Model Predictive Control Strategy of Multi-Port Interline DC Power Flow Controller

There are issues with flexible DC transmission system such as a lack of control freedom over power flow.In order to tackle these issues,a DC power flow controller(DCPFC)is incorporated into a multi-terminal,flexible DC power grid.In recent years,a multi-port DC power flow controller based on a modular multi-level converter has become a focal point of research due to its simple structure and robust scalability.This work proposes a model predictive control(MPC)strategy for multi-port interline DC power flow controllers in order to improve their steady-state dynamic performance.Initially,the mathematical model of a multi-terminal DC power grid with a multi-port interline DC power flow controller is developed,and the relationship between each regulated variable and control variable is determined;The power flow controller is then discretized,and the cost function and weight factor are built with numerous control objectives.Sub module sorting method and nearest level approximation modulation regulate the power flow controller;Lastly,theMATLAB/Simulink simulation platformis used to verify the correctness of the establishedmathematicalmodel and the control performance of the suggestedMPC strategy.Finally,it is demonstrated that the control strategy possesses the benefits of robust dynamic performance,multiobjective control,and a simple structure.

Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients

B cells play an important role in the clearance of hepatitis B virus （HBV） and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of peripheral B-cell subsets from CHB patients in different phases： immune tolerance （IT）, immune activation （IA）, immune clearance （IC）, responders with HBsAg seroconversion （resolved patients, RP）, and healthy controls （HC）. IA patients displayed lower percentages of peripheral blood memory B cells compared with the other groups. Overall polyclonal activation of B cells, indicated by higher levels of activation markers and secretion of IgG and IgM, was observed in IA patients. This B-cell hyperactivation could be induced by increased IFN-a and soluble CD40 ligands in IA patients. Notably, the expression of the co-stimulator molecule CD80 and serum HBsAb and the frequency of HBsAg-specific B cells were significantly decreased in IT, IA, and IC patients compared with HC subjects. More importantly, the B-cell hyperactivation, co-stimulatory molecule downregulation and HBsAg-specific B-cell impairment were reversed in RP patients. The reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.

Regularity Results for a Nonlinear Elliptic-Parabolic System with Oscillating Coefficients

In this paper we study the initial boundary value problem for the system div(σ(u)∇φ)=0,u_(t)−∆u=σ(u)|∇φ|2.This problem is known as the thermistor problem which models the electrical heating of conductors.Our assumptions onσ(u)leave open the possibility that lim inf_(u→∞)σ(u)=0,while lim sup_(u→∞)σ(u)is large.This means thatσ(u)can oscillate wildly between 0 and a large positive number as u→∞.Thus our degeneracy is fundamentally different from the one that is present in porous medium type of equations.We obtain a weak solution(u,ϕ)with|∇φ|,|∇u|∈L∞by first establishing a uniform upper bound for eεu for some smallε.This leads to an inequality in∇φ,from which the regularity result follows.This approach enables us to avoid first proving the Holder continuity ofφin the space variables,which would have required that the elliptic coefficientσ(u)be an A2 weight.As it is known,the latter implies that lnσ(u)is“nearly bounded”.