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In situ calibrated angle between the quantization axis and the propagating direction of the light field for trapping neutral atoms
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作者 郭瑞军 何晓东 +7 位作者 盛诚 王坤鹏 许鹏 刘敏 王谨 孙晓红 曾勇 詹明生 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期318-323,共6页
The recently developed magic-intensity trapping technique of neutral atoms efficiently mitigates the detrimental effect of light shifts on atomic qubits and substantially enhances the coherence time. This technique re... The recently developed magic-intensity trapping technique of neutral atoms efficiently mitigates the detrimental effect of light shifts on atomic qubits and substantially enhances the coherence time. This technique relies on applying a bias magnetic field precisely parallel to the wave vector of a circularly polarized trapping laser field. However, due to the presence of the vector light shift experienced by the trapped atoms, it is challenging to precisely define a parallel magnetic field, especially at a low bias magnetic field strength, for the magic-intensity trapping of85Rb qubits. In this work, we present a method to calibrate the angle between the bias magnetic field and the trapping laser field with the compensating magnetic fields in the other two directions orthogonal to the bias magnetic field direction. Experimentally, with a constantdepth trap and a fixed bias magnetic field, we measure the respective resonant frequencies of the atomic qubits in a linearly polarized trap and a circularly polarized one via the conventional microwave Rabi spectra with different compensating magnetic fields and obtain the corresponding total magnetic fields via the respective resonant frequencies using the Breit–Rabi formula. With known total magnetic fields, the angle is a function of the other two compensating magnetic fields.Finally, the projection value of the angle on either of the directions orthogonal to the bias magnetic field direction can be reduced to 0(4)° by applying specific compensating magnetic fields. The measurement error is mainly attributed to the fluctuation of atomic temperature. Moreover, it also demonstrates that, even for a small angle, the effect is strong enough to cause large decoherence of Rabi oscillation in a magic-intensity trap. Although the compensation method demonstrated here is explored for the magic-intensity trapping technique, it can be applied to a variety of similar precision measurements with trapped neutral atoms. 展开更多
关键词 quantization axis trapping laser ANGLE compensating magnetic fields
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Laparoscopic spleen-preserving total pancreatectomy for the treatment of low-grade malignant pancreatic tumors:Two case reports and review of literature
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作者 Meng-Qing Sun Xiao-Man Kang +1 位作者 xiao-dong he Xian-Lin Han 《World Journal of Clinical Cases》 SCIE 2024年第17期3206-3213,共8页
BACKGROUND Function-preserving pancreatectomy can improve the long-term quality of life of patients with benign or low-grade malignant tumors,such as intraductal papillary mucinous neoplasms(IPMNs)and mucinous cystic ... BACKGROUND Function-preserving pancreatectomy can improve the long-term quality of life of patients with benign or low-grade malignant tumors,such as intraductal papillary mucinous neoplasms(IPMNs)and mucinous cystic neoplasms.However,there is limited literature on laparoscopic spleen-preserving total pancreatectomy(LSpTP)due to technical difficulties.CASE SUMMARY Patient 1 was a 51-year-old male diagnosed with IPMN based on preoperative imaging,showing solid nodules in the pancreatic head and diffuse dilation of the main pancreatic duct with atrophy of the distal pancreas.We performed L-SpTP with preservation of the splenic vessels,and the postoperative pathology report revealed IPMN with invasive carcinoma.Patient 2 was a 60-year-old male with multiple cystic lesions in the pancreatic head and body.L-SpTP was performed,and intraoperatively,the splenic vein was injured and required ligation.Postoperative pathology revealed a mucinous cystic tumor of the pancreas with low-grade dysplasia.Both patients were discharged on postoperative day 7,and there were no major complications during the perioperative period.CONCLUSION We believe that L-SpTP is a safe and feasible treatment for low-grade malignant pancreatic tumors,but more case studies are needed to evaluate its safety,efficacy,and long-term outcomes. 展开更多
关键词 Complete laparoscopic surgery Spleen-preserving total pancreatectomy Lowgrade malignant pancreatic tumors Function-preserving pancreatectomy Case report
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Sclerosing epithelioid fibrosarcoma of the pancreas:A case report
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作者 Meng-Qing Sun Li-Na Guo +3 位作者 Yan You Yan-Yu Qiu xiao-dong he Xian-Lin Han 《World Journal of Clinical Cases》 SCIE 2024年第26期5983-5989,共7页
BACKGROUND A sclerosing epithelioid fibrosarcoma(SEF)is a rare malignant fibroblastic soft tissue tumor that rarely occurs in intra-abdominal organs.A case of a SEF in the pancreatic head is reported herein,including ... BACKGROUND A sclerosing epithelioid fibrosarcoma(SEF)is a rare malignant fibroblastic soft tissue tumor that rarely occurs in intra-abdominal organs.A case of a SEF in the pancreatic head is reported herein,including its clinical manifestations,preoperative imaging features,gross specimen and pathological findings.CASE SUMMARY A 33-year-old male patient was admitted to Peking Union Medical College Hospital in December 2023 due to a one-year history of intermittent upper abdominal pain and the discovery of a pancreatic mass.The patient underwent an enhanced computed tomography scan of the abdomen,which revealed a welldefined,round mass with clear borders and calcifications in the pancreatic head.The mass exhibited progressive,uneven mild enhancement,measuring approximately 6.6 cm×6.3 cm.The patient underwent laparoscopic pylorus-preserving pancreaticoduodenectomy.Postoperative pathological examination revealed that the lesion was consistent with a SEF.At the 3-month postoperative follow-up,the patient did not report any short-term complications,and there were no signs of tumor recurrence.CONCLUSION SEFs are rare malignant fibrous soft tissue tumors.SEFs rarely develop in the pancreas,and its preoperative diagnosis depends on imaging findings,with confirmation depending on pathological examination and immunohistochemistry.Currently,only four cases of pancreatic SEF have been reported in studies written in English.This case is the first reported case of a pancreatic SEF by a clinical physician. 展开更多
关键词 Sclerosing epithelioid fibrosarcoma of the pancreas Abdominal malignant fibroblastic soft tissue tumor Abdominal enhanced computed tomography Laparoscopic pancreaticoduodenectomy Case report
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Predictive factors for central lymph node metastases in papillary thyroid microcarcinoma 被引量:17
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作者 Xin Wu Bing-Lu Li +1 位作者 Chao-Ji Zheng xiao-dong he 《World Journal of Clinical Cases》 SCIE 2020年第8期1350-1360,共11页
Papillary thyroid microcarcinoma(PTMC)measures 1 cm or less in its longest dimension.The incidence of PTMC is increasing worldwide.Surgery is the primary treatment;however,prophylactic central lymph node dissection is... Papillary thyroid microcarcinoma(PTMC)measures 1 cm or less in its longest dimension.The incidence of PTMC is increasing worldwide.Surgery is the primary treatment;however,prophylactic central lymph node dissection is controversial,and discrepancies between different guidelines have been noted.Routine prophylactic central lymph node dissection may result in hypoparathyroidism and recurrent laryngeal nerve injury in some patients without lymph node metastasis,while simple thyroidectomy may leave metastatic lymph nodes in high-risk patients.To selectively perform prophylactic lymph node dissections in high-risk patients,it is important to identify predictive factors for lymph node metastases in patients with PTMC.Several studies have reported on this,but their conclusions are not entirely consistent.Several clinicopathologic characteristics have been identified as risk factors for central lymph node metastases,and the most commonly reported factors include age,gender,tumor size and location,multifocality,bilaterality,extrathyroidal extension,and abnormal lymph node found using ultrasound.Here,we provide an overview of previous studies along with a favorable opinion on or against these factors,with the aim of increasing the understanding of this topic among the medical community.In addition,current opinions about prophylactic central lymph node dissection are reviewed and discussed. 展开更多
关键词 PAPILLARY THYROID carcinoma PAPILLARY THYROID MICROCARCINOMA CENTRAL LYMPH node dissection PROPHYLACTIC Risk factor Prognosis
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Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis 被引量:11
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作者 Wei-Yu Xu Xiao-Bo Yang +8 位作者 Wen-Qin Wang Yi Bai Jun-Yu Long Jian-Zhen Lin Jian-Ping Xiong Yong-Chang Zheng xiao-dong he Hai-Tao Zhao Xin-Ting Sang 《World Journal of Gastroenterology》 SCIE CAS 2018年第19期2120-2129,共10页
AIM To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width(RDW) in esophageal cancer(EC). METHODS We searched the PubM ed, EMBASE, ... AIM To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width(RDW) in esophageal cancer(EC). METHODS We searched the PubM ed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible:(1) Studies including EC patients who underwent radical esophagectomy;(2) studies including patients with localized disease without distant metastasis;(3) studies including patients without preoperative neoadjuvant therapy;(4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes;(5) studies reporting association between the preoperative RDW and overall survival(OS)/disease-free survival(DFS)/cancer-specific survival(CSS); and(6) studies published in English.RESULTS A total of six articles, published between 2015 and 2017, fulfilled the selection criteria in the end. Statistical analysis showed that RDW was not associated with the prognosis of EC patients, irrespective of OS/CSS [hazard ratio(HR) = 1.27, 95% confidence interval(CI): 0.97-1.57, P = 0.000] or DFS(HR = 1.42, 95%CI: 0.96-1.88, P = 0.000). Subgroup analysis indicated that elevated RDW was significantly associated with worse OS/CSS of EC patients when RDW > 13%(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000), when the patient number ≤ 400(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000) and when the study type was retrospective(HR = 1.42, 95%CI : 1.16-1.69, P = 0.000).CONCLUSION Contrary to our general understanding, this meta-analysis revealed that RDW cannot serve as an indicator of poor prognosis in patients with EC. However, it may still be a useful predictor of unfavorable prognosis using an appropriate cut-off value. 展开更多
关键词 RED cell distribution WIDTH PROGNOSTIC IMPACT Systematic review META-ANALYSIS
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PTEN and PDCD4 are Bona Fide Targets of microRNA-21 in Human Cholangiocarcinoma 被引量:13
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作者 Chang-zheng Liu Wei Liu +5 位作者 Yi Zheng Jin-mei Su Jing--jing Li Lan Yu xiao-dong he Song-sen Chen 《Chinese Medical Sciences Journal》 CAS CSCD 2012年第2期65-72,共8页
Objective To investigate the expression profile of microRNA-21 in human cholangiocarcinoma tis- sues and to validate its bona fide targets in human cholangiocarcinoma cells. Methods The expression profile of microRNA... Objective To investigate the expression profile of microRNA-21 in human cholangiocarcinoma tis- sues and to validate its bona fide targets in human cholangiocarcinoma cells. Methods The expression profile of microRNA-21 in human cholangiocarcinoma tissues and cholan- giocarcinoma cell line, QBC939, was evaluated by using real-time PCR analysis. The bona fide targets of microRNA-21 were analyzed and confirmed by dual luciferase reporter gene assay and western blot, respec- tively. The expressional correlation of microRNA-21 and its targets was probed in human cholangiocarci- noma tissues by using real-time PCR, locked nucleic acid in situ hybridization (LNA-ISH), and immunohis- tochemistry analysis. Results Real-time PCR analysis revealed that microRNA-21 expression depicted a significant up-regulation in human cholangiocarcinoma tissues about 5.6-fold as compared to the matched normal bileduct tissues (P〈0.05). The dual luciferase reporter gene assay revealed endogenous microRNA-21 in cholan- giocarcinoma cell line, QBC939, inhibited the luciferase reporter activities of wild-type PTEN (P〈0.01) and PDCD4 (P〈0.05) and had no this effect on mutated PTEN and PDCD4. Moreover, loss of microRNA-21 function led to a significant increase of PTEN and PDCD4 protein levels in QBC939 cells. Elevated microRNA-21 levels were accompanied by marked reductions of PTEN and PDCD4 expression in the same cholangiocarcinoma tissue. Conclusion microRNA-21 expression is up PDCD4 are direct effectors of microRNA-21. regulated in human cholangiocarcinoma and PTEN, 展开更多
关键词 CHOLANGIOCARCINOMA MICRORNA-21 phosphatase and tensin homolog programmed cell death 4
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Mirizzi Syndrome: Our Experience with 27 Cases in PUMC Hospital 被引量:7
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作者 Xie-qun Xu Tao Hong +3 位作者 Bing-lu Li Wei Liu xiao-dong he Chao-ji Zheng 《Chinese Medical Sciences Journal》 CAS CSCD 2013年第3期172-177,共6页
Objective To retrospectively evaluate the diagnosis and treatment of Mirizzi syndrome (MS). Methods Patients who received elective or emergency cholecystectomies in our center during 23 years were retrospectively e... Objective To retrospectively evaluate the diagnosis and treatment of Mirizzi syndrome (MS). Methods Patients who received elective or emergency cholecystectomies in our center during 23 years were retrospectively evaluated. The data reviewed included demography, clinical presentations, diagnostic methods, surgical procedures, postoperative complications, and follow-up. 展开更多
关键词 Mirizzi syndrome CHOLECYSTECTOMY Roux-en-Y hepatico-jejunostomy
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Multi-omics: Opportunities for research on mechanism of type 2 diabetes mellitus 被引量:5
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作者 Shuai Wang Hui Yong xiao-dong he 《World Journal of Diabetes》 SCIE 2021年第7期1070-1080,共11页
Type 2 diabetes mellitus(T2DM)is a burdensome global disease.In-depth understanding of its mechanism will help to optimize diagnosis and treatment,which reduces the burden.Multi-omics research has unparalleled advanta... Type 2 diabetes mellitus(T2DM)is a burdensome global disease.In-depth understanding of its mechanism will help to optimize diagnosis and treatment,which reduces the burden.Multi-omics research has unparalleled advantages in contributing to the overall understanding of the mechanism of this chronic metabolic disease.In the past two decades,the study of multi-omics on T2DMrelated intestinal flora perturbation and plasma dyslipidemia has shown tremendous potential and is expected to achieve major breakthroughs.The regulation of intestinal flora in diabetic patients has been confirmed by multiple studies.The use of metagenomics,16S RNA sequencing,and metabolomics has comprehensively identified the overall changes in the intestinal flora and the metabolic disturbances that could directly or indirectly participate in the intestinal flora-host interactions.Lipidomics combined with other“omics”has characterized lipid metabolism disorders in T2DM.The combined application and crossvalidation of multi-omics can screen for dysregulation in T2DM,which will provide immense opportunities to understand the mechanisms behind T2DM. 展开更多
关键词 Type 2 diabetes mellitus Gastrointestinal microbiome Intestinal flora Lipid metabolism disorders DYSLIPIDEMIAS Metabolomics
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Tolerance limit of rats to normothermic hepatic inflow occlusion under portal blood bypass 被引量:4
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作者 Jia-Hong Dong xiao-dong he +3 位作者 Kun Li Heng-Chun Duan Zhi-Ming Peng Jing-Xiu Cai From the Hepatobiliary Surgery Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2002年第1期57-62,共6页
Objective: To evaluate the tolerance limit of rats tonormothermic hepatic inflow occlusion under portalblood bypass.Methods: A new rat model of normothermic hepaticinflow occlusion under portal blood bypass was estab-... Objective: To evaluate the tolerance limit of rats tonormothermic hepatic inflow occlusion under portalblood bypass.Methods: A new rat model of normothermic hepaticinflow occlusion under portal blood bypass was estab-lished by clamping temporarily the pedicles of all liverlobes while the caudal lobe was kept as a passage ofthe portal blood flow. After hepatic blood flow re-stored, the caudal lobe was cut off. On the 7th postop-erative day, survival rate, hepatic morphological changes,and the severity and reversibility of the injured energymetabolism of the liver were investigated.Results: All rats that had been subjected to 30, 60 and90 minutes of hepatic inflow occlusion under portalblood bypass survived on the 7th postoperativeday. Ischemia-reperfusion injury of the liver was re-versible and compensatory in rats with hepatic inflowocclusion within 90minutes. However, the survivalrates of rats with 100, 110 and 120 minutes of hepaticinflow occlusion were 50%, 30% and 20% respective-ly. Liver injury of rats with 120 minutes of hepatic in-flow occlusion was severe and irreversible.Conclusions: The tolerance limit of rats to normother-mic hepatic inflow occlusion is enhanced significantlyunder portal blood bypass and the upper limit is 90minutes. 展开更多
关键词 liver hepatic inflow occlusion RATS ischemia-reperfusion injury
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Association of metabolic syndromes and risk factors with ampullary tumors development: A case-control study in China 被引量:3
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作者 xiao-dong he Qiao Wu +4 位作者 Wei Liu Tao Hong Jing-Jing Li Ruo-Yu Miao Hai-Tao Zhao 《World Journal of Gastroenterology》 SCIE CAS 2014年第28期9541-9548,共8页
AIM: To evaluate the risk factors for ampullary adenoma and ampullary cancer.
关键词 Metabolic syndromes Ampullary adenoma Ampullary cancer Risk factors
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Choledochoduodenal fistula caused by migration of endoclip after laparoscopic cholecystectomy 被引量:3
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作者 Tao Hong Xie-Qun Xu +3 位作者 xiao-dong he Qiang Qu Bing-Lu Li Chao-Ji Zheng 《World Journal of Gastroenterology》 SCIE CAS 2014年第16期4827-4829,共3页
The wide use of surgical endoclips in laparoscopic surgery has led to a variety of complications.Postcholecystectomy endoclips migrating into the common bile duct after laparoscopic cholecystectomy is rare.A migrated ... The wide use of surgical endoclips in laparoscopic surgery has led to a variety of complications.Postcholecystectomy endoclips migrating into the common bile duct after laparoscopic cholecystectomy is rare.A migrated endoclip can cause obstruction,serve as a nidus for stone formation,and cause cholangitis.While the exact pathogenesis is still unknown,it is probably related to improper clip application,subclinical bile leak,inflammation,and subsequent necrosis,allowing the clips to erode directly into the common bile duct.We present a case of endoclip migrating into the common bile duct and duodenum,resulting in choledochoduodenal fistula after laparoscopic cholecystectomy and a successful reconstruction of the biliary tract by a hepaticojejunostomy with a Roux-en-Y procedure.This case shows that surgical endoclips can penetrate into the intact bile duct wall through serial maceration,and it is believed that careful application of clips may be the only way to prevent their migration after laparoscopic cholecystectomy. 展开更多
关键词 Biliary obstruction Laparoscopic cholecystectomy Choledochoduodenal fistula
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Improving Interfacial Electrochemistry of LiNi0.5Mn1.5O4 Cathode Coated by Mn3O4 被引量:2
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作者 Miao-miao Deng Da-wei Zhang +3 位作者 Yu Shao xiao-dong he Aqsa Yasmin Chun-hua Chen 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2020年第4期485-490,I0002,共7页
In this work the surface of LiNi0.5Mn1.5O4(LMN)particles is modified by Mn3O4 coating through a simple wet grinding method,the electronic conductivity is significantly improved from 1.53×10^-7 S/cm to 3.15×1... In this work the surface of LiNi0.5Mn1.5O4(LMN)particles is modified by Mn3O4 coating through a simple wet grinding method,the electronic conductivity is significantly improved from 1.53×10^-7 S/cm to 3.15×10^-5 S/cm after 2.6 wt%Mn3O4 coating.The electrochemical test results indicate that Mn3O4 coating dramatically enhances both rate performance and cycling capability(at 55℃)of LNM.Among the samples,2.6 wt%Mn3O4-coated LNM not only exhibits excellent rate capability(a large capacity of 108 m Ah/g at 10 C rate)but also shows 78%capacity retention at 55 ℃ and 1 C rate after 100 cycles. 展开更多
关键词 Lithium-ion batteries Cathode materials Spinel lithium nickel manganese oxide Surface modification Cathode-electrolyte interphase
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High-Fidelity Manipulation of the Quantized Motion of a Single Atom via Stern-Gerlach Splitting 被引量:1
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作者 Kun-Peng Wang Jun Zhuang +6 位作者 xiao-dong he Rui-Jun Guo Cheng Sheng Peng Xu Min Liu Jin Wang Ming-Sheng Zhan 《Chinese Physics Letters》 SCIE CAS CSCD 2020年第4期75-79,共5页
We demonstrate high-fidelity manipulation of the quantized motion of a single87Rb atom in an optical tweezer via microwave couplings induced by Stern–Gerlach splitting. The Stern–Gerlach splitting is mediated by pol... We demonstrate high-fidelity manipulation of the quantized motion of a single87Rb atom in an optical tweezer via microwave couplings induced by Stern–Gerlach splitting. The Stern–Gerlach splitting is mediated by polarization gradient of a strongly focused tweezer beam that functions as fictitious magnetic field gradient. The spatial splitting removes the orthogonality of the atomic spatial wavefunctions, thus enables the microwave couplings between the motional states. We obtain coherent Rabi oscillations for up to third-order sideband transitions, in which a high fidelity of larger than 0.99 is obtained for the spin-flip transition on the first order sideband after subtraction of the state preparation and detection error. The Stern–Gerlach splitting is measured at a precision of better than 0.05 nm. This work paves the way for quantum engineering of motional states of single atoms, and may have wide applications in few body physics and ultracold chemistry. 展开更多
关键词 chemistry. SPLITTING microwave
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A new model for wrinkling and collapse analysis of membrane inflated beam 被引量:2
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作者 Chang-Guo Wang Hui-Feng Tan +1 位作者 Xing-Wen Du xiao-dong he 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第4期617-623,共7页
A new model is proposed to accurately predict the wrinkling and collapse loads of a membrane inflated beam. In this model, the pressure effects are considered and a modified factor is introduced to obtain an accurate ... A new model is proposed to accurately predict the wrinkling and collapse loads of a membrane inflated beam. In this model, the pressure effects are considered and a modified factor is introduced to obtain an accurate prediction. The former is achieved by modifying the pressure-related structural parameters based on elastic small strain considerations, and the modified factor is determined by our test data. Compared with previous models and our test data, the present model, named as shell-membrane model, can accurately predict the wrinkling and collapse loads of membrane inflated beams. 展开更多
关键词 Inflated beam. Shell-membrane. Bending Wrinkling Collapse
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Huge brown tumor of the rib in an unlocatable hyperparathyroidism patient with “self-recovered” serum calcium and parathyroid hormone: A case report 被引量:1
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作者 Wen-Da Wang Ning Zhang +1 位作者 Qiang Qu xiao-dong he 《World Journal of Clinical Cases》 SCIE 2019年第24期4321-4326,共6页
BACKGROUND The brown tumor is a kind of complication of hyperparathyroidism(HPT). The ultimate therapy usually is the resolution of HPT. We herein report an unlocatable HPT patient who received resection of a huge bro... BACKGROUND The brown tumor is a kind of complication of hyperparathyroidism(HPT). The ultimate therapy usually is the resolution of HPT. We herein report an unlocatable HPT patient who received resection of a huge brown tumor of the rib, and experienced "self-recovery" of serum calcium and parathyroid hormone.CASE SUMMARY A 34-year-old female patient who suffered from a gradually increasing mass of the left chest wall since 2007 came to our hospital for treatment. The patient had a history of serum Ca and parathyroid hormone(PTH) increasing since June 2015 and received zoledronic acid treatment for 17 mo. When she came to our hospital in November 2017 after discontinuing medical treatment for 3 mo, the serum Ca and PTH levels were within normal ranges. The patient had no imaging abnormalities of parathyroid ultrasound or 99 m Tc-methoxyisobutyl isonitrile.Enhanced computed tomography revealed a local soft tissue mass of 96 mm × 113 mm with bone erosion of the left 8 th rib, and the mass presented irregular enhancement with an unclear boundary between the mass and spleen. The mass was thought to likely be caused by HPT, but a malignancy could not be ruled out.Resection of the mass was performed, and the pathology proved that the mass was a brown tumor. A diagnosis of unlocatable HPT was considered. Since the serum Ca and PTH levels were both normal pre-and post-operation, the patient did not receive exploratory surgery for HPT, and received regular follow-up.CONCLUSION The huge brown tumor of the rib and "self-recovered" serum PTH and Ca levels are relatively rare in HPT patients. An exploratory operation may be deferred for these patients, and long-term follow-up should be performed. 展开更多
关键词 Brown tumor HYPERPARATHYROIDISM Unlocatable Self-recovered RESECTION Case report
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Surgical procedure determination based on tumor-node-metastasis staging of gallbladder cancer
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作者 xiao-dong he Jing-Jing Li +6 位作者 Wei Liu Qiang Qu Tao Hong Xie-Qun Xu Bing-Lu Li Ying Wang Hai-Tao Zhao 《World Journal of Gastroenterology》 SCIE CAS 2015年第15期4620-4626,共7页
AIM: To investigate the impact of surgical procedures on prognosis of gallbladder cancer patients classified with the latest tumor-node-metastasis(TNM) staging system.METHODS: A retrospective study was performed by re... AIM: To investigate the impact of surgical procedures on prognosis of gallbladder cancer patients classified with the latest tumor-node-metastasis(TNM) staging system.METHODS: A retrospective study was performed by reviewing 152 patients with primary gallbladder carcinoma treated at Peking Union Medical College Hospital from January 2003 to June 2013. Postsurgical follow-up was performed by telephone and outpatient visits. Clinical records were reviewed and patients were grouped based on the new edition of TNM staging system(AJCC, seventh edition, 2010). Prognoses were analyzed and compared based on surgical operations including simple cholecystectomy, radical cholecystectomy(or extended radical cholecystectomy), and palliative surgery. Simple cholecystectomy is, by definition, resection of the gallbladder fossa. Radical cholecystectomy involves a wedge resection of the gallbladder fossa with 2 cm nonneoplastic liver tissue; resection of a suprapancreatic segment of the extrahepatic bile duct and extended portal lymph node dissection may also be considered based on the patient's circumstance. Palliative surgery refers to cholecystectomy with biliary drainage. Data analysis was performed with SPSS 19.0 software. KaplanMeier survival analysis and Logrank test were used for survival rate comparison. P < 0.05 was consideredstatistically significant.RESULTS: Patients were grouped based on the new 7th edition of TNM staging system, including 8 cases of stage 0, 10 cases of stage Ⅰ, 25 cases of stage Ⅱ, 21 cases of stage ⅢA, 21 cases of stage ⅢB, 24 cases of stage ⅣA, 43 cases of stage ⅣB. Simple cholecystectomy was performed on 28 cases, radical cholecystectomy or expanded gallbladder radical resection on 57 cases, and palliative resection on 28 cases. Thirty-nine cases were not operated. Patients with stages 0 and Ⅰ disease demonstrated no statistical significant difference in survival time between those receiving radical cholecystectomy and simple cholecystectomy(P = 0.826). The prognosis of stage Ⅱ patients with radical cholecystectomy was better than that of simple cholecystectomy. For stage Ⅲ patients, radical cholecystectomy was significantly superior to other surgical options(P < 0.05). For stage ⅣA patients, radical cholecystectomy was not better than palliative resection and non-surgical treatment. For stage ⅣB, patients who underwent palliative resection significantly outlived those with non-surgical treatment(P < 0.01)CONCLUSION: For stages 0 and Ⅰ patients, simple cholecystectomy is the optimal surgical procedure, while radical cholecystectomy should be actively operated for stages Ⅱ and Ⅲ patients. 展开更多
关键词 Gallbladder cancer Simple cholecystectomy Tumor-node-metastasis staging Radical cholecystectomy PROGNOSIS
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Spectral filtering of dual lasers with a high-finesse length-tunable cavity for rubidium atom Rydberg excitation
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作者 Yang-Yang Liu Zhuo Fu +3 位作者 Peng Xu xiao-dong he Jin Wang Ming-Sheng Zhan 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第7期261-268,共8页
We propose and demonstrate an alternative method for spectral filtering and frequency stabilization of both 780-nm and 960-nm lasers using a high-finesse length-tunable cavity(HFLTC).Firstly,the length of HFLTC is sta... We propose and demonstrate an alternative method for spectral filtering and frequency stabilization of both 780-nm and 960-nm lasers using a high-finesse length-tunable cavity(HFLTC).Firstly,the length of HFLTC is stabilized to a commercial frequency reference.Then,the two lasers are locked to this HFLTC using the Pound–Drever–Hall(PDH)method which can narrow the linewidths and stabilize the frequencies of both lasers simultaneously.Finally,the transmitted lasers of HFLTC with each power up to about 100μW,which act as seed lasers,are amplified using the injection locking method for single-atom Rydberg excitation.The linewidths of obtained lasers are narrowed to be less than 1 k Hz,meanwhile the obtained lasers'phase noise around 750 k Hz are suppressed about 30 d B.With the spectrally filtered lasers,we demonstrate a Rabi oscillation between the ground state and Rydberg state of single-atoms in an optical trap tweezer with a decay time of(67±37)μs,which is almost not affected by laser phase noise.We found that the maximum short-term laser frequency fluctuation of a single excitation lasers is at~3.3 k Hz and the maximum long-term laser frequency drift of a single laser is~46 k Hz during one month.Our work develops a stable and repeatable method to provide multiple laser sources of ultra-low phase noise,narrow linewidth,and excellent frequency stability,which is essential for high precision atomic experiments,such as neutral atom quantum computing,quantum simulation,quantum metrology,and so on. 展开更多
关键词 laser frequency stabilization spectral filtering Rydberg state rubidium atom
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Combining of chemotherapy with targeted therapy for advanced biliary tract cancer:A systematic review and meta-analysis
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作者 Xue-Song Bai Sheng-Nan Zhou +1 位作者 Yi-Qun Jin xiao-dong he 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第10期2061-2076,共16页
BACKGROUND Targeted therapy(TT)has resulted in controversial efficacy as first-line treatment for biliary tract cancer(BTC).More efficacy comparisons are required to clarify the overall effects of chemotherapy(CT)comb... BACKGROUND Targeted therapy(TT)has resulted in controversial efficacy as first-line treatment for biliary tract cancer(BTC).More efficacy comparisons are required to clarify the overall effects of chemotherapy(CT)combined with TT and CT alone on advanced BTC.AIM To conduct a meta-analysis of the available evidence on the efficacy of CT combined with TT for advanced BTC.METHODS The PubMed,EMBASE,ClinicalTrials,Scopus and Cochrane Library databases were systematically searched for relevant studies published from inception to August 2022.Only randomized clinical trials(RCTs)including comparisons between the combination of gemcitabine-based CT with TT and CT alone as firstline treatment for advanced BTC were eligible(PROSPERO-CRD42022313001).The odds ratios(ORs)for the objective response rate(ORR)and hazard ratios(HRs)for both progression-free survival(PFS)and overall survival(OS)were calculated and analyzed.Subgroup analyses based on different targeted agents,CT regimens and tumor locations were prespecified.RESULTS Nine RCTs with a total of 1361 individuals were included and analyzed.The overall analysis showed a significant improvement in ORR in patients treated with CT+TT compared to those treated with CT alone(OR=1.43,95%CI:1.11-1.86,P=0.007)but no difference in PFS or OS.Similar trends were observed in the subgroup treated with agents targeting epidermal growth factor receptor(OR=1.67,95%CI:1.17-2.37,P=0.004)but not in the subgroups treated with agents targeting vascular endothelial growth factor receptor or mesenchymal-epithelial transition factor.Notably,patients who received a CT regimen of gemcitabine+oxaliplatin in the CT+TT arm had both a higher ORR(OR=1.75,95%CI:1.20-2.56,P=0.004)and longer PFS(HR=0.83,95%CI:0.70-0.99,P=0.03)than those in the CT-only arm.Moreover,patients with cholangiocarcinoma treated with CT+TT had significantly increased ORR and PFS(ORR,OR=2.06,95%CI:1.27-3.35,PFS,HR=0.79,95%CI:0.66-0.94).CONCLUSION CT+TT is a potential first-line treatment for advanced BTC that leads to improved tumor control and survival outcomes,and highlighting the importance of CT regimens and tumor types in the application of TT. 展开更多
关键词 Advanced biliary tract cancer Targeted therapy CHEMOTHERAPY META-ANALYSIS Randomized controlled trial First-line treatment
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Risk factors for preoperative carcinogenesis of bile duct cysts in adults
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作者 Xin Wu Bing-Lu Li +1 位作者 Chao-Ji Zheng xiao-dong he 《World Journal of Clinical Cases》 SCIE 2021年第22期6278-6286,共9页
BACKGROUND Bile duct cyst(BDC)is a rare congenital bile duct malformation.The incidence of bile duct malignancy in BDC patients is markedly higher than that in the general population.However,few studies have been cond... BACKGROUND Bile duct cyst(BDC)is a rare congenital bile duct malformation.The incidence of bile duct malignancy in BDC patients is markedly higher than that in the general population.However,few studies have been conducted on the risk factors for preoperative carcinogenesis in BDC patients.AIM To analyze the risk factors associated with preoperative carcinogenesis in BDC patients.METHODS The medical records of BDC patients treated at our hospital between January 2012 and December 2018 were retrospectively reviewed.We constructed a database and compared the characteristics of BDC patients with dysplasia and carcinoma against those with benign cysts.The risk factors for preoperative carcinogenesis were identified using univariate and multivariate analyses.RESULTS The cohort comprised 109 BDC patients.Ten patients had preoperative dysplasia or adenocarcinoma.Univariate and multivariate analyses showed that gallbladder wall thickness>0.3 cm[odds ratio(OR),6.551;95%confidence interval(CI),1.351 to 31.763;P=0.020]and Todani type IV(OR,7.675;95%CI,1.584 to 37.192;P=0.011)were independent factors associated with preoperative carcinogenesis.CONCLUSION BDC is a premalignant condition.Our findings show that gallbladder wall thickness>0.3 cm and Todani type IV are independent risk factors for preoperative carcinogenesis of BDC.They are therefore useful for deciding on the appropriate treatment strategy,especially in asymptomatic patients. 展开更多
关键词 Choledochal cyst Carcinoma DYSPLASIA Risk factors Gallbladder wall Todani type
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Efficient Two-Dimensional Defect-Free Dual-Species Atom Arrays Rearrangement Algorithm with Near-Fewest Atom Moves
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作者 Zhi-Jin Tao Li-Geng Yu +3 位作者 Peng Xu Jia-Yi Hou xiao-dong he and Ming-Sheng Zhan 《Chinese Physics Letters》 SCIE EI CAS CSCD 2022年第8期34-38,共5页
Dual-species single-atom array in optical tweezers has several advantages over the single-species atom array as a platform for quantum computing and quantum simulation.Thus,creating the defect-free dual-species single... Dual-species single-atom array in optical tweezers has several advantages over the single-species atom array as a platform for quantum computing and quantum simulation.Thus,creating the defect-free dual-species singleatom array with atom numbers over hundreds is essential.As recent experiments demonstrated,one of the main difficulties lies in designing an efficient algorithm to rearrange the stochastically loaded dual-species atoms arrays into arbitrary demanded configurations.We propose a heuristic connectivity optimization algorithm to provide the near-fewest number of atom moves.Our algorithm introduces the concept of using articulation points in an undirected graph to optimize connectivity as a critical consideration for arranging the atom moving paths.Tested in array size of hundreds atoms and various configurations,our algorithm shows a high success rate(>97%),low extra atom moves ratio,good scalability,and flexibility.Furthermore,we propose a complementary step to solve the problem of atom loss during the rearrangement. 展开更多
关键词 DUAL hundreds CONNECTIVITY
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