Hepatocellular carcinoma(HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2(ANXA2), is found to promote cancer progression and therapeutic re...Hepatocellular carcinoma(HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2(ANXA2), is found to promote cancer progression and therapeutic resistance.However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summarized the molecular function of ANXA2 in HCC and its relationship with prognosis. Furthermore, we tentatively elucidated the underlying mechanism of ANXA2 immune escape of HCC by upregulating the proportion of regulatory T cells and the expression of several inhibitory molecules, and by downregulating the proportion of natural killer cells and dendritic cells and the expression of several inhibitory molecules or effector molecules. We expect a lot of in-depth studies to further reveal the underlying mechanism of ANXA2 in immune escape of HCC in the future.展开更多
Different types of capital are better suited to financing technologies with different risk profiles,and structural matching between finance and technology may critically influence economic growth.Using cross-province ...Different types of capital are better suited to financing technologies with different risk profiles,and structural matching between finance and technology may critically influence economic growth.Using cross-province panel data from China,we estimated the impact of the matching relationship between regions'financial structure and technology level on economic growth.We show that:(ⅰ)the matching relationship had a statistically significant positive impact on economic growth;(ⅱ)structural mismatching reduced economic growth in comparison with the optimal matching point;(ⅲ)structural matching better facilitated economic growth in more developed regions;and(ⅳ)capital accumulation and technological progress were two of the main channels through which matching influenced economic growth.We address potential endogeneity concerns and perform robustness checks,and our results remain valid.Our findings provide convincing evidence for the optimalfinancial structure theory and explain China's rapid growth despite its comparatively underdeveloped securities market.展开更多
基金Supported by the National Natural Science Foundation of China,No.81401988China Postdoctoral Science Foundation,No.2019M661907+1 种基金Jiangsu Postdoctoral Science Foundation,No.2019K159 and No.2019Z153General Project of Jiangsu Provincial Health Committee,No.H2019101.
文摘Hepatocellular carcinoma(HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2(ANXA2), is found to promote cancer progression and therapeutic resistance.However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summarized the molecular function of ANXA2 in HCC and its relationship with prognosis. Furthermore, we tentatively elucidated the underlying mechanism of ANXA2 immune escape of HCC by upregulating the proportion of regulatory T cells and the expression of several inhibitory molecules, and by downregulating the proportion of natural killer cells and dendritic cells and the expression of several inhibitory molecules or effector molecules. We expect a lot of in-depth studies to further reveal the underlying mechanism of ANXA2 in immune escape of HCC in the future.
基金supported financially by the National Social ScienceFoundation of China(No.19AJY026).
文摘Different types of capital are better suited to financing technologies with different risk profiles,and structural matching between finance and technology may critically influence economic growth.Using cross-province panel data from China,we estimated the impact of the matching relationship between regions'financial structure and technology level on economic growth.We show that:(ⅰ)the matching relationship had a statistically significant positive impact on economic growth;(ⅱ)structural mismatching reduced economic growth in comparison with the optimal matching point;(ⅲ)structural matching better facilitated economic growth in more developed regions;and(ⅳ)capital accumulation and technological progress were two of the main channels through which matching influenced economic growth.We address potential endogeneity concerns and perform robustness checks,and our results remain valid.Our findings provide convincing evidence for the optimalfinancial structure theory and explain China's rapid growth despite its comparatively underdeveloped securities market.
