A differential accelerometer comprising of two rotating masses made of the same material is proposed for drop tower-based free-fall testing of the spin-spin force between the rotating mass and the Earth. The measureme...A differential accelerometer comprising of two rotating masses made of the same material is proposed for drop tower-based free-fall testing of the spin-spin force between the rotating mass and the Earth. The measurement is performed by placing the two concentric masses of very different momenta in a vacuum drop capsule which is falling freely in the Earth＇s gravitational field. A nonzero output of the differential aeeelerometer is an indication of possible violation of new equivalence principle （NEP）. We present the conceptual design of a modified free-fall NEP experiment which can be performed at the Belting drop tower. Design and evaluation of the differential accelerometer with a hybrid electrostatic/magnetic suspension system are presented to accommodate for operation on ground and drop-tower tests. Details specific to the measurement uncertainty are discussed to yield an NEP test accuracy of 7.2×10^-9.展开更多
The differentiation process from hematopoietic stem cells(HSCs)to mature red blood cells(RBCs)is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal...The differentiation process from hematopoietic stem cells(HSCs)to mature red blood cells(RBCs)is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal differentiation.Erythropoiesis is the dynamic journey of HSCs through various functional and phenotypic stages.The physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility,necessitating precise coordination of transcription factors and epigenetic elements.This review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence the differentiation of the erythroid lineage.This encompasses the exploration of transcriptional,post-transcriptional,and post-translational regulatory processes.The intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid development.These findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 91436107 and 61374207
文摘A differential accelerometer comprising of two rotating masses made of the same material is proposed for drop tower-based free-fall testing of the spin-spin force between the rotating mass and the Earth. The measurement is performed by placing the two concentric masses of very different momenta in a vacuum drop capsule which is falling freely in the Earth＇s gravitational field. A nonzero output of the differential aeeelerometer is an indication of possible violation of new equivalence principle （NEP）. We present the conceptual design of a modified free-fall NEP experiment which can be performed at the Belting drop tower. Design and evaluation of the differential accelerometer with a hybrid electrostatic/magnetic suspension system are presented to accommodate for operation on ground and drop-tower tests. Details specific to the measurement uncertainty are discussed to yield an NEP test accuracy of 7.2×10^-9.
基金supported by the Scientific Research Fund of the First Hospital of Lanzhou University(ldyyyn2021-15)the Science and technology Fund of Gansu Province(21JR7RA391).
文摘The differentiation process from hematopoietic stem cells(HSCs)to mature red blood cells(RBCs)is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal differentiation.Erythropoiesis is the dynamic journey of HSCs through various functional and phenotypic stages.The physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility,necessitating precise coordination of transcription factors and epigenetic elements.This review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence the differentiation of the erythroid lineage.This encompasses the exploration of transcriptional,post-transcriptional,and post-translational regulatory processes.The intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid development.These findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes.
