In recent years,most studies of complex networks have focused on a single network and ignored the interaction of multiple networks,much less the coupling mechanisms between multiplex networks.In this paper we investig...In recent years,most studies of complex networks have focused on a single network and ignored the interaction of multiple networks,much less the coupling mechanisms between multiplex networks.In this paper we investigate synchronization phenomena in multilayer networks with nonidentical topological structures based on three specific coupling mechanisms:assortative,disassortative,and anti-assortative couplings.We find rich and complex synchronous dynamic phenomena in coupled networks.We also study the behavior of effective frequencies for layers I and II to understand the underlying microscopic dynamics occurring under the three different coupling mechanisms.In particular,the coupling mechanisms proposed here have strong robustness and effectiveness and can produce abundant synchronization phenomena in coupled networks.展开更多
为探究^(60)Co-γ辐照对苦荞麸皮中黄酮类物质提取效率的影响,本研究采用不同剂量(0、6、12、18、24、30 k Gy)的^(60)Co-γ对苦荞麸皮进行辐照预处理,通过热回流法提取苦荞黄酮,比较^(60)Co-γ辐照对苦荞黄酮提取得率、主要黄酮类物质...为探究^(60)Co-γ辐照对苦荞麸皮中黄酮类物质提取效率的影响,本研究采用不同剂量(0、6、12、18、24、30 k Gy)的^(60)Co-γ对苦荞麸皮进行辐照预处理,通过热回流法提取苦荞黄酮,比较^(60)Co-γ辐照对苦荞黄酮提取得率、主要黄酮类物质单体含量和总含量、抑菌活性及苦荞麸皮微观结构的影响。结果表明,6~30 k Gy剂量的^(60)Co-γ辐照预处理可提高苦荞黄酮提取得率,其中12 k Gy组提取得率最高,为6.97%,较对照组的3.27%提高3.70个百分点;6~30 k Gy剂量的^(60)Co-γ辐照预处理可提高提取物中芦丁含量,12、18、30 k Gy剂量的预处理可提高提取物中烟花苷含量,其中12 k Gy组含量最高,芦丁和烟花苷含量分别为84.52、3.92 mg·g^(-1),较对照组的53.12、3.54 mg·g^(-1)分别提高59.11%与10.73%;6~24 k Gy剂量的^(60)Co-γ辐照预处理可提高苦荞主要黄酮总含量,其中12 k Gy组最高,为89.40 mg·g^(-1),较对照组的57.95 mg·g^(-1)提高54.27%。此外,^(60)Co-γ辐照可有效破坏苦荞麸皮组织结构,有助于苦荞黄酮的溶出;6~18 k Gy剂量的^(60)Co-γ辐照预处理增强了提取物对大肠杆菌的抑菌活性,其中18 k Gy剂量组的抑菌活性最强,抑菌圈直径达9.93 mm;12~24 k Gy剂量的^(60)Co-γ辐照预处理增强了提取物对金黄色葡萄球菌的抑菌活性,其中12 k Gy剂量组的抑菌活性最强,抑菌圈直径达10.30 mm。本研究可为苦荞黄酮的高效提取提供研究基础与技术参考。展开更多
采用液相色谱-质谱联用法(Liquid Chromatography-tandem Mass Spectrometry,LC-MS/MS)结合多元统计分析对12种香型白酒中的18种吡嗪类化合物进行分析,并用S型曲线、Feller加和模型、香气活度值(Odor Activity Value,OAV)法和σ-τ模型...采用液相色谱-质谱联用法(Liquid Chromatography-tandem Mass Spectrometry,LC-MS/MS)结合多元统计分析对12种香型白酒中的18种吡嗪类化合物进行分析,并用S型曲线、Feller加和模型、香气活度值(Odor Activity Value,OAV)法和σ-τ模型研究三甲基吡嗪与乙酸乙酯、丁酸乙酯、己酸乙酯和乳酸乙酯之间的感知交互作用。LC-MS/MS方法在检测范围内线性关系良好(R2≥0.995),检出限为0.69~43.47μg/L,定量限为2.10~95.21μg/L,日内精密度≤4.71%、日间精密度≤4.11%,加标回收率82.22%~103.71%。酱香型白酒吡嗪总量最高,为10411.71~32628.30μg/L,其次是兼、芝麻和董香型白酒,四甲基吡嗪和三甲基吡嗪是白酒中含量最高的2种吡嗪类化合物。正交偏最小二乘判别分析(Orthogonal Partial Least Squares Discriminant Analysis,OPLS-DA)模型可对12种香型白酒进行大致分类,变量重要性投影值(Variable Importance in the Projection,VIP)分析筛选出9种关键差异吡嗪类化合物,2-甲基吡嗪的VIP值最高,为1.33。感知交互作用的研究结果表明三甲基吡嗪与乙酸乙酯、丁酸乙酯和己酸乙酯之间存在加成或协同作用,与乳酸乙酯之间是掩盖作用。该研究可为白酒的风味品质调控提供理论参考。展开更多
Our recent breakthrough discovery demonstrated that the anticancer drug FL118 tightly binds to and then dephosphorylates and degrades the oncogenic protein DEAD-box helicase 5(DDX5),leading to the inhibition of DDX5 d...Our recent breakthrough discovery demonstrated that the anticancer drug FL118 tightly binds to and then dephosphorylates and degrades the oncogenic protein DEAD-box helicase 5(DDX5),leading to the inhibition of DDX5 downstream targets(e.g.,survivin,myeloid cell leukemia 1(Mcl-1),X-linked inhibitor of apoptosis(XIAP),c-Myc,mutant Kras,etc.)[1].FL118 is a molecular glue(MG)that can alter the interactomes of two or more non-interacting proteins[2].Thus,FL118 exhibits high efficacy against colorectal and pancreatic cancer xenograft tumors[1,3].However,moving FL118 into clinical trials requires a clinically compatible FL118 drug product(DP)that possesses high antitumor efficacy and low toxicity via oral(ideal)or intravenous(iv)administration.Here,we report the development and characterization of a clinically and orally compatible FL118 DP.We show that(1)FL118 drug substances(DS)exhibit high chemical stability under various test conditions;(2)a clinically and orally compatible FL118 DP can be manufactured through the formulation of FL118 DS with 2-hydroxypropyl-bcyclodextrin(HPbCD)using mixed solvents of glacial acetic acid(GAA)with ethanol through microfluidizer-mediated spray dried dispersion(M-SDD).展开更多
直驱风电场并入弱交流电网次同步振荡(sub-synchronous oscillation,SSO)威胁电力系统安全运行,分析其次同步分量通路能够揭示系统内部次同步交互作用特性,并能够分别针对每条通路进行阻尼特性分析,目前尚无文献开展相关研究。针对上述...直驱风电场并入弱交流电网次同步振荡(sub-synchronous oscillation,SSO)威胁电力系统安全运行,分析其次同步分量通路能够揭示系统内部次同步交互作用特性,并能够分别针对每条通路进行阻尼特性分析,目前尚无文献开展相关研究。针对上述问题,该文首先建立直驱风电场并入弱交流电网系统闭环传递函数框图,并利用阻尼转矩法分析直驱风电机组直流电容主导的振荡模态。然后,基于传递函数框图,分析得到2条次同步分量通路:直驱风电场内部次同步分量通路以及直驱风电场和弱交流系统之间的次同步分量通路。最后,利用通路阻尼分析,结合时域仿真,分别分析直驱风电机组网侧控制器(grid side controller,GSC)参数对2条通路阻尼特性的影响。结果表明:GSC直流电压外环积分系数增大时,2条次同步分量通路的阻尼均减小;直流电压外环比例系数和电流内环比例、积分系数减小会导致直驱风电场内部次同步分量通路的阻尼减小。研究结果对阻尼控制器的设计有一定的指导意义。展开更多
基金Project supported by the National Natural Science Foundation of China(Grants Nos.71801066 and 71704046)the Natural Science Foundation of Anhui Province,China(Grant Nos.1808085QG225 and 1908085MA22)+1 种基金the FundamentalResearch Funds for the Central Universities,China(Grant Nos.JZ2020HGTB0021 and JZ2021HGTB0065)the Outstanding Young Talent Support Program in Universities of Anhui Province in 2020 year。
文摘In recent years,most studies of complex networks have focused on a single network and ignored the interaction of multiple networks,much less the coupling mechanisms between multiplex networks.In this paper we investigate synchronization phenomena in multilayer networks with nonidentical topological structures based on three specific coupling mechanisms:assortative,disassortative,and anti-assortative couplings.We find rich and complex synchronous dynamic phenomena in coupled networks.We also study the behavior of effective frequencies for layers I and II to understand the underlying microscopic dynamics occurring under the three different coupling mechanisms.In particular,the coupling mechanisms proposed here have strong robustness and effectiveness and can produce abundant synchronization phenomena in coupled networks.
文摘为探究^(60)Co-γ辐照对苦荞麸皮中黄酮类物质提取效率的影响,本研究采用不同剂量(0、6、12、18、24、30 k Gy)的^(60)Co-γ对苦荞麸皮进行辐照预处理,通过热回流法提取苦荞黄酮,比较^(60)Co-γ辐照对苦荞黄酮提取得率、主要黄酮类物质单体含量和总含量、抑菌活性及苦荞麸皮微观结构的影响。结果表明,6~30 k Gy剂量的^(60)Co-γ辐照预处理可提高苦荞黄酮提取得率,其中12 k Gy组提取得率最高,为6.97%,较对照组的3.27%提高3.70个百分点;6~30 k Gy剂量的^(60)Co-γ辐照预处理可提高提取物中芦丁含量,12、18、30 k Gy剂量的预处理可提高提取物中烟花苷含量,其中12 k Gy组含量最高,芦丁和烟花苷含量分别为84.52、3.92 mg·g^(-1),较对照组的53.12、3.54 mg·g^(-1)分别提高59.11%与10.73%;6~24 k Gy剂量的^(60)Co-γ辐照预处理可提高苦荞主要黄酮总含量,其中12 k Gy组最高,为89.40 mg·g^(-1),较对照组的57.95 mg·g^(-1)提高54.27%。此外,^(60)Co-γ辐照可有效破坏苦荞麸皮组织结构,有助于苦荞黄酮的溶出;6~18 k Gy剂量的^(60)Co-γ辐照预处理增强了提取物对大肠杆菌的抑菌活性,其中18 k Gy剂量组的抑菌活性最强,抑菌圈直径达9.93 mm;12~24 k Gy剂量的^(60)Co-γ辐照预处理增强了提取物对金黄色葡萄球菌的抑菌活性,其中12 k Gy剂量组的抑菌活性最强,抑菌圈直径达10.30 mm。本研究可为苦荞黄酮的高效提取提供研究基础与技术参考。
文摘采用液相色谱-质谱联用法(Liquid Chromatography-tandem Mass Spectrometry,LC-MS/MS)结合多元统计分析对12种香型白酒中的18种吡嗪类化合物进行分析,并用S型曲线、Feller加和模型、香气活度值(Odor Activity Value,OAV)法和σ-τ模型研究三甲基吡嗪与乙酸乙酯、丁酸乙酯、己酸乙酯和乳酸乙酯之间的感知交互作用。LC-MS/MS方法在检测范围内线性关系良好(R2≥0.995),检出限为0.69~43.47μg/L,定量限为2.10~95.21μg/L,日内精密度≤4.71%、日间精密度≤4.11%,加标回收率82.22%~103.71%。酱香型白酒吡嗪总量最高,为10411.71~32628.30μg/L,其次是兼、芝麻和董香型白酒,四甲基吡嗪和三甲基吡嗪是白酒中含量最高的2种吡嗪类化合物。正交偏最小二乘判别分析(Orthogonal Partial Least Squares Discriminant Analysis,OPLS-DA)模型可对12种香型白酒进行大致分类,变量重要性投影值(Variable Importance in the Projection,VIP)分析筛选出9种关键差异吡嗪类化合物,2-甲基吡嗪的VIP值最高,为1.33。感知交互作用的研究结果表明三甲基吡嗪与乙酸乙酯、丁酸乙酯和己酸乙酯之间存在加成或协同作用,与乳酸乙酯之间是掩盖作用。该研究可为白酒的风味品质调控提供理论参考。
文摘Our recent breakthrough discovery demonstrated that the anticancer drug FL118 tightly binds to and then dephosphorylates and degrades the oncogenic protein DEAD-box helicase 5(DDX5),leading to the inhibition of DDX5 downstream targets(e.g.,survivin,myeloid cell leukemia 1(Mcl-1),X-linked inhibitor of apoptosis(XIAP),c-Myc,mutant Kras,etc.)[1].FL118 is a molecular glue(MG)that can alter the interactomes of two or more non-interacting proteins[2].Thus,FL118 exhibits high efficacy against colorectal and pancreatic cancer xenograft tumors[1,3].However,moving FL118 into clinical trials requires a clinically compatible FL118 drug product(DP)that possesses high antitumor efficacy and low toxicity via oral(ideal)or intravenous(iv)administration.Here,we report the development and characterization of a clinically and orally compatible FL118 DP.We show that(1)FL118 drug substances(DS)exhibit high chemical stability under various test conditions;(2)a clinically and orally compatible FL118 DP can be manufactured through the formulation of FL118 DS with 2-hydroxypropyl-bcyclodextrin(HPbCD)using mixed solvents of glacial acetic acid(GAA)with ethanol through microfluidizer-mediated spray dried dispersion(M-SDD).
文摘直驱风电场并入弱交流电网次同步振荡(sub-synchronous oscillation,SSO)威胁电力系统安全运行,分析其次同步分量通路能够揭示系统内部次同步交互作用特性,并能够分别针对每条通路进行阻尼特性分析,目前尚无文献开展相关研究。针对上述问题,该文首先建立直驱风电场并入弱交流电网系统闭环传递函数框图,并利用阻尼转矩法分析直驱风电机组直流电容主导的振荡模态。然后,基于传递函数框图,分析得到2条次同步分量通路:直驱风电场内部次同步分量通路以及直驱风电场和弱交流系统之间的次同步分量通路。最后,利用通路阻尼分析,结合时域仿真,分别分析直驱风电机组网侧控制器(grid side controller,GSC)参数对2条通路阻尼特性的影响。结果表明:GSC直流电压外环积分系数增大时,2条次同步分量通路的阻尼均减小;直流电压外环比例系数和电流内环比例、积分系数减小会导致直驱风电场内部次同步分量通路的阻尼减小。研究结果对阻尼控制器的设计有一定的指导意义。
