期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
红景天苷对近视豚鼠脉络膜厚度及HIF-1α和多巴胺及其受体表达的影响 被引量:1
1
作者 赵爽 房祥杰 +4 位作者 张娟美 赵军 许莞菁 郑凌方 付艺璇 《国际眼科杂志》 CAS 北大核心 2023年第8期1264-1268,共5页
目的:探讨红景天苷(SA)对透镜诱导型近视(LIM)豚鼠脉络膜厚度及缺氧诱导因子-1α(HIF-1α)、多巴胺及其D1受体表达的影响。方法:将18只2周龄豚鼠随机分为正常对照(NC)组、LIM组和透镜诱导型近视+红景天苷(LIM+SA)组,每组6只。NC组正常饲... 目的:探讨红景天苷(SA)对透镜诱导型近视(LIM)豚鼠脉络膜厚度及缺氧诱导因子-1α(HIF-1α)、多巴胺及其D1受体表达的影响。方法:将18只2周龄豚鼠随机分为正常对照(NC)组、LIM组和透镜诱导型近视+红景天苷(LIM+SA)组,每组6只。NC组正常饲养,给予2mL/d生理盐水灌胃;LIM组豚鼠右眼前配戴-5D透镜,建立近视模型,给予2mL/d生理盐水灌胃;LIM+SA组豚鼠右眼前配戴-5D透镜同时给予2mL/d红景天苷(100mg/kg)灌胃。造模4wk后测量各组豚鼠右眼屈光度、眼轴长度及脉络膜厚度,通过实时荧光定量PCR(qPCR)和免疫组织化学(IHC)检测各组豚鼠右眼脉络膜视网膜HIF-1α mRNA及蛋白表达量,通过酶联免疫吸附实验(ELISA)和Western blot法检测多巴胺浓度及其D1受体表达量。结果:造模4wk后,与NC组比较,LIM组和LIM+SA组豚鼠右眼屈光度均负向增加,眼轴均延长,脉络膜厚度均减小,脉络膜视网膜HIF-1α mRNA和蛋白表达量均增加,多巴胺浓度及其D1受体表达量均降低;与LIM组比较,LIM+SA组豚鼠右眼近视屈光度明显减小,眼轴长度较短,脉络膜厚度增加,脉络膜视网膜HIF-1α mRNA和蛋白表达量均降低,多巴胺浓度及其D1受体表达量均增加。结论:红景天苷干预近视豚鼠可通过影响脉络膜厚度及HIF-1α、多巴胺及其D1受体的表达延缓近视进展。 展开更多
关键词 红景天苷 透镜诱导型近视 脉络膜 缺氧诱导因子-1α(HIF-1α) 多巴胺
下载PDF
Lower gastrointestinal bleeding:Role of 64-row computed tomographic angiography in diagnosis and therapeutic planning 被引量:7
2
作者 Jian-Zhuang Ren Meng-Fan Zhang +8 位作者 Ai-Mei Rong xiang-jie fang Kai Zhang Guo-Hao Huang Peng-Fei Chen Zhao-Yang Wang Xu-Hua Duan Xin-Wei Han Yan-Jie Liu 《World Journal of Gastroenterology》 SCIE CAS 2015年第13期4030-4037,共8页
AIM: To determine the value of computed tomographic angiography(CTA) for diagnosis and therapeutic planning in lower gastrointestinal(GI) bleeding.METHODS: Sixty-three consecutive patients with acute lower GI bleeding... AIM: To determine the value of computed tomographic angiography(CTA) for diagnosis and therapeutic planning in lower gastrointestinal(GI) bleeding.METHODS: Sixty-three consecutive patients with acute lower GI bleeding underwent CTA before endovascular or surgical treatment. CTA was used to determine whether the lower GI bleeding was suitable for endovascular treatment, surgical resection, or conservative treatment in each patient. Treatment planning with CTA was compared with actual treatment decisions or endovascular or surgical treatment that had been carried out in each patient based on CTA findings.RESULTS: 64-row CTA detected active extravasation of contrast material in 57 patients and six patients had no demonstrable active bleeding, resulting in an accuracy of 90.5% in the detection of acute GI bleeding(57 of 63). In three of the six patients with no demonstrable active bleeding, active lower GI bleeding recurred within one week after CTA, and angiography revealed acute bleeding. The overall location-based accuracy, sensitivity, specificity, positive predictive value(PPV) and negative predictive value(NPV) for the detection of GI bleeding by 64-row CTA were 98.8%(249 of 252), 95.0%(57 of 60), 100%(192 of 192), 100%(57 of 57), and 98.5%(192 of 195), respectively. Treatment planning was correctly established on the basis of 64-row CTA with an accuracy, sensitivity, specificity, PPV and NPV of 98.4%(248 of 252), 93.3%(56 of 60), 100%(192 of 192), 100%(56 of 56), and 97.5%(192 of 196), respectively, in a location-based evaluation. CONCLUSION: 64-row CTA is safe and effective in making decisions regarding treatment, without performing digital subtraction angiography or surgery, in the majority of patients with lower GI bleeding. 展开更多
关键词 GASTROINTESTINAL BLEEDING Digital subtractionangio
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部