Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome

BACKGROUND Cardiovascular disease is a major complication of diabetes mellitus(DM).Type-2 DM(T2DM)is associated with an increased risk of cardiovascular events and mortality,while serum biomarkers may facilitate the prediction of these outcomes.Early differential diagnosis of T2DM complicated with acute coronary syndrome(ACS)plays an important role in controlling disease progression and improving safety.AIM To investigate the correlation of serum bilirubin andγ-glutamyltranspeptidase(γ-GGT)with major adverse cardiovascular events(MACEs)in T2DM patients with ACS.METHODS The clinical data of inpatients from January 2022 to December 2022 were analyzed retrospectively.According to different conditions,they were divided into the T2DM complicated with ACS group(T2DM+ACS,n=96),simple T2DM group(T2DM,n=85),and simple ACS group(ACS,n=90).The clinical data and laboratory indices were compared among the three groups,and the correlations of serum total bilirubin(TBIL)levels and serumγ-GGT levels with other indices were discussed.T2DM+ACS patients received a 90-day follow-up after discharge and were divided into event(n=15)and nonevent(n=81)groups according to the occurrence of MACEs;Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in patients.RESULTS The T2DM+ACS group showed higherγ-GGT,total cholesterol,low-density lipoprotein cholesterol(LDL-C)and glycosylated hemoglobin(HbA1c)and lower TBIL and high-density lipoprotein cholesterol levels than the T2DM and ACS groups(P<0.05).Based on univariate analysis,the event and nonevent groups were significantly different in age(t=3.3612,P=0.0011),TBIL level(t=3.0742,P=0.0028),γ-GGT level(t=2.6887,P=0.0085),LDL-C level(t=2.0816,P=0.0401),HbA1c level(t=2.7862,P=0.0065)and left ventricular ejection fraction(LEVF)levels(t=3.2047,P=0.0018).Multivariate logistic regression analysis further identified that TBIL level and LEVF level were protective factor for MACEs,and age andγ-GGT level were risk factors(P<0.05).CONCLUSION Serum TBIL levels are decreased andγ-GGT levels are increased in T2DM+ACS patients,and the two indices are significantly negatively correlated.TBIL andγ-GGT are independent influencing factors for MACEs in such patients.

Transmission Index Research of Parallel Manipulators Based on Matrix Orthogonal Degree

Performance index mance evaluation, and is the is the standard of perfor- foundation of both perfor- mance analysis and optimal design for the parallel manipulator. Seeking the suitable kinematic indices is always an important and challenging issue for the parallel manipulator. So far, there are extensive studies in this field, but few existing indices can meet all the requirements, such as simple, intuitive, and universal. To solve this problem, the matrix orthogonal degree is adopted, and generalized transmission indices that can evaluate motion/force trans- missibility of fully parallel manipulators are proposed. Transmission performance analysis of typical branches, end effectors, and parallel manipulators is given to illus- trate proposed indices and analysis methodology. Simula- tion and analysis results reveal that proposed transmission indices possess significant advantages, such as normalized finite （ranging from 0 to l）, dimensionally homogeneous, frame-free, intuitive and easy to calculate. Besides, pro- posed indices well indicate the good transmission region and relativity to the singularity with better resolution than the traditional local conditioning index, and provide a novel tool for kinematic analysis and optimal design of fully parallel manipulators.

Short-chain fatty acids in blood pressure, friend or foe

To the Editor:Gut microbiota,the trillions of microbes living in the human and rodent gut,play a pivotal role in cardiovascular diseases,including hypertension and atherosclerosis.One of the crucial mechanisms underlying gut microbiota functions in cardiovascular diseases is the microbiota-derived metabolites such as short-chain fatty acids(SCFAs).And emerging evidence demonstrated gut microbiota-derived metabolites——SCFAs maintained stable blood pressure.[1]However,there is no large cohort study on the correlation of SCFAs with hypertension.

Research on End-force Output of 8-cable Driven Parallel Manipulator

The return capsule needs to be launched to the moon and return back to earth in the third stage of the Chinese lunar exploration project.Therefore,it is necessary to perform simulations on the ground.This paper presents an 8-cable-driven parallel manipulator to achieve end-force output in a low-gravity environment.End-force output refers to the vector sum of the external force on the end-effector.A model of end-force output is established based on a kinematics model,a dynamic model,and a force analysis of an 8-cable driven parallel manipulator.To obtain end-force output in a low-gravity environment,the cable force has to be controlled to counteract gravity.In addition,a force-position mix control strategy is proposed to proactively control the cable force according to the force optimal distribution given by the closed-form force distribution method.Furthermore,a suitable choice for an end-force output is obtained by modeling the effect of cable force on end-force output.Experimental results show that the actual cable force agrees well with the calculated force distribution,indicating that it is feasible to realize end-force output in a low gravity environment.