BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in pr...BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute STEMI.METHODS: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset <12 hours undergoing manual thrombus aspiration and Promus Element stent implantation.Patients were randomly assigned to control group(n=20) or post-dilatation group(n=21) in which a non-compliant balloon was inflated to >16 atm pressure.Strut apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month follow-up.The primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after pPCI.RESULTS: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation vs.control group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, P<0.0001), the primary study endpoint, with similar strut coverage(98.5% vs.98.4%, P=0.63) and 1-year rate of major adverse cardiovascular events(MACE).CONCLUSION: In STEMI patients, post-dilatation after stent implantation and thrombus aspiration improved strut apposition up to 7 months without affecting coronary blood flow or 1-year MACE rate.Larger and longer term studies are warranted to further assess safety(Clinical Trials.gov identifier: NCT02121223).展开更多
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular a...The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.展开更多
Objective To investigate the levels of cardiovascular disease risk factors and their relations to clinical phenotype associated with coronary artery disease(CAD).Methods The subjects were recruited from five independe...Objective To investigate the levels of cardiovascular disease risk factors and their relations to clinical phenotype associated with coronary artery disease(CAD).Methods The subjects were recruited from five independent cardiovascular centers.Coronary angiography was employed to define the CAD with stenosis in each major vessel ≥70% and control with stenosis <10% in every lesion.The classic risk factors including family history,body mass index,smoking habits,hypertension,diabetes mellitus,and serum lipid levels were surveyed according to established criteria.Associations between risk levels and clinical phenotypes were assessed by case control and correlation analysis.Results A total of 762 individuals were collected,including 481 men and 281 women,aged from 17 to 81(mean 60±10) years.The patients with CAD accounted for 55.5% of all participants,and controls 44.5%,respectively.Compared with the pattern in published data,our study showed that mean serum high density lipoprotein cholesterol(HDL-C) level was significantly lower(P<0.001) and triglycerides was significantly higher(P<0.001),while total cholesterol(TC) and low density lipoprotein cholesterol levels were comparative(both P>0.05).The prevalence of low HDL-C(<40 g/L) and hypertriglyceridemia(>150 g/L) were 27.2% and 41.4%,respectively.Mean serum levels of HDL-C and apolipoprotein A1 were significantly higher in female subjects than in male(P<0.001).Lower HDL-C functioned as an independent risk factor for CAD only in men(RR=2.8,95%CI:1.5-4.2,P<0.001),yet increased non-HDL cholesterol combined with diabetes mellitus and obesity seemed to play a key role in the development ofCAD in women.Similarity in risk association with CAD was found for hypertension and TC/HDL ratio in male and female subjects,while family history had no relationship with the presence of CAD.Conclusion It is remarkable that emphasis of intervention in future should be given on the prevalent low serum HDL-C and its strong risk correlation with the presence of CAD in male subjects of Chinese Han population.展开更多
BACKGROUND Liver abscess is a common clinical liver disease mainly caused by suppurative bacteria or amoebae,with early clinical signs of chills,high fever,jaundice,and other symptoms.Establishing its early diagnosis ...BACKGROUND Liver abscess is a common clinical liver disease mainly caused by suppurative bacteria or amoebae,with early clinical signs of chills,high fever,jaundice,and other symptoms.Establishing its early diagnosis is difficult,which may lead to misdiagnosis.AIM To observe the effects of psychological guidance combined with evidence-based health intervention in patients with liver abscess treated with ultrasound.METHODS A total of 120 patients with bacterial liver abscess admitted to our hospital from May 2018 to February 2021 were selected and divided into groups according to their intervention plan.RESULTS After the intervention,Self-Rating Depression Scale,Self-Rating Anxiety Scale,Self-Perceived Burden Scale(SPBS),and quality of life scores(physical functioning,role physical,bodily pain,general health,vitality,social functioning,role emotional,mental health)were lower than before the intervention in the two groups.The observation group had lower negative sentiment,SPBS,and quality of life scores than the control group.In the observation group,31 and 24 patients had good and general compliance,respectively,with a compliance rate of 91.67%,which was significantly higher than that in the control group.The observation group had significantly lower total incidence of incision infection,abdominal abscess,hemorrhage,and severe abdominal pain than the control group.CONCLUSION Three-dimensional psychological guidance combined with evidence-based health intervention in treating liver abscess can reduce patients’burden and negative emotions,improve patient compliance and quality of life,and reduce complications.展开更多
AIM：To detect early glaucoma by optical coherence tomography（OCT） posterior pole asymmetry analysis.METHODS：Totally 39 eyes from 39 healthy subjects,40 eyes from 40 mild glaucoma patients,33 eyes from 33 moderate ...AIM：To detect early glaucoma by optical coherence tomography（OCT） posterior pole asymmetry analysis.METHODS：Totally 39 eyes from 39 healthy subjects,40 eyes from 40 mild glaucoma patients,33 eyes from 33 moderate glaucoma patients and 41 eyes from severe glaucoma patients were included in this study.All subjects underwent posterior pole asymmetry analysis（PPAA） of OCT and the posterior pole area was divided into three zones.Means,standard deviations and 95% confidence intervals of each zone asymmetry in control group were assessed.Retina thickness asymmetry（RTA） of different stage of glaucoma were compared for each zone,and receiver operating characteristic（ROC） curves were made to test the efficacy of strategies using different zones to discriminate glaucomatous eyes from the healthy ones.RESULTS：In a healthy population,RTA of the centre zone showed the minimal mean value（3.085 μm）,standard deviation（1.756）,and the narrowest 95% confidence interval（from 2.360 to 3.810 μm）.It was only in the center zone that RTA exhibited significant difference between control and moderate glaucoma group（P〈0.01）,as well as control and severe glaucoma group（P〈0.00001）.The strategy utilized in the center zone had the strongest diagnostic capability（zone 3 AUROC=0.816,P=0.0016） in comparison to that of the periphery area（zone 1 AUROC=0.675,P=0.0016;zone 2 AUROC=0.623,P=0.0197）,the whole posterior pole involved interpreting strategy showed inferior diagnostic power than the centre zone dependent strategy（z=2.851,P=0.0044）.CONCLUSION：Utilizing the posterior pole centre zone to interpret OCT PPAA results are more effective than making use of the whole posterior pole map.展开更多
A new freshwater turbellarian species, Dugesia sinensis Chen ＆ Wang, sp. nov., is described, which was collected from Caoxi rivulet, Shaoguan, Guandong Province, China. The morphology, reproduction, histochemical loc...A new freshwater turbellarian species, Dugesia sinensis Chen ＆ Wang, sp. nov., is described, which was collected from Caoxi rivulet, Shaoguan, Guandong Province, China. The morphology, reproduction, histochemical localization of AChE and phylogenetics based on COI gene of the new species was observed and analysed. The new species differs from its sister species in the developed diagram of the male atrium, the bursal canal to the left of the copulatory apparatus and distance （1 mm） between copulatory bursa and the mouth. In addition, the results indicated that morphological differences of ACHE＋ nerve structure can be used as a distinguishable character for species identification of genera Dugesiidae.展开更多
In this study, a strategy based on the particle swarm optimization (PSO) algorithm is developed to control the microstructures of a Ni-based superalloy during hot forging. This strategy is composed of three parts, nam...In this study, a strategy based on the particle swarm optimization (PSO) algorithm is developed to control the microstructures of a Ni-based superalloy during hot forging. This strategy is composed of three parts, namely, material models, optimality criterions, and a PSO algo rithm. The material models are utilized to predict microstructure information, such as recrystallization volume fraction and average grain size. The optimality crite? non can be determined by the designed target microstructures and random errors. The developed strategy is resolved using the PSO algorithm, which is an intelligent optimal algorithm. This algorithm does not need a derivable objective function, which renders it suitable for dealing with the complex hot forging process of alloy components. The optimal processing parameters (deformation temperature and strain rate) are obtained by the developed strategy and validated by the hot forging experiments. Uniform and fine target microstructures can be obtained using the optimized processing parameters, which indicates that the developed strategy is effective for controlling the microstructural evolution during the hot forging of the studied superalloy.展开更多
The genus Girardia （Tricladida： Dugesiidae） was recorded in China for the first time. A new freshwater turbellarian species, G. sinensis Chen ＆ Wang, sp. nov., is described, which was collected from Xinghu Lake, Z...The genus Girardia （Tricladida： Dugesiidae） was recorded in China for the first time. A new freshwater turbellarian species, G. sinensis Chen ＆ Wang, sp. nov., is described, which was collected from Xinghu Lake, Zhaoqing, Guangdong Province, China. Observation and analysis of the new species was conducted on morphology, habits, reproduction, histochemistry and molecular phylogenetics. In addition, the results indicated that morphological differences of AChE^＋ nerve structure can be used as a distinguishable character for species identification of Dugesiidae.展开更多
In this paper,we derive a generalized nonisospectral semi-infinite Lotka-Volterra equation,which possesses a determinant solution.We also give its a Lax pair expressed in terms of symmetric orthogonal polynomials.In a...In this paper,we derive a generalized nonisospectral semi-infinite Lotka-Volterra equation,which possesses a determinant solution.We also give its a Lax pair expressed in terms of symmetric orthogonal polynomials.In addition,if the simplified case of the moment evolution relation is considered,that is,without the convolution term,we also give a generalized nonisospectral finite Lotka-Volterra equation with an explicit determinant solution.Finally,an application of the generalized nonisospectral continuous-time Lotka-Volterra equation in the food chain is investigated by numerical simulation.Our approach is mainly based on Hirota’s bilinear method and determinant techniques.展开更多
基金funded by grants from National Natural Science Foundation of China(81100141 and 81570322 for JJ,81320108003 for JW)jointly supported by Boston Scientific
文摘BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute STEMI.METHODS: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset <12 hours undergoing manual thrombus aspiration and Promus Element stent implantation.Patients were randomly assigned to control group(n=20) or post-dilatation group(n=21) in which a non-compliant balloon was inflated to >16 atm pressure.Strut apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month follow-up.The primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after pPCI.RESULTS: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation vs.control group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, P<0.0001), the primary study endpoint, with similar strut coverage(98.5% vs.98.4%, P=0.63) and 1-year rate of major adverse cardiovascular events(MACE).CONCLUSION: In STEMI patients, post-dilatation after stent implantation and thrombus aspiration improved strut apposition up to 7 months without affecting coronary blood flow or 1-year MACE rate.Larger and longer term studies are warranted to further assess safety(Clinical Trials.gov identifier: NCT02121223).
文摘The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.
基金Supported by a grant from Desert Foundation (2003),Salt Lake City,USA
文摘Objective To investigate the levels of cardiovascular disease risk factors and their relations to clinical phenotype associated with coronary artery disease(CAD).Methods The subjects were recruited from five independent cardiovascular centers.Coronary angiography was employed to define the CAD with stenosis in each major vessel ≥70% and control with stenosis <10% in every lesion.The classic risk factors including family history,body mass index,smoking habits,hypertension,diabetes mellitus,and serum lipid levels were surveyed according to established criteria.Associations between risk levels and clinical phenotypes were assessed by case control and correlation analysis.Results A total of 762 individuals were collected,including 481 men and 281 women,aged from 17 to 81(mean 60±10) years.The patients with CAD accounted for 55.5% of all participants,and controls 44.5%,respectively.Compared with the pattern in published data,our study showed that mean serum high density lipoprotein cholesterol(HDL-C) level was significantly lower(P<0.001) and triglycerides was significantly higher(P<0.001),while total cholesterol(TC) and low density lipoprotein cholesterol levels were comparative(both P>0.05).The prevalence of low HDL-C(<40 g/L) and hypertriglyceridemia(>150 g/L) were 27.2% and 41.4%,respectively.Mean serum levels of HDL-C and apolipoprotein A1 were significantly higher in female subjects than in male(P<0.001).Lower HDL-C functioned as an independent risk factor for CAD only in men(RR=2.8,95%CI:1.5-4.2,P<0.001),yet increased non-HDL cholesterol combined with diabetes mellitus and obesity seemed to play a key role in the development ofCAD in women.Similarity in risk association with CAD was found for hypertension and TC/HDL ratio in male and female subjects,while family history had no relationship with the presence of CAD.Conclusion It is remarkable that emphasis of intervention in future should be given on the prevalent low serum HDL-C and its strong risk correlation with the presence of CAD in male subjects of Chinese Han population.
文摘BACKGROUND Liver abscess is a common clinical liver disease mainly caused by suppurative bacteria or amoebae,with early clinical signs of chills,high fever,jaundice,and other symptoms.Establishing its early diagnosis is difficult,which may lead to misdiagnosis.AIM To observe the effects of psychological guidance combined with evidence-based health intervention in patients with liver abscess treated with ultrasound.METHODS A total of 120 patients with bacterial liver abscess admitted to our hospital from May 2018 to February 2021 were selected and divided into groups according to their intervention plan.RESULTS After the intervention,Self-Rating Depression Scale,Self-Rating Anxiety Scale,Self-Perceived Burden Scale(SPBS),and quality of life scores(physical functioning,role physical,bodily pain,general health,vitality,social functioning,role emotional,mental health)were lower than before the intervention in the two groups.The observation group had lower negative sentiment,SPBS,and quality of life scores than the control group.In the observation group,31 and 24 patients had good and general compliance,respectively,with a compliance rate of 91.67%,which was significantly higher than that in the control group.The observation group had significantly lower total incidence of incision infection,abdominal abscess,hemorrhage,and severe abdominal pain than the control group.CONCLUSION Three-dimensional psychological guidance combined with evidence-based health intervention in treating liver abscess can reduce patients’burden and negative emotions,improve patient compliance and quality of life,and reduce complications.
基金Supported by National Natural Science Foundation of China(No.81270993)National Major Scientific Equipment Program(No.2012YQ12008005)the Specialized Research Fund for the Doctoral Program of Higher Education(No.20130181110079)
文摘AIM：To detect early glaucoma by optical coherence tomography（OCT） posterior pole asymmetry analysis.METHODS：Totally 39 eyes from 39 healthy subjects,40 eyes from 40 mild glaucoma patients,33 eyes from 33 moderate glaucoma patients and 41 eyes from severe glaucoma patients were included in this study.All subjects underwent posterior pole asymmetry analysis（PPAA） of OCT and the posterior pole area was divided into three zones.Means,standard deviations and 95% confidence intervals of each zone asymmetry in control group were assessed.Retina thickness asymmetry（RTA） of different stage of glaucoma were compared for each zone,and receiver operating characteristic（ROC） curves were made to test the efficacy of strategies using different zones to discriminate glaucomatous eyes from the healthy ones.RESULTS：In a healthy population,RTA of the centre zone showed the minimal mean value（3.085 μm）,standard deviation（1.756）,and the narrowest 95% confidence interval（from 2.360 to 3.810 μm）.It was only in the center zone that RTA exhibited significant difference between control and moderate glaucoma group（P〈0.01）,as well as control and severe glaucoma group（P〈0.00001）.The strategy utilized in the center zone had the strongest diagnostic capability（zone 3 AUROC=0.816,P=0.0016） in comparison to that of the periphery area（zone 1 AUROC=0.675,P=0.0016;zone 2 AUROC=0.623,P=0.0197）,the whole posterior pole involved interpreting strategy showed inferior diagnostic power than the centre zone dependent strategy（z=2.851,P=0.0044）.CONCLUSION：Utilizing the posterior pole centre zone to interpret OCT PPAA results are more effective than making use of the whole posterior pole map.
基金supported by University Student Innovation Project of Guangdong Province,China(2014 10590027)the National Natural Science Foundation of China(41176106)+3 种基金Guangdong Natural Science Foundation for Major cultivation project(2014A030308017)Shenzhen Grant Plan for Science&Technology(JCYJ20120613112512654,JSGG20130411160539208)Shenzhen special funds for Bio-industry development(NYSW20140327010012)the Youth Innovation Fund of China:Xiaoping Technological Innovation Team Project
文摘A new freshwater turbellarian species, Dugesia sinensis Chen ＆ Wang, sp. nov., is described, which was collected from Caoxi rivulet, Shaoguan, Guandong Province, China. The morphology, reproduction, histochemical localization of AChE and phylogenetics based on COI gene of the new species was observed and analysed. The new species differs from its sister species in the developed diagram of the male atrium, the bursal canal to the left of the copulatory apparatus and distance （1 mm） between copulatory bursa and the mouth. In addition, the results indicated that morphological differences of ACHE＋ nerve structure can be used as a distinguishable character for species identification of genera Dugesiidae.
基金the National Natural Science Foundation of China (Grant No. 51775564)the Natural Science Foundation for Distinguished Young Scholars of Hunan Province (Grant No. 2016JJ1017).
文摘In this study, a strategy based on the particle swarm optimization (PSO) algorithm is developed to control the microstructures of a Ni-based superalloy during hot forging. This strategy is composed of three parts, namely, material models, optimality criterions, and a PSO algo rithm. The material models are utilized to predict microstructure information, such as recrystallization volume fraction and average grain size. The optimality crite? non can be determined by the designed target microstructures and random errors. The developed strategy is resolved using the PSO algorithm, which is an intelligent optimal algorithm. This algorithm does not need a derivable objective function, which renders it suitable for dealing with the complex hot forging process of alloy components. The optimal processing parameters (deformation temperature and strain rate) are obtained by the developed strategy and validated by the hot forging experiments. Uniform and fine target microstructures can be obtained using the optimized processing parameters, which indicates that the developed strategy is effective for controlling the microstructural evolution during the hot forging of the studied superalloy.
基金supported by the National Natural Science Foundation of China(41176106)Guangdong Natural Science Foundation for Major cultivation project(2014A030308017)+3 种基金Shenzhen Grant Plan for Science & Technology(JCYJ20120613112512654,JSGG20130411160539208)Shenzhen special funds for Bio-industry development(NYSW20140327010012)University Student Innovation Project of Guangdong Province,China(201410590027)the Youth Innovation Fund of China:Xiaoping Technological Innovation Team Project
文摘The genus Girardia （Tricladida： Dugesiidae） was recorded in China for the first time. A new freshwater turbellarian species, G. sinensis Chen ＆ Wang, sp. nov., is described, which was collected from Xinghu Lake, Zhaoqing, Guangdong Province, China. Observation and analysis of the new species was conducted on morphology, habits, reproduction, histochemistry and molecular phylogenetics. In addition, the results indicated that morphological differences of AChE^＋ nerve structure can be used as a distinguishable character for species identification of Dugesiidae.
基金supported by R&D Program of Beijing Municipal Education Commission (Grant No. KM202310005012)National Natural Science Foundation of China (Grant Nos. 11901022 and 12171461)+1 种基金Beijing Municipal Natural Science Foundation (Grant Nos. 1204027 and 1212007)supported in part by the National Natural Science Foundation of China (Grant Nos. 11931017 and 12071447)
文摘In this paper,we derive a generalized nonisospectral semi-infinite Lotka-Volterra equation,which possesses a determinant solution.We also give its a Lax pair expressed in terms of symmetric orthogonal polynomials.In addition,if the simplified case of the moment evolution relation is considered,that is,without the convolution term,we also give a generalized nonisospectral finite Lotka-Volterra equation with an explicit determinant solution.Finally,an application of the generalized nonisospectral continuous-time Lotka-Volterra equation in the food chain is investigated by numerical simulation.Our approach is mainly based on Hirota’s bilinear method and determinant techniques.
