BACKGROUND Minute gastric cancers(MGCs)have a favorable prognosis,but they are too small to be detected by endoscopy,with a maximum diameter≤5 mm.AIM To explore endoscopic detection and diagnostic strategies for MGCs...BACKGROUND Minute gastric cancers(MGCs)have a favorable prognosis,but they are too small to be detected by endoscopy,with a maximum diameter≤5 mm.AIM To explore endoscopic detection and diagnostic strategies for MGCs.METHODS This was a real-world observational study.The endoscopic and clinicopathological parameters of 191 MGCs between January 2015 and December 2022 were retrospectively analyzed.Endoscopic discoverable opportunity and typical neoplastic features were emphatically reviewed.RESULTS All MGCs in our study were of a single pathological type,97.38%(186/191)of which were differentiated-type tumors.White light endoscopy(WLE)detected 84.29%(161/191)of MGCs,and the most common morphology of MGCs found by WLE was protruding.Narrow-band imaging(NBI)secondary observation detected 14.14%(27/191)of MGCs,and the most common morphology of MGCs found by NBI was flat.Another three MGCs were detected by indigo carmine third observation.If a well-demarcated border lesion exhibited a typical neoplastic color,such as yellowish-red or whitish under WLE and brownish under NBI,MGCs should be diagnosed.The proportion with high diagnostic confidence by magnifying endoscopy with NBI(ME-NBI)was significantly higher than the proportion with low diagnostic confidence and the only visible groups(94.19%>56.92%>32.50%,P<0.001).CONCLUSION WLE combined with NBI and indigo carmine are helpful for detection of MGCs.A clear demarcation line combined with a typical neoplastic color using nonmagnifying observation is sufficient for diagnosis of MGCs.MENBI improves the endoscopic diagnostic confidence of MGCs.展开更多
To clarify the antibacterial behavior at early adhesion,two titania nanotube(TNT)arrays were fabricated on polished commercially pure titanium(Ti),and the interaction mechanisms between TNT arrays and the model bacter...To clarify the antibacterial behavior at early adhesion,two titania nanotube(TNT)arrays were fabricated on polished commercially pure titanium(Ti),and the interaction mechanisms between TNT arrays and the model bacteria(Escherichia coli,E.coli)were investigated.The results show that TNT arrays exhibit a significant early antibacterial effect,which is highly related to the surface free energy and nano-topography.The underlying antibacterial mechanisms include:(1)the anti-initial-attachment effect at the lag phase(0−4 h);(2)the anti-proliferation and physical bactericidal effects at the logarithmic phase(4−12 h);(3)the reduced antimicrobial properties probably due to the overgrowth of bacteria on TNT arrays at the stationary phase(12 h and then).展开更多
Aim:To describe the global pattern and trend of liver cancer survival,using data from the population-based studies or cancer registration.Methods:By searching CNKI,Wanfang Data,PubMed,Web of Science,EMBASE and SEER.Al...Aim:To describe the global pattern and trend of liver cancer survival,using data from the population-based studies or cancer registration.Methods:By searching CNKI,Wanfang Data,PubMed,Web of Science,EMBASE and SEER.All population-based survival studies of liver cancer from 1 January 2000 to 30 April 2020 were collected and evaluated by patient gender,time period,and country.The overall or age-standardized five-year relative survival rate was used to describe the pattern and changes in liver cancer survival over the past decades.Results:Globally,the highest age-standardized five-year relative survival rate was observed in Italy(18.0%,2005-2007)and the highest overall five-year relative survival rate was observed in Korea(34.6%,2012-2016),when compared to other countries.The most remarkable increase in overall five-year relative survival rate can be seen in Korea(from 10.7%during 1993-1995 to 34.6%during 2012-2016).In general,worldwide,the five-year relative survival rate of younger patients with liver cancer was higher than old people.For most countries,the five-year relative survival rate of liver cancer was slightly higher in women than in men.In China,the overall five-year relative survival rate of liver cancer in Taiwan was higher than that in other areas,while Cixian of Hebei and Qidong of Jiangsu were lower.Conclusion:Over the past decades,the survival rates of liver cancer have gradually improved,but great variations are also observed globally.Worldwide,younger patients with liver cancer have experienced a better prognosis.Gender disparity in liver cancer survival was not obvious.展开更多
基金Supported by the National Science Foundation Committee of China,No 81372348and Clinical Research Fund Project of Zhejiang Medical Association,No 2020ZYC-A10.
文摘BACKGROUND Minute gastric cancers(MGCs)have a favorable prognosis,but they are too small to be detected by endoscopy,with a maximum diameter≤5 mm.AIM To explore endoscopic detection and diagnostic strategies for MGCs.METHODS This was a real-world observational study.The endoscopic and clinicopathological parameters of 191 MGCs between January 2015 and December 2022 were retrospectively analyzed.Endoscopic discoverable opportunity and typical neoplastic features were emphatically reviewed.RESULTS All MGCs in our study were of a single pathological type,97.38%(186/191)of which were differentiated-type tumors.White light endoscopy(WLE)detected 84.29%(161/191)of MGCs,and the most common morphology of MGCs found by WLE was protruding.Narrow-band imaging(NBI)secondary observation detected 14.14%(27/191)of MGCs,and the most common morphology of MGCs found by NBI was flat.Another three MGCs were detected by indigo carmine third observation.If a well-demarcated border lesion exhibited a typical neoplastic color,such as yellowish-red or whitish under WLE and brownish under NBI,MGCs should be diagnosed.The proportion with high diagnostic confidence by magnifying endoscopy with NBI(ME-NBI)was significantly higher than the proportion with low diagnostic confidence and the only visible groups(94.19%>56.92%>32.50%,P<0.001).CONCLUSION WLE combined with NBI and indigo carmine are helpful for detection of MGCs.A clear demarcation line combined with a typical neoplastic color using nonmagnifying observation is sufficient for diagnosis of MGCs.MENBI improves the endoscopic diagnostic confidence of MGCs.
基金financially supported by the National Natural Science Foundation of China(No.52171114)the Innovation-oriented Advanced Technology and Industrial Technology Program Project of Hunan Province,China(No.2020SK2017)。
基金The authors are grateful for the financial supports from the National Natural Science Foundation of China(Nos.51604104,52171114,81702709)the Innovation-oriented Advanced Technology and Industrial Technology Program Project of Hunan Province,China(No.2020SK2017)+2 种基金the Central South University Postgraduate Education and Teaching Reform Project,China(No.2020JGB116)the Natural Science Foundation of Hunan Province,China(No.2020JJ4459)the Fundamental Research Funds for the Central Universities of Central South University,China(No.CX20200267).
文摘To clarify the antibacterial behavior at early adhesion,two titania nanotube(TNT)arrays were fabricated on polished commercially pure titanium(Ti),and the interaction mechanisms between TNT arrays and the model bacteria(Escherichia coli,E.coli)were investigated.The results show that TNT arrays exhibit a significant early antibacterial effect,which is highly related to the surface free energy and nano-topography.The underlying antibacterial mechanisms include:(1)the anti-initial-attachment effect at the lag phase(0−4 h);(2)the anti-proliferation and physical bactericidal effects at the logarithmic phase(4−12 h);(3)the reduced antimicrobial properties probably due to the overgrowth of bacteria on TNT arrays at the stationary phase(12 h and then).
基金supported by the National Key Project of Research and Development Program of China(No.2016YFC1302503)the National Key Basic Research Program of China“973 Program”(No.2015CB554000)the State Key Project Specialized for Infectious Diseases of China(No.2008ZX10002-015 and No.2012ZX10002008-002).
文摘Aim:To describe the global pattern and trend of liver cancer survival,using data from the population-based studies or cancer registration.Methods:By searching CNKI,Wanfang Data,PubMed,Web of Science,EMBASE and SEER.All population-based survival studies of liver cancer from 1 January 2000 to 30 April 2020 were collected and evaluated by patient gender,time period,and country.The overall or age-standardized five-year relative survival rate was used to describe the pattern and changes in liver cancer survival over the past decades.Results:Globally,the highest age-standardized five-year relative survival rate was observed in Italy(18.0%,2005-2007)and the highest overall five-year relative survival rate was observed in Korea(34.6%,2012-2016),when compared to other countries.The most remarkable increase in overall five-year relative survival rate can be seen in Korea(from 10.7%during 1993-1995 to 34.6%during 2012-2016).In general,worldwide,the five-year relative survival rate of younger patients with liver cancer was higher than old people.For most countries,the five-year relative survival rate of liver cancer was slightly higher in women than in men.In China,the overall five-year relative survival rate of liver cancer in Taiwan was higher than that in other areas,while Cixian of Hebei and Qidong of Jiangsu were lower.Conclusion:Over the past decades,the survival rates of liver cancer have gradually improved,but great variations are also observed globally.Worldwide,younger patients with liver cancer have experienced a better prognosis.Gender disparity in liver cancer survival was not obvious.
