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七氟烷调节CARMA3靶向NF-κB通路抑制胃癌细胞迁移、侵袭
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作者 贾秀萍 陈晓贞 +3 位作者 楼群兵 周振锋 高亮 周鹏飞 《世界华人消化杂志》 CAS 2019年第4期220-227,共8页
目的研究七氟烷对胃癌(gastric cancer, GC)细胞迁移、侵袭的影响,并探讨其作用机制.方法运用Transwell法检测细胞迁移、侵袭量;将siCAR MA3组(转染siCARMA3)、NC组(转染siControl)、CARMA3组(转染pcDNA3.1-CARMA3)、Vector组(转染pcDNA... 目的研究七氟烷对胃癌(gastric cancer, GC)细胞迁移、侵袭的影响,并探讨其作用机制.方法运用Transwell法检测细胞迁移、侵袭量;将siCAR MA3组(转染siCARMA3)、NC组(转染siControl)、CARMA3组(转染pcDNA3.1-CARMA3)、Vector组(转染pcDNA3.1)均用脂质体法转染至SGC7901细胞;用qRT-PCR检测细胞中CARMA3 mRNA表达;Westernblot检测细胞中CARMA3、p-p65、p65蛋白表达.结果与对照组相比,七氟烷抑制GC细胞迁移、侵袭,且抑制CARMA3表达;沉默CARMA3抑制GC细胞迁移、侵袭,过表达CARMA3促进GC细胞迁移、侵袭,且CARMA3靶向NF-κB通路;七氟烷可抑制CARMA3失活NF-κB通路抑制GC细胞迁移、侵袭.结论七氟烷可抑制GC细胞迁移、侵袭,其机制可能与失活CARMA3/NF-κB信号通路有关,将可为七氟烷用于临床治疗GC提供依据. 展开更多
关键词 七氟烷 CARMA3 NF-ΚB通路 胃癌细胞 迁移 侵袭
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Fracture of proximal radius combined with dislocation of the radial head:a case report
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作者 xiao-zhen chen Song-Ou Zhang +5 位作者 Ling-Jie Wang Yue-Gang Ma Wen-Qing Liang Song-Tao Jing Jin-Xiang Shang Xu-Jun Hu 《Clinical Research Communications》 2022年第3期34-37,共4页
Forearm fractures are prevalent which include radius fractures,ulna fractures,or both radius and ulna fractures.Proximal radius fractures combined with dislocations of the radial heads are rare and easily misdiagnosed... Forearm fractures are prevalent which include radius fractures,ulna fractures,or both radius and ulna fractures.Proximal radius fractures combined with dislocations of the radial heads are rare and easily misdiagnosed.The authors present and discuss a case of proximal radius fractures associated with radial head dislocations.A 36 years old male was admitted to the hospital due to pain and activity limitation in his left elbow for 7 hours due to a car accident.An X-ray of the left elbow joint revealed a“left radius fracture with surrounding soft tissue edema”.During the procedure,the radial head was found to be dislocated forward.A 3.0 mm anchor was used to fix the annular ligament.Radius fractures combined dislocations of the radial heads are rare and may be missing the diagnosis.Before undergoing surgery,the possibility of elbow dislocation should be evaluated.Wire anchors can provide reliable fixation. 展开更多
关键词 annular ligament case report dislocated forearm fractures radius fracture radial head
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Biphenyls from aerial parts of Ribes takare
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作者 xiao-zhen chen Sheng-Ming Lu +4 位作者 Guo-You Li Wei Jiao Tian-Fang Huang Tao Yang Dong-Mei Fang 《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第1期127-130,共4页
Three new biphenyls, 4,7,8-trimethoxy-2,3-methylenedioxydibenzofuran (1), 7-hydroxy-4,8- dimethoxy-2,3-methylenedioxydibenzofuran (2), and 3',5-dimethoxy-3,4-methylenedioxybiphenyl (3), along with eighteen know... Three new biphenyls, 4,7,8-trimethoxy-2,3-methylenedioxydibenzofuran (1), 7-hydroxy-4,8- dimethoxy-2,3-methylenedioxydibenzofuran (2), and 3',5-dimethoxy-3,4-methylenedioxybiphenyl (3), along with eighteen known compounds (4-21) were isolated from the aerial part of Ribes takare D. Don. Their structures were elucidated on the basis of spectroscopic data. Compound I and compound 2 showed mild α-glucosidase inhibitory activity. 展开更多
关键词 Biphenyl Ribes takare D. Don α-Glycosidase Inhibitory activity
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