Inactivated H9N2 vaccines developed with early strains do not protect against recent H9N2 viruses:Call for a change in H9N2 control policy

H9N2 virus has been widely distributed in wild birds and poultry around the world since its first emergence in the United States of America in 1966(Gu et al.2017;Carnaccini and Perez 2020).The virus appeared in chickens in China in the early 1990s,and over the last two decades has gradually become the dominant epidemic subtype(Sun and Liu 2015;Bi et al.2020).Although H9N2 virus infection alone cannot cause severe disease or death in poultry,H9N2 virus-infected birds experience a degree of egg production drop and can be easily infected by other pathogens,thus causing economic losses for poultry industry.

Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases

In the inflammatory microenvironment,there are numerous exosomes secreted by immune cells(Macrophages,neutrophils,dendritic cells),mesenchymal stem cells(MSCs)and platelets as intercellular communicators,which participate in the regulation of inflammation by modulating gene expression and releasing anti-inflammatory factors.Due to their good biocompatibility,accurate targeting,low toxicity and immunogenicity,these exosomes are able to selectively deliver therapeutic drugs to the site of inflammation through interactions between their surface-antibody or modified ligand with cell surface receptors.Therefore,the role of exosome-based biomimetic delivery strategies in inflammatory diseases has attracted increasing attention.Here we review current knowledge and techniques for exosome identification,isolation,modification and drug loading.More importantly,we highlight progress in using exosomes to treat chronic inflammatory diseases such as rheumatoid arthritis(RA),osteoarthritis(OA),atherosclerosis(AS),and inflammatory bowel disease(IBD).Finally,we also discuss their potential and challenges as anti-inflammatory drug carriers.

Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage Upregulation of neurotrophic factor expression

This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood. Rat models were intragastrically administered 5, 10, 20 g/kg Poxue Huayu and Tianjing Busui Decoction, supplemented with Hirudo, raw rhubarb, raw Pollen Typhae, gadfly, Fructrs Trichosanthis, Radix Notoginseng, Rhizoma Acori Talarinowii, and glue of tortoise plastron, once a day, for 14 consecutive days. Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage, and intracerebral hematoma volume markedly reduced after treat- ment. Immunohistochemical staining revealed that brain-derived neurotrophic factor, tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the sur- rounding hematoma. Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma. Neurologic impairment obviously reduced. These results indicated that Poxue Huayu and Tianjing Busui Decoction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor.

Dynamics of a multiplex neural network with delayed couplings

Multiplex networks have drawn much attention since they have been observed in many systems,e.g.,brain,transport,and social relationships.In this paper,the nonlinear dynamics of a multiplex network with three neural groups and delayed interactions is studied.The stability and bifurcation of the network equilibrium are discussed,and interesting neural activities of the network are explored.Based on the neuron circuit,transfer function circuit,and time delay circuit,a circuit platform of the network is constructed.It is shown that delayed couplings play crucial roles in the network dynamics,e.g.,the enhancement and suppression of the stability,the patterns of the synchronization between networks,and the generation of complicated attractors and multi-stability coexistence.

Multiple current peaks and spatial characteristics of atmospheric helium dielectric barrier discharges with repetitive unipolar narrow pulse excitation

Atmospheric dielectric barrier discharges driven by repetitive unipolar narrow pulse excitation are investigated numerically by using one-dimensional fluid models.The one-dimensional simulation focuses on the effects of applied voltage amplitude,pulse repetition frequency,gap width andγcoefficient on the multiple-current-pulse(MCP)discharge.The results indicate that the MCP behavior will lead to the stratification of electron density distribution in axial direction.Traditional MCP manipulating methods,such as reducing the applied voltage amplitude,increasing the applied voltage frequency,adjusting the gap width,cannot regulate MCPs exhibiting in this work.Further analyses reveal that the increasing electric field of the cathode fall region is the basis for the emergence of MCP behavior.

L^(2) EXTENSIONS WITH SINGULAR METRICS ON K?HLER MANIFOLDS

In this paper,we give a survey of our recent results on extension theorems on Kähler manifolds for holomorphic sections or cohomology classes of(pluri)canonical line bundles twisted with holomorphic line bundles equipped with singular metrics,and also discuss their applications and the ideas contained in the proofs.

PREFACE

This special issue of Acta Mathematica Scientia is dedicated to the memory of ProfessorJia-Rong Yu on the occasion of his hundredth anniversary.Professor Jia-Rong Yu, born November 16, 1920, passed away on October 14, 2020, at theage of one hundred. He is known as the founder of the Sino-French Mathematical Center inWuhan University, and was the director of this center from 1980 to 1994. In 1991, thanks to hiscolossal investment in Franco-Chinese cooperation, he was made officer in the order of academicpalms by the French Government.

全纯自同构群与开性L^(2)延拓

本文介绍作者们近期在多复变领域中若干问题上的研究进展,包括C^(n)的全纯自同构群理论和最优开性L^(2)延拓问题.

CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes

In this study,we identified that a conserved circular RNA(circRNA)DICAR,which was downregulated in diabetic mouse hearts.DICAR had an inhibitory effect on diabetic cardiomyopathy(DCM),as the spontaneous cardiac dysfunction,cardiac cell hypertrophy,and cardiac fibrosis occurred in DICAR deficiency(DICAR+/−)mice,whereas the DCM was alleviated in DICARoverexpressed DICARTg mice.At the cellular level,we found that overexpression of DICAR inhibited,but knockdown of DICAR enhanced the diabetic cardiomyocyte pyroptosis.At the molecular level,we identified that DICAR-VCP-Med12 degradation could be the underlying molecular mechanism in DICAR-mediated effects.The synthesized DICAR junction part(DICAR-JP)exhibited a similar effect to the entire DICAR.In addition,the expression of DICAR in circulating blood cells and plasma from diabetic patients was lower than that from health controls,which was consistent with the decreased DICAR expression in diabetic hearts.DICAR and the synthesized DICAR-JP may be drug candidates for DCM.

多复变简介:与单复变的联系 献给杨乐教授80华诞

本文围绕解析延拓,阐述多复变的一些基本内容、思想、方法及进展,并简述与单复变的联系.

Regularization of quasi-plurisubharmonic functions on complex manifolds

In this paper, we give a survey of various regularization theorems of quasi-plurisubharmonic functions on complex manifolds, and we also discuss the ideas used in their proofs. Moreover, we will present their applications in our studies on extension problems.

The Structure of Vector Bundles on Non-primary Hopf Manifolds

Let X be a Hopf manifold with non-Abelian fundamental group and E be a holomorphic vector bundle over X,with trivial pull-back to C^n-{0}.The authors show that there exists a line bundle L over X such that E■L has a nowhere vanishing section.It is proved that in case dim(X)≥3,π*(E)is trivial if and only if E is filtrable by vector bundles.With the structure theorem,the authors get the cohomology dimension of holomorphic bundle E over X with trivial pull-back and the vanishing of Chern class of E.

Stability of Multiplier Ideal Sheaves

In the present article, the authors find and establish stability of multiplier ideal sheaves, which is more general than strong openness.