solid Phase Synthesis of 4(1H)Quinolones from Resin-Bound Cyclic Malonic Ester

The solid phase synthesis of 4 (1H) quinolones has been reported.

A Facile Synthesis of α-Phenylthio-α, β-Unsatuated Esters

a-Phenylthio-a, b-unsaturated esters 6 were synthesized by Witting reaction of 3, which were prepared by a phenylsulfenyllation-trans-ylidation reaction.

Solid-phase synthesis of (Z)-allyl iodides from 3-acetoxy-2-methylene-alkanoates with recyclable polymer-supported selenium bromide

Reaction of polystyrene-supported lithium selenide with 3-acetoxy-2-methylene-alkanoates afforded the corresponding allyl selenide resins and subsequent cleavage from the polymer by treating with methyl iodide to furnish （Z）-allyl iodides in good yields and high purities. The polymeric selenium reagent can be regenerated and reused. So it is a environmentally benign reagent.

An Efficient Deselenenylation Reaction to the Synthesis of 3, 5-Disubstituted Isoxazoline and Isoxazole

A mild deselenenylation reaction protocol for the preparation of 3, 5-disubstituted isoxazolines and their further application to 3-methyl-5-substituted isoxazoles both in solution phase and solid phase was reported.

Solid-phase Synthesis of Unsaturated β-Dicarbonyl Compounds from Polymer-supported 4-(Phenylseleno)morpholine

The solid-phase synthesis of unsaturated ?dicarbonyl compounds has been reported.

Traceless solid-phase synthesis of 3-substituted isoxazoles from polystyrene-supported vinyl selenide

A novel facile procedure for traceless solid-phase synthesis of 3-substituted isoxazoles in good yields and with excellent purities using polymer-supported vinyl selenide has been developed.

Arylation of Allyl, Cinnamyl and Propargyl Bromide with Triarylbismuth Catalyed by Pd(0)

Allyl and cinnamyl and propargyl bromide reacted under mild conditions with triarylbismuth under catalysis by Pd(O) to give 3-arylpropenes, 1, 3-diarylpropenes and arylpropadienes in modest to excellent yields.

Poly{[4-(hydroxyl)(tosyloxyl)iodo]styrene} Promoted Halotosyloxylation Reaction of Alkynes

Halotosyloxylation reaction of alkynes with iodine or NBS or NCS was efficiently promoted by the poly{[4-(hydroxyl)(tosoyloxyl)iodo]styrene}.

Solid Phase Synthesis of 4H-Pyrimido[2,1-b] Benzothiazol-4-ones from Resin-Bound Cyclic Malonic Ester

The solid phase synthesis of 4H-pyrimido[2,1-b] benzothiazol-4-ones has been reported.

Polystyrene-supported Benzyl Selenide: An Efficient Reagent for Highly Stereocontrolled Synthesis of Substituted Olefins

Polystyrene-supported benzyl selenide has been prepared. This novel reagent was treated with LDA to produce a selenium stabilized carbanion, which reacted with alkyl halide, followed by selenoxide syn-elimination, to give substituted olefins stereospecificly.

A New and Effective Synthesis of Terminal Alkylselenylacetylenes

The terminal alkylselenylacetylenes (RSe-C = C-H) 3a-h were prepared by the reaction of ethynylmagnesium bromide at -20 degrees C in THF with alkylselenyl bromides derived from dialkyl diselenides and bromide.