In this editorial we comment on the review by Wang et al published in the recent issue of the World Journal of Gastroenterology in 2023.Small extracellular vesicles(exosomes)play important roles in the tumor microenvi...In this editorial we comment on the review by Wang et al published in the recent issue of the World Journal of Gastroenterology in 2023.Small extracellular vesicles(exosomes)play important roles in the tumor microenvironment.In this review,the authors introduce the following points:(1)The composition and function of exosomal microRNAs(miRNAs)of different cell origins in hepatocellular carcinoma(HCC);(2)the crosstalk between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC;and(3)the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC.In addition,the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC was introduced.In this review,the authors give us an overview of the exosomal RNA and summarize the function of exosomal RNA in HCC,which provides a deeper understanding of exosomal miRNAs to the readers.展开更多
BACKGROUND Acute appendicitis is one of the most common acute abdominal emergencies around the world,which is always associated with infection.Infection with Salmonella typhi,an enteric pathogen,is a rare cause of acu...BACKGROUND Acute appendicitis is one of the most common acute abdominal emergencies around the world,which is always associated with infection.Infection with Salmonella typhi,an enteric pathogen,is a rare cause of acute appendicitis.We here report a patient with acute appendicitis associated with Samonella typhi infection,accompanied with spleen and kidney infarction,providing a rare example for a common surgical emergency.CASE SUMMARY A 25-year-old Pakistani man presented to the hospital with a 3-d history of fevers,vomiting,and abdominal pain.Computed tomography(CT)revealed a thickened intestinal wall of the ileocecal junction with multiple enlarged lymph nodes nearby.He was diagnosed with acute appendicitis and received laparoscopic appendectomy,which showed mild inflammation of the appendix.After the surgery,the patient presented again with a high fever(>39℃)and diarrhea.A CT angiography scan indicated spleen and kidney infarction.According to the blood culture,the diagnosis was finally clear to be Samonella typhi infection.The pyrexia and enteric symptoms were relieved after the application of intravenous levofloxacin.CONCLUSION This case,characterized by the combination of Salmonella typhi infection,acute appendicitis,and renal and splenic infraction,serves as a rare example for a common surgical emergency.展开更多
基金Supported by the National Natural Science Foundation of China,No.82303441Natural Science Foundation of Shanghai Municipality,No.21ZR1459100 and No.22ZR1457900+1 种基金Science and Technology Commission of Shanghai Municipality,No.20DZ2254500Shanghai Anticancer Association EYAS Project.
文摘In this editorial we comment on the review by Wang et al published in the recent issue of the World Journal of Gastroenterology in 2023.Small extracellular vesicles(exosomes)play important roles in the tumor microenvironment.In this review,the authors introduce the following points:(1)The composition and function of exosomal microRNAs(miRNAs)of different cell origins in hepatocellular carcinoma(HCC);(2)the crosstalk between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC;and(3)the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC.In addition,the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC was introduced.In this review,the authors give us an overview of the exosomal RNA and summarize the function of exosomal RNA in HCC,which provides a deeper understanding of exosomal miRNAs to the readers.
基金National Natural Science Foundation of China,No.81702586.
文摘BACKGROUND Acute appendicitis is one of the most common acute abdominal emergencies around the world,which is always associated with infection.Infection with Salmonella typhi,an enteric pathogen,is a rare cause of acute appendicitis.We here report a patient with acute appendicitis associated with Samonella typhi infection,accompanied with spleen and kidney infarction,providing a rare example for a common surgical emergency.CASE SUMMARY A 25-year-old Pakistani man presented to the hospital with a 3-d history of fevers,vomiting,and abdominal pain.Computed tomography(CT)revealed a thickened intestinal wall of the ileocecal junction with multiple enlarged lymph nodes nearby.He was diagnosed with acute appendicitis and received laparoscopic appendectomy,which showed mild inflammation of the appendix.After the surgery,the patient presented again with a high fever(>39℃)and diarrhea.A CT angiography scan indicated spleen and kidney infarction.According to the blood culture,the diagnosis was finally clear to be Samonella typhi infection.The pyrexia and enteric symptoms were relieved after the application of intravenous levofloxacin.CONCLUSION This case,characterized by the combination of Salmonella typhi infection,acute appendicitis,and renal and splenic infraction,serves as a rare example for a common surgical emergency.
